J. Brender

发表

Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles

Yang Zhang, Jeffrey R. Brender, Yang Zhang, 2015, PLoS Comput. Biol..

An Evolution-Based Approach to De Novo Protein Design and Case Study on Mycobacterium tuberculosis

Yang Zhang, Pralay Mitra, David Marsh, 2013, PLoS Comput. Biol..

Quality of Prostate MRI: Is the PI-RADS Standard Sufficient?

P. Choyke, S. Harmon, E. Turkbey, 2020, Academic radiology.

PET by MRI: Glucose Imaging by 13C-MRS without Dynamic Nuclear Polarization by Noise Suppression through Tensor Decomposition Rank Reduction

Albert P. Chen, P. Choyke, H. Merkle, 2018, bioRxiv.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

James B. Mitchell, Albert P. Chen, P. Choyke, 2019, bioRxiv.

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

Shingo Matsumoto, Hellmut Merkle, Galen Reed, 2019, eLife.

Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization

Hellmut Merkle, Galen Reed, Murali C Krishna, 2019, Scientific Reports.

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.

Ayyalusamy Ramamoorthy, Jeffrey R Brender, J. Brender, 2011, Biochimica et biophysica acta.

Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.

Kevin Hartman, Ayyalusamy Ramamoorthy, Jiadi Xu, 2009, Journal of the American Chemical Society.

Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.

Gianluigi Veglia, Ayyalusamy Ramamoorthy, Jiadi Xu, 2008, Biochemistry.

Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes.

J. Brender, M. B. Banaszak Holl, U. Dürr, 2010, Journal of the American Chemical Society.

Recent advances in automated protein design and its future challenges

Yang Zhang, J. Brender, Dani Setiawan, 2018, Expert opinion on drug discovery.

Synthesis of [1‐13C‐5‐12C]‐alpha‐ketoglutarate enables noninvasive detection of 2‐hydroxyglutarate

K. Camphausen, Natsuko Miura, J. Brender, 2021, NMR in biomedicine.

Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes.

M. Meyerhoff, J. Brender, K. Kuroda, 2011, Analytical biochemistry.

Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

J. Brender, A. Ramamoorthy, D. Milardi, 2013, Biophysical journal.

Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes.

J. Brender, U. Dürr, A. Ramamoorthy, 2007, Biochimica et biophysica acta.

Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption.

J. Brender, Yuta Suzuki, A. Ramamoorthy, 2012, Biochemistry.

Binding Moiety Mapping by Saturation Transfer Difference NMR.

J. Brender, A. Bhunia, Anirban Ghosh, 2018, Methods in molecular biology.

Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

J. Brender, A. Ramamoorthy, D. Steel, 2008, Journal of the American Chemical Society.

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments.

J. Brender, A. Ramamoorthy, S. A. Kotler, 2013, Physical chemistry chemical physics : PCCP.

Non-productive Binding Modes as a Prominent Feature of Aβ1-40 Fiber Elongation: Insights from Molecular Dynamics Simulation

J. Brender, R. Kar, A. Bhunia, 2018, bioRxiv.

Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins.

N. Kotov, K. Sun, J. Brender, 2011, Angewandte Chemie.

Protein–Protein Interactions and Genetic Disease

Yang Zhang, J. Brender, 2017 .

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

James B. Mitchell, P. Choyke, J. Brender, 2020, Cancer Research.

Towards reduction of SAR in scaling up in vivo pulsed EPR imaging to larger objects

T. Pohida, J. Brender, R. Pursley, 2018, Journal of magnetic resonance.

A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc.

J. Brender, B. Ruotolo, R. Nanga, 2011, Journal of molecular biology.

Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized 13C‐MRI

K. Camphausen, P. Tofilon, J. Brender, 2021, NMR in biomedicine.

Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

J. Brender, B. Ruotolo, Suk-Joon Hyung, 2013, Proceedings of the National Academy of Sciences.

Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78).

J. Brender, A. Ramamoorthy, Dong-kuk Lee, 2013, Biochemistry.

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19 F NMR-Detected Kinetics of Monomer Consumption

J. Brender, A. Ramamoorthy, Yuta Suzuki, 2013 .

Does Cholesterol Play a Role in the Bacterial Selectivity of Antimicrobial Peptides?

J. Brender, A. Ramamoorthy, A. J. Mchenry, 2012, Front. Immun..

Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI

J. Brender, S. Eaton, G. Eaton, 2019, bioRxiv.

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

Patrick Walsh, J. Brender, Yuta Suzuki, 2015, Scientific Reports.

Probing transient non-native states in amyloid beta fiber elongation by NMR.

B. Reif, J. Brender, A. Ramamoorthy, 2019, Chemical communications.

Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion.

J. Brender, A. Ramamoorthy, Lindsey M. Gottler, 2009, Biophysical journal.

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

C. Fierke, J. Brender, A. Ramamoorthy, 2014, The journal of physical chemistry letters.

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

James B. Mitchell, D. Urban, W. Linehan, 2020, Cell reports.

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

C. Fierke, J. Brender, A. Ramamoorthy, 2015, Journal of diabetes research.

Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP.

J. Brender, A. Ramamoorthy, C. La Rosa, 2015, The journal of physical chemistry. B.

Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

J. Brender, G. Balboni, A. Ramamoorthy, 2014 .

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.

Sanghyun Lee, Jin Hoon Kim, Cheal Kim, 2014, Journal of the American Chemical Society.

Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation.

Ayyalusamy Ramamoorthy, Jeffrey R Brender, J. Brender, 2012, Biophysical journal.

Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.

N. Kotov, J. Brender, Yuta Suzuki, 2013, Biochemistry.

Role of zinc in human islet amyloid polypeptide aggregation.

J. Brender, N. Popovych, R. Nanga, 2010, Journal of the American Chemical Society.

Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

Ayyalusamy Ramamoorthy, Jeffrey R Brender, J. Brender, 2012, Biochimica et biophysica acta.

Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion.

J. Brender, A. Ramamoorthy, Lindsey M. Gottler, 2009, Biophysical journal.

Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

J. Brender, A. Ramamoorthy, Dong-kuk Lee, 2009, Journal of the American Chemical Society.

Synthesis and evaluation of 13C‐labeled 5‐5‐dimethyl‐1‐pyrroline‐N‐oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C‐MRI

James B. Mitchell, J. Brender, S. Matsumoto, 2019, Free radical biology & medicine.

Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

James B. Mitchell, J. Brender, M. Krishna, 2021, Cancer Research.

Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

James B. Mitchell, J. Brender, S. Naz, 2021, International journal of molecular sciences.

Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening.

Yang Zhang, Jian Zhang, Jeffrey R Brender, 2015, Methods.

Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.

J. Brender, A. Ramamoorthy, Janarthanan Krishnamoorthy, 2012, The journal of physical chemistry. B.

Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide

J. Brender, K. Das, A. K. Mandal, 2016, The Journal of Biological Chemistry.

Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).

J. Brender, N. Popovych, R. Soong, 2012, The journal of physical chemistry. B.

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

M. Chapman, J. Brender, N. Popovych, 2013, PeerJ.

GLASS: a comprehensive database for experimentally validated GPCR-ligand associations

Yang Zhang, Junguk Hur, Arzucan Özgür, 2015, Bioinform..

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

Patrick Walsh, J. Brender, A. Ramamoorthy, 2014, Chemical Society reviews.

A partially folded structure of amyloid-beta(1-40) in an aqueous environment.

Shirley Y. Lee, J. Brender, A. Ramamoorthy, 2011, Biochemical and biophysical research communications.

NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.

A. Naito, J. Brender, Rui Huang, 2012, Journal of molecular biology.

Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.

Ayyalusamy Ramamoorthy, Dong-Kuk Lee, Jeffrey R Brender, 2012, Biochemistry.

Hypoxia Imaging as a Guide for Hypoxia Modulated and Hypoxia Activated Therapy.

J. Brender, S. Kishimoto, Y. Saida, 2021, Antioxidants & redox signaling.

Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

Ayyalusamy Ramamoorthy, Jeffrey R Brender, J. Brender, 2012, Accounts of chemical research.

A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity.

Kevin Hartman, Ayyalusamy Ramamoorthy, Robert T Kennedy, 2008, Biochemistry.

Denoising of hyperpolarized 13C MR images of the human brain using patch‐based higher‐order singular value decomposition

Susan M. Chang, Duan Xu, P. Larson, 2021, Magnetic resonance in medicine.

Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13C MRSI

John Kurhanewicz, Daniel B Vigneron, Peder E Z Larson, 2020, Magnetic resonance in medicine.

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.

J. Brender, A. Ramamoorthy, C. La Rosa, 2013, Chemical communications.

Orientation of amide-nitrogen-15 chemical shift tensors in peptides: a quantum chemical study.

J. Brender, D. Taylor, A. Ramamoorthy, 2001, Journal of the American Chemical Society.

Imaging of Glucose Metabolism by 13 C-MRI Distinguishes Pancreatic Cancer Subtypes 1 in Mice 2 3

Krishna, James B. Mitchell, P. Choyke, 2022 .

Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine

James B. Mitchell, P. Choyke, W. Linehan, 2021, Scientific Reports.

The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.

J. Brender, N. Popovych, R. Nanga, 2011, Biochimica et biophysica acta.

NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286).

J. Brender, N. Popovych, R. Nanga, 2009, Journal of the American Chemical Society.

In vivo deuterated water labeling followed by deuterium magnetic resonance imaging of xenografted tumors

H. Merkle, J. Brender, M. Krishna, 2019, bioRxiv.

Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production.

K. Camphausen, Natsuko Miura, J. Brender, 2021, ACS chemical biology.

In vivodeuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol

H. Merkle, J. Brender, M. Krishna, 2019 .

Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies.

J. Brender, B. Entsch, D. Ballou, 2005, Journal of the American Chemical Society.

Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide.

J. Brender, A. Ramamoorthy, Pieter E. S. Smith, 2009, Journal of the American Chemical Society.

Innentitelbild: Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins (Angew. Chem. 22/2011)

N. Kotov, K. Sun, J. Brender, 2011 .

Reoxygenation after Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts is due to Decreased Oxygen Consumption and not Increased Oxygen Supply

James B. Mitchell, J. Brender, M. Krishna, 2020, bioRxiv.

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage.

J. Brender, A. Ramamoorthy, D. Milardi, 2018, Biochimica et biophysica acta. Biomembranes.

Functional dynamics in the active site of the ribonuclease binase

J. Brender, E. Zuiderweg, Lincong Wang, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species.

J. Brender, G. Balboni, A. Ramamoorthy, 2014, Chemical science.

Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy.

J. Brender, R. Soong, A. Ramamoorthy, 2009, Journal of the American Chemical Society.

Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.

J. Brender, A. Ramamoorthy, D. Steel, 2011, Biophysical journal.

Evaluation of a deuterated triarylmethyl spin probe for in vivo R2*-based EPR oximetric imaging with enhanced dynamic range

J. Brender, S. Kishimoto, Kazu Yamamoto, 2023, bioRxiv.

Hypoxia activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy.

James B. Mitchell, J. Brender, M. Krishna, 2020, Antioxidants & redox signaling.

High resolution structure of a partially folded insulin aggregation intermediate

J. Brender, R. Kar, A. Bhunia, 2019, bioRxiv.

Intrinsic disorder and structural biology: Searching where the light isn't.

J. Brender, O. Gursky, A. Ramamoorthy, 2022, Biophysical chemistry.

An Evolution-Based Approach to De Novo Protein Design.

Yang Zhang, Naureen Aslam Khattak, David Shultis, 2017, Methods in molecular biology.

Nonproductive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation

Anirban Bhunia, Anirban Ghosh, Rajiv K Kar, 2018, J. Chem. Inf. Model..

In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water

J. Brender, S. Kishimoto, Keita Saito, 2023, Scientific reports.

Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.

Jie Zheng, Ayyalusamy Ramamoorthy, Rundong Hu, 2014, Physical chemistry chemical physics : PCCP.

NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286).

J. Brender, N. Popovych, R. Nanga, 2009, Journal of the American Chemical Society.

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.

Jeffrey S Derrick, J. Brender, M. Bowers, 2014, Journal of the American Chemical Society.

A partially folded structure of amyloid-beta(1-40) in an aqueous environment.

Shirley Y. Lee, J. Brender, A. Ramamoorthy, 2011, Biochemical and biophysical research communications.

Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy.

J. Brender, R. Soong, A. Ramamoorthy, 2009, Journal of the American Chemical Society.

Probing transient non-native states in amyloid beta fiber elongation by NMR.

B. Reif, J. Brender, A. Ramamoorthy, 2019, Chemical communications.

Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

J. Brender, A. Ramamoorthy, Dong-kuk Lee, 2009, Journal of the American Chemical Society.

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

C. Fierke, J. Brender, A. Ramamoorthy, 2014, The journal of physical chemistry letters.

Pores Versus Fibrils: Calcium Ions Regulate Different IAPP-Mediated Membrane Damage Mechanisms

J. Brender, A. Ramamoorthy, D. Milardi, 2013 .

Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles

Yang Zhang, J. Brender, 2015, PLoS Comput. Biol..

Pharmacologic Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug.

J. Brender, S. Kishimoto, Kazu Yamamoto, 2024, Free radical biology & medicine.

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug

J. Brender, S. Kishimoto, Kazu Yamamoto, 2024, bioRxiv.