A. Honegger

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Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool.

A. Plückthun, A. Honegger, A. Plückthun, 2001, Journal of molecular biology.

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

A. Ullrich, J. Schlessinger, A. Honegger, 1990, Molecular and cellular biology.

Chemical modification of peptides by hydrazine.

K. Wilson, A. Honegger, G. Hughes, 1981, The Biochemical journal.

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.

A. Plückthun, A. Honegger, B. Virnekäs, 2000, Journal of molecular biology.

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system.

A. Plückthun, A. Honegger, H. Bosshard, 1997, Journal of immunological methods.

Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations

Andreas Plückthun, Annemarie Honegger, Daša Lipovšek, 2012, Proceedings of the National Academy of Sciences.

A natural antibody missing a cysteine in VH: consequences for thermodynamic stability and folding.

A. Plückthun, A. Honegger, A Plückthun, 1997, Journal of molecular biology.

Tailoring in vitro evolution for protein affinity or stability.

A. Plückthun, A. Honegger, J. Hanes, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering.

Andreas Plückthun, Annemarie Honegger, Stefan Ewert, 2004, Methods.

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

A. Plückthun, P. Ernst, O. Medalia, 2018, Nature Communications.

Mutational Analysis of the EGF Receptor Proto-Oncogene

A. Ullrich, J. Schlessinger, A. Honegger, 1989 .

Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.

A. Ullrich, J. Schlessinger, A. Honegger, 1989, Proceedings of the National Academy of Sciences of the United States of America.

DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography.

A. Plückthun, A. Honegger, A. Batyuk, 2016, Journal of molecular biology.

Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.

A. Ullrich, B. Margolis, J. Schlessinger, 1992, The Journal of biological chemistry.

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor

A. Ullrich, A. Zilberstein, B. Margolis, 1990, Molecular and cellular biology.

Kinetic parameters of the protein tyrosine kinase activity of EGF‐receptor mutants with individually altered autophosphorylation sites.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, The EMBO journal.

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains.

Andreas Plückthun, Annemarie Honegger, D. Röthlisberger, 2009, Protein engineering, design & selection : PEDS.

Correlation between in Vitro Stability and in Vivo Performance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors*

A. Plückthun, A. Barberis, A. Honegger, 2000, The Journal of Biological Chemistry.

Comparison of buffers and detection systems for high-pressure liquid chromatography of peptide mixtures.

K. Wilson, A. Honegger, G. Hughes, 1981, The Biochemical journal.

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

A. Honegger, P. Lang, G. Fey, 2016, Oncotarget.

Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants.

A. Ullrich, J. Schlessinger, R. Ballotti, 1989, The Journal of biological chemistry.

Expression of a human insulin-like growth factor II cDNA in NIH-3T3 cells.

A. Honegger, H. Gerber, B. Roth, 1990, Biochemical and biophysical research communications.

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

A. Plückthun, A. Honegger, M. Grütter, 2013, Proceedings of the National Academy of Sciences.

Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities.

A. Honegger, R. Humbel, 1986, The Journal of biological chemistry.

Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases

P. D’Eustachio, K. Huebner, O. Silvennoinen, 1993, Molecular and cellular biology.

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells

K. Spiekermann, A. Mackensen, A. Honegger, 2018, Oncoimmunology.

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1987, Molecular and cellular biology.

The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.

O. Silvennoinen, A. Honegger, G. Barnea, 1993, The Journal of biological chemistry.

A point mutation at the ATP‐binding site of the EGF‐receptor abolishes signal transduction.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, The EMBO journal.

The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

A. Honegger, S. Urlinger, B. Brocks, 2008, Journal of molecular biology.

The behaviour of peptides on reverse-phase supports during high-pressure liquid chromatography.

K J Wilson, K. Wilson, A. Honegger, 1981, The Biochemical journal.

Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment.

L. Nieba, A. Plückthun, A. Honegger, 1997, Protein engineering.

The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains.

A. Plückthun, C. Cambillau, A. Honegger, 2001, Journal of molecular biology.

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

A. Plückthun, A. Honegger, P. Mittl, 2021, Science Advances.

High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment.

A. Plückthun, R. Stahel, A. Honegger, 1999, Cancer research.

The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge.

A. Plückthun, A. Honegger, R. van Schaik, 1998, Journal of molecular biology.

Antibody scFv fragments without disulfide bonds made by molecular evolution.

A. Plückthun, A. Honegger, K. Proba, 1998, Journal of molecular biology.

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

A. Plückthun, A. Honegger, R. Tamaskovic, 2016, Nature Communications.

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

M. Jaye, J. Schlessinger, M. Mohammadi, 1991, Molecular and cellular biology.

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Nanxin Li, M. Jaye, J. Schlessinger, 1992, Nature.

tumor cell killing T-cell receptor gene transfer exclusively to human CD8+ cells enhances

Qi Zhou, W. Wels, A. Honegger, 2013 .

T-cell receptor gene transfer exclusively to human CD8(+) cells enhances tumor cell killing.

A. Schambach, Qi Zhou, W. Wels, 2012, Blood.

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

A. Plückthun, A. Honegger, F. Seehusen, 2021, Nature Communications.

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells

A. Ullrich, J. Schlessinger, A. Honegger, 1990, The Journal of cell biology.

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

A. Ullrich, J. Schlessinger, A. Honegger, 1987, Cell.

Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2.

A. Plückthun, A. Honegger, R. Tamaskovic, 2013, Structure.

Carbonic Anhydrase-Like Domain in the Extracellular Region of RPTP-y Defines a New Subfamily

P. D’Eustachio, K. Huebner, O. Silvennoinen, 2022 .

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.

A. Plückthun, D. Saul, A. Honegger, 2009, Protein engineering, design & selection : PEDS.

Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach.

Andreas Plückthun, Annemarie Honegger, Stefan Ewert, 2003, Biochemistry.

Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide.

A. Plückthun, C. Cambillau, A. Honegger, 1999, Journal of molecular biology.

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability.

D. Röthlisberger, A. Plückthun, A. Honegger, 2005, Journal of molecular biology.

A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein.

Andreas Plückthun, Amedeo Caflisch, Oliver Zerbe, 2015, Journal of molecular biology.

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.

David Baker, Patrick Ernst, Andreas Plückthun, 2016, Journal of molecular biology.

Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.

A. Plückthun, A. Honegger, P. Mittl, 2017, Journal of molecular biology.

Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library

Andreas Plückthun, Dimitrios Lagos, Annemarie Honegger, 2003, Nature Biotechnology.

DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency.

Andreas Plückthun, Annemarie Honegger, A. Plückthun, 2011, Journal of molecular biology.

Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv.

A. Plückthun, A. Honegger, H. Abken, 2015, Protein engineering, design & selection : PEDS.

Engineering antibodies for stability and efficient folding.

A. Honegger, Annemarie Honegger, 2008, Handbook of experimental pharmacology.

A mutation designed to alter crystal packing permits structural analysis of a tight‐binding fluorescein–scFv complex

A. Plückthun, C. Cambillau, A. Honegger, 2005, Protein science : a publication of the Protein Society.

Biophysical properties of human antibody variable domains.

Andreas Plückthun, Thomas Huber, Annemarie Honegger, 2003, Journal of molecular biology.

Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen.

A. Plückthun, A. Honegger, M. Grütter, 2002, Journal of molecular biology.

The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains.

A. Plückthun, A. Honegger, 2001, Journal of molecular biology.

Reproducing the natural evolution of protein structural features with the selectively infective phage (SIP) technology. The kink in the first strand of antibody kappa domains.

A. Plückthun, A. Honegger, S. Spada, 1998, Journal of molecular biology.

Regulation of the flavin redox potential by flavin-binding antibodies.

A. Honegger, A. Visser, A. Schots, 1997, European journal of biochemistry.

Specific detection of his-tagged proteins with recombinant anti-His tag scFv-phosphatase or scFv-phage fusions.

E. Kremmer, L. Nieba, A. Plückthun, 1997, BioTechniques.

Fructose-1,6-bisphosphate aldolase from Drosophila melanogaster: primary structure analysis, secondary structure prediction, and comparison with vertebrate aldolases.

K. Rose, A. Honegger, O. Brenner-Holzach, 1988, Archives of biochemistry and biophysics.

Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems.

A. Plückthun, A. Honegger, W. Verdurmen, 2015, Journal of controlled release : official journal of the Controlled Release Society.

All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

A. Ullrich, B. Margolis, I. Lax, 1989, The Journal of biological chemistry.

Direct in Vivo Screening of Intrabody Libraries Constructed on a Highly Stable Single-chain Framework*

Annemarie Honegger, Christian Cambillau, A. Plückthun, 2002, The Journal of Biological Chemistry.

Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries.

A. Plückthun, C. Cambillau, A. Honegger, 2001, Journal of molecular biology.

Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1988, The EMBO journal.

fi c uptake of binding proteins into the cytoplasm through engineered modular transport systems

A. Plückthun, A. Honegger, W. Verdurmen, 2015 .

Selection for improved protein stability by phage display.

A. Plückthun, A. Honegger, S. Jung, 1999, Journal of molecular biology.

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts

A. Plückthun, A. Honegger, P. Mittl, 2019, Scientific Reports.

Rigidly connected multispecific artificial binders with adjustable geometries

Andreas Plückthun, Yufan Wu, Alexander Batyuk, 2017, Scientific Reports.

Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates.

H. Güntherodt, T. Strunz, A. Honegger, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

A. Ullrich, J. Schlessinger, A. Honegger, 1989, The EMBO journal.

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase.

A. Ullrich, J. Schlessinger, M. Mohammadi, 1993, Biochemistry.

Folding nuclei of the scFv fragment of an antibody.

T. Holak, A. Plückthun, A. Honegger, 1996, Biochemistry.

Generation of molecular surfaces for graphic display

Laurence H. Pearl, Annemarie Honegger, L. Pearl, 1983 .

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.

A. Ullrich, J. Schlessinger, M. Mohammadi, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

living cells. autophosphorylation of the EGF receptors in (EGF)-induced intermolecular Evidence for epidermal growth factor

A. Ullrich, J. Schlessinger, A. Honegger, 2013 .

Evidence forEpidermal GrowthFactor (EGF)-Induced Intermolecular Autophosphorylation oftheEGF Receptors inLiving Cells

A. Ullrich, A. Honegger, And J. SCHLESSINGERl, 1990 .

Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

A. Ullrich, I. Lax, J. Schlessinger, 1990, Cell regulation.

A MutantEpidermal GrowthFactor Receptor withDefective Protein Tyrosine Kinase IsUnable ToStimulate Proto-Oncogene Expression andDNA Synthesis

A. Ullrich, A. Honegger, T. Dull, 1987 .

Affinity and folding properties both influence the selection of antibodies with the selectively infective phage (SIP) methodology

A. Plückthun, A. Honegger, F. Schwesinger, 1997, FEBS letters.

Carbonic Anhydrase-Like Domain in the Extracellular Region of RPTP-y Defines a New Subfamily

P. D’Eustachio, K. Huebner, A. Honegger, 2022 .

Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.

A. Caflisch, A. Plückthun, S. Fleishman, 2016 .

The Conformation of Insulin-Like Growth Factors: Relationships with Insulins

T. Blundell, A. Honegger, J. Pitts, 1985, Journal of Cell Science.

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

A. Plückthun, A. Honegger, M. Grütter, 2013, Proceedings of the National Academy of Sciences.

Signal transduction by epidermal growth factor receptor.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, Cold Spring Harbor symposia on quantitative biology.

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared‐helix DARPin‐DARPin fusions

A. Plückthun, A. Honegger, Jakob C. Stüber, 2017, Protein science : a publication of the Protein Society.

Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach.

A. Plückthun, A. Honegger, S. Ewert, 2003, Biochemistry.

Correlation between in Vitro Stability and in Vivo Performance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors*

A. Plückthun, A. Barberis, A. Honegger, 2000, The Journal of Biological Chemistry.

A. Honegger, S. Urlinger, B. Brocks, 2008, Journal of molecular biology.