M. Yokoyama

发表

Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate).

T. Okano, M. Yamato, Y. Sakurai, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Polyion complex micelle MRI contrast agents from poly(ethylene glycol)-b-poly(l-lysine) block copolymers having Gd-DOTA; preparations and their control of T(1)-relaxivities and blood circulation characteristics.

M. Yokoyama, Y. Maitani, K. Shiraishi, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers.

T. Okano, M. Yokoyama, M. Kurisawa, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging.

M. Yokoyama, Y. Maitani, K. Shiraishi, 2014, Biological & pharmaceutical bulletin.

Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. A new type of polymeric anticancer agent

K. Kataoka, Y. Sakurai, M. Yokoyama, 1987 .

Molecular design for missile drug: Synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier

T. Okano, K. Kataoka, Y. Sakurai, 1989 .

A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors.

Y. Tabata, M. Yokoyama, K. Shiraishi, 2011, International journal of pharmaceutics.

Preparation of Perfluorocarbon/Fluoroalkyl Polymer Nanodroplets for Cancer-targeted Ultrasound Contrast Agents

M. Yokoyama, Masamichi Nishihara, K. Imai, 2009 .

Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors.

Yusuke Sanada, Kazuo Sakurai, Kouichi Shiraishi, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system.

T. Okano, S. Fukushima, K. Kataoka, 1999, Journal of drug targeting.

What are determining factors for stable drug incorporation into polymeric micelle carriers? Consideration on physical and chemical characters of the micelle inner core.

M. Yokoyama, P. Opanasopit, Y. Maitani, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control.

S. Kawakami, M. Hashida, M. Yokoyama, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Encapsulation of a hydrophobic drug into a polymer-micelle core explored with synchrotron SAXS.

M. Yokoyama, Taku Sato, N. Yagi, 2010, Langmuir : the ACS journal of surfaces and colloids.

Polymeric micelles as a new drug carrier system and their required considerations for clinical trials

M. Yokoyama, 2010, Expert opinion on drug delivery.

Composition dependence of the micellar architecture made from poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid).

Y. Amemiya, M. Yokoyama, N. Yagi, 2012, The journal of physical chemistry. B.

Hydrophobic molecules infiltrating into the poly(ethylene glycol) domain of the core/shell interface of a polymeric micelle: evidence obtained with anomalous small-angle X-ray scattering.

Y. Amemiya, M. Yokoyama, E. Mylonas, 2013, Journal of the American Chemical Society.

Influence of serum and albumins from different species on stability of camptothecin-loaded micelles.

Teruo Okano, Praneet Opanasopit, Masato Watanabe, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Incorporation of the Anticancer Agent KRN5500 into Polymeric Micelles Diminishes the Pulmonary Toxicity

T. Okano, M. Yokoyama, F. Moriyasu, 2002, Japanese journal of cancer research : Gann.

Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting

T. Okano, M. Yokoyama, P. Opanasopit, 2004, Pharmaceutical Research.

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.

M. Yokoyama, K. Shiraishi, N. Oku, 2012, International journal of pharmaceutics.

Particle size-dependent triggering of accelerated blood clearance phenomenon.

M. Yokoyama, N. Oku, Hiroyuki Koide, 2008, International journal of pharmaceutics.

A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood–brain barrier (BBB) permeability for macromolecules in cerebral ischemia‐reperfusion injury

I. Aoki, D. Kokuryo, M. Yokoyama, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Accelerated Blood Clearance Was Not Induced for a Gadolinium-Containing PEG-poly(L-lysine)-Based Polymeric Micelle in Mice

M. Yokoyama, Y. Maitani, K. Shiraishi, 2010, Pharmaceutical Research.

Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration.

T. Okano, S. Kawakami, M. Hashida, 2005, Journal of pharmaceutical sciences.

The combretastatin derivative (Cderiv), a vascular disrupting agent, enables polymeric nanomicelles to accumulate in microtumors.

M. Yokoyama, K. Shiraishi, Masamichi Nishihara, 2010, Journal of pharmaceutical sciences.

Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide)

T. Okano, M. Yamato, Y. Sakurai, 1999 .

Roles of adriamycin and adriamycin dimer in antitumor activity of the polymeric micelle carrier system

T. Okano, S. Fukushima, K. Kataoka, 1999 .

Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide).

T. Okano, Y. Sakurai, M. Yokoyama, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor.

T. Okano, S. Fukushima, K. Kataoka, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Active platelet movements on hydrophobic/hydrophilic microdomain-structured surfaces.

T. Okano, M. Yamato, Y. Sakurai, 1998, Journal of biomedical materials research.

Adhesion behavior of rat lymphocytes to poly(ether)-poly(amino acid) block and graft copolymers.

K. Kataoka, M. Yokoyama, S. Inoue, 1986, Journal of biomedical materials research.

Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models.

M. Yokoyama, T. Tominaga, Y. Sonoda, 2009, Neuro-oncology.

Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents.

Kouichi Shiraishi, M. Yokoyama, Y. Maitani, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Stability evaluation of Gd chelates for macromolecular MRI contrast agents

M. Yokoyama, K. Shiraishi, 2019, Magnetic Resonance Materials in Physics, Biology and Medicine.

PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography

O. Abe, K. Ohtomo, M. Nojima, 2018, Journal of magnetic resonance imaging : JMRI.

Preparation and Characterization of Self-Assembled Polymer−Metal Complex Micelle from cis-Dichlorodiammineplatinum(II) and Poly(ethylene glycol)−Poly(α,β-aspartic acid) Block Copolymer in an Aqueous Medium

T. Okano, N. Nishiyama, K. Kataoka, 1999 .

Block copolymers as drug carriers.

M. Yokoyama, 1992, Critical reviews in therapeutic drug carrier systems.

Biodistribution of Micelle-Forming Polymer–Drug Conjugates

T. Okano, K. Kataoka, G. Kwon, 1993, Pharmaceutical Research.

Preparation of micelle-forming polymer-drug conjugates.

T. Okano, K. Kataoka, G. Kwon, 1992, Bioconjugate chemistry.

Polymeric micelles as drug carriers: their lights and shadows

M. Yokoyama, 2014, Journal of drug targeting.

Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy of cancers.

M. Yokoyama, K. Ono, Minoru Suzuki, 2013, Bioconjugate chemistry.

Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.

M. Yokoyama, T. Tominaga, Y. Sonoda, 2010, The Tohoku journal of experimental medicine.

Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells.

M. Yokoyama, Katsuhiko Aoki, K. Ohkawa, 2018, Anticancer research.

Heterobifunctional poly(ethylene oxide)

T. Okano, K. Kataoka, Y. Sakurai, 1994 .

Reduction of the Side Effects of an Antitumor Agent, KRN5500, by Incorporation of the Drug into Polymeric Micelles

T. Okano, K. Kataoka, Y. Sakurai, 1999, Japanese journal of cancer research : Gann.

Stabilization of disulfide linkage in drug-polymer-immunoglobulin conjugate by microenvironmental control.

T. Okano, K. Kataoka, Y. Sakurai, 1989, Biochemical and biophysical research communications.

Block copolymer micelles as vehicles for hydrophobic drugs

T. Okano, K. Kataoka, G. Kwon, 1994 .

Effects of organic solvents on drug incorporation into polymeric carriers and morphological analyses of drug-incorporated polymeric micelles.

M. Yokoyama, Y. Maitani, K. Kawano, 2011, International journal of pharmaceutics.

Polymeric micelles possessing polyethyleneglycol as outer shell and their unique behaviors in accelerated blood clearance phenomenon.

M. Yokoyama, K. Shiraishi, 2013, Biological & pharmaceutical bulletin.

The Effect of the Liquid-Crystalline Order on Releasing Dye Molecules from Liquid-Crystalline Nano-Emulsions

Y. Takanishi, M. Yokoyama, J. Yamamoto, 2015 .

Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin

T. Okano, K. Kataoka, Y. Sakurai, 1994 .

IN VIVO REAL-TIME TRACKING OF POLYMERIC MICELLES FOR DRUG DELIVERY SYSTEM VISUALIZATION

M. Takeda, N. Ohuchi, M. Yokoyama, 2012 .

Targetable drug carriers: present status and a future perspective

T. Okano, M. Yokoyama, 1996 .

Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate)

T. Okano, K. Kataoka, G. Kwon, 1993 .

Synthesis of poly(ethylene oxide) with heterobifunctional reactive groups at its terminals by an anionic initiator.

T. Okano, A. Kikuchi, K. Kataoka, 1992, Bioconjugate chemistry.

A simple hemostasis model for the quantitative evaluation of hydrogel-based local hemostatic biomaterials on tissue surface.

Y. Tomizawa, H. Nishida, M. Yokoyama, 2008, Colloids and surfaces. B, Biointerfaces.

Polymeric Micelles for the Targeting of Hydrophobic Drugs

M. Yokoyama, 2005 .

Melting temperatures of thermally reversible gels IV. Methyl cellulose-water gels

M. Yokoyama, A. Takahashi, Tadaya Kato, 1978 .

Block copolymer micelles for drug delivery: Loading and release of doxorubicin

Teruo Okano, Kazunori Kataoka, Glen S. Kwon, 1997 .

Molecular design of biodegradable polymeric micelles for temperature-responsive drug release.

T. Okano, M. Yokoyama, K. Sakai, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH

T. Okano, A. Kikuchi, K. Kataoka, 1995 .

A novel drug carrier system with polymeric micelles.

T. Okano, K. Kataoka, Y. Sakurai, 1991 .

Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability.

T. Okano, M. Yokoyama, P. Opanasopit, 2006, International journal of pharmaceutics.

Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance.

T. Okano, S. Fukushima, K. Kataoka, 2000, Journal of controlled release : official journal of the Controlled Release Society.

In vivo and in vitro evaluation of gelation and hemostatic properties of a novel tissue-adhesive hydrogel containing a cross-linkable polymeric micelle.

Yasuko Tomizawa, Hiromi Kurosawa, Yoshihiko Murakami, 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

Synthesis and Characterization of a Temperature-responsive Amphiphilic Block Copolymer Containing a Liquid Crystalline Unit

M. Yokoyama, Y. Murakami, Masamichi Nishihara, 2008 .

A novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle.

Teruo Okano, Yasuko Tomizawa, Hiromi Kurosawa, 2007, Journal of biomedical materials research. Part A.

Synthesis and permeation behavior of membranes from segmented multiblock copolymers containing poly(ethylene oxide) and poly(β‐benzyl L‐aspartate) blocks

K. Kataoka, Y. Sakurai, M. Yokoyama, 1990 .

Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.

T. Okano, K. Kataoka, Y. Sakurai, 1990, Cancer research.

Effect of molecular architecture of hydrophobically modified poly(N-isopropylacrylamide) on the formation of thermoresponsive core-shell micellar drug carriers.

T. Okano, Y. Sakurai, J. Chung, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Gene expression control by temperature with thermo-responsive polymeric gene carriers.

T. Okano, M. Yokoyama, M. Kurisawa, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Development of the polymer micelle carrier system for doxorubicin.

T. Okano, S. Fukushima, K. Kataoka, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.

T. Okano, K. Kataoka, Y. Sakurai, 1991, Cancer research.

Introduction of cisplatin into polymeric micelle

Teruo Okano, Kazunori Kataoka, Yasuhisa Sakurai, 1996 .

Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles.

Tatsuhiro Yamamoto, Teruo Okano, Praneet Opanasopit, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Influential factors on temperature-controlled gene expression using thermoresponsive polymeric gene carriers

T. Okano, M. Yokoyama, M. Kurisawa, 2001, Journal of Artificial Organs.

Gene delivery using temperature-responsive polymeric carriers.

M. Yokoyama, 2002, Drug discovery today.

Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size.

T. Okano, K. Kataoka, Y. Sakurai, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Inner core segment design for drug delivery control of thermo-responsive polymeric micelles.

T. Okano, J. Chung, M. Yokoyama, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Reversibly thermo-responsive alkyl-terminated poly(N-isopropylacrylamide) core-shell micellar structures

T. Okano, Y. Sakurai, J. Chung, 1997 .

Process design for efficient and controlled drug incorporation into polymeric micelle carrier systems.

T. Okano, M. Yokoyama, K. Sakai, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Clinical Diagnostic Imaging

M. Yokoyama, K. Shiraishi, 2018 .

Clinical Applications of Polymeric Micelle Carrier Systems in Chemotherapy and Image Diagnosis of Solid Tumors

M. Yokoyama, 2011 .

Tumor Environment Changed by Combretastatin Derivative (Cderiv) Pretreatment That Leads to Effective Tumor Targeting, MRI Studies, and Antitumor Activity of Polymeric Micelle Carrier Systems

M. Yokoyama, K. Yanagihara, Y. Maitani, 2011, Pharmaceutical Research.

Drug Targeting with Polymeric Micelle Drug Carriers

M. Yokoyama, 2002 .

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon.

K. Ishii, M. Yokoyama, T. Aoshi, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Histological study on side effects and tumor targeting of a block copolymer micelle on rats.

M. Yokoyama, Masamichi Nishihara, Tatsuhiro Yamamoto, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review

M. Yokoyama, K. Shiraishi, 2019, Science and technology of advanced materials.

Drug targeting with nano-sized carrier systems

M. Yokoyama, Masayuki Yokoyama, 2005, Journal of Artificial Organs.

Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.

S. Kawakami, M. Hashida, F. Yamashita, 2009, International journal of pharmaceutics.

Electrochemical control of drug release from redox-active micelles

T. Okano, Y. Sakurai, M. Yokoyama, 1995 .

Polymer Design and Incorporation Methods for Polymeric Micelle Carrier System Containing Water-insoluble Anti-cancer Agent Camptothecin

T. Okano, M. Yokoyama, P. Opanasopit, 2004, Journal of drug targeting.

Physical Entrapment of Adriamycin in AB Block Copolymer Micelles

Teruo Okano, Kazunori Kataoka, Glen S. Kwon, 1995, Pharmaceutical Research.

Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugates

Teruo Okano, Kazunori Kataoka, Glen S. Kwon, 1994 .

Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles

M. Yokoyama, K. Shiraishi, Masanori Ito, 2017, Polymers.

Vital microscopic analysis of polymeric micelle extravasation from tumor vessels: macromolecular delivery according to tumor vascular growth stage.

M. Yokoyama, Masamichi Nishihara, K. Hori, 2010, Journal of pharmaceutical sciences.

Anti-tumor Effect of All-Trans Retinoic Acid Loaded Polymeric Micelles in Solid Tumor Bearing Mice

S. Kawakami, M. Hashida, M. Yokoyama, 2008, Pharmaceutical Research.

A polymeric micelle MRI contrast agent with changeable relaxivity.

T. Okano, M. Yokoyama, Tatsuhiro Yamamoto, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Thermal modulation of intracellular drug distribution using thermoresponsive polymeric micelles

T. Okano, J. Chung, M. Yokoyama, 2007 .

A Self-Regulated Insulin Delivery System Using Boronic Acid Gel

T. Okano, K. Kataoka, Y. Sakurai, 1994 .

Temperature-responsive polymeric carriers incorporating hydrophobic monomers for effective transfection in small doses.

T. Okano, M. Yokoyama, N. Takeda, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.

S. Kawakami, M. Hashida, F. Yamashita, 2008, International journal of pharmaceutics.

Polymeric micelles modified by folate-PEG-lipid for targeted drug delivery to cancer cells in vitro.

M. Yokoyama, Y. Maitani, K. Kawano, 2008, Journal of Nanoscience and Nanotechnology.

Preparation of micelle-forming polymer-drug conjugates. [Erratum to document cited in CA117(6):55779a]

T. Okano, K. Kataoka, G. Kwon, 1993 .

Nano-sized drug carriers : their present status and future perspective

M. Yokoyama, 2006 .

composition-dependent in vivo antitumor activity of adriamycin-conjugated polymeric micelle against murine colon adenocarcinoma 26

Kazuya Okamoto, Teruo Okano, Kazunori Kataoka, 1993 .

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance.

K. Ishii, M. Yokoyama, T. Aoshi, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Preparation and characterization of a glucose-responsive insulin-releasing polymer device.

T. Okano, K. Kataoka, Y. Sakurai, 1994, Biomaterials.

In vivo antitumor activity of polymeric micelle anticancer drug against murine C 26 tumor

T. Okano, K. Kataoka, G. Kwon, 1994 .

Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography

Teruo Okano, Kazunori Kataoka, Yasuhisa Sakurai, 1993, Pharmaceutical Research.

Novel Synthesis of Perfluoroalkylated Phenylboronic Acid with Low pKa Using Bis(heptafluorobutyryl)peroxide as Perfluoroalkylation Reagent

T. Okano, K. Kataoka, Y. Sakurai, 1993 .