C. Wegner

发表

Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.

J. Greer, J. Randolph, Philip L. Waid, 2004, Journal of medicinal chemistry.

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Paul Morgan, J. Arrowsmith, P. H. van der Graaf, 2012, Drug discovery today.

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Jonathan B. Mitchem, S. Hewitt, C. Wegner, 2013, Cancer research.

Role of intercellular adhesion molecule-1 in the inflammatory response.

R. Rothlein, C. Wegner, 1992, Kidney international.

Incidence of recall, nightmares, and hallucinations during analgosedation in intensive care

C. Wegner, K. Schnabel, I. Rundshagen, 2001, Intensive Care Medicine.

A PAF receptor antagonist inhibits acute airway inflammation and late-phase responses but not chronic airway inflammation and hyperresponsiveness in a primate model of asthma

C. Wegner, H. Heuer, L. Letts, 1992, Mediators of inflammation.

Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion

J. Crapo, C. Wegner, B. Cox, 2003, Journal of cardiovascular pharmacology.

Intercellular adhesion molecule-1 expression on the alveolar epithelium and its modification by hyperoxia.

J. Crapo, C. Wegner, L. Chang, 1993, American journal of respiratory cell and molecular biology.

Hypertension induced by blockade of ET(B) receptors in conscious nonhuman primates: role of ET(A) receptors.

C. Wegner, B. Cox, G. Reinhart, 2002, American journal of physiology. Heart and circulatory physiology.

Evidence for vasoconstriction mediated by the endothelin-B receptor in domestic swine.

C. Wegner, B. Cox, S. Burke, 2000, Journal of cardiovascular pharmacology.

P2 Receptors in the Respiratory System

C. Wegner, 2001 .

Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.

R. Rothlein, C. Wegner, L. Letts, 1990, Science.

3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.

Xiaoping Zhou, U. Warrior, C. Wegner, 2000, Journal of medicinal chemistry.

Selective antagonism of the ET(A) receptor reduces neointimal hyperplasia after balloon-induced vascular injury in pigs.

C. Wegner, B. Dayton, J. Wessale, 1997, Journal of cardiovascular pharmacology.

Profile of Recombinant Pro-urokinase Given by Intraarterial versus Intravenous Routes of Administration in a Canine Thrombosis Model

C. Wegner, B. Cox, S. Burke, 1999, Thrombosis and Haemostasis.

The Role of Platelet Activating Factor in Airway Inflammation, Airway Hyperresponsiveness, and Pulmonary Function in Monkeys

C. Wegner, L. Letts, R. Gundel, 1991, Annals of the New York Academy of Sciences.

Inflammation and cell-cell interactions in airway hyperresponsiveness.

C. Wegner, K. Hamann, A. Leff, 1991, The American journal of physiology.

Antigen-coated sepharose beads induce airway eosinophilia and airway hyperresponsiveness in cynomolgus monkeys.

C. Wegner, M. Gerritsen, R. Gundel, 1989, The American review of respiratory disease.

Antigen-induced mediator release in primates.

C. Homon, C. Wegner, C. Torcellini, 1991, The American review of respiratory disease.

Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria

C. Wegner, S. Saini, K. Chichester, 2019, International Archives of Allergy and Immunology.

The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis.

S. Davidsen, C. Wegner, P. Tapang, 1998, The Journal of pharmacology and experimental therapeutics.

Adhesion molecules that regulate inflammatory cell interactions

C. Wegner, R. Wallace, 1993 .

Effects of single and multiple inhalations of platelet‐activating factor on airway cell composition and responsiveness in monkeys

C. Wegner, C. Torcellini, L. Letts, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The onset and recovery from airway hyperresponsiveness: relationship with inflammatory cell infiltrates and release of cytotoxic granule proteins

C. Wegner, L. Letts, R. Gundel, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Nonatopic asthma: in vivo airway hyperreactivity adoptively transferred to naive mice by THY-1(+) and B220(+) antigen-specific cells that lack surface expression of CD3.

C. Wegner, P. Askenase, G. Geba, 1997, The Journal of clinical investigation.

Pioneering government-sponsored drug repositioning collaborations: progress and learning

M. Pangalos, K. J. Escott, C. Wegner, 2015, Nature Reviews Drug Discovery.

Novel mechanistic targets for the treatment of sub-acute and chronic bronchitis.

C. Wegner, 2001, Current pharmaceutical design.

Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates.

C. Wegner, M. Gerritsen, G. Gleich, 1990, Journal of applied physiology.

The Role of Cellular Adhesion Molecules in Acute and Chronic Airway Inflammation

C. Wegner, L. Letts, R. Gundel, 1993 .

Adhesion molecules in acute and chronic lung inflammation.

C. Wegner, L. Letts, R. Gundel, 1993, Advances in experimental medicine and biology.

5-Lipoxygenase inhibition

C. Wegner, J. Masferrer, M. Graneto, 2010 .

Changes in T lymphocyte subsets and activation following chronic antigen inhalations in monkeys.

C. Wegner, R. Barton, C. Torcellini, 1993, Chest.

Polymyxin B-induced bronchial neutrophilia does not alter airway responsiveness to methacholine in cynomolgus monkeys.

C. Wegner, M. Gerritsen, R. Gundel, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

CD18 Dependence of Primate Eosinophil Adherence In Vitro

C. Smith, R. Rothlein, C. Wegner, 1990 .

BI-L-239, a 5-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs

C. Wegner, L. Letts, W. Wolyniec, 1991, Agents and Actions.

The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates.

C. Wegner, C. Torcellini, S. Desai, 1991, Advances in prostaglandin, thromboxane, and leukotriene research.

Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys.

R. Rothlein, C. Wegner, K. Pinkerton, 1999, The American journal of physiology.

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis

G. Gintant, C. Wegner, B. Cox, 2001, Journal of cardiovascular pharmacology.

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

D. Rohrer, C. Carron, C. Wegner, 2010, ACS medicinal chemistry letters.

Eosinophils and Late-Phase Reactions in Primates

C. Wegner, L. Letts, R. Gundel, 2019, Eosinophils in Allergy and Inflammation.

Endothelin and ET(A) receptors in long-term arterial pressure homeostasis in conscious nonhuman primates.

C. Wegner, B. Cox, G. Reinhart, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

Effect of novel motilide ABT-229 versus erythromycin and cisapride on gastric emptying in dogs.

T. Seifert, L. Besecke, J. Segreti, 2000, The Journal of pharmacology and experimental therapeutics.

Effect of antiseptic irrigation on infection rates of traumatic soft tissue wounds: a longitudinal cohort study.

A. Kramer, C. Wegner, O. Assadian, 2017, Journal of wound care.

Expression and probable roles of cell adhesion molecules in lung inflammation.

R. Rothlein, C. Wegner, L. Letts, 1992, Chest.

Effects of single and multiple inhalations of antigen on airway responsiveness in monkeys.

C. Wegner, C. Torcellini, L. Letts, 1991, The Journal of allergy and clinical immunology.

Adhesion molecules in a primate model of allergic asthma: clinical implications for respiratory care

C. Wegner, L. Letts, R. Gundel, 2004, Springer Seminars in Immunopathology.

Pharmacological and endocrine characterization of A‐198401, an orally active GnRH antagonist, in intact and castrate male rat models

J. Greer, J. Randolph, F. Haviv, 2001 .

Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys.

C. Smith, R. Rothlein, C. Wegner, 1991, The Journal of clinical investigation.

Intercellular Adhesion Molecules in the Pathogenesis of Airway Hyperresponsiveness

C. Wegner, L. Letts, Gundel Rh, 1993 .

Antigen-induced acute and late-phase responses in primates.

C. Wegner, L. Letts, R. Gundel, 1992, The American review of respiratory disease.

Models of pulmonary disease: acute and chronic allergic asthma in the monkey and acute and chronic viral pulmonitis in the mouse.

C. Wegner, T. Shaughnessy, D. Mussatto, 2001, Current protocols in pharmacology.

Contribution of specific cell-adhesive glycoproteins to airway and alveolar inflammation and dysfunction.

C. Wegner, L. Churchill, L. Letts, 1993, The American review of respiratory disease.

The role of intercellular adhesion molecule‐1 in chronic airway inflammation

C. Wegner, C. Torcellini, L. Letts, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: Role of leukocytes revised

R. Rothlein, C. Wegner, L. Letts, 2004, Lung.

Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy.

C. Wegner, D. Pollock, D M Pollock, 1997, Renal failure.

IMMUNOLOCALIZATION OF INHALED RECOMBINANT HUMAN MANGANESE SUPEROXIDE DISMUTASE REVEALS A PROLONGED RETENTION IN LUNG SURFACE LINING FLUIDS

J. Crapo, C. Wegner, Ling-Yi L Chang, 1995 .

Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral rapamycin.

C. Wegner, G. Hsieh, S. Burke, 1999, Journal of cardiovascular pharmacology.

Efficacy of monoclonal antibodies against adhesion molecules in animal models of asthma.

C. Wegner, L. Letts, R. Gundel, 1993, Agents and actions. Supplements.

Dynamic respiratory mechanics in monkeys measured by forced oscillations.

J. D. Berry, A. Jackson, C. Wegner, 1984, Respiration physiology.

Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes.

C. Wegner, B. Cox, J. Polakowski, 2002, European journal of pharmacology.

Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.

G. Diaz, C. Wegner, B. Cox, 2002, European journal of pharmacology.

Acute pulmonary response to cotton bract extract in monkeys: Lung function and effects of mediator modifying compounds

C. Wegner, T. Witek, M. Buck, 2007, Lung.

A method for determining whether hypotension caused by novel compounds in preclinical development results from histamine release.

C. Wegner, M. S. South, J. J. Parlow, 2004, Journal of pharmacological and toxicological methods.

The role of 5-lipoxygenase products in preclinical models of asthma.

C. Homon, C. Wegner, A. G. Graham, 1993, The Journal of allergy and clinical immunology.

Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys.

R. Rothlein, C. Wegner, K. Pinkerton, 1999, American journal of physiology. Lung cellular and molecular physiology.

Effect of Colchicine on Clostridium Difficile Infection Incidence, Recurrence, and Severity

P. Mills, C. Wegner, Y. Young-Xu, 2015 .