P. Dent

发表

Molecular mechanisms of radiation-induced accelerated repopulation.

R. Schmidt-Ullrich, J. Contessa, P. Dent, 1999, Radiation oncology investigations.

Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.

R. Schmidt-Ullrich, P. Dent, K. Valerie, 1999, Molecular biology of the cell.

Autocrine loops with positive feedback enable context-dependent cell signaling.

D. Lauffenburger, S. Shvartsman, H. Wiley, 2002, American journal of physiology. Cell physiology.

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways1

R. Schmidt-Ullrich, J. Contessa, P. Dent, 2003, Radiation research.

Signal Transduction and Cellular Radiation Responses

Paul Dent, R. Schmidt-Ullrich, P. Dent, 2000, Radiation research.

oxidative stress and histone deacetylase inhibitors involves Akt down-regulation and Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME)

Xianglin Shi, P. Dent, S. Grant, 2013 .

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.

Xianglin Shi, P. Dent, S. Grant, 2006, Blood.

2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process

P. Dent, S. Grant, N. Gao, 2005, Oncogene.

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

D. Conrad, P. Dent, S. Grant, 2003, Cancer research.

Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.

Paul Dent, Chunrong Yu, P. Dent, 2002, Cancer research.

Flavopiridol Potentiates STI 571-induced Mitochondrial Damage and Apoptosis in BCR-ABL-positive Human Leukemia Cells 1

P. Dent, S. Grant, Chunrong Yu, 2002 .

The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.

P. Dent, S. Grant, L. Cartee, 2001, Cancer research.

The Cyclin-dependent Kinase Inhibitor ( CDKI ) Flavopiridol Disrupts Phorbol 12-Myristate 13-Acetate-induced Differentiation and CDKI Expression while Enhancing Apoptosis in Human Myeloid Leukemia Cells 1

P. Dent, S. Grant, L. Cartee, 2001 .

Differentiation therapy of human cancer: basic science and clinical applications.

P. Fisher, P. Dent, S. Grant, 2001, Pharmacology & therapeutics.

Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway*

P. Dent, S. Gupta, R. Stravitz, 2001, The Journal of Biological Chemistry.

Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase*

J. Hell, P. Dent, E. Maizels, 2003, The Journal of Biological Chemistry.

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.

P. Dent, T. Sturgill, M. Weber, 1993, Science.

Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.

A. Saunders, P. Dent, S. Grant, 1999, Biochemical pharmacology.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Anna C. Salzberg, Y. Rojanasakul, M. Kirsch‐Volders, 2015, Carcinogenesis.

The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts.

P. Dent, A. Yacoub, R. Loria, 2010, The international journal of biochemistry & cell biology.

Bile acids as regulatory molecules

P. Dent, P. Hylemon, S. Ren, 2009, Journal of Lipid Research.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.

P. Dent, S. Grant, M. Rahmani, 2004, Experimental cell research.

Expression of Human Papilloma Virus E7 Protein Causes Apoptosis and Inhibits DNA Synthesis in Primary Hepatocytes via Increased Expression of p21Cip-1/WAF1/MDA6 *

P. Fisher, P. Dent, G. Firestone, 2000, The Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Synergistic Interactions between Vorinostat and Sorafenib in Chronic Myelogenous Leukemia Cells Involve Mcl-1 and p21CIP1 Down-Regulation

P. Dent, S. Grant, Yun Dai, 2007, Clinical Cancer Research.

The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress

P. Dent, S. Grant, M. Rahmani, 2007, Molecular and Cellular Biology.

Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation*

P. Dent, S. Grant, M. Rahmani, 2005, Journal of Biological Chemistry.

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.

D. Conrad, P. Dent, S. Grant, 2003, Cancer research.

Irofulven: Resurgence for alkylating therapy in cancer?

P. Dent, S. Grant, 2004, Cancer biology & therapy.

Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

E. Reiman, P. Dent, D. Cridebring, 2021, Aging.

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

P. Dent, S. Nakielny, A. Lavoinne, 1990, Nature.

Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

P. Fisher, K. Shah, J. Bruce, 2010, Molecular Cancer Therapeutics.

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

S. Milstien, S. Spiegel, P. Dent, 2009, Cancer research.

The NF (Nuclear factor)‐κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1‐dependent apoptosis in human acute myeloid leukaemia cells

P. Dent, S. Grant, Yun Dai, 2010, British journal of haematology.

Melanoma Differentiation Associated Gene-7/Interleukin-24 Potently Induces Apoptosis in Human Myeloid Leukemia Cells through a Process Regulated by Endoplasmic Reticulum Stress

P. Fisher, P. Dent, S. Grant, 2010, Molecular Pharmacology.

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

P. Dent, S. Grant, Yun Dai, 2011, Blood.

Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors □ S

P. Dent, S. Grant, Yun Dai, 2012 .

Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors

P. Dent, S. Grant, Yun Dai, 2012, Molecular Pharmacology.

PARP Inhibitors Synergize With Loss of Checkpoint Control to Kill Mammary Carcinoma Cells

P. Dent, Yong Tang, 2011 .

TITLE: PARP Inhibitors Synergize With Loss of Checkpoint Control to Kill Mammary Carcinoma Cells

P. Dent, 2011 .

Correction to “Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells”

P. Dent, A. Yacoub, Chen Yang, 2010 .

Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells

P. Dent, A. Yacoub, Chen Yang, 2010, Molecular Pharmacology.

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

John D. Roberts, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor re-growth

John D. Roberts, P. Dent, A. Yacoub, 2005, Cancer biology & therapy.

Kinase Inhibitors and Cytotoxic Drug Resistance

P. Dent, S. Grant, Steven Grant, 2004, Clinical Cancer Research.

PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib]

P. Dent, L. Booth, Jane L. Roberts, 2017, Oncotarget.

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727*

P. Dent, K. Valerie, A. Yacoub, 2013, The Journal of Biological Chemistry.

Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.

P. Dent, J. Park, S. Grant, 2000, International journal of oncology.

Phase I study of pemetrexed with sorafenib in advanced solid tumors

John D. Roberts, C. Geyer, P. Dent, 2016, Oncotarget.

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

P. Atadja, P. Dent, S. Grant, 2008, Molecular Cancer Therapeutics.

Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)

P. Fisher, P. Dent, A. Yacoub, 2005, Oncogene.

mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

P. Fisher, P. Dent, K. Valerie, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms.

P. Dent, D. Price, Sarah M. Shore, 2005, Gene.

Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3β androstene 17α diol neuro-steroid on malignant glioma cells

P. Dent, R. Loria, W. Jia, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells

J. Kirkwood, J. Hancock, P. Dent, 2019, Cancer biology & therapy.

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics 17-Allylamino-17-Demethoxygeldanamycin and MEK 1 / 2 Inhibitors Kill GI Tumor Cells via Ca 2 +-Dependent Suppression of GRP 78 / BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010 .

Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.

T. Haystead, P. Dent, P. Fadden, 1994, The Journal of biological chemistry.

Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells

P. Dent, S. Grant, Yun Dai, 2008, Clinical Cancer Research.

Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.

S. Fuqua, Menghong Sun, K. Nephew, 2011, Cancer research.

Tumor and Stem Cell Biology Cytokine Receptor CXCR 4 Mediates Estrogen-Independent Tumorigenesis , Metastasis , and Resistance to Endocrine Therapy in Human Breast Cancer

S. Fuqua, Menghong Sun, K. Nephew, 2011 .

Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

P. Dent, S. Grant, F. Fornari, 1997, Molecular pharmacology.

Combined Inhibition of Chk1 and MEK1/2 Leads to Tumor Cell Death In Vivo

P. Dent, 2005 .

Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.

P. Dent, S. Grant, Chunrong Yu, 2001, Molecular pharmacology.

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins

P. Dent, E. Damonte, M. Tuñón, 2016, Journal of clinical & cellular immunology.

AR‐12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication

P. Dent, C. García, Federico Giovannoni, 2016, Journal of cellular physiology.

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

P. Dent, S. Grant, R. Rosato, 2007, Molecular Cancer Therapeutics.

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.

P. Fisher, S. Spiegel, P. Dent, 2010, Cancer research.

Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

P. Dent, T. Sturgill, M. Weber, 1996, Molecular and cellular biology.

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways

D. Conrad, P. Dent, S. Grant, 2003, Cancer biology & therapy.

Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?

P. Dent, S. Grant, 2004, Molecular cancer therapeutics.

Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes

S. Payne, S. Spiegel, P. Dent, 2004, Journal of Biological Chemistry.

Kinase 1 Activation Downregulation, and C-jun N-terminal Mediated by Oxidative Damage, Xiap Leukemia Cells through a Process B Activation Potentiates Apoptosis in Κ Nf- Inhibitor-induced Rela/p65 Acetylation and Blockade of Histone Deacetylase

P. Dent, S. Grant, M. Rahmani, 2005 .

MDA-7/IL-24: multifunctional cancer killing cytokine.

P. Fisher, P. Dent, P. Bhoopathi, 2014, Advances in experimental medicine and biology.

Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.

P. Dent, S. Grant, M. Rahmani, 2003, Cancer research.

Targeting breast cancer‐initiating/stem cells with melanoma differentiation‐associated gene‐7/interleukin‐24

P. Fisher, P. Dent, S. Bhutia, 2013, International journal of cancer.

Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.

P. Fisher, P. Dent, D. Curiel, 2006, Gynecologic oncology.

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

S. Milstien, S. Spiegel, P. Dent, 2011, Cell Death and Differentiation.

Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways

P. Dent, S. Grant, M. Rahmani, 2005, Molecular Cancer Therapeutics.

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

E. Sausville, P. Dent, S. Grant, 2003, Blood.

NF-κB protects rat ARL-6 hepatocellular carcinoma cells against hydrogen peroxide-induced apoptosis

P. Dent, G. Farrell, Jun Yu, 2005, Cancer biology & therapy.

The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

P. Dent, S. Grant, N. Gao, 2006, Molecular Pharmacology.

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

P. Dent, A. Koromilas, D. Boone, 2016, Oncotarget.

Differential regulation of autophagy and cell viability by ceramide species

S. Spiegel, P. Dent, N. Cruickshanks, 2015, Cancer biology & therapy.

MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.

P. Fisher, P. Dent, S. Grant, 2013, Cancer research.

The Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 synergistically increases proteasome inhibitor activity in diffuse large‐B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib

J. Friedberg, R. Fisher, P. Dent, 2013, British journal of haematology.

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

P. Dent, A. Yacoub, S. Grant, 2007, Molecular Cancer Therapeutics.

CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

S. Vicent, Yung-Hyun Choi, P. Dent, 2002, Oncogene.

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

D. Häussinger, P. Dent, A. Yacoub, 2010, Molecular Cancer Therapeutics.

Discovery afenib Activates CD 95 and Promotes Autophagy and Cell Ther th via Src Family Kinases in Gastrointestinal Tumor Cells

D. Häussinger, P. Dent, A. Yacoub, 2010 .

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

John D. Roberts, P. Fisher, P. Dent, 2008, Clinical Cancer Research.

Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS

P. Dent, W. Mcguire, L. Booth, 2016, Oncotarget.

Induced G 2 M Arrest and Attenuates Mitochondrial Injury and Apoptosis in p53-Null Human Leukemia Cells

P. Dent, S. Grant, M. Rahmani, 2004 .

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

P. Fisher, John Calvin Reed, P. Dent, 2011, Proceedings of the National Academy of Sciences.

Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis

Z. Su, P. Fisher, L. Lin, 2006, Cell Death and Differentiation.

Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo

K. Nephew, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

K. Nephew, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Dysregulation of the Cyclin-dependent Kinase Inhibitor p21 the Susceptibility of Human Leukemia Cells (U937) to 1- b - D -Arabinofuranosylcytosine-mediated Mitochondrial Dysfunction and Apoptosis 1

P. Fisher, D. Conrad, P. Dent, 1999 .

Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus

P. Fisher, P. Dent, D. Curiel, 2006, Molecular Cancer Therapeutics.

resistant to STI 571 cells sensitive and + deacetylase inhibitors to induce apoptosis in Bcr / Abl

D. Conrad, P. Dent, S. Grant, 2003 .

Coadministration of UCN-01 with MEK1/2 Inhibitors Potently Induces Apoptosis in

P. Dent, S. Grant, Chunrong Yu, 2002, Cancer biology & therapy.

CellsSynergistically Induces Apoptosis in Human Leukemia Suberoylanilide Hydroxamic Acid or Sodium Butyrate 17-Allylamino-17-demethoxygeldanamycin with Coadministration of the Heat Shock Protein 90 Antagonist Updated

P. Dent, S. Grant, M. Rahmani, 2003 .

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Cancer Therapeutics.

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network*

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011, The Journal of Biological Chemistry.

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

P. Fisher, C. Chen, P. Dent, 2008, Autophagy.

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

P. Fisher, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic.

P. Fisher, P. Dent, S. Grant, 2011, Discovery medicine.

Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.

P. Fisher, A. Brunetti, M. Salvatore, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Enhanced delivery of mda‐7/IL‐24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the apogossypol derivative BI‐97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells

P. Fisher, John Calvin Reed, P. Dent, 2012, Journal of cellular physiology.

mda‐7/IL‐24 differentially regulates soluble and nuclear clusterin in prostate cancer

P. Fisher, P. Dent, S. Grant, 2012, Journal of cellular physiology.

Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

P. Dent, S. Grant, Yun Dai, 2011, Blood.

Cytokinetically quiescent ( G 0 / G 1 ) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk 1 and MEK 1 / 2

P. Dent, S. Grant, Yun Dai, 2011 .

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.

P. Dent, S. Grant, Yun Dai, 2008, Blood.

FADD the bad in head and neck cancer

P. Dent, 2013, Cancer biology & therapy.

Histone Deacetylase Inhibitors Activate NF-κB in Human Leukemia Cells through an ATM/NEMO-related Pathway*

P. Fisher, P. Atadja, P. Dent, 2010, The Journal of Biological Chemistry.

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.

P. Dent, S. Grant, Yun Dai, 2007, Blood.

Molecular target-based therapy of pancreatic cancer.

P. Fisher, P. Dent, K. Valerie, 2006, Cancer research.

Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer research.

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

P. Fisher, S. Spiegel, P. Dent, 2008, Autophagy.

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

P. Fisher, S. Spiegel, P. Dent, 2008, Molecular Cancer Therapeutics.

on tyrosine phosphorylation . Ras-induced activation of Raf-1 is dependent

P. Dent, T. Sturgill, M. Weber, 1995 .

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

P. Fisher, P. Dent, D. Curiel, 2007, Molecular Cancer Therapeutics.

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

B. Shuch, C. Chen, Dasheng Wang, 2016, Oncotarget.

Multi-kinase inhibition in ovarian cancer

P. Dent, 2013, Cancer biology & therapy.

Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and −

P. Fisher, S. Spiegel, P. Dent, 2010 .

Preparation and use of semiintact mammalian cells for analysis of signal transduction.

P. Dent, T. Sturgill, D. Castle, 1995, Methods in enzymology.

An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations.

P. Fisher, P. Dent, D. Curiel, 2010, Virology.

Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.

P. Fisher, P. Dent, M. Athar, 2008, Cancer research.

Gene-7 / Interleukin-24 and Perillyl Alcohol Associated − Inhibition by Melanoma Differentiation Pancreatic Cancer Cell Growth In vitro Mechanism

P. Fisher, P. Dent, M. Athar, 2008 .

Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase (*)

R. Jove, P. Dent, T. Sturgill, 1995, The Journal of Biological Chemistry.

Contribution of Disruption of the Nuclear Factor-κB Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol

P. Dent, S. Grant, N. Gao, 2004, Molecular Pharmacology.

Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes

S. Spiegel, P. Dent, Xiqiao Zhou, 2012, Hepatology.

Protein Kinase C-dependent Activation of the Tumor Necrosis Factor Receptor-mediated Extrinsic Cell Death Pathway Underlies Enhanced Apoptosis in Human Myeloid Leukemia Cells Exposed to Bryostatin 1 and Flavopiridol1

P. Dent, S. Grant, L. Cartee, 2003 .

Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.

P. Dent, S. Grant, L. Cartee, 2003, Molecular cancer therapeutics.

Activation of the Raf‐1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

P. Dent, R. Stravitz, P. Hylemon, 2002, Hepatology.

Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.

P. Dent, L. He, M. Spector, 2000, Experimental cell research.

Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gαi Signaling

P. Dent, S. Grant, W. Pandak, 2007, Molecular Pharmacology.

Targeting Mcl-1 for the therapy of cancer

P. Fisher, John Calvin Reed, P. Dent, 2011, Expert opinion on investigational drugs.

Cystine dimethyl ester induces apoptosis through regulation of PKC-δ and PKC-ε in prostate cancer cells.

P. Dent, S. Sikka, Asim B Abdel Mageed, 2015, Anti-cancer agents in medicinal chemistry.

TNF‐α signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF‐α receptor

C. Croce, M. Latronico, G. Condorelli, 2002 .

Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx.

P. Dent, K. Catt, R. Smith, 1999, Endocrinology.

Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness.

P. Dent, D. Reardon, T. Sturgill, 1997, Molecular endocrinology.

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

S. Spiegel, P. Dent, Clint Mitchell, 2005, Hepatology.

Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.

R. Jove, D. Morrison, P. Dent, 1994, The Biochemical journal.

Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition

P. Dent, A. Lalani, R. Cutler, 2018, Cancer biology & therapy.

Activation of the Mitogen-Activated Protein Kinase Pathway in Triton X-100 Disrupted NIH-3T3 Cells by p21 ras and In Vitro by Plasma Membranes from NIH 3T3 Cells

P. Dent, T. Sturgill, J. Wu, 2022 .

MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.

P. Dent, S. Grant, Z. Wang, 2001, Biochemical and biophysical research communications.

A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.

C. Benz, P. Dent, J. Park, 2000, Molecular biology of the cell.

Acquired and innate resistance to the cancer-specific apoptosis-inducing Cytokine, mda-7/IL-24: Not insurmountable therapeutic problems

P. Fisher, P. Dent, D. Curiel, 2008, Cancer biology & therapy.

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a ‘magic bullet’ for cancer therapy?

P. Fisher, P. Dent, D. Curiel, 2007, Expert opinion on biological therapy.

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.

P. Fisher, P. Dent, K. Valerie, 2004, Cancer research.

Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma.

P. Fisher, P. Dent, D. Curiel, 2004, Gynecologic oncology.

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.

D. Conrad, P. Dent, S. Grant, 2004, Blood.

Interruption of the NF-B pathway by Bay 11-7082 promotes UCN-01 – mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

D. Conrad, P. Dent, S. Grant, 2003 .

Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation.

P. Dent, J. Park, S. Grant, 1999, The Journal of pharmacology and experimental therapeutics.

Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.

G. Schwartz, P. Dent, S. Grant, 1998, Molecular pharmacology.

Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes

P. Dent, R. Mikkelsen, S. Grant, 1997 .

oxygen species (ROS)-dependent mechanism inhibitors to induce apoptosis in human leukemia cells through a reactive The tyrphostin adaphostin interacts synergistically with proteasome

P. Dent, S. Grant, M. Rahmani, 2013 .

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.

P. Dent, S. Grant, M. Rahmani, 2006, Blood.

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*

P. Fisher, P. Dent, S. Grant, 2008, Journal of Biological Chemistry.

Conjugated bile acids regulate hepatic gluconeogenic genes via Gαi protein-coupled receptor(s) and the insulin signalling pathway

P. Dent, P. Hylemon, W. Pandak, 2009 .

Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells

P. Dent, S. Grant, Chunrong Yu, 2005, Leukemia.

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

P. Fisher, S. Spiegel, P. Dent, 2011, Molecular Pharmacology.

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

P. Fisher, P. Dent, A. Yacoub, 2008, Molecular Cancer Therapeutics.

Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Pharmacology.

Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells

P. Dent, S. Grant, C. Yu, 2016, Leukemia.

Chemotherapy resistance and YY1

P. Dent, 2021 .

Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis

P. Fisher, P. Dent, M. Athar, 2008, Molecular Cancer Therapeutics.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24

P. Fisher, John Calvin Reed, P. Dent, 2003, Oncogene.

α‐Adrenergic inhibition of proliferation in HepG2 cells stably transfected with the α1B‐adrenergic receptor through a p42MAP kinase/p21Cip1/WAF1‐dependent pathway

P. Fisher, P. Dent, P. Seth, 1998 .

The Ras / Rac 1 / Cdc 42 / SEK / JNK / c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes

L. Pirola, A. Abo, J. Contessa, 1998 .

CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.

P. Dent, S. Grant, R. Orlowski, 2012, Cancer research.

Targeting the Bcl-2 family for cancer therapy

P. Fisher, John Calvin Reed, P. Dent, 2013, Expert opinion on therapeutic targets.

Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes

P. Dent, M. Spector, B. Gao, 1997, Molecular and cellular biology.

Multisite phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G by cyclic AMP‐dependent protein kinase and glycogen synthase kinase‐3

P. Cohen, P. Dent, D. Campbell, 1989, FEBS letters.

Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells

P. Dent, L. Booth, Jane L. Roberts, 2021, Frontiers in Oncology.

Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells

P. Dent, A. Yacoub, S. Grant, 2012, Cancer biology & therapy.

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

P. Dent, Anindita Das, Margaret A. Park, 2010, Proceedings of the National Academy of Sciences.

Adenovirus‐mediated hPNPaseold‐35 gene transfer as a therapeutic strategy for neuroblastoma

F. Speleman, P. Fisher, P. Dent, 2009, Journal of cellular physiology.

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia.

P. Dent, Daniel P. Bailey, A. Wickrema, 2003, Blood.

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF‐κB and Bim

P. Dent, S. Grant, Yun Dai, 2011, British journal of haematology.

Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.

P. Fisher, K. Shah, P. Dent, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Ceramide in the prostate

P. Dent, 2013, Cancer biology & therapy.

mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.

P. Fisher, P. Dent, A. Yacoub, 2010, Cytokine & growth factor reviews.

Inactivation of Raf-1 by a Protein-tyrosine Phosphatase Stimulated by GTP and Reconstituted by G Subunits (*)

P. Dent, D. Reardon, T. Sturgill, 1996, The Journal of Biological Chemistry.

mechanisms in vitro . Ras-dependent and Ras-independent Regulation of Raf-1 and Raf-1 mutants

D. Morrison, P. Dent, D. Reardon, 1995 .

PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

P. Dent, S. Grant, Yun Dai, 2013, Cancer biology & therapy.

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody

P. Dent, L. Booth, Jane L. Roberts, 2018, Cancer biology & therapy.

Neratinib augments the lethality of [regorafenib + sildenafil]

J. Hancock, P. Dent, A. Lalani, 2018, Journal of cellular physiology.

AP‐1 and C/EBP transcription factors contribute to mda‐7 gene promoter activity during human melanoma differentiation

P. Fisher, P. Dent, M. Madireddi, 2000, Journal of cellular physiology.

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.

S. Milstien, S. Spiegel, P. Dent, 2007, Cancer research.

Radiation‐induced PARP activation is enhanced through EGFR‐ERK signaling

P. Dent, M. Hagan, A. Yacoub, 2007, Journal of cellular biochemistry.

P. Dent, S. Grant, L. Cartee, 2003 .

Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.

P. Dent, S. Grant, L. Cartee, 2002, Molecular pharmacology.

Janus-faced Kupffer cells in tumor metastasis

P. Dent, 2013, Cancer biology & therapy.

Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

P. Dent, N. Cruickshanks, L. Booth, 2015, Journal of cellular physiology.

Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours

J. Hancock, P. Dent, L. Booth, 2022, European Medical Journal.

Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells

P. Fisher, P. Dent, S. Grant, 2014, Molecular Pharmacology.

Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Derick R. Peterson, J. Friedberg, R. Fisher, 2012, Molecular Cancer Therapeutics.

Preclinical Development Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Car fi lzomib in GC-and ABC-DLBCL Cells In Vitro and In Vivo

Derick R. Peterson, J. Friedberg, R. Fisher, 2012 .

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition

P. Dent, S. Grant, M. Rahmani, 2003, Oncogene.

Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.

P. Dent, S. Grant, R. Decker, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

normal erythropoiesis and erythroleukemia or induced by erythropoietin has negative and stimulatory roles in Tumor necrosis factor-alpha expressed constitutively in erythroid cells

P. Dent, Daniel P. Bailey, D. Barber, 2013 .

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3

P. Fisher, P. Dent, S. Grant, 2003, Journal of gastroenterology and hepatology.

Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.

P. Fisher, John Calvin Reed, P. Dent, 2003, Cancer research.

ERK plays the baddie (again)

P. Dent, 2013, Cancer biology & therapy.

Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition

S. Spiegel, P. Dent, L. Booth, 2018, Cancer biology & therapy.

GZ17-6.02 kills prostate cancer cells in vitro and in vivo

P. Dent, L. Booth, Jane L. Roberts, 2022, Frontiers in Oncology.

zeta PKC induces phosphorylation and inactivation of I kappa B‐alpha in vitro.

P. Dent, T. Sturgill, R. Hay, 1994, The EMBO journal.

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.

P. Fisher, P. Dent, D. Curiel, 2007, Cancer research.

Identification of three in vivo phosphorylation sites on the glycogen‐binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline

P. Cohen, P. Dent, D. Campbell, 1990, FEBS letters.

The MPM-2 antibody inhibits mitogen-activated protein kinase activity by binding to an epitope containing phosphothreonine-183.

P. Dent, T. Sturgill, J. Her, 1994, Molecular biology of the cell.

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

S. Batra, P. Dent, Anindita Das, 2015, Oncotarget.

Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth

A. Sabichi, P. Dent, M. Birrer, 2003, Oncogene.

Preclinical Development Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

J. Friedberg, R. Fisher, P. Dent, 2011 .

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

P. Dent, K. Valerie, G. Amorino, 2003, Molecular and Cellular Biology.

Reversing Translational Suppression and Induction of Toxicity in Pancreatic Cancer Cells Using a Chemoprevention Gene Therapy Approach

P. Fisher, P. Dent, D. Sarkar, 2015, Molecular Pharmacology.

Ceramide plays a prominent role in MDA‐7/IL‐24‐induced cancer‐specific apoptosis

P. Fisher, S. Spiegel, P. Dent, 2009, Journal of cellular physiology.

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis

P. Fisher, P. Dent, I. Lebedeva, 2008, Proceedings of the National Academy of Sciences.

HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.

Lixin Sun, P. Dent, P. Hylemon, 2009, Biochemical pharmacology.

Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats.

P. Dent, Bao-Hong Zhang, G. Farrell, 2006, Journal of hepatology.

The switch from DNA repair to apoptosis: discovery of a refractory period for radiation-induced EGFR-MAPK signaling following irradiation

P. Dent, M. Hagan, A. Yacoub, 2003 .

Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies

P. Dent, L. Booth, A. Poklepovic, 2019, Immunometabolism.

Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib.

D. V. Von Hoff, Yong Zhou, J. Hancock, 2021, Biochemical pharmacology.

Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor.

R. Schmidt-Ullrich, J. Contessa, P. Dent, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine.

S. Pestka, P. Fisher, P. Dent, 2003, Cytokine & growth factor reviews.

Regulation of mda-7 gene expression during human melanoma differentiation

Paul Dent, P. Fisher, P. Dent, 2000, Oncogene.

The role of cell signalling in the crosstalk between autophagy and apoptosis.

P. Dent, N. Cruickshanks, L. Booth, 2014, Cellular signalling.

Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

P. Dent, S. Grant, Chunrong Yu, 2001, Cancer research.

Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway

P. Dent, S. Grant, R. Rosato, 2012, Molecular Pharmacology.

Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.

P. Dent, S. Grant, Steven Grant, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib.

P. Dent, L. Booth, Jane L. Roberts, 2020, Seminars in cancer biology.

Cell Signaling and Translational Developmental Therapeutics

P. Dent, 2020, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

Epidermal Growth Factor and Ionizing Radiation Up-regulate the DNA Repair Genes XRCC1 and ERCC1 in DU145 and LNCaP Prostate Carcinoma through MAPK Signaling

P. Dent, M. Hagan, A. Yacoub, 2003, Radiation research.

MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

P. Dent, M. Hagan, A. Yacoub, 2001, International journal of radiation biology.

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

M. Malkin, P. Dent, S. Grant, 2014, Cancer biology & therapy.

Hepatitis B virus X protein increases expression of p21Cip‐1/WAF1/MDA6 and p27Kip‐1 in primary mouse hepatocytes, leading to reduced cell cycle progression

P. Fisher, P. Dent, A. Yacoub, 2001 .

Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells.

P. Dent, K. Valerie, G. Amorino, 2002, Molecular biology of the cell.

Gene therapy in the treatment of human cancer

P. Fisher, P. Dent, D. Curiel, 2017 .

Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.

Paul Dent, P. Fisher, P. Dent, 2009, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-beta-D-arabinofuranosylcytosine.

P. Dent, S. Grant, Z. Wang, 2000, Differentiation; research in biological diversity.

Correction to: “Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment”

John D. Roberts, P. Fisher, P. Dent, 2016, Molecular Pharmacology.

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

P. Fisher, P. Dent, M. Hagan, 2008, Molecular Pharmacology.

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

P. Dent, S. Grant, H. Harada, 2007, Cancer research.

Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells

J. Contessa, P. Dent, R. Mikkelsen, 1999, Oncogene.

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.

S. Payne, S. Spiegel, P. Dent, 2005, Cancer research.

AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication

P. Dent, J. Rayner, Jane L. Roberts, 2020, Biochemical Pharmacology.

Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation.

P. Dent, S. Grant, J. Vrana, 1999, Radiation research.

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

P. Fisher, S. Spiegel, K. Ryan, 2008, Cancer biology & therapy.

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

W. Linehan, P. Fisher, P. Dent, 2003, Molecular cancer therapeutics.

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

Paul Dent, Chunrong Yu, D. Conrad, 2003, Blood.

Neratinib kills B‐RAF V600E melanoma via ROS‐dependent autophagosome formation and death receptor signaling

J. Kirkwood, P. Dent, A. Poklepovic, 2021, Pigment cell & melanoma research.

Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis*

Ngoc Thang Vu, P. Fisher, P. Dent, 2016, The Journal of Biological Chemistry.

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

PI3K: a rational target for ovarian cancer therapy?

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Autophagy: cancer's friend or foe?

P. Fisher, M. Mandal, P. Dent, 2013, Advances in cancer research.

EGFRvIII-mediated radioresistance through a strong cytoprotective response

J. Contessa, P. Dent, K. Valerie, 2003, Oncogene.

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

J. Contessa, P. Dent, R. Mikkelsen, 2002, Oncogene.

Sorafenib/Regorafenib and Lapatinib Interact to kill CNS Tumor Cells

P. Dent, S. Grant, A. Poklepovic, 2015, Journal of cellular physiology.

The Multikinase Inhibitor Sorafenib Induces Apoptosis in Highly Imatinib Mesylate-Resistant Bcr/Abl+ Human Leukemia Cells in Association with Signal Transducer and Activator of Transcription 5 Inhibition and Myeloid Cell Leukemia-1 Down-Regulation

Paul Dent, P. Dent, S. Grant, 2007, Molecular Pharmacology.

Rationally Repurposing Ruxolitinib (Jakafi®) as a Solid Tumor Therapeutic

P. Dent, Jane L. Roberts, A. Poklepovic, 2016, Front. Oncol..

Enhancing CHK1 inhibitor lethality in glioblastoma

Yun Dai, Paul Dent, P. Dent, 2012, Cancer biology & therapy.

Obatoclax and Lapatinib Interact to Induce Toxic Autophagy through NOXA

P. Fisher, P. Dent, S. Grant, 2012, Molecular Pharmacology.

Signaling alterations caused by drugs and autophagy.

J. Hancock, P. Dent, A. Poklepovic, 2019, Cellular signalling.

The regulation of tumor suppressor genes by oncogenes.

P. Fisher, P. Dent, S. Grant, 2003, Methods in molecular biology.

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

P. Dent, M. Hagan, A. Yacoub, 2005, Molecular cancer therapeutics.

Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.

P. Dent, K. Valerie, L. Povirk, 2007, Cancer research.

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo

P. Dent, A. Lalani, R. Cutler, 2017, Oncotarget.

CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle.

Yun Dai, Paul Dent, P. Fisher, 2011, Molecular interventions.

Abl/Src inhibitor BMS-354/825 MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual

P. Dent, S. Grant, H. Harada, 2013 .

MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825.

P. Dent, S. Grant, H. Harada, 2007, Blood.

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

R. Schmidt-Ullrich, P. Dent, S. Grant, 1998, Leukemia.

New methods to control neuroblastoma growth

P. Dent, 2014, Cancer biology & therapy.

Loss of the BCL-2 Phosphorylation Loop Domain Is Required to Protect Human Myeloid Leukemia Cells from Flavopiridol-Mediated Mitochondrial Damage and Apoptosis

P. Dent, S. Grant, R. Decker, 2002, Cancer biology & therapy.

Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

P. Dent, S. Grant, G. Krystal, 1997, Molecular pharmacology.

Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl+ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate

B. Druker, P. Dent, S. Grant, 2006, Clinical Cancer Research.

Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.

P. Dent, S. Grant, Chunrong Yu, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Anna C. Salzberg, Y. Rojanasakul, M. Kirsch‐Volders, 2015, Carcinogenesis.

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.

D. Conrad, P. Dent, S. Grant, 2003, Cancer research.

Resistance/Signaling Pathways

P. Fisher, P. Dent, D. Curiel, 2007 .

Response and Resistance to Ionizing Radiation

P. Dent, M. Hagan, A. Yacoub, 2006 .

MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival

P. Dent, 2005 .

MAPK pathways in radiation responses

Paul Dent, P. Fisher, P. Dent, 2003, Oncogene.

The role of signal transduction pathways in drug and radiation resistance.

P. Fisher, P. Dent, S. Grant, 2002, Cancer treatment and research.

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

P. Dent, R. Mikkelsen, K. Valerie, 1998, The Biochemical journal.

MDA-9/syntenin is a key regulator of glioma pathogenesis.

P. Fisher, J. Bruce, P. Dent, 2014, Neuro-oncology.

REVIEW Signal Transduction and Cellular Radiation Responses

P. Dent, R. Mikkelsen, K. Valerie, 2000 .

Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.

D. Conrad, P. Dent, S. Grant, 1999, Cancer research.

OSU‐03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood–Brain Barrier: Implications for Anti‐Cancer Therapies

P. Dent, Jane L. Roberts, A. Poklepovic, 2015, Journal of cellular physiology.

GRP78/BiP/HSPA5/Dna K is a Universal Therapeutic Target for Human Disease

P. Dent, Jane L. Roberts, Kelly A. Cycon, 2014, Journal of cellular physiology.

Radiation-induced cell signaling: inside-out and outside-in

P. Fisher, P. Dent, K. Valerie, 2007, Molecular Cancer Therapeutics.

Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation.

P. Dent, T. Sturgill, M. Weber, 1993, The Biochemical journal.

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.

William H. Bisson, C. Naus, A. Colacci, 2015, Carcinogenesis.

Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.

P. Dent, S. Grant, Yun Dai, 2002, Cell cycle.

Induction of Apoptosis in Human Leukemia Cells by the CDK1 Inhibitor

P. Dent, S. Grant, Yun Dai, 2002 .

Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.

R. DePinho, R. Coffey, A. Abo, 1998, The Biochemical journal.

Targeted combinatorial therapy of non‐small cell lung carcinoma using a GST‐fusion protein of full‐length or truncated MDA‐7/IL‐24 with Tarceva

P. Fisher, J. Settleman, P. Dent, 2008, Journal of cellular physiology.

Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

P. Dent, X. Fang, A. Mukherjee, 2010, Molecular Cancer.

Transcriptional and post‐transcriptional mechanisms for lysophosphatidic acid‐induced cyclooxygenase‐2 expression in ovarian cancer cells

P. Dent, J. Chen, X. Fang, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL

P. Dent, S. Grant, Z. Wang, 1999, Leukemia.

Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hydroxystaurosporine-Induced Apoptosis in Human Multiple Myeloma Cells

P. Dent, S. Grant, Weiqun Li, 2006, Molecular Pharmacology.

Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2

Z. Su, John Calvin Reed, P. Dent, 2006, Oncogene.

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.

P. Fisher, John Calvin Reed, P. Dent, 2010, Cancer research.

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

P. Dent, S. Grant, M. Rahmani, 2005, Blood.

INTERRUPTION OF BOTH AKT AND MEK / ERK PATHWAYS AND ACTIVATION OF SEK 1 / JNK

P. Dent, S. Grant, M. Rahmani, 2004 .

Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival.

Liang Qiao, Paul Dent, P. Dent, 2002, Frontiers in bioscience : a journal and virtual library.

Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis.

J. Friedberg, R. Fisher, P. Dent, 2010, Leukemia research.

Sorafenib/Regorafenib and Phosphatidyl Inositol 3 Kinase/Thymoma Viral Proto-Oncogene Inhibition Interact to Kill Tumor Cells

P. Dent, S. Grant, N. Cruickshanks, 2013, Molecular Pharmacology.

The Cyclin-Dependent Kinase Inhibitor p21CIP1/WAF1 Blocks Paclitaxel-Induced G2M Arrest and Attenuates Mitochondrial Injury and Apoptosis in p53-Null Human Leukemia Cells

P. Dent, S. Grant, M. Rahmani, 2004 .

Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis.

P. Dent, S. Grant, Z. Wang, 1999, Biochemical and biophysical research communications.

Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells

P. Fisher, K. Nephew, P. Dent, 2011, Autophagy.

Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.

P. Fisher, K. Nephew, P. Dent, 2011, Cancer research.

Cyclin D1 Overexpression Increases the Susceptibility of Human U266 Myeloma Cells to CDK Inhibitors through a Process Involving p130-, p107- and E2F-Dependent S-Phase Entry

P. Dent, S. Grant, Yun Dai, 2006, Cell cycle.

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

S. Milstien, S. Spiegel, P. Dent, 2018, Autophagy.

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.

G. Mills, P. Wipf, P. Dent, 2009, Cancer research.

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro.

T. Haystead, T. Roberts, W. Haser, 1992, Science.

GZ17-6.02 and axitinib interact to kill renal carcinoma cells

P. Dent, D. Hoff, C. West, 2022, Oncotarget.

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

P. Dent, A. Yacoub, S. Grant, 2012, Cancer biology & therapy.

Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.

R. Schmidt-Ullrich, P. Dent, D. Reardon, 1999, Molecular biology of the cell.

Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials

P. Fisher, P. Dent, D. Sarkar, 2014, Expert opinion on investigational drugs.

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

P. Fisher, S. Spiegel, D. Häussinger, 2010, Cancer research.

The development of multi-kinase inhibitors as pancreatic cancer therapeutics

J. Hancock, P. Dent, A. Poklepovic, 2021, Anti-cancer drugs.

GZ17-6.02 and Pemetrexed Interact to Kill Osimertinib-Resistant NSCLC Cells That Express Mutant ERBB1 Proteins

P. Dent, D. Von Hoff, C. West, 2021, Frontiers in Oncology.

GZ17-6.02 Interacts With [MEK1/2 and B-RAF Inhibitors] to Kill Melanoma Cells

J. Kirkwood, D. V. Von Hoff, P. Dent, 2021, Frontiers in Oncology.

GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling

P. Dent, D. Hoff, C. West, 2020, Frontiers in Oncology.

GZ17‐6.02 initiates DNA damage causing autophagosome‐dependent HDAC degradation resulting in enhanced anti‐PD1 checkpoint inhibitory antibody efficacy

D. V. Von Hoff, P. Dent, Jane L. Roberts, 2020, Journal of cellular physiology.

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells

Z. Su, N. Goldstein, P. Fisher, 2001, Proceedings of the National Academy of Sciences of the United States of America.

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

P. Dent, S. Grant, N. Cruickshanks, 2014, Cancer biology & therapy.

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.

P. Atadja, S. Payne, S. Spiegel, 2006, Molecular pharmacology.

Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

P. Dent, A. Yacoub, S. Grant, 2011, Cancer biology & therapy.

Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells

P. Atadja, P. Dent, S. Grant, 2005, Molecular Cancer Therapeutics.

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.

P. Dent, S. Grant, M. Rahmani, 2004, Blood.

Pazopanib and HDAC inhibitors interact to kill sarcoma cells

P. Dent, S. Grant, A. Poklepovic, 2014, Cancer biology & therapy.

The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib

P. Dent, Jane L. Roberts, A. Poklepovic, 2019, Front. Oncol..

HDAC inhibitors enhance the immunotherapy response of melanoma cells.

J. Kirkwood, P. Dent, Jane L. Roberts, 2017, Oncotarget.

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

J. Kirkwood, P. Dent, C. Sander, 2017, Oncotarget.

Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

P. Dent, S. Grant, N. Cruickshanks, 2013, Cancer biology & therapy.

Ionizing radiation enhances adenoviral vector expressing mda‐7/IL‐24‐mediated apoptosis in human ovarian cancer

P. Fisher, P. Dent, D. Curiel, 2006, Journal of cellular physiology.

Enhanced Prostate Cancer Gene Transfer and Therapy Using a Novel Serotype Chimera Cancer Terminator Virus (Ad.5/3‐CTV)

P. Fisher, John Calvin Reed, P. Dent, 2013, Journal of cellular physiology.

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

Paul Dent, Hisashi Harada, Andrea Ferreira-Gonzalez, 2009, Blood.

A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2*

Yun Dai, Paul Dent, Seth J Corey, 2004, Journal of Biological Chemistry.

Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

P. Dent, Anindita Das, R. Kukreja, 2015, Molecular Pharmacology.

Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl.

P. Dent, S. Grant, Tri K. Nguyen, 2006, Leukemia research.

Phase I Study of Sorafenib and Vorinostat in Advanced Hepatocellular Carcinoma

John D. Roberts, P. Dent, R. Sterling, 2019, American journal of clinical oncology.

Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway

E. Petricoin, M. David, O. Silvennoinen, 1997, Molecular and cellular biology.

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation

P. Dent, T. Sturgill, D. Marshak, 1994, Molecular and cellular biology.

The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy

P. Dent, S. Grant, Shiyu Song, 2009 .

Mda‐7/IL‐24 induces apoptosis of diverse cancer cell lines through JAK/STAT‐independent pathways

S. Pestka, P. Fisher, P. Dent, 2003, Journal of cellular physiology.

A phase 1 study of neoadjuvant chemotherapy followed by concurrent chemoradiation with gemcitabine, sorafenib, and vorinostat in pancreatic cancer.

P. Dent, K. Matin, E. Fields, 2021 .

Discovery of a ‘Grail-Shaped’ Drug: Ne-ratinib and the Downregulation of Mutant RAS

P. Dent, A. Poklepovic, Laurence A Booth, 2019, EMJ Oncology.

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

P. Dent, S. Grant, S. Han, 2004, Hepatology.

Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases.

D. Morrison, P. Dent, T. Sturgill, 1995, Science.

Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts.

P. Dent, T. Sturgill, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

D. Morrison, P. Dent, D. Reardon, 1995, Molecular and cellular biology.

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2

P. Dent, T. Sturgill, M. Weber, 1993, Molecular and cellular biology.

Ordered phosphorylation of p42mapk by MAP kinase kinase

T. Haystead, P. Dent, T. Sturgill, 1992, FEBS letters.

PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells.

Z. Su, P. Dent, Y. Shi, 2001, Nucleic acids research.

Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas

Jennifer A. Clark, P. Fisher, N. Turro, 2007, Proceedings of the National Academy of Sciences.

RLIP76 in defense of radiation poisoning.

Sumihiro Suzuki, D. Armstrong, P. Dent, 2008, International journal of radiation oncology, biology, physics.

RLIP76 is a major determinant of radiation sensitivity.

P. Dent, A. Yacoub, P. Boor, 2005, Cancer research.

Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.

R. Schmidt-Ullrich, J. Contessa, P. Dent, 2001, Journal of the National Cancer Institute.

Activation of Raf by ionizing radiation

T. Whiteside, P. Dent, T. Sturgill, 1996, Nature.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.

P. Dent, S. Grant, Yun Dai, 2003, Molecular pharmacology.

Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.

P. Fisher, P. Dent, R. Dash, 2012, Advances in cancer research.

Progression elevated gene‐3, PEG‐3, induces genomic instability in rodent and human tumor cells

P. Fisher, P. Dent, R. Gopalkrishnan, 2002, Journal of cellular physiology.

Non-canonical p53 signaling to promote invasion

P. Dent, 2013, Cancer biology & therapy.

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells

P. Fisher, P. Dent, A. Yacoub, 2004, Cancer biology & therapy.

NEDD4 over-expression regulates the afatinib resistant phenotype of NSCLC cells.

P. Dent, Jane L. Roberts, A. Poklepovic, 2017, Oncology signaling.

Radiotherapy-induced signal transduction.

P. Fisher, P. Dent, M. Hagan, 2006, Endocrine-related cancer.

Kinase inhibitors: look beyond the label on the bottle

J. Hancock, P. Dent, A. Poklepovic, 2019, Cancer drug resistance.

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide

P. Dent, Jane L. Roberts, A. Poklepovic, 2016, Oncotarget.

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling

P. Dent, W. Mcguire, Jane L. Roberts, 2016, Oncotarget.

farnesylation and activation lethality in human leukemia and myeloma cells by disrupting Ras Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01)

P. Dent, S. Grant, Yun Dai, 2013 .

BCL-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

J. Friedberg, R. Fisher, P. Dent, 2009, Cancer biology & therapy.

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.

P. Dent, S. Grant, Yun Dai, 2007, Blood.

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

E. Sausville, P. Dent, S. Grant, 2004, Oncogene.

MEK1/2 Inhibitors Promote Ara-C-Induced Apoptosis but Not Loss of ΔΨm in HL-60 Cells

P. Dent, S. Grant, Chunrong Yu, 2001 .

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

P. Dent, S. Grant, H. Harada, 2007, Blood.

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.

P. Dent, S. Grant, Yun Dai, 2002, Blood.

Inhibitors of MEK1/2 Interact with UCN-01 to Induce Apoptosis and Reduce Colony Formation in Mammary and Prostate Carcinoma Cells

P. Dent, A. Yacoub, S. Grant, 2002, Cancer biology & therapy.

Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).

P. Dent, S. Grant, L. Boise, 2000, Biochemical pharmacology.

mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.

P. Fisher, P. Dent, S. Grant, 2006, Pharmacology & therapeutics.

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

P. Fisher, P. Dent, S. Grant, 2002, Hepatology.

Not the comfy chair! Cancer drugs that act against multiple active sites

P. Dent, A. Poklepovic, Laurence A Booth, 2019, Expert opinion on therapeutic targets.

The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells

P. Dent, Jane L. Roberts, A. Poklepovic, 2018, Cancer biology & therapy.

The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells

P. Dent, A. Lalani, R. Cutler, 2018, Cancer biology & therapy.

[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration

J. Kirkwood, P. Dent, A. Lalani, 2017, Oncotarget.

Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells.

J. Kirkwood, P. Dent, Jane L. Roberts, 2018, Advances in cancer research.

[pemetrexed + sildenafil], via autophagy-dependent HDAC downregulation, enhances the immunotherapy response of NSCLC cells

P. Dent, Jane L. Roberts, A. Poklepovic, 2017, Cancer biology & therapy.

Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].

J. Hancock, P. Dent, A. Poklepovic, 2020, Cellular signalling.

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

D. Tuveson, J. Hancock, P. Dent, 2019, Oncogene.

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

J. Kirkwood, P. Dent, C. Sander, 2017, Cancer biology & therapy.

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

P. Dent, T. Albers, Jane L. Roberts, 2016, Oncotarget.

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

P. Dent, S. Grant, N. Cruickshanks, 2014, Molecular Cancer Therapeutics.

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

S. Spiegel, P. Dent, S. Grant, 2012, Cancer biology & therapy.

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

J. Grandis, P. Dent, A. Yacoub, 2005, Biochemical pharmacology.

Apoptotic Response of Hepatocytes-Terminal Kinase Pathways , Modulates the 2 Signal-Regulated Kinase and c-Jun NH c-Jun Function , via the Extracellular , CREB , and β Bile Acid Regulation of C / EBP

P. Dent, K. Valerie, G. Amorino, 2003 .

Pharmocologic Inhibitors of the Mitogen Activated Protein Kinase Cascade Have the Potential to Interact with Ionizing Radiation Exposure to Induce Cell Death in Carcinoma Cells by Multiple Mechanisms

P. Fisher, P. Dent, M. Hagan, 2002, Cancer biology & therapy.

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

P. Fisher, P. Nagarkatti, R. Schmidt-Ullrich, 2001, Molecular biology of the cell.

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

G. Duigou, C. S. Young, P. Fisher, 2001, Oncogene.

Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression.

P. Dent, K. Valerie, M. Taher, 1999, Biochemistry.

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.

L. Pirola, A. Abo, J. Contessa, 1998, Molecular biology of the cell.

Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway.

P. Dent, P. Seth, P. Fisher, 1998, FEBS letters.

Ionizing Radiation Causes a Dose-Dependent Release of Transforming Growth Factor α In vitro from Irradiated Xenografts and during Palliative Treatment of Hormone-Refractory Prostate Carcinoma

P. Dent, M. Hagan, A. Yacoub, 2004, Clinical Cancer Research.

Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

J. Friedberg, R. Fisher, P. Dent, 2011, Molecular Cancer Therapeutics.

Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.

P. Dent, C. Röcken, M. Ebert, 2006, Human gene therapy.

Title Constitutive activation of NF-κ B in human hepatocellularcarcinoma : Evidence of a cytoprotective role Author ( s )

P. Dent, C. Röcken, M. Ebert, 2006 .

Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).

P. Dent, S. Grant, S. Wang, 1998, Biochemical pharmacology.

GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

P. Dent, C. Doern, P. Plamondon, 2015, Journal of cellular physiology.

Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors*

P. Dent, S. Grant, Yun Dai, 2011, The Journal of Biological Chemistry.

LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism.

P. Dent, S. Grant, R. Rosato, 2012, Leukemia research.

Minting a new class of Polo-like-kinase inhibitors

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

P. Dent, S. Grant, Weiqun Li, 2004, Hepatology.

mda-7/IL-24, A Novel Cancer Selective Apoptosis Inducing Cytokine Gene: From the Laboratory into the Clinic

Paul Dent, Elizabeth A Grimm, P. Fisher, 2003, Cancer biology & therapy.

mda-7 (IL-24): signaling and functional roles.

P. Fisher, P. Dent, R. Gopalkrishnan, 2002, BioTechniques.

PARP inhibitors are not all equal

P. Dent, 2013, Cancer biology & therapy.

Simultaneous interruption of signal transduction and cell cycle regulatory pathways: implications for new approaches to the treatment of childhood leukemias.

P. Dent, S. Grant, 2007, Current drug targets.

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells

P. Fisher, P. Dent, S. Grant, 2013, Cancer biology & therapy.

Histone Deacetylase Inhibitors Interact with Melanoma Differentiation Associated-7/Interleukin-24 to Kill Primary Human Glioblastoma Cells

P. Fisher, P. Dent, A. Yacoub, 2013, Molecular Pharmacology.

Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

The development of MDA-7/IL-24 as a cancer therapeutic.

P. Fisher, P. Dent, A. Yacoub, 2010, Pharmacology & therapeutics.

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

P. Fisher, P. Dent, A. Yacoub, 2010, Anti-cancer drugs.

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

Cisplatin Enhances Protein Kinase R-Like Endoplasmic Reticulum Kinase- and CD95-Dependent Melanoma Differentiation-Associated Gene-7/Interleukin-24–Induced Killing in Ovarian Carcinoma Cells

P. Fisher, P. Dent, A. Yacoub, 2010, Molecular Pharmacology.

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

P. Fisher, S. Spiegel, P. Dent, 2009, Molecular Cancer Therapeutics.

Cisplatin enhances PERK- and CD95-dependent MDA-7/IL-24-induced killing in ovarian carcinoma cells

P. Fisher, P. Dent, A. Yacoub, 2009 .

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.

P. Fisher, N. Senzer, J. Nemunaitis, 2007, Toxicology and applied pharmacology.

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

S. Inoue, P. Fisher, R. Ramesh, 2007, International journal of oncology.

MDA‐7/IL‐24 regulates proliferation, invasion and tumor cell radiosensitivity: A new cancer therapy?

Paul Dent, P. Fisher, P. Dent, 2005, Journal of cellular biochemistry.

mda-7/IL-24: exploiting cancer's Achilles' heel.

P. Fisher, J. Nemunaitis, P. Dent, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.

P. Fisher, P. Dent, A. Yacoub, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

mda-7 (IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling

P. Fisher, P. Dent, A. Yacoub, 2003, Cancer biology & therapy.

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

P. Fisher, P. Dent, K. Valerie, 2003, Oncogene.

Lapatinib and Obatoclax Kill Tumor Cells through Blockade of ERBB1/3/4 and through Inhibition of BCL-xL and MCL-1

P. Fisher, P. Dent, S. Grant, 2012, Molecular Pharmacology.

The potential of virus-based gene therapies for treatment of metastatic kidney cancer

P. Fisher, P. Dent, D. Curiel, 2011, Expert review of anticancer therapy.

Regulation of autophagy by ceramide-CD95-PERK signaling

P. Fisher, P. Dent, S. Grant, 2008, Autophagy.

Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein

P. Fisher, P. Dent, A. Yacoub, 2004, Oncogene.

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)

P. Fisher, P. Dent, D. Curiel, 2011, Autophagy.

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

Z. Su, P. Fisher, P. Dent, 2010, Cancer Gene Therapy.

Characterization of infectivity of knob-modified adenoviral vectors in glioma

P. Fisher, M. Lamfers, P. Dent, 2008, Cancer biology & therapy.

A cancer terminator virus eradicates both primary and distant human melanomas

Z. Su, P. Fisher, P. Dent, 2008, Cancer Gene Therapy.

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

P. Houghton, P. Dent, A. Yacoub, 2009, Molecular Pharmacology.

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

A. Thorburn, D. Häussinger, P. Dent, 2009, Molecular Pharmacology.

Searching for a cure: Gene therapy for glioblastoma

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

P. Fisher, S. Spiegel, P. Dent, 2008, Molecular Pharmacology.

OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells

P. Dent, A. Yacoub, S. Grant, 2006, Molecular Pharmacology.

Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells

C. James, P. Fisher, P. Dent, 2005, Oncogene.

Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance

P. Dent, W. Mcguire, Jane L. Roberts, 2015, Cancer biology & therapy.

Lapatinib and Obatoclax Kill Breast Cancer Cells through Reactive Oxygen Species-Dependent Endoplasmic Reticulum Stress

P. Dent, S. Grant, N. Cruickshanks, 2012, Molecular Pharmacology.

Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells

P. Fisher, P. Dent, D. Curiel, 2010, The Prostate.

Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells

P. Dent, S. Grant, Yukihiro Yamaguchi, 2013, Journal of cellular physiology.

A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin.

P. Cohen, P. Dent, D. Campbell, 1992, European journal of biochemistry.

The BH 3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI 3 K / Akt and MEK / ERK 1 / 2 pathways

P. Dent, S. Grant, H. Harada, 2009 .

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

P. Fisher, P. Dent, D. Curiel, 2007, Clinical Cancer Research.

Recombinant adenoviral expression of dominant-negative Ras N17 blocking radiation-induced activation of mitogen-activated protein kinase pathway.

B. Nicke, R. Schmidt-Ullrich, P. Dent, 2001, Methods in enzymology.

Ionizing Radiation-Induced Mitogen-Activated Protein (MAP) Kinase Activation in DU145 Prostate Carcinoma Cells: MAP Kinase Inhibition Enhances Radiation-Induced Cell Killing and G2/M-Phase Arrest

P. Dent, M. Hagan, Li Wang, 2000 .

Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest.

P. Dent, J. Park, M. Hagan, 2000, Radiation research.

Fingolimod Augments Monomethylfumarate Killing of GBM Cells

J. Hancock, P. Dent, Jane L. Roberts, 2020, Frontiers in Oncology.

Potentiation of 1-β- d-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01) ∗ ∗ Portions of this work have been reported in preliminary form at the Meeting for the American Ass

P. Dent, S. Grant, L. Boise, 2000 .

Inhibition of the MAPK and PI3K pathways enhances UDCA‐induced apoptosis in primary rodent hepatocytes

P. Dent, A. Yacoub, S. Grant, 2002, Hepatology.

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008, Clinical Cancer Research.

S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ.

R. Mangues, P. Dent, D. Reardon, 1997, Cellular signalling.

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

P. Dent, D. Reardon, G. Bell, 1996, The Biochemical journal.

AFiber-ModifiedMesothelin Promoter ^ Based Conditionally Replicating Adenovirus forTreatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008 .

Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer

P. Dent, 2019, Expert opinion on investigational drugs.

RAF-INDUCED KINASES MAY BE NECESSARY BUT ARE NOT SUFFICIENT FOR RAS-P21-PROTEIN INDUCTION OF OOCYTE MATURATION

M. Pincus, T. Haystead, P. Dent, 1995 .

Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells

P. Fisher, P. Dent, R. Mikkelsen, 1998, Oncogene.

Phosphorylation of the Myosin-binding Subunit of Myosin Phosphatase by Raf-1 and Inhibition of Phosphatase Activity*

P. Dent, C. Broustas, U. Kasid, 2002, The Journal of Biological Chemistry.

Approaches for monitoring signal transduction changes in normal and cancer cells.

P. Fisher, P. Dent, S. Grant, 2007, Methods in molecular biology.

7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.

P. Dent, P. Lin, S. Grant, 2002, International journal of oncology.

The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

R. Schmidt-Ullrich, P. Dent, R. Mikkelsen, 2001, Oncogene.

The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells.

R. Schmidt-Ullrich, J. Contessa, P. Dent, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Suppression of growth factor-mediated MAP kinase activation by v-raf in macrophages: a putative role for the MKP-1 phosphatase.

P. Dent, M. Baccarini, S. Krautwald, 1995, Oncogene.

Is a Major Determinant of Radiation Sensitivity

P. Dent, A. Yacoub, P. Boor, 2005 .

The multi-hit hypothesis in basal-like breast cancer

P. Dent, 2013, Cancer biology & therapy.

A role for MAP kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells

P. Fisher, P. Dent, J. Park, 2000 .

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

P. Dent, M. Hagan, A. Yacoub, 2005, Molecular cancer therapeutics.

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo.

J. Friedberg, R. Fisher, P. Dent, 2010, Blood.

The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells.

P. Dent, S. Grant, M. Rahmani, 2004, Cell cycle.

TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor.

C. Croce, M. Latronico, G. Condorelli, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

B. Kavanagh, J. Contessa, P. Dent, 1997, Oncogene.

Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells.

P. Dent, G. Krystal, J. Litz, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The flip side of doxorubicin

P. Dent, 2013, Cancer biology & therapy.

Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

J. Friedberg, R. Fisher, P. Dent, 2019, Molecular Cancer Therapeutics.

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gαi-protein-coupled receptors and the AKT pathway[S]

Lixin Sun, P. Dent, P. Hylemon, 2010, Journal of Lipid Research.

Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo

P. Dent, A. Yacoub, S. Grant, 2008, Cancer biology & therapy.

Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.

J. Chen, P. Dent, B. Gao, 1998, The Biochemical journal.

DMC: Novel celecoxib derivatives to rap cancer

P. Dent, A. Yacoub, S. Grant, 2005, Cancer biology & therapy.

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

S. Spiegel, P. Dent, N. Cruickshanks, 2015, Journal of cellular physiology.

Current advances in ER stress intervention therapies

P. Fisher, P. Dent, S. Grant, 2012 .

Crosstalk between ERK, AKT, and cell survival

P. Dent, 2014, Cancer biology & therapy.

Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus.

P. Fisher, P. Dent, A. Klibanov, 2014, Current molecular medicine.

myeloma cells through an IL-6-independent mechanism inhibitors potently induces apoptosis in drug-sensitive and-resistant Combined treatment with the checkpoint abrogator UCN-01 and MEK 1

P. Dent, S. Grant, S. Rosen, 2002 .

AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

E. Reiman, P. Dent, Jennifer Martinez, 2022, Aging.

AR12 increases BAG3 expression via ER stress signaling which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

P. Dent, 2022 .

OSU-03012 interacts with lapatinib to kill brain cancer cells

P. Dent, S. Grant, N. Cruickshanks, 2012, Cancer biology & therapy.

The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells.

P. Dent, Jane L. Roberts, A. Poklepovic, 2020, Cellular signalling.

Radiation-Stimulated ERK1/2 and JNK1/2 Signaling can Promote Cell Cycle Progression in Human Colon Cancer Cells

P. Dent, M. Hagan, A. Yacoub, 2005, Cell cycle.

GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells

P. Dent, D. Von Hoff, C. West, 2022, Oncotarget.

Neratinib decreases pro-survival responses of [sorafenib + vorinostat] in pancreatic cancer.

P. Dent, A. Poklepovic, Laurence A Booth, 2020, Biochemical pharmacology.

Regulation of dimethyl-fumarate toxicity by proteasome inhibitors

P. Dent, N. Cruickshanks, Jane L. Roberts, 2014, Cancer biology & therapy.

A novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations

P. Dent, S. Kwatra, Z. Bordeaux, 2023, Anti-cancer drugs.

A novel plant-derived compound is synergistic with 5-fluorouracil and has increased apoptotic activity through autophagy in the treatment of actinic keratoses

D. V. Von Hoff, P. Dent, S. Kwatra, 2020, The Journal of dermatological treatment.

The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

P. Dent, S. Grant, M. Rahmani, 2005, Clinical Cancer Research.

Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.

P. Dent, J. Park, A. Yacoub, 2001, Hepatology.

Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis

P. Fisher, P. Dent, A. Yacoub, 2005, Oncogene.

Valproate augments Niraparib killing of tumor cells

P. Dent, Jane L. Roberts, A. Poklepovic, 2018, Cancer biology & therapy.

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo

J. Hancock, P. Dent, Jane L. Roberts, 2020, Journal of cellular physiology.

HDAC inhibitors enhance the immunotherapy response of melanoma cells

J. Kirkwood, P. Dent, Jane L. Roberts, 2017, Oncotarget.

Conversion of Drug-Induced Differentiation to Apoptosis by Pharmacologic Cyclin-Dependent Kinase Inhibitors

P. Dent, S. Grant, 2002, Cell cycle.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

MEK1/2 inhibition promotes Taxotere® lethality in mammary tumors in vivo

P. Fisher, P. Dent, M. Hagan, 2006, Cancer biology & therapy.

Sequence Dependent Exposure of Mammary Carcinoma Cells to Taxotere® and the MEK1/2 Inhibitor U0126 Causes Enhanced Cell Killing In Vitro

P. Dent, A. Yacoub, R. Carón, 2003, Cancer biology & therapy.

HSPA5/Dna K may be a useful target for human disease therapies.

Paul Dent, P. Dent, Laurence Booth, 2015, DNA and cell biology.

Ribonucleotide Reductase Inhibition: Regulation of the Radiosensitive Phenotype via NFkB and Bcl-2

P. Dent, 2002, Cancer Biology & Therapy.

Repurposing Tecfidera for cancer

M. Malkin, P. Dent, Laurence A Booth, 2016, Aging.

Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling

J. Hancock, P. Dent, Jennifer Martinez, 2020, Journal of cellular physiology.

Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.

P. Dent, S. Grant, Zhiliang Wang, 2003, Blood.

Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.

R. Schmidt-Ullrich, P. Dent, R. Mikkelsen, 1998, Radiation research.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

cells sensitive and resistant to STI-571 in association with down-regulation of Bcr- Abl, abrogation of STAT5 activity, and Bax conformational change.

R. Jove, Meijuan Huang, P. Dent, 2004 .

Phase I trial of dimethyl fumarate, temozolomide, and radiation therapy in glioblastoma multiforme.

M. Malkin, P. Dent, Zhi-Jian Chen, 2017 .

Met in lung cancer

P. Dent, 2014, Cancer biology & therapy.

The irreversible ERBB1/2/4 inhibitor neratinib interacts with the BCL-2 inhibitor venetoclax to kill mammary cancer cells

P. Dent, A. Lalani, R. Cutler, 2018, Cancer biology & therapy.

Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells

P. Dent, W. Anderson, U. Kasid, 1997, Oncogene.

The BH3-only protein Bim plays a critical role in cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK pathways in human leukemia cells

P. Dent, S. Grant, M. Rahmani, 2008 .

Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

P. Dent, S. Grant, N. Cruickshanks, 2019, Molecular Cancer Therapeutics.

Abstract 796: Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

P. Dent, S. Grant, N. Cruickshanks, 2014 .

Future approaches for the therapy of malignant glioma: targeting genes mediating invasion.

P. Fisher, P. Dent, D. Sarkar, 2012, Future oncology.

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

G. Duigou, C. S. Young, P. Fisher, 2001, Oncogene.

Mechanisms of GZ17-6.02 resistance

P. Dent, D. Von Hoff, C. West, 2022, Anti-cancer drugs.

Arsenic in leukemia

P. Dent, 2013, Cancer Biology & Therapy.

Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogen.

P. Cohen, C. Smythe, P. Dent, 1990, European journal of biochemistry.

Radiosensitization of Human Mammary Carcinoma Cells by Specific Inhibition of Signal Transduction Cascades

P. Dent, 2002 .

Targeting CDK9 Dramatically Potentiates ABT-737-Induced Apoptosis in Human Multiple Myeloma Cells through a Bim-Dependent Mechanism.

Michael L. Wang, P. Dent, S. Grant, 2009 .

Alteration of Ceramide Synthase 6/C 16 -Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011 .

The effect of endothelin antagonists on renal ischaemia-reperfusion injury and the development of acute renal failure in the rat.

P. Dent, Chunhua Huang, E. Johns, 2002, Nephrology, Dialysis and Transplantation.

Not so WEE

P. Dent, 2014, Cancer Biology & Therapy.

The epigenetic regulation of cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrence.

H. Bear, P. Dent, S. Grant, 2023, Advances in cancer research.

The kinase inhibitor sorafenib induces cell death through a process involving induction of ER stress

P. Dent, S. Grant, M. Rahmani, 2007 .

Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Pharmacology.

THE MULTIKINASE INHIBITOR SORAFENIB INDUCES APOPTOSIS IN HIGHLY IMATINIB MESYLATE-RESISTANT BCR/ABL + HUMAN LEUKEMIA CELLS IN ASSOCIATION WITH STAT5 INHIBITION AND MCL-1 DOWN-REGULATION

P. Dent, S. Grant, M. Rahmani, 2007 .

Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer research.

Searching for a cure: Gene therapy for glioblastoma

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008, Clinical Cancer Research.

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

John D. Roberts, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes

S. Spiegel, P. Dent, Xiqiao Zhou, 2012, Hepatology.

Lapatinib and Obatoclax Kill Breast Cancer Cells through Reactive Oxygen Species-Dependent Endoplasmic Reticulum Stress

P. Dent, S. Grant, Yong Tang, 2012, Molecular Pharmacology.

The role of cell signalling in the crosstalk between autophagy and apoptosis.

P. Dent, Hossein A. Hamed, S. Tavallai, 2014, Cellular Signalling.

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

A. Thorburn, D. Häussinger, P. Dent, 2009, Molecular Pharmacology.

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

P. Houghton, P. Dent, A. Yacoub, 2009, Molecular Pharmacology.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

William H. Bisson, Anna C. Salzberg, Y. Rojanasakul, 2015, Carcinogenesis.

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF‐κB and Bim

P. Dent, S. Grant, Yun Dai, 2011, British journal of haematology.

Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation

P. Dent, S. Grant, M. Rahmani, 2005, Molecular and Cellular Biology.

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

E. Sausville, P. Dent, S. Grant, 2003, Blood.

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

P. Fisher, John Calvin Reed, P. Dent, 2011, Proceedings of the National Academy of Sciences.

Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo

P. Dent, A. Yacoub, Chen Yang, 2010, Cancer biology & therapy.

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.

P. Dent, S. Grant, Yun Dai, 2008, Blood.