J. Segreti

发表

Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.

J. Greer, J. Randolph, Philip L. Waid, 2004, Journal of medicinal chemistry.

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

J. Segreti, S. Baker, Robert G. Schmidt, 2011, PAIN.

Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2004, Cancer Chemotherapy and Pharmacology.

TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

A. Gomtsyan, J. Segreti, Robert G. Schmidt, 2015, Temperature.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats

M. Nakane, J. Segreti, J. R. Wu-wong, 2010, International journal of endocrinology.

Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster

A. Souers, J. Segreti, A. King, 2009, Journal of Pharmacology and Experimental Therapeutics.

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

A. Souers, J. Segreti, A. King, 2010, European journal of pharmacology.

Evoked Changes in Cardiovascular Function in Rats by Infusion of Levosimendan, OR-1896 [(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], Dobutamine, and Milrinone: Comparative Effects on Peripheral R

J. Segreti, R. Fryer, K. Marsh, 2008, Journal of Pharmacology and Experimental Therapeutics.

Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema

J. Segreti, R. Fryer, J. Trevillyan, 2008, British journal of pharmacology.

Dobutamine , and Milrinone : Comparative Effects on Peripheral Resistance , Cardiac Output , dP / dt , Pulse Rate , and Blood Pressure

J. Segreti, R. Fryer, K. Marsh, 2008 .

ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

S. Davidsen, G. Gintant, J. Segreti, 2009, Journal of cardiovascular pharmacology.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

K. Longenecker, J. Segreti, H. Sham, 2006, Journal of medicinal chemistry.

Effect of novel motilide ABT-229 versus erythromycin and cisapride on gastric emptying in dogs.

T. Seifert, L. Besecke, J. Segreti, 2000, The Journal of pharmacology and experimental therapeutics.

Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats

D. B. Duignan, G. Gintant, J. Segreti, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.

A. Gomtsyan, Jill M. Wetter, J. Segreti, 2006, Bioorganic & Medicinal Chemistry.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Tumour‐selective antivascular effects of the novel anti‐mitotic compound A‐318315: An in vivo rat regional haemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2010, Clinical and experimental pharmacology & physiology.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

Defect in Interleukin-1β Secretion Prevents Sickness Behavior in C3H/HeJ Mice

R. Dantzer, J. Segreti, G. Gheusi, 1997, Physiology & Behavior.

Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition

S. Davidsen, G. Gintant, J. Segreti, 2009, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological and endocrine characterization of A‐198401, an orally active GnRH antagonist, in intact and castrate male rat models

J. Greer, J. Randolph, F. Haviv, 2001 .

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.

J. Segreti, K. Marsh, J. J. Lynch, 2019, Journal of pharmacological and toxicological methods.

Evaluation of tissue perfusion in a rat model of hind‐limb muscle ischemia using dynamic contrast‐enhanced magnetic resonance imaging

J. Segreti, Yanping Luo, V. Hradil, 2002, Journal of magnetic resonance imaging : JMRI.

Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

J. Segreti, J. Brioni, R. Moreland, 2004, Clinical and experimental pharmacology & physiology.

Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic and Normal Rats: Focus on Central versus Peripheral Control of Vascular Tone and Blood Pressure by Cinacalcet

M. Nakane, J. Segreti, R. Fryer, 2007, Journal of Pharmacology and Experimental Therapeutics.

Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats

J. Segreti, R. Fryer, C. Faltynek, 2009, Brain Research.

Simultaneous measurement of arterial and left ventricular pressure in conscious freely moving rats by telemetry.

J. Segreti, A. King, E. Blomme, 2011, Journal of pharmacological and toxicological methods.

Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.

J. Segreti, M. Brand, T. Vortherms, 2023, Free radical biology & medicine.

Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.

Ju Gao, Anil Vasudevan, John K Lynch, 2006, Journal of medicinal chemistry.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of medicinal chemistry.