I. Brabet

发表

Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.

J. Pin, N. Triballeau, F. Acher, 2005, Journal of medicinal chemistry.

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

J. Javitch, J. Pin, I. Brabet, 2010, Nature chemical biology.

Molecular Determinants Involved in the Allosteric Control of Agonist Affinity in the GABAB Receptor by the GABAB2 Subunit*

J. Pin, I. Brabet, P. Rondard, 2004, Journal of Biological Chemistry.

LSP5-2157 a new inhibitor of vesicular glutamate transporters

Christian Rosenmund, P. Dutar, B. Giros, 2019, Neuropharmacology.

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.

J. Bockaert, J. Pin, I. Brabet, 1996, Molecular pharmacology.

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.

L. Prézeau, J. Pin, I. Brabet, 2000, Molecular pharmacology.

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.

L. Prézeau, J. Bockaert, J. Pin, 2001, Molecular pharmacology.

Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.

L. Fagni, J. Pin, F. Acher, 1997, Journal of medicinal chemistry.

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

J. Pin, A. Mann, I. Brabet, 2006, Biochemical and biophysical research communications.

Allosteric modulation of metabotropic glutamate receptors by chloride ions

Y. de Koninck, J. Pin, F. Acher, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists

L. Prézeau, J. Pin, N. Triballeau, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A novel site on the Galpha -protein that recognizes heptahelical receptors.

J. Bockaert, J. Pin, I. Brabet, 2001, The Journal of biological chemistry.

Ca 2 1 Requirement for High-Affinity g-Aminobutyric Acid ( GABA ) Binding at GABAB Receptors : Involvement of Serine 269 of the GABABR 1 Subunit

L. Prézeau, J. Pin, I. Brabet, 2000 .

Determination of the absolute configuration of phosphinic analogues of glutamate.

J. Pin, F. Acher, I. Brabet, 2015, Organic & biomolecular chemistry.

First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist.

L. Prézeau, J. Pin, F. Acher, 2000, Bioorganic & medicinal chemistry letters.

Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.

J. Pin, F. Acher, I. Brabet, 1998, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

M. Amalric, J. Pin, F. Acher, 2007, Journal of medicinal chemistry.

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

J. Pin, N. Triballeau, F. Acher, 2010, Journal of medicinal chemistry.

Comparative effect of l-CCG-I, DCG-IV and γ-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes

J. Bockaert, J. Pin, F. Acher, 1998, Neuropharmacology.

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

J. Bockaert, J. Pin, I. Brabet, 1995, Neuropharmacology.

Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.

N. Jullian, J. Pin, F. Acher, 1999, Journal of medicinal chemistry.

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

J. Pin, I. Brabet, P. Rondard, 2021, eLife.

Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8

F. Ferraguti, J. Pin, I. Brabet, 1998, The European journal of neuroscience.

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

J. Bockaert, J. Pin, I. Brabet, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.

J. Pin, I. Brabet, G. Costantino, 1998, Bioorganic & medicinal chemistry letters.

Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein–Coupled Receptor

G. Labesse, L. Prézeau, J. Pin, 2019, Molecular Pharmacology.

Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR

I. Brabet, Magali Cazade, M. Hajj, 2020 .

The Second Intracellular Loop of Metabotropic Glutamate Receptors Recognizes C Termini of G-protein α-Subunits*

L. Prézeau, J. Pin, I. Brabet, 2003, Journal of Biological Chemistry.

A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors*

J. Bockaert, J. Pin, I. Brabet, 2001, The Journal of Biological Chemistry.

Extreme C Terminus of G Protein α-Subunits Contains a Site That Discriminates between Gi-coupled Metabotropic Glutamate Receptors*

J. Bockaert, J. Pin, I. Brabet, 1998, The Journal of Biological Chemistry.

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

H. Daniel, M. Amalric, J. Pin, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

H. Daniel, J. Pin, Laetitia Mony, 2018, Journal of medicinal chemistry.

Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors

J. Bockaert, J. Pin, F. Acher, 1995 .