B. Himes

发表

Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation

S. Margulies, T. Dolinay, B. Himes, 2017, American journal of respiratory cell and molecular biology.

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

L. Edwards, E. Regan, D. DeMeo, 2012, Human molecular genetics.

High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report

Ivana V. Yang, M. Tobin, John Quackenbush, 2019, Annals of the American Thoracic Society.

Whole genome sequencing of pharmacogenetic drug response in racially and ethnically diverse children with asthma

Zachary A. Szpiech, Weiss, Erick, 2017, bioRxiv.

Whole‐Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma

Zachary A. Szpiech, Ryan D. Hernandez, Kevin L. Keys, 2018, American journal of respiratory and critical care medicine.

Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene

Yusuke Nakamura, Scott T. Weiss, Xiaofeng Jiang, 2012, PLoS genetics.

Electronic Medical Records Disease ( COPD ) in Asthma Patients Using Prediction of Chronic Obstructive Pulmonary

I. Kohane, S. Weiss, M. Ramoni, 2010 .

Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks

Manuel A. R. Ferreira, Cameron D. Palmer, M. Jarvelin, 2017, Nature Genetics.

Inclusion of Unstructured Clinical Text Improves Early Prediction of Death or Prolonged ICU Stay*

L. Ungar, R. Hubbard, S. Halpern, 2018, Critical care medicine.

Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes

J. Celedón, A. Litonjua, R. Lazarus, 2011, BMC Medical Genetics.

Predictive genomics in asthma management using probabilistic graphical models

B. Himes, 2007 .

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole genome sequencing studies at scale

Ivana V. Yang, Andrew D. Johnson, Ryan D. Hernandez, 2020, Nature Genetics.

Using omics approaches to understand pulmonary diseases

B. Himes, M. Shumyatcher, M. Kan, 2017, Respiratory Research.

Personal Environmental Monitoring

B. Himes, S. Xie, 2020 .

Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation

Joyce B. Kang, M. Cho, Andrew Lamb, 2019, Respiratory Research.

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.

S. Weiss, D. Roden, J. Denny, 2015, The Journal of allergy and clinical immunology.

RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells

Scott T. Weiss, Xiaofeng Jiang, Blanca E. Himes, 2014, PloS one.

Insights into glucocorticoid responses derived from omics studies.

B. Himes, M. Kan, 2020, Pharmacology & therapeutics.

Airway Smooth Muscle–Specific Transcriptomic Signatures of Glucocorticoid Exposure

B. Himes, M. Shumyatcher, R. Panettieri, 2019, American journal of respiratory cell and molecular biology.

Ideas for how informaticians can get involved with COVID-19 research

Jeffrey S. Morris, Jason W. Moore, Do Kyoon Kim, 2020, BioData Mining.

Precision in Pulmonary, Critical Care, and Sleep Medicine: A Clinical and Research Guide

N. Kaminski, B. Himes, Jose L. Gomez, 2020 .

Enhancing Electronic Health Record Data with Geospatial Information

B. Himes, M. Levy, S. Xie, 2017, AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science.

Novel KITLG regulatory variants are associated with lung function in African American children with asthma

Kevin L. Keys, G. Abecasis, H. Kang, 2020, medRxiv.

Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction

Kevin L. Keys, G. Abecasis, H. Kang, 2020, Genetics.

COVID-19 Pandemic–Related Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections

B. Himes, S. Henrickson, D. A. Hill, 2021, The Journal of Allergy and Clinical Immunology: In Practice.

Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease

E. Silverman, S. Bhattacharya, A. Gulsvik, 2011, Thorax.

Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease

E. Silverman, S. Bhattacharya, A. Gulsvik, 2011, Thorax.

Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement

E. Burchard, J. Galanter, J. Clancy, 2018, American journal of respiratory and critical care medicine.

Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.

Yusuke Nakamura, T. Tsunoda, S. Weiss, 2011, American journal of respiratory cell and molecular biology.

Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management.

B. Himes, A. Wu, L. Leszinsky, 2019, The journal of allergy and clinical immunology. In practice.

PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma

D. Postma, D. Nickle, J. Vonk, 2017, Allergy.

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.

A. Dahlin, C. Iribarren, B. Himes, 2019, The Journal of allergy and clinical immunology.

ITGB5 and AGFG1 variants are associated with severity of airway responsiveness

D. Postma, J. Vonk, G. Koppelman, 2013, BMC Medical Genetics.

Factors associated with exacerbations among adults with asthma according to electronic health record data

R. Hubbard, B. Himes, S. Henrickson, 2019, Asthma Research and Practice.

HLA‐DQ strikes again: Genome‐wide association study further confirms HLA‐DQ in the diagnosis of asthma among adults

H. Hakonarson, E. Israel, H. Boushey, 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Analysis of Spatial Trends in Smoking Status Among Patients with Obstructive Airway Diseases Highlight Potential for Targeted Smoking Cessation Interventions.

R. Hubbard, B. Himes, S. Xie, 2020, AMIA ... Annual Symposium proceedings. AMIA Symposium.

Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma

A. Litonjua, B. Himes, B. Klanderman, 2015, PloS one.

Consolidated Environmental and Social Data Facilitates Neighborhood-Level Health Studies in Philadelphia

B. Himes, S. Xie, R. Greenblatt, 2021, AMIA.

Impact of Individual versus Geographic-Area Measures of Socioeconomic Status on Health Associations Observed in the Behavioral Risk Factor Surveillance System

R. Hubbard, B. Himes, S. Xie, 2020, AMIA.

A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

E. Israel, A. Dahlin, B. Himes, 2018 .

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

Ingo Ruczinski, Christoph Lange, James W Baurley, 2009, American journal of human genetics.

Assessing the reproducibility of asthma genome-wide association studies in a general clinical population.

Scott T. Weiss, Isaac S. Kohane, Blanca E. Himes, 2011, The Journal of allergy and clinical immunology.

Skin fibroblast metabolomic profiling reveals that lipid dysfunction predicts the severity of Friedreich’s ataxia

Elaine S. Ho, B. Himes, M. Napierala, 2022, Journal of lipid research.

Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness

H. Hakonarson, E. Burchard, G. Canino, 2022, Scientific Reports.

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.

Blanca E Himes, W James Gauderman, Esteban G Burchard, 2012, The Journal of allergy and clinical immunology.

Late-breaking abstract: Genome-wide association of GLCCI1 with asthma steroid treatment response

Yusuke Nakamura, A. Litonjua, W. Qiu, 2011 .

Epinephrine evokes shortening of human airway smooth muscle cells following β2 adrenergic receptor desensitization

B. Himes, R. Panettieri, S. An, 2022, American journal of physiology. Lung cellular and molecular physiology.

Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD

B. Himes, J. Joo, 2021, AMIA.

Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices

D. Zaller, M. Crackower, P. Cooper, 2016, British journal of pharmacology.

A genome-wide association study of COPD identiﬁes a susceptibility locus on chromosome 19q13 behalf ICGN, ECLIPSE, COPDGene

L. Edwards, E. Regan, D. DeMeo, 2012 .

CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids

B. Himes, Xiaofeng Jiang, Q. Lu, 2022, Respiratory Research.

Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management.

B. Himes, A. Wu, L. Leszinsky, 2019, The journal of allergy and clinical immunology. In practice.

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Yusuke Nakamura, A. Litonjua, W. Qiu, 2011, The New England journal of medicine.

Title Inhibition of PI 3 K promotes dilation of human small airways in a rho kinase-dependent manner

R. Damoiseaux, S. Liggett, B. Himes, 2016 .

Plasma multi-omics analysis reveals very long chain ceramides as validated biomarkers of Friedreich's ataxia

B. Himes, D. Lynch, C. Mesaros, 2022, medRxiv.

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19 q 13

L. Edwards, E. Regan, D. DeMeo, 2012 .

Facilitating Inclusion of Geocoded Pollution Data into Health Studies.

B. Himes, R. Greenblatt, 2019, AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science.

Predicting response to short-acting bronchodilator medication using Bayesian networks.

Blanca E Himes, Marco F Ramoni, Scott T Weiss, 2009, Pharmacogenomics.

Genome-wide association study of the age of onset of childhood asthma.

M. Wickman, J. Brehm, J. Celedón, 2012, The Journal of allergy and clinical immunology.

Skin ﬁ broblast metabolomic pro ﬁ ling reveals that lipid dysfunction predicts the severity of Friedreich ’ s ataxia

Elaine S. Ho, B. Himes, M. Napierala, 2022 .

Shared Genetic and Experimental Links between Obesity-Related Traits and Asthma Subtypes in UK Biobank.

L. Liang, F. Hu, W. Cookson, 2020, The Journal of allergy and clinical immunology.

Mobile health applications for asthma.

Blanca E Himes, Ann Chen Wu, B. Himes, 2015, The journal of allergy and clinical immunology. In practice.

TSLP polymorphisms are associated with asthma in a sex‐specific fashion

I. Ruczinski, E. Israel, G. O'Connor, 2010, Allergy.

RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

E. Silverman, C. Hersh, P. Castaldi, 2017, BMC Medical Genomics.

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.

D. Nicolae, G. Diette, Jinshui Fan, 2014, The Journal of allergy and clinical immunology.

Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function

Kevin L. Keys, E. Burchard, Sam S. Oh, 2020, bioRxiv.

Preparing next-generation scientists for biomedical big data: artificial intelligence approaches.

Mary Regina Boland, Blanca E Himes, John H Holmes, 2019, Personalized medicine.

A genome-wide association study of bronchodilator response in asthmatics

J. Celedón, A. Litonjua, W. Qiu, 2013, The Pharmacogenomics Journal.

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function

Kevin L. Keys, E. Burchard, Sam S. Oh, 2020, Genetic epidemiology.

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

E. Israel, A. Dahlin, C. Iribarren, 2018, The Journal of allergy and clinical immunology.

The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex

M. Cho, B. Himes, A. Murphy, 2011, BMC pulmonary medicine.

Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations

Ryan D. Hernandez, Christopher R. Gignoux, L. Liang, 2011, Nature Genetics.

Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions.

M. Cho, B. Himes, B. Hobbs, 2020, AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science.

Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner

Dino Di Carlo, Jie Zhang, Blanca E Himes, 2016, British journal of pharmacology.

Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.

E. Bleecker, A. Litonjua, S. Liggett, 2011, American journal of respiratory and critical care medicine.

Development of a Pharmacogenetic Predictive Test in asthma: proof of concept

A. Litonjua, C. Lange, B. Himes, 2010, Pharmacogenetics and genomics.

University of Groningen Integration of mouse and human genome-wide association data identifies KCNIP 4 as an asthma gene

Keith S. Sheppard, Christopher R. Gignoux, D. Postma, 2017 .

Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene

Keith S. Sheppard, Christopher R. Gignoux, D. Postma, 2013, PloS one.

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.

Christian Gieger, Blanca E Himes, Scott T Weiss, 2012, The Journal of allergy and clinical immunology.

Association of SERPINE2 with asthma.

E. Silverman, T. Mariani, J. Celedón, 2011, Chest.

The impact of self‐identified race on epidemiologic studies of gene expression

G. Diette, M. Cho, N. Hansel, 2011, Genetic epidemiology.

PDE11A associations with asthma: results of a genome-wide association scan.

D. Strachan, G. O'Connor, M. Bracken, 2010, The Journal of allergy and clinical immunology.

Analyses of shared genetic factors between asthma and obesity in children.

J. Brehm, B. Himes, J. Sylvia, 2010, The Journal of allergy and clinical immunology.

Asthma-susceptibility variants identified using probands in case-control and family-based analyses

E. Silverman, G. O'Connor, J. Celedón, 2010, BMC Medical Genetics.

Multi-ancestry association study identifies new asthma risk loci that co-localize with 1 immune cell enhancer marks 2

Sina A. Gharib, Cameron D. Palmer, L. Liang, 2017 .

Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine

N. Kaminski, B. Himes, Jose L. Gomez, 2020 .

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Yusuke Nakamura, Tatsuhiko Tsunoda, Scott T. Weiss, 2011, Nature Genetics.

Genetics and Pharmacogenetics of Asthma

B. Himes, M. Kan, 2020 .

Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness

J. Fredberg, A. Kho, E. Israel, 2023, Nature Communications.

Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures

Blanca E. Himes, Mengyuan Kan, Maya Shumyatcher, 2018, AMIA.

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

Weiliang Qiu, Eric E Schadt, Blanca E Himes, 2014, BMC Medical Genomics.

Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells

D. Christiani, B. Himes, J. Vallarino, 2021, Scientific Reports.

Why Is the Electronic Health Record So Challenging for Research and Clinical Care?

Charles E. Kahn, Jason W. Moore, T. Cook, 2021, Methods of Information in Medicine.

Gene Expression Profiles in Children With Suspected Sepsis.

E. Alpern, B. Himes, E. Lautenbach, 2020, Annals of emergency medicine.

Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers

Blanca E Himes, Jen-hwa Chu, Scott T Weiss, 2011, BMC Medical Genetics.

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by &bgr;2‐Adrenergic Receptors and Adenylyl Cyclase 6

B. Himes, R. Ostrom, R. Panettieri, 2017, American journal of respiratory cell and molecular biology.

Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes

D. Christiani, B. Himes, J. Vallarino, 2019, Scientific Reports.

Production and transplantation of bioengineered lung into a large-animal model

Jean A. Niles, D. Christiani, B. Himes, 2018, Science Translational Medicine.

Gender-specific determinants of asthma among U.S. adults

Michelle L. Ross, B. Himes, O. Mansour, 2017, Asthma Research and Practice.

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

B. Himes, Q. Lu, Maoyun Sun, 2019, Proceedings of the National Academy of Sciences.

Pediatric Asthma Health Care Utilization, Viral Testing, and Air Pollution Changes During the COVID-19 Pandemic

B. Himes, S. Henrickson, R. Grundmeier, 2020, The Journal of Allergy and Clinical Immunology: In Practice.

COVID-19 PandemiceRelated Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections

B. Himes, S. Henrickson, PhDb, 2022 .

Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group

B. Himes, V. Ortega, 2017, European Respiratory Journal.

TGF‐&bgr;1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3

B. Himes, R. Panettieri, S. An, 2017, American journal of respiratory cell and molecular biology.

Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records.

Scott T. Weiss, Isaac S. Kohane, Yi Dai, 2009, Journal of the American Medical Informatics Association : JAMIA.

Neighborhood-level measures of socioeconomic status are more correlated with individual-level measures in urban areas compared with less urban areas.

R. Hubbard, B. Himes, S. Xie, 2020, Annals of epidemiology.

Innovations in health information technologies for chronic pulmonary diseases

Elissa R. Weitzman, Blanca E. Himes, B. Himes, 2016, Respiratory Research.

Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins

Blanca E Himes, Susan M Dallabrida, B. Himes, 2005, Circulation research.

Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications.

D. Christiani, B. Himes, Q. Lu, 2021, Journal of hazardous materials.

Association of variants in innate immune genes with asthma and eczema

M. Bracken, A. Litonjua, K. Belanger, 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.

Yusuke Nakamura, M. Kubo, A. Litonjua, 2014, The Journal of allergy and clinical immunology.

Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation.

Raúl San José Estépar, D. Lynch, G. Washko, 2012, American journal of respiratory and critical care medicine.

Characterization of Patients who Suffer Asthma Exacerbations using Data Extracted from Electronic Medical Records

Scott T. Weiss, Isaac S. Kohane, Marco Ramoni, 2008, AMIA.

Approaches to Link Geospatially Varying Social, Economic, and Environmental Factors with Electronic Health Record Data to Better Understand Asthma Exacerbations

Sherrie Xie, Blanca E. Himes, B. Himes, 2018, AMIA.

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes

E. Stahl, R. Plenge, M. Ritchie, 2013, Pharmacogenetics and genomics.

Facilitating Analysis of Publicly Available ChIP-Seq Data for Integrative Studies

Avantika R Diwadkar, Mengyuan Kan, Blanca E Himes, 2019, AMIA.

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.

Christopher R. Gignoux, P. Kwok, E. Burchard, 2013, The Journal of allergy and clinical immunology.

Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells

Jilly F. Evans, B. Himes, M. Bartolomei, 2018, PloS one.

Feasibility and acceptability of monitoring personal air pollution exposure with sensors for asthma self-management

A. Localio, F. Barg, B. Himes, 2021, Asthma Research and Practice.

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

T. Beaty, E. Burchard, Bin Zhang, 2014, BMC Medical Genomics.

Introduction

N. Kaminski, B. Himes, J. L. Gómez, 2020, Precision in Pulmonary, Critical Care, and Sleep Medicine.

Disease-Specific Integration of Omics Data to Guide Functional Validation of Genetic Associations

Rui Hong, Blanca E. Himes, Maya Shumyatcher, 2017, AMIA.

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Andrew D. Johnson, May E. Montasser, Nicholette D. Palmer, 2020, Nature Genetics.

Improving Genetic Association Studies with a Novel Methodology that Unveils the Hidden Complexity of All-Cause Heart Failure

John T. Gregg, B. Himes, F. Asselbergs, 2023, medRxiv.

Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?

J. Mainland, B. Himes, Luis R. Saraiva, 2023, International journal of molecular sciences.