H. Biebermann

发表

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Tanya M. Teslovich, Ayellet V. Segrè, P. Elliott, 2010 .

Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors.

M. Tschöp, H. Biebermann, R. DiMarchi, 2017, Endocrine development.

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

A. Grüters, H. Biebermann, H. Krude, 2014, Journal of molecular endocrinology.

Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Henrik, Tanya M. Teslovich, Jennie, 2012 .

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

Raimund Erbel, Barbara Heude, Mark I. McCarthy, 2010, PLoS genetics.

Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism.

A. Grüters, H. Biebermann, H. Krude, 2007, European journal of endocrinology.

MC4R oligomerizes independently of extracellular cysteine residues

A. Grüters, H. Biebermann, H. Krude, 2006, Peptides.

Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia

D. Grandy, H. Biebermann, J. Köhrle, 2015, European Thyroid Journal.

The Multitarget Ligand 3-Iodothyronamine Modulates β-Adrenergic Receptor 2 Signaling

T. Schöneberg, H. Biebermann, J. Köhrle, 2015, European Thyroid Journal.

Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent.

A. Grüters, H. Biebermann, J. Köhrle, 2009, Journal of molecular endocrinology.

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

W. Wurst, H. Biebermann, M. Klingenspor, 2011, The Pharmacogenomics Journal.

Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor.

T. Gudermann, T. Schöneberg, A. Grüters, 1998, The Journal of clinical endocrinology and metabolism.

Mutations of the human thyrotropin receptor gene causing thyroid hypoplasia and persistent congenital hypothyroidism.

T. Gudermann, T. Schöneberg, G. Schultz, 1997, The Journal of clinical endocrinology and metabolism.

A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R

J. Hebebrand, A. Hinney, K. Widhalm, 2008, Obesity Facts.

The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency

R. Rossi, A. Grüters, H. Biebermann, 2009, European journal of endocrinology.

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants

H. Wichmann, T. Illig, H. Grallert, 2012, BMC Medical Genomics.

A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity

H. Biebermann, C. Roth, Zhen‐Chuan Fan, 2009, Endocrine.

The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity

H. Biebermann, U. Schweizer, Mathias Schmidt, 2016, Molecular and Cellular Endocrinology.

Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism.

A. Grüters, H. Biebermann, P. Ambrugger, 2001, European journal of endocrinology.

Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency

A. Grüters, H. Biebermann, B. Köhler, 2008, Human mutation.

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

B. Wiesner, H. Biebermann, H. Krude, 2018, Cellular and Molecular Life Sciences.

Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum

H. Ropers, H. Christen, A. Grüters, 2014, Journal of Medical Genetics.

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

M. Lohse, P. Annibale, H. Biebermann, 2020, International journal of molecular sciences.

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment.

H. Biebermann, H. Krude, P. Kühnen, 2019, Trends in molecular medicine.

Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside‐Mediated Read‐Through

J. Hebebrand, A. Hinney, A. Grüters, 2012, Obesity.

A NOVEL MUTATION Thr 162 Arg OF THE MELANOCORTIN 4 RECEPTOR GENE IN A SPANISH CHILDREN AND ADOLESCENTS POPULATION

A. Martí, J. Hebebrand, A. Hinney, 2010 .

A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population

A. Martí, J. Martínez, J. Hebebrand, 2007, Clinical endocrinology.

Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity*

T. Schöneberg, A. Grüters, H. Biebermann, 2003, Journal of Biological Chemistry.

Analysis of the Wilms' tumor suppressor gene (WT1) in patients 46,XY disorders of sex development.

A. Grüters, H. Biebermann, H. Krude, 2011, The Journal of clinical endocrinology and metabolism.

Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency.

A. von Deimling, A. Grüters, H. Biebermann, 2002, The Journal of clinical investigation.

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling

M. Tschöp, A. Grüters, H. Biebermann, 2016, Front. Endocrinol..

TSH induces metallothionein 1 in thyrocytes via Gq/11- and PKC-dependent signaling.

T. Gudermann, H. Biebermann, A. Breit, 2013, Journal of molecular endocrinology.

Proinsulin and the proinsulin/insulin ratio in overweight and obese children and adolescents: relation to clinical parameters, insulin resistance, and impaired glucose regulation

H. Biebermann, S. Wiegand, H. Krude, 2011, Pediatric diabetes.

Neonatal Thyroid Disorders

A. Grüters, H. Biebermann, H. Krude, 2003, Hormone Research in Paediatrics.

A role for β-melanocyte-stimulating hormone in human body-weight regulation

M. Tschöp, J. Hebebrand, A. Hinney, 2006 .

3-Iodothyronamine-A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action.

H. Biebermann, J. Köhrle, 2019, Endocrine reviews.

Pharmacological treatment strategies for patients with monogenic obesity

H. Biebermann, S. Wiegand, P. Kühnen, 2020, Journal of pediatric endocrinology & metabolism : JPEM.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

M. Laakso, J. Toppari, H. Biebermann, 2016, Thyroid : official journal of the American Thyroid Association.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

H. Fuchs, M. Angelis, K. Schramm, 2016, Cell.

Melanocortin 4 receptor mutations become common.

H. Biebermann, H. Krude, P. Kühnen, 2021, Cell metabolism.

Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin- and melanocortin-3 receptors

T. Schöneberg, M. Tschöp, A. Grüters, 2012 .

Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression.

H. Biebermann, R. Opitz, P. Kühnen, 2021, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Mutations in the Human Proopiomelanocortin Gene

A. Grüters, H. Biebermann, H. Krude, 2003, Annals of the New York Academy of Sciences.

A role for b-melanocyte-stimulating hormone in human bodyweight regulation

M. Tschöp, J. Hebebrand, A. Hinney, 2022 .

A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity.

D. Prayer, J. Hebebrand, A. Hinney, 2007, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

Catherine L. Worth, H. Biebermann, P. Scheerer, 2017, Front. Endocrinol..

Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients.

H. Biebermann, G. Kleinau, F. Winkler, 2010, Frontiers in bioscience.

Constitutively activating TSH-receptor mutations as a molecular cause of non-autoimmune hyperthyroidism in childhood

T. Gudermann, T. Schöneberg, A. Grüters, 2000, Langenbeck's Archives of Surgery.

Alterations of neonatal thyroid function

T. Schöneberg, A. Grüters, H. Biebermann, 1999, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Differential Modulation of Beta-Adrenergic Receptor Signaling by Trace Amine-Associated Receptor 1 Agonists

T. Schöneberg, A. Grüters, H. Biebermann, 2011, PloS one.

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

H. Biebermann, M. Szczepek, P. Scheerer, 2018, Front. Pharmacol..

Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

A. Uitterlinden, T. Visser, H. Biebermann, 2004, The Lancet.

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

H. Biebermann, P. Scheerer, P. Kühnen, 2022, Biomolecules.

Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.

T. Illig, H. Grallert, J. Hebebrand, 2010, European journal of endocrinology.

3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes.

H. Biebermann, J. Köhrle, N. Khajavi, 2017, Thyroid : official journal of the American Thyroid Association.

Frequent TSH receptor genetic alterations with variable signaling impairment in a large series of children with nonautoimmune isolated hyperthyrotropinemia.

H. Biebermann, D. Libri, C. Mian, 2012, The Journal of clinical endocrinology and metabolism.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

S. Woods, P. Pfluger, M. Tschöp, 2013, Nature Communications.

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

T. Gudermann, M. Tschöp, H. Biebermann, 2018, Cellular signalling.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

T. Schöneberg, A. Grüters, H. Biebermann, 2015, Journal of molecular endocrinology.

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

P. Pfluger, M. Tschöp, H. Biebermann, 2013, Diabetes.

Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information

A. Grüters, H. Biebermann, H. Krude, 2011, Thyroid research.

G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity

M. Tschöp, A. Grüters, H. Biebermann, 2013, PloS one.

V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms

T. Gudermann, T. Schöneberg, G. Schultz, 1998, Human mutation.

Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.

I. Bechmann, H. Biebermann, H. Krude, 2020, Thyroid : official journal of the American Thyroid Association.

Seven Years of Active Thyroid Hormone Research in Germany: Thyroid Hormone Action beyond Classical Concepts.

H. Biebermann, D. Führer, K. Brix, 2020, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice

H. Biebermann, L. Schomburg, T. Scanlan, 2019, European Thyroid Journal.

3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines

H. Biebermann, N. Khajavi, Mark Rosowski, 2018, Front. Endocrinol..

Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.

H. Biebermann, U. Schweizer, A. von Moers, 2005, European journal of endocrinology.

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR

H. Biebermann, P. Scheerer, G. Kleinau, 2019, International journal of molecular sciences.

Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation

A. Grüters, H. Biebermann, H. Krude, 2011, Thyroid research.

A role for beta-melanocyte-stimulating hormone in human body-weight regulation.

A. von Deimling, M. Tschöp, J. Hebebrand, 2006, Cell metabolism.

Decreased melanocortin‐4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene

J. Hebebrand, A. Hinney, H. Biebermann, 2016, Obesity.

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

P. Annibale, H. Biebermann, P. Scheerer, 2022, Life.

Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.

M. Dattani, D. Gerrelli, H. Biebermann, 2008, Human molecular genetics.

Molecular genetic defects in congenital hypothyroidism.

A. Grüters, H. Biebermann, H. Krude, 2004, European journal of endocrinology.

Severe Congenital Hypothyroidism Due to a Homozygous Mutation of the βTSH Gene

A. Grüters, H. Biebermann, M. Obladen, 1999, Pediatric Research.

Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups.

A. Grüters, H. Biebermann, S. Wiegand, 2004, European journal of endocrinology.

Congenital hypothyroidism caused by mutations in the thyrotropin-receptor gene.

T. Gudermann, T. Schöneberg, A. Grüters, 1997, The New England journal of medicine.

Mutant G-protein-coupled receptors as a cause of human diseases.

Katrin Sangkuhl, Torsten Schöneberg, K. Sangkuhl, 2004, Pharmacology & therapeutics.

Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells

H. Biebermann, Huan Luo, V. Kakkassery, 2020, Laboratory Investigation.

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

A. Grüters, H. Biebermann, H. Krude, 1998, Nature Genetics.

Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.

A. Grüters, H. Biebermann, H. Krude, 2003, The Journal of clinical endocrinology and metabolism.

Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations

H. Biebermann, H. Krude, B. Köhler, 2012, European journal of endocrinology.

Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X.

H. Biebermann, L. Schomburg, J. Köhrle, 2016, Molecular endocrinology.

Novel insights on thyroid-stimulating hormone receptor signal transduction.

A. Grüters, H. Biebermann, H. Krude, 2013, Endocrine reviews.

Analysis of the gene coding for steroidogenic factor 1 (SF1, NR5A1) in a cohort of 50 Egyptian patients with 46,XY disorders of sex development.

A. Grüters, H. Biebermann, H. Krude, 2014, European journal of endocrinology.

Treatment of congenital thyroid dysfunction: Achievements and challenges.

H. Biebermann, H. Krude, P. Kühnen, 2015, Best practice & research. Clinical endocrinology & metabolism.

A Novel Hemizygous Mutation of MAMLD1 in a Patient with 46,XY Complete Gonadal Dysgenesis

A. Grüters, H. Biebermann, H. Krude, 2015, Sexual Development.

Increased constraints on MC4R during primate and human evolution

M. Stoneking, J. Hebebrand, A. Hinney, 2008, Human Genetics.

Pharmacotherapy in Childhood Obesity

H. Biebermann, S. Wiegand, P. Kühnen, 2021, Hormone Research in Paediatrics.

Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization.

T. Gudermann, A. Grüters, H. Biebermann, 2003, Diabetes.

The Thyroid and Its Regulation by the TSHR: Evolution, Development, and Congenital Defects

H. Biebermann, H. Krude, 2019, The Thyroid and Its Diseases.

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

H. Biebermann, D. Führer, K. Brix, 2011, Thyroid research.

Molecular Pathogenesis of Neonatal Hypothyroidism

A. Grüters, H. Biebermann, H. Krude, 2000, Hormone Research in Paediatrics.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

K. Clément, A. Grüters, H. Biebermann, 2018, Nature Medicine.

Oligomerization of GPCRs involved in endocrine regulation.

H. Biebermann, G. Kleinau, A. Müller, 2016, Journal of molecular endocrinology.

A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2

M. Schuelke, H. Biebermann, H. Krude, 2021, International journal of molecular sciences.

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

H. Biebermann, H. Krude, M. Szczepek, 2019, Front. Endocrinol..

Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.

T. Meitinger, M. Platzer, T. Illig, 2006, The Journal of clinical endocrinology and metabolism.

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.

T. Gudermann, M. Platzer, T. Illig, 2004, American journal of human genetics.

V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis.

K. Sangkuhl, J. Wess, T. Schöneberg, 2008, American journal of physiology. Renal physiology.

Increased constraints on MC4R during primate and human evolution

M. Stoneking, J. Hebebrand, A. Hinney, 2008, Human Genetics.

Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis.

A. Grüters, H. Biebermann, H. Krude, 2014, The Journal of clinical endocrinology and metabolism.

Congenital Central Hypothyroidism due to Homozygous Thyrotropin β 313ΔT Mutation Is Caused by a Founder Effect

A. Pfeufer, A. Grüters, H. Biebermann, 2002 .

A New Multisystem Disorder Caused by the G&agr;s Mutation p.F376V

M. Dattani, A. Grüters, H. Biebermann, 2018, The Journal of clinical endocrinology and metabolism.

Screening chromosomal aberrations by array comparative genomic hybridization in 80 patients with congenital hypothyroidism and thyroid dysgenesis.

H. Biebermann, H. Krude, R. Ullmann, 2010, The Journal of clinical endocrinology and metabolism.

A new multi-system disorder caused by the Gαs mutation p.F376V

M. Dattani, A. Grüters, H. Biebermann, 2018 .

Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect.

A. Pfeufer, A. Grüters, H. Biebermann, 2002, The Journal of clinical endocrinology and metabolism.

Allan-Herndon-Dudley-Syndrome: Considerations about the Brain Phenotype with Implications for Treatment Strategies.

M. Tschöp, M. Schuelke, H. Biebermann, 2020, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Transient congenital hypothyroidism and hyperthyrotropinemia: normal thyroid function and physical development at the ages of 6-14 years.

A. Grüters, H. Biebermann, B. Köhler, 1996, The Journal of clinical endocrinology and metabolism.

Do Common Variants Separate between Obese Melanocortin-4 Receptor Gene Mutation Carriers and Non-Carriers? The Impact of Cryptic Relatedness

T. Illig, H. Grallert, J. Hebebrand, 2012, Hormone Research in Paediatrics.

Identification of the Translation Start Site of the Human Melanocortin 3 Receptor

A. Grüters, H. Biebermann, A. Rediger, 2012, Obesity Facts.

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.

H. Biebermann, H. Krude, G. Kleinau, 2012, Handbook of experimental pharmacology.

Mutation screen and association studies in the Diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13

T. Meitinger, M. Platzer, J. Hebebrand, 2007, BMC Genetics.

Relevance of polymorphisms in MC4R and BDNF in short normal stature

S. Grant, J. Hebebrand, A. Hinney, 2018, BMC Pediatrics.

Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus

J. Hebebrand, A. Hinney, A. Scherag, 2010, PloS one.

Loss-of-Function Variants in a Hungarian Cohort Reveal Structural Insights on TSH Receptor Maturation and Signaling.

H. Biebermann, G. Kovacs, E. Mezosi, 2015, The Journal of clinical endocrinology and metabolism.

Differential Modulation of Adrenergic Receptor Signaling by Octopamine, Tyramine, Phenylethylamine, and 3-Iodothyronamine

H. Biebermann, J. Köhrle, N. Khajavi, 2016 .

The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidism.

T. Gudermann, T. Schöneberg, A. Grüters, 2001, The Journal of clinical endocrinology and metabolism.

G13-dependent Activation of MAPK by Thyrotropin*

T. Gudermann, H. Biebermann, K. Aktories, 2008, Journal of Biological Chemistry.

3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?

H. Biebermann, N. Khajavi, S. Mergler, 2017, Front. Endocrinol..

Involvement of the chemokine-like receptor GPR33 in innate immunity.

T. Schöneberg, M. Stumvoll, D. Gašperíková, 2010, Biochemical and biophysical research communications.

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

F. Kronenberg, M. McCarthy, F. Hu, 2009, PLoS genetics.

Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation

A. Grüters, H. Biebermann, H. Krude, 2009, Obesity Facts.

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

B. Kobilka, T. Mielke, C. Spahn, 2021, Cell Research.

Constitutive activities in the thyrotropin receptor: regulation and significance.

H. Biebermann, G. Kleinau, 2014, Advances in pharmacology.

N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.

T. Schöneberg, M. Augustin, S. Wattler, 2006, Physiological genomics.

Reinhard models for mutant G protein-coupled receptors-nitrosourea-based generation of mouseN-ethyl-N

T. Schöneberg, M. Augustin, S. Wattler, 2006 .

A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6.

A. Grüters, H. Biebermann, H. Krude, 2010, The Journal of clinical endocrinology and metabolism.

Mutation analysis of the MCHR1 gene in human obesity.

K. Huse, O. Pedersen, K. Clément, 2005, European journal of endocrinology.

Forschungsgemeinschaft SPP1629 „ THYROID TRANS ACT “ – Neue Aspekte in der Schilddrüsenforschung Priority program “ THYROID TRANS ACT “ (SPP1629) of the German Research Foundation – New Aspects in Thyroid Research

H. Biebermann, D. Führer, K. Brix, 2019 .

Lifestyle Intervention in Obese Children With Variations in the Melanocortin 4 Receptor Gene

J. Hebebrand, A. Hinney, H. Biebermann, 2009, Obesity.

MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?

M. Tschöp, A. Grüters, H. Biebermann, 2012, Neuroendocrinology.

Plasma bile acids are associated with energy expenditure and thyroid function in humans.

Julian R. E. Davis, G. Brabant, H. Biebermann, 2012, The Journal of clinical endocrinology and metabolism.

Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors*

T. Schöneberg, M. Tschöp, A. Grüters, 2011, The Journal of Biological Chemistry.

[Thyroid hormone action beyond classical concepts. The priority programme "Thyroid Trans Act" (SPP 1629) of the German Research Foundation].

H. Biebermann, D. Führer, K. Brix, 2014, Deutsche medizinische Wochenschrift.

Understanding the Healthy Thyroid State in 2015

H. Biebermann, D. Führer, K. Brix, 2015, European Thyroid Journal.

Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.

A. Grüters, H. Biebermann, H. Krude, 2013, Journal of molecular endocrinology.

New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.

A. Grüters, B. Wiesner, H. Biebermann, 2012, The Journal of clinical endocrinology and metabolism.

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor.

Thomas Gudermann, Torsten Schöneberg, T. Gudermann, 2007, Endocrinology.

Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5

T. Schöneberg, M. Tschöp, A. Grüters, 2015, PloS one.

Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile

G. Homuth, M. Tschöp, H. Biebermann, 2014, International journal of molecular sciences.

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83

H. Biebermann, P. Scheerer, G. Kleinau, 2016, PloS one.

3-Iodothyronamine Induces Diverse Signaling Effects at Different Aminergic and Non-Aminergic G-Protein Coupled Receptors.

H. Biebermann, G. Kleinau, 2019, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

H. Biebermann, G. Rutigliano, G. Kleinau, 2019, Front. Pharmacol..

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1

H. Völzke, G. Homuth, A. Teumer, 2017, Front. Pharmacol..

Evolutionary Conservation of 3-Iodothyronamine as an Agonist at the Trace Amine-Associated Receptor 1

T. Schöneberg, H. Biebermann, Maxi Cöster, 2015, European Thyroid Journal.

A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G‐protein coupling

T. Gudermann, T. Schöneberg, G. Schultz, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Screening for mutations of the human thyroid peroxidase gene in patients with congenital hypothyroidism

A. Grüters, H. Biebermann, H. Krude, 1997, Experimental and clinical endocrinology & diabetes.

The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist

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