I. Farooqi

发表

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Tanya M. Teslovich, Ayellet V. Segrè, P. Elliott, 2010 .

Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity

S. O’Rahilly, I. Farooqi, 2008, Nature Clinical Practice Endocrinology &Metabolism.

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Christian Gieger, Thomas Meitinger, Inês Barroso, 2009, Nature Genetics.

The Hormonal Control of Food Intake

S. O’Rahilly, I. Farooqi, A. Coll, 2007, Cell.

Dopamine Modulates the Neural Representation of Subjective Value of Food in Hungry Subjects

W. Schultz, P. Fletcher, M. Vestergaard, 2014, The Journal of Neuroscience.

EJE Prize 2012: Obesity: from genes to behaviour.

I. Farooqi, 2014, European journal of endocrinology.

Obesity: from genes to behaviour

I. Farooqi, 2014 .

Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum

Sam R. Miller, E. Bullmore, P. Fletcher, 2010, The Journal of Neuroscience.

The UK10K project identifies rare variants in health and disease

Tom R. Gaunt, Hashem A. Shihab, Gail P. Clement, 2016 .

Congenital leptin deficiency is associated with severe early-onset obesity in humans

S. O’Rahilly, N. Wareham, J. Hurst, 1997, Nature.

A Quantitative Trait Locus on Chromosome 18q for Physical Activity and Dietary Intake in Hispanic Children

S. O’Rahilly, S. Cole, H. Göring, 2006, Obesity.

Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Henrik, Tanya M. Teslovich, Jennie, 2012 .

Early childhood infection and atopic disorder

I. Farooqi, S. Farooqi, J. Hopkin, 1998, Thorax.

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

C. Donaldson, A. Saghatelian, D. Siegel, 2018, Cell metabolism.

Genetics of body-weight regulation

Gregory S. Barsh, G. Barsh, S. O’Rahilly, 2000, Nature.

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Subhajyoti De, Inês Barroso, Philippe Froguel, 2008, Nature Genetics.

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

A. E. Sullivan, P. Froguel, D. Peet, 2014, The Biochemical journal.

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Christopher D. Brown, A. Uitterlinden, I. Ntalla, 2020, PLoS genetics.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Philippe Froguel, David Meyre, Arnold Munnich, 2009, American journal of human genetics.

Increased body mass index is associated with specific regional alterations in brain structure

E. Bullmore, P. Fletcher, P. Nathan, 2016, International Journal of Obesity.

Leptin Regulates Striatal Regions and Human Eating Behavior

E. Bullmore, P. Fletcher, S. O’Rahilly, 2007, Science.

Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors

I. Farooqi, 2022, Biological Psychiatry.

Monogenic human obesity syndromes.

I. Farooqi, 2021, Handbook of clinical neurology.

Genetic Obesity Syndromes

S. O’Rahilly, I. Farooqi, 2019, Brook's Clinical Pediatric Endocrinology.

Oxytocin administration suppresses hypothalamic activation in response to visual food cues

P. Fletcher, I. Farooqi, H. Ziauddeen, 2017, Scientific Reports.

Chapter 2 Genetic Obesity Syndromes

S. O’Rahilly, I. Farooqi, 2017 .

Chapter 28 – Genetic Syndromes Associated with Obesity∗

S. O’Rahilly, I. Farooqi, 2016 .

Wired for Obesity?

I. Farooqi, D. Selvarajah, P. Choudhary, 2014, Diabetes.

Human disorders of leptin action

S. O’Rahilly, I. Farooqi, 2014 .

20 YEARS OF LEPTIN Human disorders of leptin action

S. O’Rahilly, I. Farooqi, S. Farooqi, 2014 .

Genetic, molecular and physiological insights into human obesity

I. Farooqi, 2011, European journal of clinical investigation.

Leptin: a pivotal regulator of human energy homeostasis.

S. O’Rahilly, I. Farooqi, 2009, The American journal of clinical nutrition.

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying

I. Farooqi, D. Gillett, J. Buscombe, 2021, Clinical endocrinology.

Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription

E. Zeggini, C. Lelliott, G. Marenne, 2020, Cell metabolism.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, Dajiang J. Liu, Sara M. Willems, 2018, Nature Genetics.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2017, Nature Genetics.

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

S. O’Rahilly, I. Barroso, I. Farooqi, 2012, The Journal of clinical investigation.

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

S. O’Rahilly, P. Froguel, M. Dattani, 2009, Human molecular genetics.

Leptin-Mediated Changes in the Human Metabolome

L. Bottolo, S. O’Rahilly, I. Farooqi, 2020, The Journal of clinical endocrinology and metabolism.

Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.

S. O’Rahilly, J. Griffin, I. Farooqi, 2008, Endocrinology.

Melanocortin receptors weigh in

S. O’Rahilly, G. Yeo, I. Farooqi, 2004, Nature Medicine.

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

S. O’Rahilly, G. Yeo, I. Farooqi, 2004, Nature Neuroscience.

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

K. Clément, S. Wiegand, I. Farooqi, 2021, Skin Pharmacology and Physiology.

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2017, Scientific Reports.

Genetic and hereditary aspects of childhood obesity.

I. Farooqi, 2005, Best practice & research. Clinical endocrinology & metabolism.

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

S. O’Rahilly, F. Horber, C. Dina, 2008, Diabetes.

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

S. O’Rahilly, G. Yeo, I. Farooqi, 2009, Endocrinology.

Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity

S. O’Rahilly, K. Banerjee, I. Farooqi, 2007, International Journal of Obesity.

Ambulatory blood pressure monitoring in acute stroke. The West Birmingham Stroke Project.

G. Lip, I. Farooqi, D. Beevers, 1997, Stroke.

A mutation in the thyroid hormone receptor alpha gene.

K. Downes, F. Vargha-Khadem, F. Muntoni, 2012, The New England journal of medicine.

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.

S. O’Rahilly, I. Farooqi, A. Depaoli, 2004, The Journal of clinical endocrinology and metabolism.

Metabolism: Partial leptin deficiency and human adiposity

S. O’Rahilly, I. Farooqi, S. Jebb, 2001, Nature.

Screening the human prepro-orexin gene in a single-centre narcolepsy cohort.

I. Farooqi, I. Smith, J. Shneerson, 2007, Sleep Medicine.

Universitet Low-frequency variation in TP 53 has large effects on head circumference and intracranial

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2019 .

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Tom R. Gaunt, Hashem A. Shihab, Gail P. Clement, 2018, bioRxiv.

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans

S. O’Rahilly, J. Biernacka, I. Farooqi, 2006, Diabetes.

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.

S. O’Rahilly, A. Motala, F. Pirie, 2004, Diabetes.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2018, Nature Genetics.

Abnormal haemorheology, endothelial function and thrombogenesis in relation to hypertension in acute (ictus < 12 h) stroke patients: the West Birmingham Stroke Project

G. Lip, I. Farooqi, A. Blann, 2001, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2

P. Elliott, M. Jarvelin, L. Coin, 2009, Nature.

Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

I. Barroso, I. Farooqi, P. Clayton, 2021, The New England journal of medicine.

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.

W. Chung, K. Clément, I. Farooqi, 2020, The lancet. Diabetes & endocrinology.

Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.

S. O’Rahilly, I. Farooqi, Y. Lee, 2008, The Journal of clinical endocrinology and metabolism.

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

S. O’Rahilly, I. Farooqi, J. Creemers, 2007, The Journal of clinical endocrinology and metabolism.

WNT10B mutations in human obesity

S. O’Rahilly, G. Pergola, I. Farooqi, 2006, Diabetologia.

Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1

S. O’Rahilly, I. Barroso, S. Shoelson, 2014, Endocrinology.

Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH 2 B 1

S. O’Rahilly, I. Barroso, S. Shoelson, 2014 .

Genetic aspects of severe childhood obesity.

I. Farooqi, 2006, Pediatric endocrinology reviews : PER.

Weight Regulation and Monogenic Obesity

I. Farooqi, 2010 .

Monogenic human obesity.

I. Farooqi, I. Farooqi, 2008, Frontiers of hormone research.

Monogenic human obesity syndromes.

S. O’Rahilly, I. Farooqi, Stephen O’Rahilly, 2004, Recent progress in hormone research.

Human Obesity — Lessons from Monogenic Disorders

S. O’Rahilly, G. Yeo, I. Farooqi, 2003 .

Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.

S. O’Rahilly, I. Farooqi, A. Haqq, 2003, The Journal of clinical endocrinology and metabolism.

A comparative study of risk factors for acute myocardial infarction amongst men of Indo-origin in Trinidad and the UK.

G. Lip, I. Farooqi, D. Beevers, 1994, International journal of cardiology.

Genetics of obesity

S. O’Rahilly, I. Farooqi, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

OBESITY AS A DISEASE STATE OR ADIPOSITY

S. O’Rahilly, I. Farooqi, 2006 .

FTO and obesity: the missing link.

I. Farooqi, 2011, Cell metabolism.

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.

J. Holst, S. O’Rahilly, K. Polonsky, 2003, The Journal of clinical investigation.

Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency☆

S. O’Rahilly, I. Farooqi, P. Papenhausen, 2013, Molecular genetics and metabolism.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

S. O’Rahilly, F. Reimann, F. Gribble, 2018, Molecular metabolism.

Human POMC processing in vitro and in vivo revealed by quantitative peptidomics

S. O’Rahilly, F. Reimann, F. Gribble, 2018, bioRxiv.

Melanocortin receptors as targets in the treatment of obesity.

I. Farooqi, L. Heisler, D. Lam, 2007, Current topics in medicinal chemistry.

A novel mutation in the leptin gene (W121X) in an Egyptian family

I. Farooqi, I. Mazen, K. Amr, 2014, Molecular genetics and metabolism reports.

Leptin and the Onset of Puberty

I. Farooqi, 2003 .

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

J. Holst, A. M. Habib, F. Reimann, 2009, The American journal of clinical nutrition.

Melanocortin receptors and energy homeostasis

S. O’Rahilly, G. Yeo, I. Farooqi, 2005 .

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

K. Clément, S. O’Rahilly, R. Cone, 2017, Molecular metabolism.

Is leptin an important physiological regulator of CRP?

S. O’Rahilly, I. Farooqi, 2007, Nature Medicine.

SnapShot: The Hormonal Control of Food Intake

S. O’Rahilly, G. Yeo, I. Farooqi, 2008, Cell.

Monogenic obesity in humans.

S. O’Rahilly, I. Farooqi, 2005, Annual review of medicine.

Modulation of blood pressure by central melanocortinergic pathways.

S. O’Rahilly, S. Brage, D. Lomas, 2009, The New England journal of medicine.

The severely obese patient—a genetic work-up

I. Farooqi, 2006, Nature Clinical Practice Endocrinology &Metabolism.

POMC and PC1 Mutations

S. O’Rahilly, I. Farooqi, 2007 .

Monogenic human obesity syndromes.

S. O’Rahilly, I. Farooqi, 2006, Progress in brain research.

Genetic Disorders Involving Leptin and the Leptin Receptor

I. Farooqi, 2006 .

Leptin and the Onset of Puberty: Insights from Rodent and Human Genetics

I. Farooqi, M. D. Bruce R. Carr, V. Guest, 2002, Seminars in reproductive medicine.

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

Vanisha Mistry, P. Fischer-Posovszky, I. Farooqi, 2015, The Journal of clinical endocrinology and metabolism.

Leptin Substitution Results in the Induction of Menstrual Cycles in an Adolescent with Leptin Deficiency and Hypogonadotropic Hypogonadism

I. Farooqi, M. Wabitsch, K. Debatin, 2012, Hormone Research in Paediatrics.

The energy balance model of obesity: beyond calories in, calories out.

E. Ravussin, L. Redman, S. O’Rahilly, 2022, The American journal of clinical nutrition.

Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue.

J. Holst, I. Farooqi, J. Greenfield, 2012, European journal of endocrinology.

TPIT mutations are associated with early-onset, but not late-onset isolated ACTH deficiency.

M. Dattani, I. Farooqi, P. Clayton, 2004, European journal of endocrinology.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2018, Nature Genetics.

Edinburgh Research Explorer Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

S. O’Rahilly, S. Bouret, I. Barroso, 2019 .

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

M. Ridderstråle, J. Hirschhorn, S. O’Rahilly, 2013, Science.

Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity.

I. Farooqi, M. Abdel-Hamid, I. Mazen, 2011, Molecular genetics and metabolism.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2019, Nature Genetics.

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2019, Nature Communications.

A genome-wide association meta-analysis identifies new childhood obesity loci

Inês Barroso, Mark I. McCarthy, Philippe Froguel, 2012, Nature Genetics.

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

Inês Barroso, Hannah Blackburn, Matthew E Hurles, 2013, Nature Genetics.

Response to Letter: "Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline".

M. Murad, I. Farooqi, D. Styne, 2017, The Journal of clinical endocrinology and metabolism.

Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.

S. O’Rahilly, N. Wareham, J. Luan, 2004, Obesity research.

Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition.

J. Hodges, G. Halliday, O. Piguet, 2017, Journal of Alzheimer's disease : JAD.

Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.

S. Bhattacharyya, S. O’Rahilly, L. Jorde, 2004, The Journal of endocrinology.

Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians

S. O’Rahilly, J. Luan, I. Farooqi, 2004, International Journal of Obesity.

High protein intake stimulates postprandial GLP1 and PYY release

I. Farooqi, M. Ghatei, W. Dhillo, 2013, Obesity.

Insulin resistance, high prevalence of diabetes, and cardiovascular risk in immigrant Asians

G. Lip, I. Farooqi, G. Beevers, 1995, British heart journal.

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

M. Stoffel, I. Farooqi, K. Lawler, 2022, Nature Communications.

Binge eating as a phenotype of melanocortin 4 receptor gene mutations.

S. O’Rahilly, G. Yeo, I. Farooqi, 2003, The New England journal of medicine.

Food addiction: is there a baby in the bathwater?

P. Fletcher, I. Farooqi, H. Ziauddeen, 2012, Nature Reviews Neuroscience.

Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

I. Farooqi, A. Haqq, J. Purnell, 2013, The Journal of clinical endocrinology and metabolism.

The Hunger Genes: Pathways to Obesity

I. Farooqi, S. Farooqi, A. Klaauw, 2015, Cell.

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

I. Farooqi, R. Ahmed, 2017, Journal of Neurology, Neurosurgery, and Psychiatry.

Obesity associated genetic variation in FTO is associated with diminished satiety.

J. Wardle, S. O’Rahilly, R. Plomin, 2008, The Journal of clinical endocrinology and metabolism.

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

Tim Cheetham, S. O’Rahilly, G. Yeo, 2003, The New England journal of medicine.

Evaluation of Prader-Willi Syndrome gene MAGEL2 in severe childhood-onset obesity.

I. Farooqi, R. Wevrick, M. A. O’Neill, 2005, Obesity research.

Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.

S. Sealfon, S. Bhattacharyya, S. O’Rahilly, 2004, Canadian journal of physiology and pharmacology.

A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism

I. Farooqi, O. Koulouri, M. Gurnell, 2016, The Journal of clinical endocrinology and metabolism.

Human obesity as a heritable disorder of the central control of energy balance

S. O’Rahilly, I. Farooqi, 2008, International Journal of Obesity.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Tom R. Gaunt, Thomas M. Keane, Chin Yang Shapland, 2018, bioRxiv.

Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people

I. Farooqi, R. Ruijschop, N. Medic, 2016, Appetite.

Erratum: Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007)

R. Wysocki, J. Friedman, R. Ahima, 2010 .

CNS Leptin Action Modulates Immune Response and Survival in Sepsis

S. O’Rahilly, S. Woods, M. Tschöp, 2010, The Journal of Neuroscience.

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Tom R. Gaunt, Klaudia Walter, Nicholas J Timpson, 2015, Nature Communications.

Triple H syndrome: a novel autoimmune endocrinopathy characterized by dysfunction of the hippocampus, hair follicle, and hypothalamic-pituitary adrenal axis.

J. Hodges, S. O’Rahilly, I. Farooqi, 2000, The Journal of clinical endocrinology and metabolism.

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila

A. Brand, I. Barroso, I. Farooqi, 2021, PLoS biology.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2017, Nature Genetics.

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Graham M Lord, S. O’Rahilly, R. Lechler, 2002, The Journal of clinical investigation.

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

A. Prentice, S. O’Rahilly, I. Farooqi, 1999, The New England journal of medicine.

Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort

N. Timpson, S. O’Rahilly, Xiaomin Liu, 2021, Nature Medicine.

Prevalence and expressivity of loss of function mutations in the Melanocortin 4 Receptor (MC4R) in a UK birth cohort

S. O’Rahilly, I. Farooqi, A. Mörseburg, 2020, medRxiv.

A Metabolomic Signature of Acute Caloric Restriction

I. Farooqi, Lining Guo, T. Sonoyama, 2017, The Journal of clinical endocrinology and metabolism.

Leptin Mediates the Increase in Blood Pressure Associated with Obesity

Eric Ravussin, Julio Licinio, Joel K. Elmquist, 2014, Cell.

Defining the neural basis of appetite and obesity: from genes to behaviour.

I. Farooqi, 2014, Clinical medicine.

Genetic approaches to understanding human obesity.

I. Farooqi, Shwetha Ramachandrappa, I Sadaf Farooqi, 2011, The Journal of clinical investigation.

Antidiabetic effects of IGFBP2, a leptin-regulated gene.

R. Wysocki, J. Friedman, R. Ahima, 2010, Cell metabolism.

Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions

S. O’Rahilly, I. Farooqi, 2008, Diabetes.

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.

Spain, S. O’Rahilly, M. Dattani, 2007, The New England journal of medicine.

Molecular Genetic Analysis of Normosmic Hypogonadotropic Hypogonadism in a Turkish Population: Identification and Detailed Functional Characterization of a Novel Mutation in the Gonadotropin-Releasing Hormone Receptor Gene

S. O’Rahilly, I. Farooqi, A. Topaloğlu, 2007, Neuroendocrinology.

New advances in the genetics of early onset obesity

S. O’Rahilly, I. Farooqi, S O'Rahilly, 2005, International Journal of Obesity.

Minireview: human obesity-lessons from monogenic disorders.

S. O’Rahilly, G. Yeo, I. Farooqi, 2003, Endocrinology.

Recent advances in the genetics of severe childhood obesity

S. O’Rahilly, I. Farooqi, 2000, Archives of disease in childhood.

The CART gene and human obesity: mutational analysis and population genetics.

S. O’Rahilly, N. Wareham, J. Luan, 2000, Diabetes.

A frameshift mutation in MC4R associated with dominantly inherited human obesity

S. O’Rahilly, G. Yeo, I. Farooqi, 1998, Nature Genetics.

Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

J Ellery, S. O’Rahilly, I. Farooqi, 2005, The Journal of clinical endocrinology and metabolism.

Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling.

I. Farooqi, T. Cole, R. Talbi, 2019, The Journal of clinical endocrinology and metabolism.

CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1

N. Freimer, E. Cook, G. Bedoya, 2013, PloS one.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

K. Clément, A. Grüters, H. Biebermann, 2018, Nature Medicine.

Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.

M Hassan Murad, M. Murad, I. Farooqi, 2017, The Journal of clinical endocrinology and metabolism.

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

S. O’Rahilly, G. Yeo, I. Farooqi, 2000, The Journal of clinical investigation.

Rare variants in single-minded 1 (SIM1) are associated with severe obesity.

Mehul Dattani, Sumedha Garg, Soren Brage, 2013, The Journal of clinical investigation.

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Chris P. Ponting, Christopher J. Schofield, Patrik Rorsman, 2007, Science.

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene

J. Hodges, S. O’Rahilly, G. Yeo, 2006, Diabetes.

Proopiomelanocortin and energy balance: insights from human and murine genetics.

S. O’Rahilly, G. Yeo, I. Farooqi, 2004, The Journal of clinical endocrinology and metabolism.

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

S. O’Rahilly, S. Bouret, I. Barroso, 2019, Cell.

Studies of the SIM1 gene in relation to human obesity and obesity-related traits

S. O’Rahilly, J. Luan, I. Farooqi, 2007, International Journal of Obesity.

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

S. O’Rahilly, D. Meyre, P. Froguel, 2006, Cell metabolism.

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations.

M. Pembrey, D. Dunger, N. Wareham, 2003, Diabetes.

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

S. Bhattacharyya, S. O’Rahilly, N. Wareham, 2002, Human molecular genetics.

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population

S. O’Rahilly, J. Luan, D. Halsall, 2001, International Journal of Obesity.

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

J. Oppert, M. Neovius, T. Sørensen, 2020, Obesity Facts.

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

D. Barford, S. O’Rahilly, N. Wareham, 2013, Cell.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

S. O’Rahilly, G. Yeo, I. Farooqi, 2003, Human molecular genetics.

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

S. O’Rahilly, G. Yeo, I. Farooqi, 2000, QJM : monthly journal of the Association of Physicians.

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2017, Scientific Reports.

UK 10 K Consortium

Tom R. Gaunt, Hashem A. Shihab, Gail P. Clement, 2019 .

Large, rare chromosomal deletions associated with severe early-onset obesity

M. Hurles, S. O’Rahilly, J. Clayton-Smith, 2010, Nature.

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression

I. Farooqi, L. Rui, E. Henning, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Homozygous Mutation in the TUB Gene Associated with Retinal Dystrophy and Obesity

U. Wolfrum, K. Nagel-Wolfrum, V. Plagnol, 2013, Human mutation.

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

James Hadfield, Poul Nissen, Sumedha Garg, 2013, Nature Genetics.

Genetic architecture of human thinness compared to severe obesity

E. Zeggini, S. O’Rahilly, I. Barroso, 2019, PLoS genetics.

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.

S. O’Rahilly, J. Tavernier, I. Farooqi, 2008, Endocrinology.

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

Kirsten B. Andersen, A. Hauser, D. Gloriam, 2017, Neurochemistry International.

Genetic factors in human obesity

S. O’Rahilly, I. Farooqi, Stephen O’Rahilly, 2007, Obesity reviews : an official journal of the International Association for the Study of Obesity.

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity

Zhengzheng S Liang, C. Lelliott, B. Yalcin, 2020, PLoS genetics.

Early nutrition and leptin concentrations in later life.

T. Cole, S. O’Rahilly, I. Farooqi, 2002, The American journal of clinical nutrition.

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

Chen Li, Stephen J. Sharp, Claudia Langenberg, 2019, Cell.

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

S. O’Rahilly, F. Horber, B. Balkau, 2009, Diabetes.

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N. Freimer, E. Cook, G. Bedoya, 2013 .

Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.

U. Ekelund, S. O’Rahilly, N. Wareham, 2005, Obesity research.

The Impact of Acute Nutritional Interventions on the Plasma Proteome

Christoph B. Messner, R. Marioni, C. Gille, 2023, The Journal of clinical endocrinology and metabolism.

Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition?

M. Wong, S. O’Rahilly, N. Wareham, 2003, The Journal of clinical endocrinology and metabolism.

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

K. Petersen, S. Dufour, D. Befroy, 2010, The Journal of clinical investigation.

Obesity and the brain: how convincing is the addiction model?

P. Fletcher, I. Farooqi, H. Ziauddeen, 2012, Nature Reviews Neuroscience.

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.

E. Puelles, M. Dattani, D. Gerrelli, 2011, The Journal of clinical endocrinology and metabolism.

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

I. Barroso, I. Farooqi, J. Stuckey, 2019, Diabetes.

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

G. Bray, L. Redman, S. O’Rahilly, 2019, Cell Metabolism.

Sequential alterations in haemorheology, endothelial dysfunction, platelet activation and thrombogenesis in relation to prognosis following acute stroke: The West Birmingham Stroke Project

G. Lip, I. Farooqi, A. Blann, 2002, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Bed sharing and smoking in the sudden infant death syndrome

I. Farooqi, D. Beevers, G. Lip, 1994, BMJ.

Sudden infant death syndrome among Asians in Britain

I. Farooqi, D. Beevers, G. Lip, 1994, BMJ.

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls

Stephanie A. Santorico, E. Zeggini, S. Billups, 2018, bioRxiv.

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

Jack Humphrey, Katherine Lawler, Vincent Plagnol, 2018, Cell reports.

Oxytocin administration suppresses hypothalamic activation in response to visual food cues

P. Fletcher, I. Farooqi, H. Ziauddeen, 2017, Scientific Reports.

Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease?

T. Cole, S. O’Rahilly, I. Farooqi, 2002, Circulation.

Increased Soluble Adhesion Molecule P-Selectin, Von Willebrand Factor and Fibrinogen in Acute Stroke: Evidence for Early Endothelial and Haemorheological Dysfunction

I. Farooqi, A. Blann, D. Beevers, 1996 .

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

G. Bray, L. Redman, S. O’Rahilly, 2019, Cell metabolism.

The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance.

S. Schmid, I. Farooqi, E. Henning, 2016, Sleep.

Obesity-Associated Melanocortin-4 Receptor Mutations Are Associated With Changes in the Brain Response to Food Cues

A. Lawrence, A. Calder, S. O’Rahilly, 2014, The Journal of clinical endocrinology and metabolism.

Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities

K. Clément, E. Godfrey, I. Farooqi, 2022, The Journal of clinical endocrinology and metabolism.

Visualization of sympathetic neural innervation in human white adipose tissue

I. Farooqi, E. Henning, J. Keogh, 2021, bioRxiv.

Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity.

E. Gregg, I. Farooqi, R. Batterham, 2023, The lancet. Diabetes & endocrinology.

The central melanocortin system directly controls peripheral lipid metabolism.

S. O’Rahilly, S. Woods, P. Howles, 2007, The Journal of clinical investigation.

Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature

J. Hodges, O. Piguet, I. Farooqi, 2021, Annals of clinical and translational neurology.

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

R. Cox, S. O’Rahilly, S. Kirsch, 2017, Molecular metabolism.

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

M. Babu, I. Farooqi, M. Bouvier, 2021, Cell reports.

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Paul C. Fletcher, P. Fletcher, S. O’Rahilly, 2016, Nature Communications.

Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood

J. Milunsky, I. Farooqi, James Douglas Allan Gray, 2007, Pediatrics.

Studying Food Reward and Motivation in Humans

P. Fletcher, I. Farooqi, V. Cambridge, 2014, Journal of visualized experiments : JoVE.

A New Drug Target for Type 2 Diabetes

I. Farooqi, L. Stadler, I. Farooqi, 2017, Cell.

Monogenic human obesity.

I. Farooqi, 2008, Frontiers of hormone research.

Neural networks associated with body composition in frontotemporal dementia

J. Hodges, O. Piguet, I. Farooqi, 2019, Annals of clinical and translational neurology.

Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels Published, JLR Papers in Press, January 25, 2006.

S. Bhattacharyya, S. O’Rahilly, N. Wareham, 2006, Journal of Lipid Research.

Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Gail Clement, Jie Huang, Inês Barroso, 2016, Nature Communications.

Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

N. Stylopoulos, R. Cone, L. Kaplan, 2012, The Journal of clinical endocrinology and metabolism.

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.

S. O’Rahilly, H. Pijl, I. Farooqi, 2011, The Journal of clinical endocrinology and metabolism.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2018, Nature Genetics.

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

S. O’Rahilly, V. Saudek, G. Yeo, 2021, Scientific Reports.

A Transcriptomic Signatur e of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome Graphical

S. Bouret, V. Plagnol, I. Farooqi, 2018 .

Accelerated waning of the humoral response to COVID-19 vaccines in obesity

P. Klenerman, I. Farooqi, M. Linterman, 2023, Nature Medicine.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Marcelo P. Segura-Lepe, A. J. Slater, Dajiang J. Liu, 2019, Nature Genetics.

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

M. P. Concas, M. Jarvelin, E. Demerath, 2023, medRxiv.

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities

Mingyan Zhu, S. Appleyard, I. Barroso, 2020, Scientific Reports.

Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.

S. Savvides, P. Fischer-Posovszky, I. Farooqi, 2023, The New England journal of medicine.

The UK10K project identifies rare variants in health and disease

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2015, Nature.

Food images engage subliminal motivation to seek food

I. Farooqi, H. Ziauddeen, H Ziauddeen, 2011, International Journal of Obesity.

Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity

S. O’Rahilly, E. Gardner, F. Day, 2023, Cell genomics.

Two novel missense mutations in GPR54 in a subject with hypogonadotropic hypogonadism

I. Farooqi, F. Karet, S. Aparicio, 2005 .

Cardiovascular Disease? Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and

T. Cole, I. Farooqi, A. Lucas, 2008 .

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Tom R. Gaunt, Thomas M. Keane, Colin A. Johnson, 2015, Nature Communications.

Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.

S. Bhattacharyya, S. O’Rahilly, N. Wareham, 2003, Diabetes.

Elucidating the aetiology of Prader-Willi syndrome: deletion of the HBII-85 class of snoRNA is associated with hyperphagia, obesity and hypogonadism

S. O’Rahilly, P. Froguel, M. Dattani, 2009 .

Association analyses of 249 , 796 individuals reveal 18 new loci associated with body mass index

Tanya M. Teslovich, Eric, P. Elliott, 2012 .

A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2

P. Elliott, M. Jarvelin, L. Coin, 2009, Nature.

Antidiabetic effects of IGFBP2, a leptin-regulated gene.

J. Friedman, R. Ahima, I. Farooqi, 2010, Cell metabolism.

Genetic Evaluation of Obese Patients

S. O’Rahilly, I. Farooqi, 2008 .

Genetic, molecular and physiological insights into human obesity

I. Farooqi, 2011, European journal of clinical investigation.

Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Tanya M. Teslovich, M. Jarvelin, L. Coin, 2010, Nature genetics.

Neural and Behavioral Effects of a Novel Mu Opioid Receptor Antagonist in Binge-Eating Obese People

E. Bullmore, C. Dodds, P. Fletcher, 2013, Biological Psychiatry.

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects

E. Bullmore, L. Cheke, P. Fletcher, 2012, Molecular Psychiatry.

Leptin: a pivotal regulator of human energy homeostasis.

S. O’Rahilly, I. Farooqi, 2009, The American journal of clinical nutrition.

Dopamine Modulates the Neural Representation of Subjective Value of Food in Hungry Subjects

W. Schultz, P. Fletcher, M. Vestergaard, 2014, The Journal of Neuroscience.

Genetics of body-weight regulation

G. Barsh, S. O’Rahilly, I. Farooqi, 2000, Nature.

Monogenic human obesity syndromes.

I. Farooqi, 2006, Progress in brain research.

Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease

A. Reymond, Z. Kutalik, H. Firth, 2023, Cell reports. Medicine.

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Tom R. Gaunt, Thomas M. Keane, Hashem A. Shihab, 2015, Nature Communications.

A genome-wide association meta-analysis identifies new childhood obesity loci

P. Elliott, M. Jarvelin, D. Postma, 2012, Nature Genetics.

Biallelic mutations in P4HTM cause syndromic obesity.

John F. Trant, P. Froguel, A. Bonnefond, 2023, Diabetes.

A Metabolomic Signature of Acute Caloric Restriction

I. Farooqi, Lining Guo, T. Sonoyama, 2017, The Journal of clinical endocrinology and metabolism.

High protein intake stimulates postprandial GLP1 and PYY release

I. Farooqi, M. Ghatei, W. Dhillo, 2013, Obesity.

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

D. Saleheen, F. Day, I. Farooqi, 2024, Nature genetics.

A rare human variant that disrupts GPR10 signalling causes weight gain in mice

D. Bechtold, P. Froguel, I. Barroso, 2023, Nature Communications.