R. Wrigglesworth

发表

Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.

A. Doherty, C. Burnouf, E. Auclair, 2000, Journal of medicinal chemistry.

Quality of life for renal transplant recipients of organs from non-heart-beating donors, heart-beating cadaveric donors, and living-related donors.

R. Wrigglesworth, M. Metcalfe, S. White, 2001, Transplantation proceedings.

NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro.

R. Wrigglesworth, A. Dray, J. Bettaney, 1990, European journal of pharmacology.

Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.

S. Bevan, R. Wrigglesworth, J. Winter, 1996, Journal of medicinal chemistry.

Efficient synthesis of thiazoloquinazolinone derivatives

R. Wrigglesworth, T. Besson, F. Alexandre, 2003 .

Bradyzide, a potent non‐peptide B2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia

P. McIntyre, R. Wrigglesworth, C. Snell, 2000, British journal of pharmacology.

A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay.

R. Wrigglesworth, P. Weston, R. J. Duncan, 1983, Analytical biochemistry.

Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.

R. Wrigglesworth, C. Snell, J. Wood, 2001, Bioorganic & medicinal chemistry letters.

Thiophene and bioisostere derivatives as new MMP12 inhibitors.

R. Wrigglesworth, S. Blais, A. Dublanchet, 2011, Bioorganic & medicinal chemistry letters.

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.

P. Soulard, P. Berna, B. Bertin, 2004, Bioorganic & medicinal chemistry letters.

Long-lasting agonist activity produced by a capsaicin-like photoaffinity probe.

J. Hixon, R. Wrigglesworth, J. Wood, 1988, Molecular pharmacology.

Conjugation of enzymes to immunoglobulins using dimaleimides.

R. Wrigglesworth, P. Weston, J. Devries, 1980, Biochimica et biophysica acta.

Synthesis of novel 1,3,4-benzotriazepine derivatives from 4-oxo-3,1-benzoxazine and 3,1-benzothiazine-2-carbonitriles

R. Wrigglesworth, J. Leger, V. Thiéry, 2005 .

Regiocontrolled synthesis of furans by a mercury(II) catalysed isomerisation of 1-alkynyl-2,3-epoxyalcohols

S. Harper, R. Wrigglesworth, C. Marson, 1994 .

Facile rearrangement of 5-carbomethoxymethyl-2-cyanoiminoimidazolones. Synthesis of 6-carboxyhexahydropyridimines, potential dihydroorotate dehydrogenase inhibitors

R. Wrigglesworth, P. Garratt, S. Thorn, 1992 .

One-carbon compounds as synthetic intermediates. The synthesis of hydropyrimidines and hydroquinazolines by sequential nucleophilic addition to diphenyl cyanocarbonimidate with concomitant cyclization

R. Wrigglesworth, P. Garratt, C. J. Hobbs, 1989 .

Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

C. Durand, V. Fasquelle, H. Jacobelli, 2011 .

Synthesis of 1,2,4-triazoles and 1,2,4,6-tetraazabicyclo[3.3.0]octanes from diphenyl cyanocarbonimidate. Competition between addition of hydrazines to esters or nitriles

R. Wrigglesworth, P. Garratt, S. Thorn, 1993 .

Novel series of 8H-quinazolino[4,3-b]quinazolin-8-ones via two Niementowski condensations

R. Wrigglesworth, T. Besson, F. Alexandre, 2003 .

Specific enzyme inhibitors in vitamin biosynthesis. Part 6. Identification of an affinity chromatography ligand for the purification of riboflavin synthase

R. Wrigglesworth, C. Suckling, H. Wood, 1984 .

Synthesis of 2-amino-4H-3,1-benzoxazines from diphenyl cyanocarbonimidate. Facile replacement of the N-cyanoimine function by nitrogen nucleophiles

R. Wrigglesworth, P. Garratt, C. J. Hobbs, 1989 .

Resolution of trans -3-aminocyclohexanol

R. Wrigglesworth, E. Lorthiois, A. Manage, 2004 .

New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors.

C. Durand, V. Fasquelle, H. Jacobelli, 2004, Bioorganic & medicinal chemistry letters.

Efficient routes to cyclic 2,3-epoxyalcohols from cycloalkenyl ketones, via cycloalkenyl alcohols

S. Harper, R. Wrigglesworth, C. Marson, 1993 .

Stereoselective construction of quaternary centers at ambient temperature by the highly stereocontrolled migration of groups containing sp-, sp2-, and sp3-hybridized carbon atoms

A. Hobson, R. Wrigglesworth, C. Marson, 1993 .

STEREOISOMERISM IN N-CYANO-O-PHENYLISOUREAS AND RELATED COMPOUNDS

R. Wrigglesworth, P. Garratt, S. Thorn, 1995 .

Lewis acid mediated reactions of 2,3-epoxyalcohols: an efficient stereocontrolled route to polycyclic diols

S. Harper, R. Wrigglesworth, C. Marson, 1993 .

Stereoselective Construction of Quaternary Centers at Ambient Temperature by the Highly Stereocontrolled Migration of Groups Containing sp‐, sp2‐, and sp3‐Hybridized Carbon Atoms.

A. Hobson, R. Wrigglesworth, C. Marson, 1994 .

Regioselective and enantiospecific synthesis of 6-substituted and 5,6-disubstituted hexahydropyrimidines

R. Wrigglesworth, P. Garratt, S. Thorn, 1991 .

Ring size preference in the intramolecular cyclisation of amines with esters. Synthesis of aminoacid derived hexahydropyrimidines and tetrahydroimidazoles

R. Wrigglesworth, P. Garratt, C. J. Hobbs, 1990 .

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region".

S. Bevan, R. Wrigglesworth, J. Winter, 1993, Journal of medicinal chemistry.

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".

S. Bevan, R. Wrigglesworth, J. Winter, 1993, Journal of medicinal chemistry.

Latent inhibitors. Part 2. Allylic inhibitors of alcohol dehydrogenase

R. Wrigglesworth, C. Suckling, I. Macinnes, 1981 .

Inhibition of carboxypeptidase by cyclopropane-containing peptides

R. Wrigglesworth, C. Suckling, A. Bell, 1987 .

Latent inhibitors. Part 3. The inhibition of lactate dehydrogenase and alcohol dehydrogenase by cyclopropane-containing compounds

R. Wrigglesworth, S. Orszulik, C. Suckling, 1984 .

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region".

S. Bevan, R. Wrigglesworth, A. Dray, 1993, Journal of medicinal chemistry.

A chemiluminescent Schiff's base: a possible mechanism for Latia and bacterial bioluminescence

R. Wrigglesworth, F. McCapra, 1969 .

Specific enzyme inhibitors in vitamin biosynthesis. Part 3. The synthesis and inhibitory properties of some substrates and transition state analogues of riboflavin synthase

R. Ferone, R. Wrigglesworth, C. Suckling, 1980 .

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.

P. Soulard, P. Berna, B. Bertin, 2004, Bioorganic & medicinal chemistry letters.

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.

P. Berna, R. Wrigglesworth, P. Ducrot, 2004, Bioorganic & medicinal chemistry letters.

Purification of riboflavin synthase by affinity chromatography using 7-oxolumazines

R. Wrigglesworth, C. Ginger, H. Wood, 1975 .

Specific enzyme inhibitors in vitamin biosynthesis. II. Revised structures for some 8-substituted pyrido(2,3-d)pyrimidines.

R. Wrigglesworth, D. Yeowell, H. Wood, 1974, Journal of the Chemical Society. Perkin transactions 1.

SPECIFIC ENZYME INHIBITORS IN VITAMIN BIOSYNTHESIS. PART 3. THE SYNTHESIS AND D INHIBITORY PROPERTIES OF SOME SUBSTRATES AND TRANSITION STATE ANALOGS OF RIBOFLAVIN SYNTHASE

R. Ferone, R. Wrigglesworth, C. Suckling, 1981 .

CAPSAICIN-LIKE AGONISTS

R. Wrigglesworth, C. Walpole, 1998 .

CoMFA and CoMSIA 3D-quantitative structure-activity relationship model on benzodiazepine derivatives, inhibitors of phosphodiesterase IV

Pierre Ducrot, Charles R. Andrianjara, Roger Wrigglesworth, 2001, J. Comput. Aided Mol. Des..

Synthesis and reactions of 2,3-dihydro-oxazolo[2,3-a]isoindol-5(9bH)-ones

R. Wrigglesworth, C. Wharton, 1985 .

Pyrimidine biosynthesis in Plasmodium berghei.

R. Wrigglesworth, R. McIntosh, B. Hill, 1981, The International journal of biochemistry.

Latent inhibitors. Part 9. Substrate activated time-dependent inhibition of carboxypeptidase A by aminocyclopropanecarboxylic acid derivatives and analogues

R. Wrigglesworth, M. C. Tedford, C. Suckling, 1993 .