M. Rynkiewicz

发表

Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide.

M. Rynkiewicz, Zhaohua Lu, Julia H. Hui, 2012, Biochemistry.

Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation.

Klaus Schulten, Peter H Seeberger, Boon Chong Goh, 2013, Biochemistry.

X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity.

D. Cane, M. Rynkiewicz, D. Christianson, 2002, Biochemistry.

Discovery of protective B‐cell epitopes for development of antimicrobial vaccines and antibody therapeutics

M. Rynkiewicz, Zhaohua Lu, J. Sharon, 2014, Immunology.

B-Cell Epitopes in GroEL of Francisella tularensis

M. Rynkiewicz, Zhaohua Lu, J. Sharon, 2014, PloS one.

Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.

R. Babine, M. Rynkiewicz, Lei Jin, 2006, Bioorganic & medicinal chemistry letters.

Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states

Stefan Fischer, M. Rynkiewicz, W. Lehman, 2018, The Journal of general physiology.

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Marek Orzechowski, Stefan Fischer, M. Rynkiewicz, 2015, Journal of Muscle Research and Cell Motility.

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

R. Babine, S. Abdel-Meguid, M. Rynkiewicz, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.

R. Babine, S. Abdel-Meguid, M. Rynkiewicz, 2006, Journal of medicinal chemistry.

Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.

M. Rynkiewicz, B. Seaton, Tanya R. Cafarella, 2017, Biochemistry.

Molecular Mechanisms of Influenza Inhibition by Surfactant Protein D Revealed by Large-scale Molecular Dynamics Simulation†

K. Schulten, M. Rynkiewicz, B. Seaton, 2014 .

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

D. Swank, M. Rynkiewicz, M. Preller, 2020, Nature Communications.

Introduction of N-Linked Glycans in the Lectin Domain of Surfactant Protein D

M. Rynkiewicz, B. Seaton, B. W. van Balkom, 2011, The Journal of Biological Chemistry.

Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation.

I. Gould, M. Rynkiewicz, W. Lehman, 2022, Archives of biochemistry and biophysics.

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis

Guangshun Wang, M. Rynkiewicz, B. Seaton, 2015, PloS one.

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Ferhaan Ahmad, T. Wong, B. Keavney, 2021, Cell reports. Medicine.

Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane attack complex (C5b-9).

M. Rynkiewicz, J. Halperin, A. Nicholson-Weller, 1993, Blood.

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, bioRxiv.

Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.

M. Rynkiewicz, U. Holmskov, K. Hartshorn, 2010, American journal of physiology. Lung cellular and molecular physiology.

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

S. Fischer, M. Rynkiewicz, K. Trybus, 2017, Biophysical journal.

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Stefan Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2016, Structural dynamics.

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade

D. Cane, M. Rynkiewicz, D. Christianson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The binding sites of monoclonal antibodies to the non‐reducing end of Francisella tularensis O‐antigen accommodate mainly the terminal saccharide

J. Zaia, M. Rynkiewicz, Zhaohua Lu, 2013, Immunology.

Protein Crystallography in Medicine

M. Rynkiewicz, B. Seaton, 1997 .

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments.

M. Rynkiewicz, W. Lehman, Anita Ghosh, 2019, Biophysical journal.

The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine

Eugene C. Petrella, R. Babine, K. Seidl, 2004, Journal of Biological Chemistry.

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2021, The Journal of general physiology.

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

Lyndsay A. Staley, K. Lunetta, J. Haines, 2019, JAMA network open.

Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

M. Rynkiewicz, G. Rimmelzwaan, K. Hartshorn, 2019, Front. Immunol..

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus

N. Leymarie, J. Zaia, M. Rynkiewicz, 2018, The Journal of Biological Chemistry.

A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D*

K. Schulten, M. Rynkiewicz, B. Seaton, 2012, The Journal of Biological Chemistry.

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

D. Swank, M. Rynkiewicz, M. Preller, 2020, Nature Communications.

Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments.

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2020, Biophysical journal.

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.

M. Regnier, M. Rynkiewicz, Jeffrey R. Moore, 2020, Biophysical journal.

Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

S. Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2018, Biophysical journal.

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Marek Orzechowski, Stefan Fischer, M. Rynkiewicz, 2015, Journal of Muscle Research and Cell Motility.

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.

Klaus Schulten, Boon Chong Goh, K. Schulten, 2016, Biochemistry.

Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti *

D. Cane, M. Rynkiewicz, D. Christianson, 2000, The Journal of Biological Chemistry.

Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Marek Orzechowski, M. Rynkiewicz, Jeffrey R. Moore, 2018, Archives of biochemistry and biophysics.

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, The Journal of general physiology.

Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity.

M. Rynkiewicz, Zhaohua Lu, J. Sharon, 2014, Monoclonal antibodies in immunodiagnosis and immunotherapy.

Mutagenesis of Surfactant Protein D Informed by Evolution and X-ray Crystallography Enhances Defenses against Influenza A Virus in Vivo*

Nikolaos M. Nikolaidis, N. Leymarie, J. Zaia, 2011, The Journal of Biological Chemistry.

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

J. Katz, M. Rynkiewicz, A. Cammarato, 2017, Cell reports.

Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change*

M. Rynkiewicz, B. Seaton, J. Head, 2010, The Journal of Biological Chemistry.

Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

D. Cane, M. Rynkiewicz, D. Christianson, 2005, Biochemistry.

Modeling Human Cardiac Thin Filament Structures

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2022, Frontiers in Physiology.

C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state.

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2021, Biochemical and biophysical research communications.

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2023, PNAS nexus.

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

E. Hardeman, P. Gunning, M. Rynkiewicz, 2019, Scientific Reports.

Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids

M. Rynkiewicz, O. Gursky, Emily Lewkowicz, 2023, bioRxiv.

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

E. Hardeman, P. Gunning, M. Rynkiewicz, 2019, Scientific Reports.

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Ferhaan Ahmad, T. Wong, B. Keavney, 2022, Cell Reports Medicine.

The Mouseion at the JAXlibrary The Mouseion at the JAXlibrary

Ferhaan Ahmad, M. Rynkiewicz, A. Bais, 2022 .

Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2024, Journal of Molecular and Cellular Cardiology.

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

The propensity for tropomyosin twisting in the presence and absence of F-actin.

Stefan Fischer, M. Rynkiewicz, W. Lehman, 2016, Archives of biochemistry and biophysics.

Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids

M. Rynkiewicz, O. Gursky, Emily Lewkowicz, 2023, Cellular and Molecular Life Sciences.

Introduction of N-Linked Glycans in the Lectin Domain of Surfactant Protein D

M. Rynkiewicz, B. Seaton, B. W. van Balkom, 2011, The Journal of Biological Chemistry.