J. Randolph

发表

Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.

J. Greer, J. Randolph, Philip L. Waid, 2004, Journal of medicinal chemistry.

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.

D. Kempf, J. Randolph, W. Kati, 2008, Bioorganic & medicinal chemistry letters.

Desymmetrization of pibrentasvir for efficient prodrug synthesis†

J. Randolph, Jan E. Waters, E. Voight, 2021, Chemical science.

Chapter 12. Non-HIV antiviral agents

J. Randolph, L. L. Klein, 2001 .

An Interactive Strategy for the Assembly of Complex, Branched Oligosaccharide Domains on a Solid Support: A Concise Synthesis of the Lewisb Domain in Bioconjugatable Form

J. Randolph, S. Danishefsky, 1994 .

In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir

Liangjun Lu, T. Pilot‐Matias, J. Randolph, 2017, Antimicrobial Agents and Chemotherapy.

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.

K. Longenecker, A. C. Krueger, A. Molla, 2013, Bioorganic & medicinal chemistry letters.

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells.

J. Randolph, R. Kolesnick, W. Bornmann, 1994, The Journal of biological chemistry.

Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.

A. Molla, D. Kempf, H. Mo, 2006, Bioorganic & Medicinal Chemistry.

Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease.

P. Richardson, U. Warrior, J. Randolph, 2007, Analytical biochemistry.

Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen

J. Randolph, S. Danishefsky, M. Bilodeau, 1996 .

TOTAL SYNTHESIS OF A HUMAN BREAST TUMOR ASSOCIATED ANTIGEN

J. Randolph, S. Danishefsky, S. Zhang, 1995 .

Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.

Christian Goess, A. Hobson, S. Mathieu, 2022, Journal of medicinal chemistry.

Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.

A. Molla, J. Randolph, C. Flentge, 2012, Bioorganic & medicinal chemistry letters.

Pharmacokinetic Enhancement of the Hepatitis C Virus Protease Inhibitors VX-950 and SCH 503034 by Co-Dosing with Ritonavir

D. Kempf, J. Randolph, K. Marsh, 2007, Antiviral chemistry & chemotherapy.

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

A. C. Krueger, A. Molla, T. Pilot‐Matias, 2014, Journal of medicinal chemistry.

A strategy for the solid-phase synthesis of oligosaccharides.

J. Randolph, S. Danishefsky, K. McClure, 1993, Science.

First Synthesis of a Digitalis Saponin. Demonstration of the Scope and Limitations of a Convergent Scheme for Branched Oligosaccharide Synthesis by the Logic of Glycal Assembly

J. Randolph, S. Danishefsky, 1995 .

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

A. Molla, D. Kempf, J. Randolph, 2009, Journal of medicinal chemistry.

Oximinoarylsulfonamides as potent HIV protease inhibitors.

V. Stoll, D. Kempf, J. Randolph, 2005, Bioorganic & medicinal chemistry letters.

Desymmetrization of pibrentasvir for efficient prodrug synthesis†

J. Randolph, Jan E. Waters, E. Voight, 2021, Chemical science.

Application of the Glycal Assembly Method to the Concise Synthesis of Neoglycoconjugates of Ley and Leb Blood Group Determinants and of H-Type I and H-Type II Oligosaccharides

J. Randolph, S. Danishefsky, K. Lloyd, 1995 .

Peptidomimetic inhibitors of HIV protease.

J. Randolph, David A DeGoey, John T Randolph, 2004, Current topics in medicinal chemistry.

Major Simplifications in Oligosaccharide Syntheses Arising from a Solid-Phase Based Method: An Application to the Synthesis of the Lewis b Antigen

J. Randolph, S. Danishefsky, K. McClure, 1995 .

Application of the glycal assembly strategy to the synthesis of a branched oligosaccharide: the first synthesis of a complex saponin

J. Randolph, S. Danishefsky, 1993 .

Application of the Glycal Assembly Strategy to the Synthesis of a Branched Oligosaccharide: The First Synthesis of a Complex Saponin.

J. Randolph, S. Danishefsky, 1994 .

Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro

A. Molla, H. Mo, T. Pilot‐Matias, 2004, Antimicrobial Agents and Chemotherapy.

4 Pharmacokinetic boosting of VX-950, an inhibitor of HCV protease, by co-dosing with ritonavir

D. Kempf, J. Randolph, K. Marsh, 2006 .

Prodrug Strategies to Improve the Solubility of HCV NS5A Inhibitor Pibrentasvir (ABT-530).

Brice E. Uno, J. Randolph, Deanne F. Stolarik, 2020, Journal of medicinal chemistry.

Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A.

J. Greer, J. Randolph, D. Sauer, 2004, Bioorganic & Medicinal Chemistry Letters.

Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.

V. Stoll, S. Vasavanonda, D. Kempf, 2004, Bioorganic & medicinal chemistry letters.

Pharmacological and endocrine characterization of A‐198401, an orally active GnRH antagonist, in intact and castrate male rat models

J. Greer, J. Randolph, F. Haviv, 2001 .

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).

A. C. Krueger, T. Pilot‐Matias, J. Randolph, 2018, Journal of medicinal chemistry.

Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.

Eric B. Roesch, D. Corey, J. Randolph, 2010, Biochemistry.

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.

J. Randolph, Hui-ju Chen, Deanne F. Stolarik, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.

J. Randolph, R. Henry, Hui-ju Chen, 2019, Bioorganic & medicinal chemistry.

2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.

V. Stoll, A. Molla, D. Kempf, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.

D. Kempf, J. Randolph, K. Marsh, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.

Mikkel A. Algire, Chaohong Sun, J. Randolph, 2023, Journal of medicinal chemistry.

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

D. Corey, J. Randolph, C. Bennett, 2011, Biological chemistry.

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia

J. Waring, D. Kempf, J. Randolph, 2010, Archives of Toxicology.

HCV NS5A as an Antiviral Therapeutic Target: From Validation to the Discovery and Development of Ombitasvir and Pibrentasvir as Components of IFN-Sparing HCV Curative Treatments

J. Randolph, W. Kati, R. Wagner, 2019, Topics in Medicinal Chemistry.

Discovery of fluorobenzimidazole HCV NS5A inhibitors.

T. Pilot‐Matias, J. Randolph, D. Beno, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.

K. Longenecker, A. C. Krueger, A. Molla, 2018, Journal of medicinal chemistry.

Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.

Eric B. Roesch, D. Corey, J. Randolph, 2010, Biochemistry.

Practical Preclinical Model for Assessing the Potential for Unconjugated Hyperbilirubinemia Produced by Human Immunodeficiency Virus Protease Inhibitors

J. Waring, D. Kempf, J. Randolph, 2006, Antimicrobial Agents and Chemotherapy.