A. Waller

发表

High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL

M. Loh, Dominique R. Perez, C. Nickl, 2018, SLAS discovery : advancing life sciences R & D.

Drug Repurposing from an Academic Perspective.

Tudor I. Oprea, Susan M. Young, T. Oprea, 2011, Drug discovery today. Therapeutic strategies.

Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay

A. Waller, B. Edwards, L. Sklar, 2010, Journal of biomolecular screening.

Drug repurposing Drug repurposing from an academic perspective

Tudor I. Oprea, Susan M. Young, T. Oprea, 2012 .

An Automated High-Throughput Cell-Based Multiplexed Flow Cytometry Assay to Identify Novel Compounds to Target Candida albicans Virulence-Related Proteins

Tudor I. Oprea, Susan M. Young, T. Oprea, 2014, PloS one.

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

Tudor I. Oprea, T. Oprea, L. Hudson, 2015, PloS one.

Activation of Rho Family GTPases by Small Molecules

Tudor I. Oprea, Terry D. Foutz, Susan M. Young, 2018, ACS chemical biology.

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition.

Tudor I. Oprea, Chad E. Schroeder, Jennifer E. Golden, 2012, ACS chemical biology.

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.

Tudor I. Oprea, Susan M. Young, Mark B. Carter, 2013, Analytical biochemistry.

Figure 16, Validated hit and SAR strategy

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Glutathione‐S‐transferase‐green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH

D. Cimino, A. Waller, L. Sklar, 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Conformational Unbending of Regulation of Cell Adhesion by Affinity and

A. Waller, A. Chigaev, L. Sklar, 2007 .

Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils.

Tamara L. Kinzer-Ursem, J. Linderman, A. Waller, 2004, Biochemistry.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Larry A. Sklar, Stuart L. Schreiber, Anna Waller, 2016, Cell.

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

S. Schreiber, D. Scadden, B. Muñoz, 2015 .

Supplemental File S1 Supplemental Materials and Methods

T. Oprea, L. Hudson, O. Ursu, 2022 .

Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.

Susan M. Young, Sandra D. Melman, Rebecca M. Johnson, 2010, Analytical biochemistry.

Identification of Inhibitors of V-ATPase Pumps in Yeast by HTS Flow Cytometry

Sandra D. Melman, Rebecca M. Johnson, A. Waller, 2010 .

Threshold and graded response behavior in human neutrophils: effect of varying G-protein or ligand concentrations.

J. Linderman, A. Waller, T. Riccobene, 1998, Biochemistry.

Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin.

A. Waller, A. Chigaev, L. Sklar, 2007, Journal of immunology.

TIGA: Target illumination GWAS analytics

Christophe G. Lambert, Tudor I. Oprea, Lars Juhl Jensen, 2020, bioRxiv.

FRET detection of lymphocyte function–associated antigen-1 conformational extension

Tudor I. Oprea, Mark B. Carter, T. Oprea, 2015, Molecular biology of the cell.

Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands.

Tamara L. Kinzer-Ursem, Karyn L. Sutton, J. Linderman, 2006, Cellular signalling.

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.

Tudor I. Oprea, Radleigh G. Santos, T. Oprea, 2018, Methods in molecular biology.

Pharos: Collating protein information to shed light on the druggable genome

Rajarshi Guha, Tudor I. Oprea, Larry A. Sklar, 2016, Nucleic Acids Res..

TCRD and Pharos 2021: mining the human proteome for disease biology

Anton Simeonov, Tudor I. Oprea, Noel Southall, 2020, Nucleic Acids Res..

A Potent and Selective Inhibitor of Cdc42 GTPase

Cristian G. Bologa, Larry A. Sklar, Chad E. Schroeder, 2010 .

A Pan-GTPase Inhibitor as a Molecular Probe

Jennifer E. Golden, Mark B. Carter, O. Ursu, 2015, PloS one.

TIGA: Target illumination GWAS analytics

Tudor I. Oprea, Lars Juhl Jensen, Anna Waller, 2020, bioRxiv.

Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples

Anna Waller, Susan M. Young, Mark B. Carter, 2011, Nature Protocols.

A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry

Tudor I. Oprea, Terry D. Foutz, Brooks E. Maki, 2013, Journal of biomolecular screening.

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

Steven B. Bradfute, A. Waller, L. Sklar, 2015, Nature Communications.

A Novel Flow Cytometric HTS Assay Reveals Functional Modulators of ATP Binding Cassette Transporter ABCB6

Tudor I. Oprea, Susan M. Young, Stephanie E. Chavez, 2012, PloS one.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

Identification of a small molecule yeast TORC 1 inhibitor with a flow cytometry-based multiplex screen

Terry D. Foutz, Jennifer E. Golden, Susan M. Young, 2012 .

How to Illuminate the Druggable Genome Using Pharos

Tudor I. Oprea, Noel Southall, Dac-Trung Nguyen, 2020, Current protocols in bioinformatics.

Techniques: GPCR assembly, pharmacology and screening by flow cytometry.

Sean M. Biggs, A. Waller, B. Edwards, 2004, Trends in pharmacological sciences.

Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation*S⃞

A. Waller, A. Chigaev, L. Sklar, 2009, Journal of Biological Chemistry.

TIN-X: target importance and novelty explorer

Tudor I. Oprea, Cristian G. Bologa, Larry A. Sklar, 2017, Bioinform..

Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen–Fluorogen Activating Protein Binding Pair

Mark B. Carter, A. Waggoner, J. Jarvik, 2016, Journal of biomolecular screening.

Real-time Analysis of the Inside-out Regulation of Lymphocyte Function-associated Antigen-1 Revealed Similarities to and Differences from Very Late Antigen-4*

A. Waller, A. Chigaev, L. Sklar, 2011, The Journal of Biological Chemistry.

Galphas-coupled receptor signaling actively down-regulates α4β1-integrin affinity: A possible mechanism for cell de-adhesion

A. Waller, A. Chigaev, L. Sklar, 2008, BMC Immunology.

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.

Sean M. Biggs, A. Waller, L. Sklar, 2007, Advances in protein chemistry.

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining

O. Ursu, A. Waller, B. Edwards, 2018, SLAS discovery : advancing life sciences R & D.

ATP-Binding Cassette Sub-Family G Member 2

Hadya M. Njus, Terry D. Foutz, Brooks E. Maki, 2013 .

Real-time Analysis of Ternary Complex on Particles

Terry D. Foutz, Anna Waller, Larry A Sklar, 2004, Journal of Biological Chemistry.

Regulation of Cell Adhesion by Affinity and Conformational Unbending of α4β1 Integrin1

A. Waller, A. Chigaev, L. Sklar, 2007, The Journal of Immunology.

Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe

Tudor I. Oprea, Larry A. Sklar, Chad E. Schroeder, 2013, The Journal of Biological Chemistry.

Inhibitor and Its Use as a Molecular Probe Characterization of a Cdc 42 Protein Cell

Tudor I. Oprea, Chad E. Schroeder, Jennifer E. Golden, 2013 .

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Terry D. Foutz, Tuanli Yao, Jennifer E. Golden, 2012, ACS chemical biology.

An Overview of the Challenges in Designing, Integrating, and Delivering BARD

Tudor I. Oprea, Noel Southall, Stephan C Schürer, 2014, Journal of biomolecular screening.

Conformational mAb as a tool for integrin ligand discovery.

Tudor I. Oprea, O. Ursu, A. Waller, 2009, Assay and drug development technologies.

Detection of Intracellular Granularity Induction in Prostate Cancer Cell Lines by Small Molecules Using the HyperCyt® High-Throughput Flow Cytometry System

Tudor I. Oprea, Anna Waller, Bruce S Edwards, 2009, Journal of biomolecular screening.

A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

Cristian G. Bologa, Larry A. Sklar, Chad E. Schroeder, 2013 .

Three small molecule pan activator families of Ras-related GTPases

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2010 .

Identifying Small Molecules That Overcome HoxA9-Mediated Differentiation Arrest in Acute Myeloid Leukemia

L. Zon, D. Scadden, A. Waller, 2012 .

High throughput screening of G-protein coupled receptors via flow cytometry.

L A Sklar, B S Edwards, A. Waller, 2003, Combinatorial chemistry & high throughput screening.

Figure 6, Schematic of screen strategy

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Validation of flow cytometric competitive binding protocols and characterization of fluorescently labeled ligands.

J. Linderman, A. Waller, G. Omann, 2001, Cytometry.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

P. Clemons, S. Schreiber, Mathias Wawer, 2016, Cell.

High‐Throughput Flow Cytometry

Tudor I. Oprea, Eric R. Prossnitz, Cristian G. Bologa, 2010 .

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining

O. Ursu, A. Waller, B. Edwards, 2018, SLAS discovery : advancing life sciences R & D.

An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system.

Anna Waller, Bruce S Edwards, Larry A Sklar, 2004, Analytical chemistry.

Figure 10, TORC1 bypass cell growth analysis on the probe ML231 and SID 96099781

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Best practices for managing and disseminating resources and outreach and evaluating the impact of the IDG Consortium.

A. Waller, Jayme Holmes, D. Vidović, 2024, Drug discovery today.

Real-time Analysis of Ternary Complex on Particles DIRECT EVIDENCE FOR PARTIAL AGONISM AT THE AGONIST-RECEPTOR-G PROTEIN COMPLEX ASSEMBLY STEP OF SIGNAL TRANSDUCTION*

Terry D. Foutz, Sean M. Biggs, R. Neubig, 2004 .