L. Pfeffer

L. Pfeffer, J. Mullersman, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway*

L. Pfeffer, A. Davidoff, M. Fan, 2013, The Journal of Biological Chemistry.

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

L. Pfeffer, M. Fan, R. Laribee, 2012, Nucleic acids research.

Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition.

L. Pfeffer, C. Morton, A. Davidoff, 2012, Surgery.

Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells.

Duane D. Miller, L. Pfeffer, Yinan Wang, 2021, Bioorganic & medicinal chemistry.

Targeting the Bromodomain of BRG-1/BRM Subunit of the SWI/SNF Complex Increases the Anticancer Activity of Temozolomide in Glioblastoma

Duane D. Miller, L. Pfeffer, Yinan Wang, 2021, Pharmaceuticals.

Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells

L. Pfeffer, M. Fan, C. Cai, 2018, Stem cells.

SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.

P. Yue, J. Turkson, J. Buolamwini, 2022, Cancer letters.

Interferon-beta inhibition of concanavalin A-stimulated calcium uptake and exchange in HeLa cells.

L. Pfeffer, I. Tamm, 1986, Journal of interferon research.

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

L. Pfeffer, Zhao-Hui Wu, M. Fan, 2018, Breast Cancer Research.

Detection of Exosomal miRNAs in the Plasma of Melanoma Patients

L. Kopelovich, L. Pfeffer, S. Pfeffer, 2015, Journal of clinical medicine.

Growth rate of control and beta-interferon-treated human fibroblast populations over the course of their in vitro life span.

E. Wang, L. Pfeffer, I. Tamm, 1984, Cancer research.

Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer

Jiong Wu, L. Pfeffer, Z. Shao, 2015, Oncogene.

Silencing the Double-Stranded RNA Binding Protein DGCR8 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion

L. Pfeffer, Hongwei Li, J. Yue, 2015, Pharmaceutical Research.

MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway

L. Pfeffer, P. He, J. Yue, 2017, Oncotarget.

Assay of the inhibitory activities of human interferons on the proliferation and locomotion of fibroblasts.

L. Pfeffer, I. Tamm, J. Murphy, 1981, Methods in enzymology.

STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor.

L. Pfeffer, S. Pfeffer, C. Yang, 1997, Science.

Ovarian Primary and Metastatic Tumors Suppressed by Survivin Knockout or a Novel Survivin Inhibitor

P. Dong, H. Watari, L. Pfeffer, 2019, Molecular Cancer Therapeutics.

Expression of the IFNα receptor in hairy cell leukaemia

L. Platanias, L. Pfeffer, J. Vardiman, 1992 .

APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade

L. Pfeffer, A. Saad, Jinjun Cheng, 2019, Pharmaceuticals.

The effects of type I interferon on glioblastoma cancer stem cells.

L. Pfeffer, A. Davidoff, F. Boop, 2017, Biochemical and biophysical research communications.

Cells Regulates the Notch Pathway Signaling in Glioblastoma Cancer Stem B κ 3 ( STAT 3 ) and Nuclear Factor Transducer and Activator of Transcription Constitutive Activation of Signal Molecular Bases of Disease

L. Pfeffer, A. Davidoff, M. Fan, 2013 .

Dysregulated signaling pathways in glioblastoma cancer stem-like cells: potential targets for therapeutic intervention

L. Pfeffer, 2016 .

The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma

M. Roussel, D. Finkelstein, L. Pfeffer, 2018, Oncotarget.

MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers

L. Pfeffer, M. Fan, A. Sethuraman, 2014, Breast Cancer Research.

DNA Damage Induces NF-κB-dependent MicroRNA-21 Up-regulation and Promotes Breast Cancer Cell Invasion*

L. Pfeffer, Zhao-Hui Wu, Meiyun Fan, 2012, The Journal of Biological Chemistry.

Interferon-α Modulates the Plasma Membrane–Cytoskeletal Complex of Human Lymphoblastoid Cells Sensitive to the Antiproliferative Action of Interferon-α

L. Pfeffer, F. Landsberger, 1990 .

Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.

L. Pfeffer, D. Donner, D. Guo, 1998, Journal of immunology.

Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo*

M. Fishbein, Lai Wei, L. Pfeffer, 2007, Journal of Biological Chemistry.

Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independent*

S. Lemon, L. Pfeffer, Kui Li, 2010, The Journal of Biological Chemistry.

The role of nuclear factor κB in the interferon response.

L. Pfeffer, 2011, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

A novel cytoplasmic homology domain in interferon receptors.

L. Pfeffer, J. Mullersman, 1995, Trends in biochemical sciences.

NFκB Negatively Regulates Interferon-induced Gene Expression and Anti-influenza Activity*

R. Webby, R. Homayouni, P. Thomas, 2006, Journal of Biological Chemistry.

Isolation of circulating microRNAs from microvesicles found in human plasma.

J. Quackenbush, L. Kopelovich, L. Pfeffer, 2014, Methods in molecular biology.

Oral cancer: enduring characteristics and emerging trends.

L. Pfeffer, W. Gu, C. Handorf, 2011, The Journal of the Michigan Dental Association.

Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.

Nicole M. Chapman, H. Chi, L. Pfeffer, 2019, Cancer research.

Identification of CXCL11 as a STAT3-Dependent Gene Induced by IFN1

Lai Wei, L. Pfeffer, S. Pfeffer, 2007, The Journal of Immunology.

Identification of CXCL 11 as a STAT 3-Dependent Gene Induced by IFN 1

Lai Wei, L. Pfeffer, S. Pfeffer, 2006 .

Multichain structure of the IFN-alpha receptor on hematopoietic cells.

L. Platanias, R. Nordan, L. Pfeffer, 1992, Journal of immunology.

Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1.

L. Pfeffer, C. Morton, A. Davidoff, 2012, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interferon Induces NF-κB-inducing Kinase/Tumor Necrosis Factor Receptor-associated Factor-dependent NF-κB Activation to Promote Cell Survival*

L. Pfeffer, Chuanhe Yang, A. Murti, 2005, Journal of Biological Chemistry.

The Type I IFN-Induced miRNA, miR-21

L. Pfeffer, S. Pfeffer, Kui Li, 2015, Pharmaceuticals.

Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes.

Ramin Homayouni, Lijing Xu, Lai Wei, 2008, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interferon-γ potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-α in U937 cells

L. Pfeffer, R. Pine, T. Improta, 1992 .

Interferon-resistant Daudi Cell Line with a Stat2 Defect Is Resistant to Apoptosis Induced by Chemotherapeutic Agents*

Lai Wei, L. Pfeffer, Jong-Gwan Kim, 2009, The Journal of Biological Chemistry.

Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons.

L. Pfeffer, S. Pfeffer, M. Fan, 2017, Biochemical and biophysical research communications.

MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis

L. Pfeffer, S. Pfeffer, P. He, 2016, Oncotarget.

The Oncogenic MicroRNA-21 Inhibits the Tumor Suppressive Activity of FBXO11 to Promote Tumorigenesis*

L. Pfeffer, S. Pfeffer, A. Davidoff, 2015, The Journal of Biological Chemistry.

An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients

L. Pfeffer, S. Pfeffer, Kui Li, 2014, PloS one.

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention

L. Kopelovich, L. Pfeffer, S. Pfeffer, 2013, Oncotarget.

The Role of TRAF2 Binding to the Type I Interferon Receptor in Alternative NFκB Activation and Antiviral Response*

L. Pfeffer, S. Pfeffer, M. Fan, 2008, Journal of Biological Chemistry.

Non‐conventional signal transduction by type 1 interferons: The NF‐κB pathway

Lai Wei, Lawrence M. Pfeffer, Lai Wei, 2007 .

The Interferon-γ-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor α (TNF-α) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-κB and Rac Protein*

L. Pfeffer, J. Trendel, M. Fan, 2011, The Journal of Biological Chemistry.

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon Receptor (*)

S. Constantinescu, L. Pfeffer, E. Croze, 1996, The Journal of Biological Chemistry.

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript.

B. Strulovici, L. Dekker, S. Constantinescu, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.

B. Strulovici, N. Reich, L. Pfeffer, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Cells resistant to interferon are defective in activation of a promoter‐binding factor.

D. Levy, L. Pfeffer, R. Pine, 1988, The EMBO journal.

Cytoskeletal association of human alpha-interferon-receptor complexes in interferon-sensitive and -resistant lymphoblastoid cells.

L. Pfeffer, D. Donner, N. Stebbing, 1987, Proceedings of the National Academy of Sciences of the United States of America.

MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells*

Junming Yue, L. Pfeffer, S. Pfeffer, 2011, The Journal of Biological Chemistry.

EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway

P. Dong, H. Watari, L. Pfeffer, 2021, Cell & bioscience.

KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.

Tao Zhang, P. Dong, H. Watari, 2017, Biochemical and biophysical research communications.

Human renal cancers resistant to IFN's antiproliferative action exhibit sensitivity to IFN's gene-inducing and antiviral actions.

S. Constantinescu, L. Pfeffer, A. Albino, 1996, The Journal of urology.

The induction of type I interferon production in hepatitis C-infected patients.

L. Pfeffer, C. Riely, J. Fleckenstein, 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Inhibition of ornithine decarboxylase induces STAT3 tyrosine phosphorylation and DNA binding in IEC-6 cells.

L. Pfeffer, S. Pfeffer, L. Johnson, 2000, American journal of physiology. Cell physiology.

The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action*

L. Pfeffer, S. Pfeffer, E. Croze, 1997, The Journal of Biological Chemistry.

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.

B. Strulovici, L. Pfeffer, A. Saltiel, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Interferonα Activates NF-κB in JAK1-deficient Cells through a TYK2-dependent Pathway*

Lawrence M. Pfeffer, William J. Valentine, L. Pfeffer, 2005, Journal of Biological Chemistry.

Recombinant replication-restricted VSV as an expression vector for murine cytokines.

Mark A. Miller, L. Pfeffer, M. Whitt, 2004, Protein expression and purification.

Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model.

Z. Xiang, Qihong Zhou, L. Pfeffer, 2004, Journal of neurosurgery.

Recent studies on the identification of proliferative abnormalities and of oncogenic potential of cutaneous cells in individuals at increased risk of colon cancer.

M. Lipkin, L. Kopelovich, L. Pfeffer, 1976, Seminars in oncology.

Expression of the IFN alpha receptor in hairy cell leukaemia.

L. Platanias, L. Pfeffer, J. Vardiman, 1992, British journal of haematology.

Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells

Peng Zhang, P. Dong, H. Watari, 2018, Journal of Cancer.

Adiponectin and its receptors in chronic hepatitis B patients with metabolic syndrome in China.

L. Pfeffer, Hao Wu, W. Ling, 2012, Hepato-gastroenterology.

KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells

L. Pfeffer, J. Yue, Yinan Wang, 2015, PloS one.

Continuous Delivery of IFN-β Promotes Sustained Maturation of Intratumoral Vasculature

R. Gilbertson, L. Pfeffer, S. Skapek, 2007, Molecular Cancer Research.

Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.

Tao Zhang, P. Dong, H. Watari, 2018, Oncology letters.

Early Events in the Interaction of IFN-α with IFN-Sensitive and IFN-Resistant Daudi Cells

T. Arakawa, L. Pfeffer, D. Donner, 1987 .

Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody.

R. Nordan, L. Pfeffer, O. Colamonici, 1992, European cytokine network.

EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells.

L. Pfeffer, S. Pfeffer, L. Johnson, 1999, American journal of physiology. Cell physiology.

Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis*

L. Pfeffer, S. Goelz, S. Pellegrini, 1998, The Journal of Biological Chemistry.

The Human Type I Interferon Receptor

T. C. Wagner, L. Pfeffer, E. Croze, 1996, The Journal of Biological Chemistry.

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

L. Pfeffer, Zhao-Hui Wu, M. Fan, 2016, Breast Cancer Research.

Characterization of the alpha subunit of the IFN-alpha receptor. Evidence of N- and O-linked glycosylation and association with other surface proteins.

L. Platanias, L. Pfeffer, O. Colamonici, 1993, Journal of immunology.

Duane D. Miller, L. Pfeffer, Yinan Wang, 2021, Journal of cellular and molecular medicine.

Mitochondria Control Functional CaV1.2 Expression in Smooth Muscle Cells of Cerebral Arteries

L. Pfeffer, J. Jaggar, Damodaran Narayanan, 2010, Circulation research.

Silencing the Double-Stranded RNA Binding Protein DGCR8 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion

L. Pfeffer, Hongwei Li, J. Yue, 2013, Pharmaceutical Research.

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

L. Pfeffer, Zhao-Hui Wu, M. Fan, 2018, Breast Cancer Research.

Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition.

P. Dong, H. Watari, L. Pfeffer, 2020, Free radical biology & medicine.

Beta-interferon-induced time-dependent changes in the plasma membrane lipid bilayer of cultured cells.

L. Pfeffer, I. Tamm, F. Landsberger, 1981, Journal of interferon research.

Interferon inhibits the redistribution of cell surface components

E. Wang, L. Pfeffer, I. Tamm, 1980, The Journal of experimental medicine.

Interferons α and β as cellular regulatory MOLECULES

L. Pfeffer, P. Sehgal, I. Tamm, 1987 .

Interaction of retinoic acid and interferon in renal cancer cell lines.

L. Pfeffer, S. Pfeffer, D. Nanus, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The STAT3-Regulated Autophagy Pathway in Glioblastoma

L. Pfeffer, Andrew B. Boucher, Saivikram Madireddy, 2023, Pharmaceuticals.

Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.

L. Pfeffer, Chuanhe Yang, A. Murti, 2005, The Journal of biological chemistry.

TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation

A. Reiner, N. D. Del Mar, L. Pfeffer, 2019, Stem Cell Research & Therapy.

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

L. Pfeffer, Zhao-Hui Wu, M. Fan, 2016, Breast Cancer Research.

Oral cancer: enduring characteristics and emerging trends.

L. Pfeffer, W. Gu, C. Handorf, 2011, The Journal of the Tennessee Dental Association.

Renal Cell Carcinoma and Interferon at the Millennium

L. Pfeffer, D. Nanus, R. Pastore, 2001, Cancer investigation.

224 The role of TRAF2 binding to the Type I IFN receptor in alternative NFκB activation and antiviral response

L. Pfeffer, S. Pfeffer, M. Fan, 2008 .

Biologic activities of natural and synthetic type I interferons.

L. Pfeffer, 1997, Seminars in oncology.

miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer.

L. Pfeffer, Guannan Zhao, J. Yue, 2015, Journal of cancer science & therapy.

Lentiviral CRISPR / Cas 9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells

P. Dong, H. Watari, E. Chaum, 2017 .

Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer

Duane D. Miller, E. Petricoin, L. Pfeffer, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The down-regulation of alpha-interferon receptors in human lymphoblastoid cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferon.

L. Pfeffer, D. Donner, 1990, Cancer research.

Lentiviral vector mediated-ASAP 1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells

Tao Zhang, P. Dong, H. Watari, 2018 .

A life support system for stimulation of and recording from rodent neuron networks grown on multi-electrode arrays

Craig Stewart, Dietmar Plenz, David Ide, 2004, Proceedings. 17th IEEE Symposium on Computer-Based Medical Systems.

MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin.

L. Pfeffer, Yinan Wang, Chuanhe Yang, 2019, Cancer letters.

Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.

L. Pfeffer, R. Pine, T. Improta, 1992, Journal of interferon research.

Role of the JAK/STAT Pathway in the Regulation of IL-8 Transcription by Oxidized Phospholipids in vitro and in Atherosclerosis in vivo

Lai Wei, L. Pfeffer, Jackelyn A. Alva, 2007 .

Next‐generation bromodomain inhibitors of the SWI/SNF complex enhance DNA damage and cell death in glioblastoma

Duane D. Miller, L. Pfeffer, Yinan Wang, 2023, Journal of cellular and molecular medicine.

The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action.

L. Pfeffer, S. Pfeffer, E. Croze, 1997, Journal of Biological Chemistry.

Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells

Duane D. Miller, L. Pfeffer, Yinan Wang, 2021, Proceedings of 7th International Electronic Conference on Medicinal Chemistry.

IFN-β sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression

L. Pfeffer, A. Davidoff, C. Stewart, 2008, Molecular Cancer Therapeutics.

The induction of type I interferon production in hepatitis C-infected patients.

L. Pfeffer, C. Riely, J. Fleckenstein, 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor.

N. Reich, L. Platanias, L. Pfeffer, 1994, The Journal of biological chemistry.

Ccr4-Not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy

L. Pfeffer, R. Laribee, Daniel L. Johnson, 2023, bioRxiv.

The Role of TRAF2 Binding to the Type I Interferon Receptor in Alternative NFκB Activation and Antiviral Response*

L. Pfeffer, S. Pfeffer, M. Fan, 2008, Journal of Biological Chemistry.