B. van de Water

发表

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

Marja Moerkens, Yinghui Zhang, Lynn Wester, 2014, BMC Cancer.

Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks.

R. Sharan, B. van de Water, J. Rudolph, 2016, Cell systems.

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Paul Jennings, Alice Limonciel, Bob van de Water, 2018, Archives of Toxicology.

Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment.

B. van de Water, G. Hendriks, M. Atallah, 2011, Mutation research.

Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells.

B. van de Water, I. Tijdens, G. Mulder, 2001 .

Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells

J. Olsen, C. D. Kelstrup, E. Danen, 2011, Molecular and Cellular Biology.

Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues

F. Verbeek, B. van de Water, J. Meerman, 2014, PloS one.

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

B. van de Water, Huan Yang, Marije Niemeijer, 2020, iScience.

Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development

D. Ingber, B. Li, L. Smirnova, 2020, ALTEX.

Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

G. Kéri, B. van de Water, L. Őrfi, 2016, Journal of biomolecular screening.

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Mardas Daneshian, Bob van de Water, Hennicke Kamp, 2016, Archives of Toxicology.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

Jesper V Olsen, Bob van de Water, Harry Vrieling, 2013, Science Signaling.

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

J. Timmer, M. Schilling, Daniel Kaschek, 2018, npj Systems Biology and Applications.

The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitros.

R. Pieters, R. Weaver, B. van de Water, 2020, Toxicology and applied pharmacology.

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling

B. van de Water, Huan Yang, J. Beltman, 2017, Expert opinion on drug metabolism & toxicology.

High‐Throughput Live Cell Imaging of Apoptosis

E. Danen, B. van de Water, J. C. Puigvert, 2010, Current protocols in cell biology.

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening

Fons J. Verbeek, Bob van de Water, Kuan Yan, 2012, PloS one.

The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Giulia Callegaro, Bob van de Water, Maarten Coonen, 2019, Archives of Toxicology.

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

A. Kopp-Schneider, F. Bois, B. van de Water, 2018, Front. Genet..

New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies.

J. C. Gómez-Tamayo, M. J. Moné, G. Ecker, 2021, ALTEX.

Systems microscopy approaches to understand cancer cell migration and metastasis

Sylvia E. Le Dévédec, F. Verbeek, Veerander P. S. Ghotra, 2010, Cellular and Molecular Life Sciences.

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2−/− γc−/− mouse

Bob van de Water, Sylvia E. Le Dévédec, B. van de Water, 2009, Clinical & Experimental Metastasis.

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Bob van de Water, Lisa Fredriksson, B. van de Water, 2013, Biochemical pharmacology.

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

Gerard J. P. van Westen, Bob van de Water, Kuan Yan, 2017, SLAS discovery : advancing life sciences R & D.

Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2022, Frontiers in Cell and Developmental Biology.

Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells

Arnoud Boot, H. Morreau, Yinghui Zhang, 2016, The Journal of pathology.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Ursula Klingmüller, Bob van de Water, K. G. Jensen, 2019, Nature Reviews Drug Discovery.

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.

A. IJzerman, T. Schwartz, Kristoffer L Egerod, 2015, Cellular signalling.

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

Sylvia E. Le Dévédec, J. Foekens, M. Timmermans, 2019, Nature Communications.

Uncovering the signaling landscape controlling breast cancer cell migration identifies splicing factor PRPF4B as a metastasis driver

Sylvia E. Le Dévédec, J. Foekens, M. Smid, 2018, bioRxiv.

Co-regulated gene expression of splicing factors as drivers of cancer progression

Sylvia E. Le Dévédec, J. Foekens, M. Smid, 2019, Scientific Reports.

Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling.

B. van de Water, G. Mulder, C. Pont, 2006, Biochemical pharmacology.

Endoplasmic Reticulum Stress Proteins Block Oxidant-induced Ca2+ Increases and Cell Death*

B. van de Water, H. Liu, J. Stevens, 1998, The Journal of Biological Chemistry.

Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance.

A. Cleton-Jansen, B. van de Water, H. Gelderblom, 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour

F. Verbeek, E. Danen, B. van de Water, 2016, Scientific Reports.

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Alice Krebs, Barbara M. A. van Vugt-Lussenburg, Tanja Waldmann, 2020, Archives of Toxicology.

High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors

Sylvia E. Le Dévédec, E. Danen, B. van de Water, 2022, Cell Biology and Toxicology.

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.

B. van de Water, M. V. van Nimwegen, D. Burg, 2005, Cancer research.

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

Sylvia E. Le Dévédec, H. Overkleeft, G. V. van Westen, 2019, ACS central science.

Next-generation risk assessment of chemicals - Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective.

M. J. Moné, B. van de Water, H. Kamp, 2022, ALTEX.

Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study

S. Auerbach, Ruchir R. Shah, R. Paules, 2020, Bioinformatics and biology insights.

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

G. V. van Westen, B. van de Water, D. Peters, 2019, Journal of molecular cell biology.

Model-based translation of DNA damage signaling dynamics across cell types

B. van de Water, H. Yang, S. L. Le Dévédec, 2022, PLoS Comput. Biol..

Linking gene expression to mechanisms of toxicity.

B. van de Water, Q. Chen, H. Liu, 2000, Toxicology letters.

Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer

J. Foekens, J. Martens, G. V. van Westen, 2019, Breast Cancer Research and Treatment.

Transformation-sensitive changes in expression, localization, and phosphorylation of adducins in renal proximal tubule epithelial cells.

B. van de Water, L. Dong, J. Stevens, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

N. Vermeulen, B. van de Water, Shalenie P. den Braver-Sewradj, 2018, Front. Pharmacol..

Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells.

N. Vermeulen, B. van de Water, I. Andreadou, 1996, Toxicology and applied pharmacology.

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

Marja Moerkens, Yinghui Zhang, B. van de Water, 2011, Breast Cancer Research.

Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment.

B. van de Water, H. Liu, J. Stevens, 1999, Chemical research in toxicology.

Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain.

B. van de Water, G. Mulder, Emile de Heer, 1997, The Journal of pharmacology and experimental therapeutics.

Role of microtubuli in secretion of very‐low‐density lipoprotein in isolated rat hepatocytes: Early effects of thiol reagents

B. van de Water, G. Mulder, J. Nagelkerke, 1991, Hepatology.

Inhibition of Protein Kinase C Enhances Anticancer Agent-Induced Loss of Anchorage-Independent Growth Regardless of Protection against Apoptosis by Bcl-2

B. van de Water, M. Huigsloot, B. Water, 2003 .

The membrane attack complex of complement induces caspase activation and apoptosis

B. van de Water, M. Daha, A. Nauta, 2002, European journal of immunology.

A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer.

W. V. van IJcken, J. Martens, B. van de Water, 2022, Biochemical pharmacology.

Targeting the Heterogeneous Genomic Landscape in Triple-Negative Breast Cancer through Inhibitors of the Transcriptional Machinery

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2022, Cancers.

Targeting survivin as a potential new treatment for chondrosarcoma of bone

A. Cleton-Jansen, E. Danen, B. van de Water, 2016, Oncogenesis.

Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Daniel Kaschek, M. Fehling-Kaschek, B. van de Water, 2022, Scientific Reports.

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses.

B. van de Water, B. Ter Braak, S. Wink, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Cardiovascular , Pulmonary , and Renal Pathology Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia / Reperfusion

B. van de Water, M. de Graauw, J. Bonventre, 2011 .

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation

Bob van de Water, Anne-Marie Cleton-Jansen, Marieke L. Kuijjer, 2015, Genes & cancer.

F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells.

B. van de Water, M. Kruidering, J. Nagelkerke, 1996, The American journal of physiology.

Identification of proteome markers for drug-induced liver injury in zebrafish embryos.

H. Spaink, J. Pennings, B. van de Water, 2022, Toxicology.

Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

J. Hengstler, B. van de Water, H. Kamp, 2021, Cell Biology and Toxicology.

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

J. Kleinjans, J. Hengstler, A. Ghallab, 2020, Archives of Toxicology.

Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation.

H. Putter, R. Tollenaar, C. V. D. van de Velde, 2008, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Suppression of Chemically Induced Apoptosis but Not Necrosis of Renal Proximal Tubular Epithelial (LLC-PK1) Cells by Focal Adhesion Kinase (FAK)

B. van de Water, I. Tijdens, M. Huigsloot, 2001, The Journal of Biological Chemistry.

Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells*

B. van de Water, J. Stevens, J. Nagelkerke, 1999, The Journal of Biological Chemistry.

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model

B. van de Water, H. van Steeg, E. Speksnijder, 2015, Breast Cancer Research.

Protein Kinase C Mediates Cisplatin-Induced Loss of Adherens Junctions Followed by Apoptosis of Renal Proximal Tubular Epithelial Cells

B. van de Water, M. de Graauw, R. Imamdi, 2004, Journal of Pharmacology and Experimental Therapeutics.

In Vitro Three-Dimensional Liver Models for Nanomaterial DNA Damage Assessment.

M. J. Moné, B. van de Water, S. Doak, 2021, Small.

Integrins Uncouple Src-induced Morphological and Oncogenic Transformation*

A. Sonnenberg, E. Danen, B. van de Water, 2008, Journal of Biological Chemistry.

cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac

F. Verbeek, B. van de Water, M. de Graauw, 2012, British journal of pharmacology.

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

Sylvia E. Le Dévédec, B. van de Water, J. W. van der Laan, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, eLife.

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, Molecular systems biology.

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, Molecular Systems Biology.

Squaramide‐Based Supramolecular Materials Drive HepG2 Spheroid Differentiation

B. van de Water, Tingxian Liu, D. Heinrich, 2021, Advanced healthcare materials.

Current EU research activities on combined exposure to multiple chemicals☆

Erik Lebret, Werner Brack, Bob van de Water, 2018, Environment international.

Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes.

B. van de Water, G. Mulder, J. Nagelkerke, 1992, The Biochemical journal.

The role of a purinergic P2z receptor in calcium‐dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate

B. van de Water, J. Nagelkerke, H. D. de Bont, 1996, Hepatology.

Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

B. van de Water, E. Vreugdenhil, B. Håvik, 2013, PloS one.

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Barbara Zdrazil, Ciarán Fisher, Jan G. Hengstler, 2019, Archives of Toxicology.

NAM-supported read-across: From case studies to regulatory guidance in safety assessment.

Nisha S. Sipes, S. H. Bennekou, G. Patlewicz, 2021, ALTEX.

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Bertrand Desprez, Martina Klaric, Gladys Ouédraogo, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells*

Hong Liu, B. van de Water, J. Stevens, 1997, The Journal of Biological Chemistry.

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

G. Groothuis, E. Danen, B. van de Water, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Sylvia E. Le Dévédec, M. Smid, J. Martens, 2021, Scientific Reports.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

K. G. Jensen, Amy E. Chadwick, Dominic P. Williams, 2019, Nature Reviews Drug Discovery.

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2014, Chemical research in toxicology.

Differential Regulation of Doxorubicin-induced Mitochondrial Dysfunction and Apoptosis by Bcl-2 in Mammary Adenocarcinoma (MTLn3) Cells*

B. van de Water, I. Tijdens, G. Mulder, 2002, The Journal of Biological Chemistry.

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Sylvia E. Le Dévédec, E. Danen, B. van de Water, 2021, Archives of toxicology.

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage and regeneration response after cisplatin

K. Bodie, B. van de Water, S. J. Kunnen, 2023, bioRxiv.

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes

T. Breit, B. van de Water, M. Jonker, 2012, Archives of Toxicology.

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

S. H. Bennekou, B. van de Water, M. Leist, 2021, Archives of Toxicology.

A quantitative AOP of mitochondrial toxicity based on data from three cell lines.

B. van de Water, M. Leist, G. Carta, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

S. H. Bennekou, E. Danen, B. van de Water, 2020, Archives of Toxicology.

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Anna Forsby, Paul Jennings, Bob van de Water, 2019, Archives of Toxicology.

An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer

J. Foekens, M. Smid, Yinghui Zhang, 2019, Scientific Reports.

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

J. Foekens, M. Timmermans, M. Smid, 2019, Nature Communications.

Splicing regulatory factors in breast cancer hallmarks and disease progression

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2019, Oncotarget.

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Sylvia E. Le Dévédec, J. Martens, H. Ovaa, 2019, Clinical Cancer Research.

Cleavage of the Actin-capping Protein α-Adducin at Asp-Asp-Ser-Asp633-Ala by Caspase-3 Is Preceded by Its Phosphorylation on Serine 726 in Cisplatin-induced Apoptosis of Renal Epithelial Cells*

B. van de Water, I. Tijdens, G. Mulder, 2000, The Journal of Biological Chemistry.

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

Jaana M. Hartikainen, C. Vachon, J. Olson, 2015, BMC Medicine.

E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines

P. Eilers, A. Cleton-Jansen, B. van de Water, 2006, British Journal of Cancer.

Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes

R. Paules, F. Bois, B. van de Water, 2021, bioRxiv.

Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

Sylvia E. Le Dévédec, M. J. Moné, C. Verfaillie, 2021, Archives of Toxicology.

Stem cell-derived systems in toxicology assessment.

Paul Jennings, Bob van de Water, Angelo Moretto, 2015, Stem cells and development.

Mining a human transcriptome database for chemical modulators of NRF2

J. Corton, D. Bell, B. van de Water, 2020, PloS one.

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.

R. Versteeg, E. Danen, B. van de Water, 2010, Endocrine-related cancer.

Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes (PHH) and HepaRG cells using concentration-response modelling of gene co-expression networks

M. Vinken, B. van de Water, S. J. Kunnen, 2023, bioRxiv.

Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo.

B. van de Water, Wies van Roosmalen, S. L. Le Dévédec, 2011, Methods in molecular biology.

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

P. Shepard, M. Vinken, B. Seligmann, 2018, Archives of Toxicology.

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Bob van de Water, Steven Wink, B. van de Water, 2016, Archives of Toxicology.

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

Marja Moerkens, Yinghui Zhang, B. van de Water, 2014, BMC Cancer.

Focal adhesion kinase: a potential target in cancer therapy.

Bob van de Water, B. van de Water, Maroesja J van Nimwegen, 2007, Biochemical pharmacology.

Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression

J. Foekens, M. Smid, J. Martens, 2020, Oncogene.

Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity

E. Danen, B. van de Water, S. Huveneers, 2009, Molecular Pharmacology.

Density-dependent migration characteristics of cancer cells driven by pseudopod coordination

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2021 .

Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia

Sylvia E. Le Dévédec, E. Danen, B. van de Water, 2023, Breast Cancer Research and Treatment.

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.

Benjamin Geiger, Bob van de Water, Gabriella Rustici, 2015, The Journal of clinical investigation.

Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE‐deficient mice

I. van der Made, B. van de Water, J. Jonkers, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Automated Whole Animal Bio-Imaging Assay for Human Cancer Dissemination

H. Spaink, L. Rénia, Shuning He, 2012, PloS one.

Tumor-induced remote ECM network orientation steers angiogenesis

E. Danen, B. van de Water, H. E. Balcioglu, 2016, Scientific Reports.

ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.

Mohamed Hamdi, F. Carlotti, B. van de Water, 2008, DNA repair.

Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research

B. van de Water, K. Knipping, N. Kramer, 2022, Trends in Food Science & Technology.

Co-regulated gene expression of splicing factors as drivers of cancer progression

J. Foekens, M. Smid, J. Martens, 2019, Scientific Reports.

IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer

M. Look, E. Berns, Jean C. A. Helmijr, 2018, Oncogene.

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

B. van de Water, R. González-Prieto, A. Vertegaal, 2021, Journal of Experimental & Clinical Cancer Research.

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy

J. Foekens, M. Smid, J. Martens, 2019, Breast Cancer Research.

β1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

Bob van de Water, Sylvia E. Le Dévédec, B. Ewa Snaar-Jagalska, 2014, Science Signaling.

The E3 Ubiquitin Ligase ARIH1 Protects against Genotoxic Stress by Initiating a 4EHP-Mediated mRNA Translation Arrest

E. Danen, B. van de Water, L. Mullenders, 2015, Molecular and Cellular Biology.

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

E. Ruppin, J. Lee, B. van de Water, 2017, Breast Cancer Research.

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

M. Schmidt, P. Vestergaard, M. D. De Bruin, 2015, Breast Cancer Research.

Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.

B. van de Water, J. Bos, Emile de Heer, 2011, Journal of the American Society of Nephrology : JASN.

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

A. Cleton-Jansen, E. Danen, B. van de Water, 2015, Oncotarget.

Finding synergies for the 3Rs - Repeated dose toxicity testing: Report from an EPAA partners' forum.

Bertrand Desprez, Gianni Dal Negro, Bob van de Water, 2019, Regulatory toxicology and pharmacology : RTP.

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation

B. van de Water, J. Jonkers, R. Kuiper, 2014, British Journal of Cancer.

Heat Shock Protein 27 Is the Major Differentially Phosphorylated Protein Involved in Renal Epithelial Cellular Stress Response and Controls Focal Adhesion Organization and Apoptosis*

B. van de Water, M. de Graauw, I. Tijdens, 2005, Journal of Biological Chemistry.

Aven‐mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma

Bob van de Water, Anne-Marie Cleton-Jansen, A. Cleton-Jansen, 2015, The Journal of pathology.

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

Esther I Verhoef, Bob van de Water, Guido Jenster, 2015, Cancer research.

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Carsten Kneuer, Giuseppe Testa, Thomas Backhaus, 2019, Environment international.

Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens.

Veerander P. S. Ghotra, E. Danen, B. van de Water, 2012, Biomaterials.

Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells

Sylvia E. Le Dévédec, M. Schmidt, A. Cleton-Jansen, 2010, Proceedings of the National Academy of Sciences.

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival

A. Cleton-Jansen, E. Danen, B. van de Water, 2019, Journal of bone oncology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Bob van de Water, Steven Wink, B. van de Water, 2018, Archives of Toxicology.

Cellular stress responses and molecular mechanisms of nephrotoxicity.

Sylvia E. Le Dévédec, B. van de Water, M. de Graauw, 2006, Toxicology letters.

Combining Doublecortin-Like Kinase Silencing and Vinca Alkaloids Results in a Synergistic Apoptotic Effect in Neuroblastoma Cells

Bob van de Water, E. Danen, B. van de Water, 2012, Journal of Pharmacology and Experimental Therapeutics.

Vaccine-Induced Tumor Necrosis Factor–Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death

S. H. van der Burg, E. Jordanova, M. Welters, 2014, Clinical Cancer Research.

Phospho‐proteomic analysis of cellular signaling

B. van de Water, M. de Graauw, P. Hensbergen, 2006, Electrophoresis.

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

A. Jochemsen, B. van de Water, A. Teunisse, 2009, Atherosclerosis.

Advancing human health risk assessment

Heather M. Wallace, P. Vineis, M. Siegrist, 2019, EFSA journal. European Food Safety Authority.

Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury.

B. van de Water, M. de Graauw, C. Pont, 2007, The American journal of pathology.

Hepatocyte growth factor induces tubulogenesis of primary renal proximal tubular epithelial cells

B. van de Water, J. Stevens, R. Lightfoot, 1999, Journal of cellular physiology.

Annexin A2 Phosphorylation Mediates Cell Scattering and Branching Morphogenesis via Cofilin Activation

B. van de Water, M. de Graauw, I. Tijdens, 2007, Molecular and Cellular Biology.

Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary

N Kleinstreuer, B van de Water, G. Daston, 2018, Archives of Toxicology.

Functional analysis of high-content high-throughput imaging data

Annette Kopp-Schneider, Bob van de Water, Xiaoqi Jiang, 2017 .

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Bas ter Braak, Bob van de Water, Jan Willem van der Laan, 2015, Breast Cancer Research.

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

M. Schmidt, P. Vestergaard, M. D. De Bruin, 2015, Breast Cancer Research.

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways.

Bob van de Water, Martijn H Breuning, Dorien J M Peters, 2009, Human molecular genetics.

Current approaches and future role of high content imaging in safety sciences and drug discovery.

Mardas Daneshian, Peter Macko, Imran Shah, 2014, ALTEX.

In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function.

B. van de Water, G. Mulder, J. Nagelkerke, 1994, The American journal of physiology.

Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids.

M. J. Moné, N. Jacobsen, B. van de Water, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Pathways of proximal tubular cell death in bismuth nephrotoxicity.

B. van de Water, Emile de Heer, A. Srinivasan, 2002, Toxicology and applied pharmacology.

Epac-Rap signaling reduces oxidative stress in the tubular epithelium.

B. van de Water, R. Kok, S. Florquin, 2014, Journal of the American Society of Nephrology : JASN.

Integration of temporal single cell cellular stress response activity with Logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.

Sylvia E. Le Dévédec, J. Saez-Rodriguez, J. Hengstler, 2021, Biochemical pharmacology.

Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Bob van de Water, Sanja Dragovic, Lisa Fredriksson, 2011, Hepatology.

Computational Approaches for Drug-Induced Liver Injury (DILI) Prediction: State of the Art and Challenges

G. V. van Westen, M. Cronin, B. van de Water, 2021, Systems Medicine.

Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes and HepaRG cells using concentration-response modelling of gene co-expression networks

M. Vinken, B. van de Water, S. J. Kunnen, 2023, bioRxiv.

Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid.

M. J. Moné, B. van de Water, S. J. Kunnen, 2022, ALTEX.

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

E. Guney, J. Saez-Rodriguez, L. Furlong, 2021, Archives of Toxicology.

Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury

R. Fontana, M. Ingelman-Sundberg, R. Weaver, 2017, Hepatology.

A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.

Thomas E. Exner, E. Benfenati, O. Taboureau, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

A Network-based Transcriptomic Landscape of HepG2 cells to Uncover Causal Gene Cytotoxicity Interactions Underlying Drug-Induced Liver Injury

Sylvia E. Le Dévédec, J. Saez-Rodriguez, B. van de Water, 2023, bioRxiv.

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Andrea Paola Cediel Ulloa, Ugis Sarkans, C. Rovida, 2020, Archives of Toxicology.

Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo

B. van de Water, S. L. Le Dévédec, C. Pont, 2010, Molecular Imaging and Biology.

Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action

J. Olsen, B. van de Water, L. Mullenders, 2020, Archives of Toxicology.

Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.

B van de Water, B. van de Water, G. Mulder, 1994, The Journal of biological chemistry.

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

B. van de Water, H. Gelderblom, B. Herpers, 2013, British Journal of Cancer.

The Use of Porcine Proximal Tubular Cells for Studying Nephrotoxicity In Vitro: The Role of Oxidative Stress in Cisplatin-induced Cell Death

B. van de Water, G. Mulder, Emile de Heer, 1996 .

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

Yinghui Zhang, B. van de Water, Jichao He, 2019, Biochemical pharmacology.

The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine.

B. van de Water, G. Mulder, J. Nagelkerke, 1993, Biochemical pharmacology.

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

J. Pennings, B. van de Water, M. Luijten, 2023, Chemical research in toxicology.

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

B. van de Water, M. Leist, G. Carta, 2022, Archives of Toxicology.

Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells

B. van de Water, I. Tijdens, M. Huigsloot, 2006, Molecular Pharmacology.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience

Thomas E. Exner, Marcel Leist, T Steger-Hartmann, 2020, Archives of Toxicology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

B. van de Water, S. Wink, S. Hiemstra, 2018, Archives of Toxicology.

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

E. Giovannetti, L. McDonnell, E. Danen, 2023, bioRxiv.

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors

Sylvia E. Le Dévédec, G. Ecker, R. Beijersbergen, 2023, Breast Cancer Research.

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare.

D. Ingber, L. Smirnova, I. Rusyn, 2020, ALTEX.

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

B. van de Water, B. K. Park, B. Herpers, 2012, Molecular medicine.

The Nuclear Factor κB Family Member RelB Facilitates Apoptosis of Renal Epithelial Cells Caused by Cisplatin/Tumor Necrosis Factor α Synergy by Suppressing an Epithelial to Mesenchymal Transition–Like Phenotypic Switch

B. van de Water, J. Meerman, B. Herpers, 2013, Molecular Pharmacology.

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

E. Danen, B. van de Water, Huan Yang, 2021, Frontiers in Pharmacology.

The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status

Sylvia E. Le Dévédec, F. Verbeek, A. Houtsmuller, 2012, Journal of Cell Science.

New approach methodologies in human regulatory toxicology - Not if, but how and when!

T. Hartung, V. Rogiers, M. Vinken, 2023, Environment international.

Proteomic Analysis of Alternative Protein Tyrosine Phosphorylation in 1,2-Dichlorovinyl-Cysteine-Induced Cytotoxicity in Primary Cultured Rat Renal Proximal Tubular Cells

André M Deelder, Bob van de Water, Sylvia E. Le Dévédec, 2007, Journal of Pharmacology and Experimental Therapeutics.

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response.

M. Giphart-Gassler, B. van de Water, J. Svensson, 2007, Mutation research.

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

S. H. Bennekou, B. van de Water, M. Leist, 2023, Cell Biology and Toxicology.

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

X. Coumoul, E. Benfenati, B. van de Water, 2023, Frontiers in toxicology.

The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

E. Guney, J. Saez-Rodriguez, L. Furlong, 2021, bioRxiv.

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

J. Martens, B. van de Water, R. González-Prieto, 2021, Journal of experimental & clinical cancer research : CR.

Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

Bob van de Water, Jeroen L A Pennings, Leo T M van der Ven, 2014, Toxicology letters.

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Yongxiang Fang, L. Rainbow, J. Sutherland, 2018, Archives of Toxicology.

Focal adhesion kinase: a potential target in cancer therapy.

B. van de Water, B. Water, M. V. van Nimwegen, 2007, Biochemical pharmacology.

Identifying multiscale translational safety biomarkers using a network-based systems approach

L. Furlong, J. Sutherland, J. González, 2023, iScience.

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

E. Guney, N. Blomberg, M. Mayer, 2021, Pharmaceuticals.

Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.

C. Verfaillie, B. van de Water, R. Boon, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety

B. van de Water, María Aránzazu Tabernero Urbieta, K. Venema, 2020 .

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

E. Ruppin, J. Lee, B. van de Water, 2017, Breast Cancer Research.

User-friendly high-content imaging analysis on a single desktop: R package H5CellProfiler

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2022, bioRxiv.

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

B. van de Water, M. de Graauw, B. Herpers, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition.

B. van de Water, J. Nagelkerke, J. Zoeteweij, 1996, Archives of Biochemistry and Biophysics.

FAIR High Content Screening in Bioimaging

J. Willemse, B. van de Water, Rohola Hosseini, 2023, Scientific Data.

Papyrus: a large-scale curated dataset aimed at bioactivity predictions

A. IJzerman, B. van de Water, G. V. Westen, 2021, Journal of Cheminformatics.

Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells

E. Danen, B. van de Water, Louise von Stechow, 2013, PloS one.

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model

B. van de Water, H. van Steeg, E. Speksnijder, 2015, Breast Cancer Research.

Drug-Induced Liver Injury and TNFα Signaling: From In Vivo Understanding to In Vitro Testing Approaches

B. van de Water, S. Huppelschoten, van de WaterBob, 2016 .

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium.

B. van de Water, G. Mulder, J. Nagelkerke, 1993, The Journal of biological chemistry.

Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

B. van de Water, E. Vreugdenhil, B. Håvik, 2013, PloS one.

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.

Sylvia E. Le Dévédec, J. Foekens, M. Look, 2015, The Journal of clinical investigation.

Functional screening with a live cell imaging-based random cell migration assay.

Sylvia E. Le Dévédec, B. van de Water, Wies van Roosmalen, 2011, Methods in molecular biology.

eTRANSAFE: data science to empower translational safety assessment

N. Blomberg, M. Mayer, F. Sanz, 2023, Nature Reviews Drug Discovery.

The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

B. van de Water, G. Hendriks, M. Atallah, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals.

B. van de Water, B. van der Burg, J. W. van der Laan, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model

B. van de Water, H. van Steeg, E. Speksnijder, 2015, Breast Cancer Research.