B. Kennedy

发表

oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes

David J. Arenillas, W. Wasserman, Shannan J. Ho Sui, 2005, Nucleic acids research.

The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

M. Percival, D. Riendeau, B. Kennedy, 1999, Bioorganic & medicinal chemistry letters.

Development of a robust scintillation proximity assay for protein tyrosine phosphatase 1B using the catalytically inactive (C215S) mutant.

B. Kennedy, C. Ramachandran, K. Skorey, 2001, Analytical biochemistry.

Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.

Y. Boie, B. Kennedy, P. A. Forsell, 2000, Gene.

Protein tyrosine phosphatase-1B in diabetes.

B. Kennedy, C. Ramachandran, 2000, Biochemical pharmacology.

Role of protein tyrosine phosphatase-1B in diabetes and obesity.

B. Kennedy, 1999, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

B. Kennedy, W. Cromlish, M. Gresser, 1999, Science.

Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis

B. Kennedy, T. Rideout, K. Bateman, 2015, BMC Research Notes.

Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.

P. Paré, C. Roberts, J. Hogg, 2008, American journal of respiratory and critical care medicine.

Basal Activation of p70S6K Results in Adipose-specific Insulin Resistance in Protein-tyrosine Phosphatase 1B–/– Mice*

Kenny K. Wong, B. Kennedy, W. Cromlish, 2007, Journal of Biological Chemistry.

The YRD Motif Is a Major Determinant of Substrate and Inhibitor Specificity in T-cell Protein-tyrosine Phosphatase*

C. Bayly, C. Desponts, E. Asante-Appiah, 2001, The Journal of Biological Chemistry.

Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.

D. Slipetz, J. Tam, J. Mortimer, 2005, American journal of respiratory cell and molecular biology.

Lack of Phosphatidylethanolamine N-Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

G. Francis, J. Brosnan, D. Vance, 2009, Arteriosclerosis, thrombosis, and vascular biology.

The development of potent non-peptidic PTP-1B inhibitors.

E. Asante-Appiah, Y. Boie, B. Kennedy, 2004, Bioorganic & medicinal chemistry letters.

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

D. Riendeau, B. Kennedy, S. Charleson, 1997, Inflammation Research.

Enhancement of leukocyte response to lipopolysaccharide by secretory group IIA Phospholipase A2

R. Thieringer, B. Kennedy, S. Wright, 1999, Journal of leukocyte biology.

Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity*

J. Dyck, D. Vance, B. Kennedy, 2010, The Journal of Biological Chemistry.

Therapeutic strategies for targeting PTP1B in diabetes

B. Kennedy, J. Montalibet, 2005 .

Protein Tyrosine Phosphatase-1B Dephosphorylation of the Insulin Receptor Occurs in a Perinuclear Endosome Compartment in Human Embryonic Kidney 293 Cells*

E. Asante-Appiah, B. Kennedy, J. Gauthier, 2004, Journal of Biological Chemistry.

Multiple Splice Variants of the Human Calcium-independent Phospholipase A2 and Their Effect on Enzyme Activity*

B. Kennedy, H. Claésson, P. Larsson, 1998, The Journal of Biological Chemistry.

Renin and Prorenin Activate Pathways Implicated in Organ Damage in Human Mesangial Cells Independent of Angiotensin II Production

Y. Boie, M. Percival, B. Kennedy, 2009, American Journal of Nephrology.

Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients.

B. Kennedy, S. Gallinger, B. Bapat, 1998, Cancer research.

Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B.

B. Kennedy, J. Montalibet, 2004, Biochemical pharmacology.

Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12.

J. Drazen, C. Yandava, B. Kennedy, 1999, Genomics.

Secretory non-pancreatic phospholipase A2 and cyclooxygenase-2 expression by tracheobronchial smooth muscle cells.

B. Kennedy, B. Grouix, P. Vadas, 1996, European journal of biochemistry.

Selective inhibitors of COX-2.

J. Falgueyret, B. Kennedy, C. Chan, 1995, Agents and actions. Supplements.

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1

S. Lipton, C. Hetz, B. Kennedy, 2020 .

Attenuation of Adhesion-dependent Signaling and Cell Spreading in Transformed Fibroblasts Lacking Protein Tyrosine Phosphatase-1B

B. Kennedy, M. Tremblay, Alan Cheng, 2001, Journal of Biological Chemistry.

Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).

R. Dixon, Y. Boie, B. Kennedy, 1991, The Journal of biological chemistry.

Human cytosolic phospholipase A2 expressed in insect cells is extensively phosphorylated on Ser-505.

B. Kennedy, W. Cromlish, P. Payette, 1995, Biochimica et biophysica acta.

Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth factors.

B. Kennedy, P. Vadas, W. Pruzanski, 1998, Biochimica et biophysica acta.

Induction of Secretory Phospholipase A2 Confirms the Systemic Inflammatory Nature of Adjuvant Arthritis

B. Kennedy, P. Vadas, W. Pruzanski, 1998, Inflammation.

Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA.

B. Kennedy, W. Cromlish, C. Chan, 1993, Biochemical and biophysical research communications.

High-level expression of active human cyclooxygenase-2 in insect cells.

M. Percival, B. Kennedy, W. Cromlish, 1994, Archives of biochemistry and biophysics.

Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.

C. Bayly, E. Asante-Appiah, Y. Boie, 2004, Bioorganic & medicinal chemistry letters.

Development and validation of an intact cell assay for protein tyrosine phosphatases using recombinant baculoviruses.

B. Kennedy, W. Cromlish, P. Payette, 1999, Biochemical pharmacology.

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

David A. Powell, Lei Zhang, R. Oballa, 2011, Journal of medicinal chemistry.

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.

Claude Dufresne, Yves Leblanc, Michel Therien, 2008, Bioorganic & medicinal chemistry letters.

Protein tyrosine phosphatase: enzymatic assays.

B. Kennedy, K. Skorey, J. Montalibet, 2005, Methods.

The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.

C. Bayly, C. Desponts, E. Asante-Appiah, 2003, Biochemistry.

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

H Perrier, R Gordon, M. Percival, 1999, The Journal of pharmacology and experimental therapeutics.

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.

B. Zinman, R. Hegele, A. Hanley, 2002, The Journal of clinical endocrinology and metabolism.

The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

J. Lamb, E. Schadt, B. Kennedy, 2009, Diabetes.

The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.

B. Kennedy, P. Forsell, H. Claesson, 1999, European journal of biochemistry.

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

B. Kennedy, M. Tremblay, Alan Cheng, 2002, Developmental cell.

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

B. Kennedy, W. Muller, M. Tremblay, 2007, Nature Genetics.

Protein tyrosine phosphatases: the quest for negative regulators of insulin action.

E. Asante-Appiah, B. Kennedy, 2003, American journal of physiology. Endocrinology and metabolism.

Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding*

E. Asante-Appiah, B. Kennedy, G. Scapin, 2006, Journal of Biological Chemistry.

Purification and characterization of T cell protein tyrosine phosphatase reveals significant functional homology to protein tyrosine phosphatase-1B.

E. Asante-Appiah, B. Kennedy, Y. Romsicki, 2003, Archives of biochemistry and biophysics.

Refinement of an in vitro cell model for cytochrome P450 induction.

B. Kennedy, T. Rushmore, P. Payette, 1998, Drug metabolism and disposition: the biological fate of chemicals.

PTP1B-dependent insulin receptor phosphorylation/residency in the endocytic recycling compartment of CHO-IR cells.

B. Kennedy, W. Cromlish, Robert Kyskan, 2006, Biochemical pharmacology.

Functional Characterization and Crystal Structure of the C215D Mutant of Protein-tyrosine Phosphatase-1B*

E. Asante-Appiah, B. Kennedy, G. Scapin, 2003, Journal of Biological Chemistry.

The structure of apo protein‐tyrosine phosphatase 1B C215S mutant: More than just an S → O change

B. Kennedy, G. Scapin, Sangita Patel, 2001, Protein science : a publication of the Protein Society.

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.

Claude Dufresne, Yves Leblanc, E. Asante-Appiah, 2002, Biochemistry.

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

J. Falgueyret, B. Kennedy, W. Cromlish, 1994, Molecular pharmacology.

Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase*

C. Desponts, E. Asante-Appiah, B. Kennedy, 2006, Journal of Biological Chemistry.

Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity.

B. Kennedy, C. Ramachandran, 2003, Current topics in medicinal chemistry.

Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.

B. Kennedy, W. Cromlish, P. Payette, 1996, Biochemistry.

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.

Jilly F. Evans, J. Falgueyret, D. Riendeau, 1996, Biochemical pharmacology.

Secretory PLAA2-Deficient and Transgenic Mice in Phospholipase A2 Research

B. Kennedy, P. Vadas, W. Pruzanski, 1997 .

Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis

B. Kennedy, T. Rideout, K. Bateman, 2015, BMC Research Notes.

M. Obeidat, S. Stepaniants, D. Sin, 2014, BMC Pulmonary Medicine.

Purification and characterization of recombinant human cyclooxygenase-2.

M. Percival, B. Kennedy, G. O'neill, 1994, Archives of biochemistry and biophysics.

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.

B. Kennedy, Q. Ye, D. Waddleton, 2001, Journal of medicinal chemistry.

Dephosphorylation of the Insulin Receptor Occurs in a Perinuclear Endosome Compartment in HEK 293 Cells

E. Asante-Appiah, B. Kennedy, J. Gauthier, 2003 .

Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays.

B. Kennedy, W. Cromlish, 1996, Biochemical pharmacology.

Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity*

J. Dyck, D. Vance, B. Kennedy, 2010, The Journal of Biological Chemistry.

Protein Tyrosine Phosphatase-1B Dephosphorylation of the Insulin Receptor Occurs in a Perinuclear Endosome Compartment in Human Embryonic Kidney 293 Cells*

E. Asante-Appiah, B. Kennedy, J. Gauthier, 2004, Journal of Biological Chemistry.

Human group II phospholipase A2 expressed in Trichoplusia ni larvae--isolation and kinetic properties of the enzyme.

B. Kennedy, I. Street, P. Weech, 1993, Protein expression and purification.