C. Kleanthous

发表

The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction

D. Baker, S. Fleishman, Nicola A. G. Meenan, 2010, Proceedings of the National Academy of Sciences.

Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes.

A. Pommer, G. Moore, C. Kleanthous, 2000, Journal of molecular biology.

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.

David Baker, Colin Kleanthous, D. Baker, 2008, Journal of molecular biology.

Immunity proteins and their specificity for endonuclease colicins: telling right from wrong in protein–protein recognition

G. Moore, C. Kleanthous, G. Moore, 1998, Molecular microbiology.

Protein-protein recognition

Colin Kleanthous, C. Kleanthous, 2000 .

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria

Mark S.P. Sansom, Matthieu Chavent, Jacob Piehler, 2015, Nature.

Colicin Biology

Colin Kleanthous, S. Buchanan, R. Lloubès, 2007, Microbiology and Molecular Biology Reviews.

RsrA, an anti‐sigma factor regulated by redox change

J. Hahn, J. Bae, C. Kleanthous, 1999, The EMBO journal.

Blind prediction of interfacial water positions in CAPRI

Kengo Kinoshita, Haruki Nakamura, Xiaoqin Zou, 2014, Proteins.

Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae

J. Parkhill, C. Kleanthous, P. Taylor, 2020, Infection and Immunity.

Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae

J. Parkhill, C. Kleanthous, Nathalie T. Reichmann, 2020 .

Conformational Properties of the Unfolded State of Im7 in Nondenaturing Conditions

Sheena E. Radford, Gary S. Thompson, Colin Kleanthous, 2012, Journal of molecular biology.

Killing of E coli cells by E group nuclease colicins.

G. Moore, C. Kleanthous, R. James, 2002, Biochimie.

Rapid Detection of Colicin E9-Induced DNA Damage Using Escherichia coli Cells Carrying SOS Promoter-lux Fusions

G. Moore, C. Kleanthous, R. James, 2005, Journal of bacteriology.

Protein-Protein Interaction Specificity of Im9 for the Endonuclease Toxin Colicin E9 Defined by Homologue-scanning Mutagenesis*

Colin Kleanthous, Wei Li, G. Moore, 1997, The Journal of Biological Chemistry.

Molecular mimicry enables competitive recruitment by a natively disordered protein.

Colin Kleanthous, C. Kleanthous, E. Dodson, 2007, Journal of the American Chemical Society.

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

C. Kleanthous, E. Lowe, E. Seiradake, 2018, Nature Communications.

Intermembrane crosstalk drives inner-membrane protein organization in Escherichia coli

C. Kleanthous, P. Rassam, Renata Kaminska, 2018, Nature Communications.

Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases.

A. Pommer, T. Georgiou, G. Moore, 2002, Nucleic acids research.

A 76‐residue polypeptide of colicin E9 confers receptor specificity and inhibits the growth of vitamin B12‐dependent Escherichia coli 113/3 cells

G. Moore, C. Kleanthous, G. Moore, 2000, Molecular microbiology.

Homing in on the Role of Transition Metals in the HNH Motif of Colicin Endonucleases*

A. Pommer, G. Moore, C. Kleanthous, 1999, The Journal of Biological Chemistry.

Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.

A. Heck, Anthony H Keeble, W. Jiskoot, 2004, Biochemistry.

Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time‐of‐flight mass spectrometry

A. Heck, W. Jiskoot, G. Moore, 2002, Protein science : a publication of the Protein Society.

Pyocin S5 Import into Pseudomonas aeruginosa Reveals a Generic Mode of Bacteriocin Transport

C. Robinson, C. Kleanthous, E. Lowe, 2020, mBio.

Orientation of the OmpF Porin in Planar Lipid Bilayers

H. Bayley, C. Kleanthous, N. G. Housden, 2017, Chembiochem : a European journal of chemical biology.

Structural and Functional Analysis of SGT1 Reveals That Its Interaction with HSP90 Is Required for the Accumulation of Rx, an R Protein Involved in Plant Immunity

F. Ochsenbein, G. Moore, C. Kleanthous, 2007 .

Pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis

C. Kleanthous, T. Evans, D. Walker, 2020, bioRxiv.

Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

C. Robinson, C. Kleanthous, P. White, 2017, Angewandte Chemie.

Metal induced selectivity in phosphate ion binding in E9 DNase.

A. Heck, C. Kleanthous, E. T. van den Bremer, 2005, Chemical communications.

Distinct conformational stability and functional activity of four highly homologous endonuclease colicins

A. Heck, W. Jiskoot, G. Moore, 2004, Protein science : a publication of the Protein Society.

Exploitation of an iron transporter for bacterial protein antibiotic import

S. Mohammed, C. Kleanthous, P. White, 2017, Proceedings of the National Academy of Sciences.

A Kinetic Analysis of Regiospecific Glucosylation by Two Glycosyltransferases of Arabidopsis thaliana

C. Kleanthous, D. Bowles, Eng‐Kiat Lim, 2008, Journal of Biological Chemistry.

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Anna L. Duncan, B. Hambly, M. Chavent, 2018, Nature Communications.

Transmembrane Epitope Delivery by Passive Protein Threading through the Pores of the OmpF Porin Trimer

H. Bayley, C. Kleanthous, N. G. Housden, 2020, Journal of the American Chemical Society.

Thermodynamic consequences of bipartite immunity protein binding to the ribosomal ribonuclease colicin E3.

G. Moore, C. Kleanthous, R. James, 2003, Biochemistry.

Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9.

A. Pommer, C. Kleanthous, U. C. Kühlmann, 2001, Journal of molecular biology.

Peptidoglycan maturation controls outer membrane protein assembly

C. Kleanthous, Ruth Cohen-Khait, W. Vollmer, 2022, Nature.

Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm

H. Bayley, S. Khalid, C. Kleanthous, 2018, Biochemistry.

Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9.

G. Moore, C. Kleanthous, R. James, 2002, Biochemistry.

Flexibility in the Receptor-Binding Domain of the Enzymatic Colicin E9 Is Required for Toxicity against Escherichia coli Cells

R. Boetzel, G. Moore, C. Kleanthous, 2004, Journal of bacteriology.

Global structural rearrangement of the cell penetrating ribonuclease colicin E3 on interaction with phospholipid membranes

G. Moore, C. Kleanthous, R. James, 2006, Protein science : a publication of the Protein Society.

Targeted Killing of Pseudomonas aeruginosa by Pyocin G Occurs via the Hemin Transporter Hur

C. Kleanthous, N. G. Housden, Renata Kaminska, 2020, Journal of molecular biology.

Destabilization of the Colicin E9 Endonuclease Domain by Interaction with Negatively Charged Phospholipids

G. Moore, C. Kleanthous, R. James, 2004, Journal of Biological Chemistry.

Structural and mechanistic basis of immunity toward endonuclease colicins

Sheena E. Radford, Neil Ferguson, Andrew M. Hemmings, 1999, Nature Structural Biology.

Site-specific labeling of proteins with cyclen-bound transition metal ions

T. Georgiou, R. Boetzel, G. Moore, 2002 .

Lipids mediate supramolecular outer membrane protein assembly in bacteria

S. Mohammed, C. Robinson, S. Khalid, 2022, Science advances.

Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

C. Kleanthous, Ruth Cohen-Khait, W. Vollmer, 2022, bioRxiv.

Structure and Function of the Escherichia coli Tol-Pal Stator Protein TolR

C. Robinson, D. Staunton, C. Kleanthous, 2015, The Journal of Biological Chemistry.

Protein–protein interactions and the spatiotemporal dynamics of bacterial outer membrane proteins

C. Kleanthous, P. Rassam, C. Baumann, 2015, Current opinion in structural biology.

Identification of residues in the putative TolA box which are essential for the toxicity of the endonuclease toxin colicin E9.

C. Kleanthous, G. Moore, R. James, 1997, Microbiology.

The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor.

Wei Li, C. Kleanthous, M. Buttner, 2003, Journal of molecular biology.

Conformational changes and the role of metals in the mechanism of type II dehydroquinase from Aspergillus nidulans.

A. Hawkins, C. Kleanthous, J. Bottomley, 1996, The Biochemical journal.

Mechanism of SigR inhibition by the anti-sigma factor RsrA from Streptomyces coelicolor

C. Kleanthous, 2015 .

Tools and Approaches for Dissecting Protein Bacteriocin Import in Gram-Negative Bacteria

C. Kleanthous, Iva M. Atanasković, Iva Atanasković, 2019, Front. Microbiol..

Re-evaluating the Role of His-143 in the Mechanism of Type I Dehydroquinase from Escherichia coli Using Two-dimensional1H,13C NMR*

J. Coggins, R. Boetzel, G. Moore, 1998, The Journal of Biological Chemistry.

The therapeutic potential of bacteriocins as protein antibiotics

C. Kleanthous, D. Walker, H. Behrens, 2017, Emerging topics in life sciences.

Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3

Colin Kleanthous, C. Kleanthous, R. James, 2004, Protein science : a publication of the Protein Society.

The multifarious roles of Tol-Pal in Gram-negative bacteria

C. Kleanthous, J. Szczepaniak, Cara Press, 2020, FEMS microbiology reviews.

A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes.

N. C. Price, J. Coggins, A. Hawkins, 1992, The Biochemical journal.

Clusters in an intrinsically disordered protein create a protein-binding site: the TolB-binding region of colicin E9.

C. Macdonald, G. Moore, C. Kleanthous, 2005, Biochemistry.

Characterisation of a mobile protein-binding epitope in the translocation domain of colicin E9

C. Macdonald, G. Moore, C. Kleanthous, 2004, Journal of biomolecular NMR.

Force-Generation by the Trans-Envelope Tol-Pal System

C. Kleanthous, M. N. Webby, Cara Press, 2022, Frontiers in Microbiology.

The lipoprotein Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism

Seán M. Murray, S. Khalid, C. Kleanthous, 2020, Nature Communications.

The biology of E colicins: paradigms and paradoxes.

G. Moore, C. Kleanthous, G. Moore, 1996, Microbiology.

3-(Bromoacetyl)chloramphenicol, an active site directed inhibitor for chloramphenicol acetyltransferase.

P M Cullis, W V Shaw, W. V. Shaw, 1985, Biochemistry.

O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli

Amy K. Cain, Christine J. Boinett, J. Parkhill, 2018, Journal of bacteriology.

Observation of an imine intermediate on dehydroquinase by electrospray mass spectrometry

J. Coggins, C. Kleanthous, C. Abell, 1991 .

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

Olwyn Byron, Jacqueline M. Matthews, Nicholas P. Tucker, 2016, The Biochemical journal.

Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor sigma(R) from Streptomyces coelicolor.

Wei Li, C. Kleanthous, M. Buttner, 2002, Journal of molecular biology.

Bacterial Competition Systems Share a Domain Required for Inner Membrane Transport of the Bacteriocin Pyocin G from Pseudomonas aeruginosa

C. Kleanthous, Renata Kaminska, Connor Sharp, 2022, mBio.

Bacterial competition systems share a domain required for inner membrane transport of the nuclease bacteriocin pyocin G

C. Kleanthous, Renata Kaminska, Connor Sharp, 2021, bioRxiv.

Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes

M. Rodnina, W. Wintermeyer, C. Kleanthous, 2008, Molecular microbiology.

Mechanism of targeted killing of P. aeruginosa by pyocins SX1 and SX2

C. Kleanthous, D. Walker, K. Mosbahi, 2022, bioRxiv.

Pyocin S5 Import into Pseudomonas aeruginosa Reveals a Generic Mode of Bacteriocin Transport

C. Robinson, C. Kleanthous, E. Lowe, 2019, mBio.

Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models

Martin C. J. Maiden, James E. Bray, Connor Sharp, 2017, PLoS Comput. Biol..

The Role of Electrostatics in Colicin Nuclease Domain Translocation into Bacterial Cells*

Colin Kleanthous, C. Kleanthous, R. James, 2007, Journal of Biological Chemistry.

The cytotoxic domain of colicin E9 is a channel-forming endonuclease

Bertrand Morel, G. Moore, C. Kleanthous, 2002, Nature Structural Biology.

Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF

C. Kleanthous, N. G. Housden, Renata Kaminska, 2021, The EMBO journal.

Toxin import through the antibiotic efflux channel TolC

C. Robinson, C. Kleanthous, E. Lowe, 2021, Nature Communications.

Passive receptor dissociation driven by porin threading establishes active colicin transport through Escherichia coli OmpF

C. Kleanthous, N. G. Housden, Renata Kaminska, 2021, bioRxiv.

Im7 folding mechanism: misfolding on a path to the native state

Sheena E. Radford, Colin Kleanthous, S. Radford, 2002, Nature Structural Biology.

Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate

Sheena E. Radford, Colin Kleanthous, S. Radford, 2001, Nature Structural Biology.

Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9.

S. Radford, N. Ferguson, C. Kleanthous, 1999, Journal of molecular biology.

Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.

Justyna Aleksandra Wojdyla, Sarel J Fleishman, Colin Kleanthous, 2012, Journal of molecular biology.

Calorimetric dissection of colicin DNase--immunity protein complex specificity.

Seishi Shimizu, Colin Kleanthous, Anthony H Keeble, 2006, Biochemistry.

Dual recognition and the role of specificity-determining residues in colicin E9 DNase-immunity protein interactions.

C. Kleanthous, G. Moore, R. James, 1998, Biochemistry.

Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 2. Cognate and noncognate interactions that span the millimolar to femtomolar affinity range.

H Videler, A. Pommer, G. Moore, 1995, Biochemistry.

The CcmC–CcmE interaction during cytochrome c maturation by System I is driven by protein–protein and not protein–heme contacts

C. Kleanthous, D. Mavridou, S. Ferguson, 2018, The Journal of Biological Chemistry.

Analysis of the mechanism of chloramphenicol acetyltransferase by steady-state kinetics. Evidence for a ternary-complex mechanism.

W V Shaw, W. V. Shaw, C. Kleanthous, 1984, The Biochemical journal.

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

Orly Dym, Dan S. Tawfik, Shlomo Magdassi, 2009, Nature Structural &Molecular Biology.

A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

S. Radford, C. Kleanthous, D. Brockwell, 2013, PLoS biology.

Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding.

G. Moore, C. Kleanthous, R. James, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core

Konrad Zdanowski, Shabaz Mohammed, Connor Sharp, 2016, Nature Communications.

The quantitative basis for the redistribution of immobile bacterial lipoproteins to division septa

Seán M. Murray, Colin Kleanthous, Lara Connolley, 2021, PLoS Comput. Biol..

Spatiotemporal organization of BamA governs the pattern of outer membrane protein distribution in growing Escherichia coli cells

C. Kleanthous, J. Payandeh, Ruth Cohen-Khait, 2021, bioRxiv.

Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF

Nicholas G. Housden, Colin Kleanthous, C. Kleanthous, 2010, Proceedings of the National Academy of Sciences.

Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3

A. Kelley, V. Ramakrishnan, Nicola A. G. Meenan, 2010, Nature Structural &Molecular Biology.

Inhibition of a ribosome-inactivating ribonuclease: the crystal structure of the cytotoxic domain of colicin E3 in complex with its immunity protein.

C. Kleanthous, S. Carr, R. James, 2000, Structure.

Structural dynamics of the receptor-binding domain of colicin E9.

R. Boetzel, G. Moore, C. Kleanthous, 2003, Faraday discussions.

Substitutions in the active site of chloramphenicol acetyltransferase: role of a conserved aspartate.

I A Murray, A Lewendon, P M Cullis, 1988, Biochemistry.

The Role of an Activating Peptide in Protease-mediated Suicide of Escherichia coli K12*

C. Kleanthous, N. Copeland, 2005, Journal of Biological Chemistry.

Self‐association of TPR domains: Lessons learned from a designed, consensus‐based TPR oligomer

Anne Marie Krachler, Colin Kleanthous, C. Kleanthous, 2010, Proteins.

Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori.

C. Kleanthous, C. Clayton, P. Chalk, 1996, The Biochemical journal.

High-resolution mass spectrometry of small molecules bound to membrane proteins

Weston B Struwe, Alexander Makarov, Joseph Gault, 2016, Nature Methods.

TPR-Mediated self-association of plant SGT1.

C. Kleanthous, K. Shirasu, A. Rowe, 2007, Biochemistry.

Structural and Functional Analysis of SGT1 Reveals That Its Interaction with HSP90 Is Required for the Accumulation of Rx, an R Protein Involved in Plant Immunity[W][OA]

R. Guérois, F. Ochsenbein, G. Moore, 2007, The Plant Cell Online.

Compartmentalizing acid stress in bacteria

C. Kleanthous, 2018, Nature Chemical Biology.

Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu.

T. Georgiou, C. Kleanthous, M. Buttner, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Crystallization of the cytotoxic domain of a ribosome-inactivating colicin in complex with its immunity protein.

C. Kleanthous, S. Carr, R. James, 2000, Acta crystallographica. Section D, Biological crystallography.

Stabilization of the shikimate pathway enzyme dehydroquinase by covalently bound ligand.

N. C. Price, J. Coggins, C. Kleanthous, 1991, The Journal of biological chemistry.

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity

G. Moore, C. Kleanthous, R. James, 2004, Journal of bacteriology.

Structural aspects of the inhibition of DNase and rRNase colicins by their immunity proteins.

A. Pommer, C. Kleanthous, S. Carr, 2002, Biochimie.

Immunity proteins: enzyme inhibitors that avoid the active site.

C. Kleanthous, D. Walker, C Kleanthous, 2001, Trends in biochemical sciences.

Assignment of the zinc ligands in RsrA, a redox-sensing ZAS protein from Streptomyces coelicolor.

K. Zdanowski, C. Kleanthous, M. Buttner, 2006, Biochemistry.

The kinetic basis for dual recognition in colicin endonuclease-immunity protein complexes.

C. Kleanthous, Anthony H. Keeble, 2005, Journal of molecular biology.

Phase separation in the outer membrane of Escherichia coli

B. Hoogenboom, T. Silhavy, C. Kleanthous, 2021, Proceedings of the National Academy of Sciences.

Allosteric β‐propeller signalling in TolB and its manipulation by translocating colicins

G. Moore, C. Kleanthous, R. James, 2009, The EMBO journal.

Bifurcated binding of the OmpF receptor underpins import of the bacteriocin colicin N into Escherichia coli

C. Robinson, H. Bayley, C. Kleanthous, 2020, The Journal of Biological Chemistry.

NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase

M. Czisch, R. Kaptein, R. Boetzel, 2000, Protein science : a publication of the Protein Society.

Product-induced stabilization of tertiary and quaternary structure in Escherichia coli dehydroquinase.

N. C. Price, J. Coggins, C. Kleanthous, 1994, The Journal of biological chemistry.

Colicin-Mediated Transport of DNA through the Iron Transporter FepA

Jeffrey J. Gray, S. Mohammed, J. J. Gray, 2021, bioRxiv.

Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9.

G. Moore, C. Kleanthous, R. Wallis, 1994, European journal of biochemistry.

Energy-dependent Immunity Protein Release during tol-dependent Nuclease Colicin Translocation*

Colin Kleanthous, G. Moore, C. Kleanthous, 2009, The Journal of Biological Chemistry.

Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.

Wei Li, Colin Kleanthous, Wei Li, 2004, Journal of molecular biology.

Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB.

C. Macdonald, R. Boetzel, G. Moore, 2002, Journal of molecular biology.

Lipid binding attenuates channel closure of the outer membrane protein OmpF

Thomas D. Newport, C. Robinson, H. Bayley, 2018, Proceedings of the National Academy of Sciences.

Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9

G. Moore, C. Kleanthous, R. James, 2006, Proceedings of the National Academy of Sciences.

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

C. Kleanthous, E. Lowe, E. Seiradake, 2018, Nature Communications.

A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity.

H Videler, G. Moore, C. Kleanthous, 1998, The Biochemical journal.

Swimming against the tide: progress and challenges in our understanding of colicin translocation

Colin Kleanthous, C. Kleanthous, 2010, Nature Reviews Microbiology.

TolA modulates the oligomeric status of YbgF in the bacterial periplasm.

C. Kleanthous, A. Krachler, G. Papadakos, 2010, Journal of molecular biology.

Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9.

Renata Kaminska, Colin Kleanthous, C. Kleanthous, 2012, Journal of molecular biology.

Nuclease colicins and their immunity proteins

Colin Kleanthous, C. Kleanthous, J. Wojdyla, 2011, Quarterly Reviews of Biophysics.

NMR studies of metal ion binding to the Zn-finger-like HNH motif of colicin E9.

C. Kleanthous, G. Moore, R. James, 2000, Journal of inorganic biochemistry.

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Anna L. Duncan, B. Hambly, M. Chavent, 2018, Nature Communications.

Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9.

S. Radford, S. Gorski, C. Kleanthous, 2001, Journal of molecular biology.

Ultrahigh specificity in a network of computationally designed protein-interaction pairs

O. Dym, S. Albeck, S. Fleishman, 2018, Nature Communications.

Specificity in protein-protein recognition: conserved Im9 residues are the major determinants of stability in the colicin E9 DNase-Im9 complex.

C. Kleanthous, R. Wallis, G. Moore, 1998, Biochemistry.

In vivo and in vitro characterization of overproduced colicin E9 immunity protein.

C. Kleanthous, R. Wallis, G. Moore, 1992, European journal of biochemistry.

Preliminary X-ray crystallographic analysis of the complex between the DNAase domain of colicin E9 and its cognate immunity protein.

C. Kleanthous, U. C. Kühlmann, G. Moore, 1999, Acta crystallographica. Section D, Biological crystallography.

The Major Head Protein of Bacteriophage T4 Binds Specifically to Elongation Factor Tu*

C. Kleanthous, L. Snyder, Ryan P. Bingham, 2000, The Journal of Biological Chemistry.

Translational regulation by modifications of the elongation factor Tu

C. Kleanthous, B. Kraal, C. Lippmann, 2008, Folia Microbiologica.

The effect of protein complexation on the mechanical stability of Im9.

Colin Kleanthous, Sheena E Radford, David J Brockwell, 2007, Biophysical journal.

Translocator hunt comes full Cir‐Col

C. Kleanthous, 2010, Molecular microbiology.

How bugs kill bugs: progress and challenges in bacteriocin research.

C. Kleanthous, C. Penfold, D. Walker, 2012, Biochemical Society transactions.

Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex.

G. Moore, C. Kleanthous, R. Wallis, 1995, Biochemistry.

Structure-based Analysis of the Metal-dependent Mechanism of H-N-H Endonucleases*

Colin Kleanthous, C. Kleanthous, M. Maté, 2004, Journal of Biological Chemistry.

Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement

C. Kleanthous, R. James, N. G. Housden, 2013, MicrobiologyOpen.

Intrinsically Disordered Protein Threads Through the Bacterial Outer-Membrane Porin OmpF

Carol V. Robinson, Helen R. Saibil, Renata Kaminska, 2013, Science.

Mutational analysis of RsrA, a zinc‐binding anti‐sigma factor with a thiol–disulphide redox switch

W. Li, J. Bae, C. Kleanthous, 2001, Molecular microbiology.

The bacterial cell envelope

J. Armitage, C. Kleanthous, 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

Colicins exploit native disorder to gain cell entry: a hitchhiker's guide to translocation.

Nicola A. G. Meenan, C. Kleanthous, D. Bonsor, 2008, Biochemical Society transactions.

Colicin translocation across the Escherichia coli outer membrane.

C. Kleanthous, N. G. Housden, 2012, Biochemical Society transactions.

Macromolecular complexes involving nuclease toxins, immunity proteins & DNA

C. Kleanthous, 1999 .

Mutagenesis of Active Site Residues in Type I Dehydroquinase from Escherichia coli

J. Coggins, C. Kleanthous, A. Leech, 1995, Journal of Biological Chemistry.

Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry

A. Heck, C. Kleanthous, P. Gerbaux, 2005, Nucleic acids research.

Identification of putative active-site residues in the DNase domain of colicin E9 by random mutagenesis.

A. Pommer, G. Moore, C. Kleanthous, 1996, Journal of molecular biology.

Structural and biophysical analysis of nuclease protein antibiotics

Justyna Aleksandra Wojdyla, Olwyn Byron, Renata Kaminska, 2016, The Biochemical journal.

Ultrahigh specificity in a network of computationally designed protein-interaction pairs

Rosalie Lipsh, Orly Dym, Orli Knop, 2018, Nature Communications.

Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases

J. Coggins, A. Hawkins, C. Kleanthous, 1993 .

C. Robinson, C. Kleanthous, E. Lowe, .

Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.

S. Fleishman, C. Kleanthous, J. Wojdyla, 2012, Journal of molecular biology.

Reversible alkylation of an active site methionine residue in dehydroquinase.

J. Coggins, C. Kleanthous, 1990, The Journal of biological chemistry.

Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA

C. Kleanthous, D. Walker, K. Mosbahi, 2023, The Biochemical journal.

Mechanism of targeted killing of P. aeruginosa by pyocins SX1 and SX2

C. Kleanthous, D. Walker, K. Mosbahi, 2023, bioRxiv.

Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase.

C. Kleanthous, D. Campbell, C. MacKintosh, 1989, The Biochemical journal.

NMR detection of slow conformational dynamics in an endonuclease toxin

A. Pommer, C. Macdonald, R. Boetzel, 1998, Journal of biomolecular NMR.

Crystallization of a type I 3-dehydroquinase from Salmonella typhi.

I. Charles, J. Coggins, J. Moore, 1992, Journal of molecular biology.

OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity

G. Moore, C. Kleanthous, R. James, 2003, FEBS letters.

Blind prediction of interfacial water positions in CAPRI

Julie C. Mitchell, Jeffrey J. Gray, H. Wolfson, 2014, Proteins.

Slow conformational dynamics of an endonuclease persist in its complex with its natural protein inhibitor

M. Czisch, R. Kaptein, G. Moore, 2008, Protein science : a publication of the Protein Society.

Consequences of inducing intrinsic disorder in a high-affinity protein-protein interaction.

C. Kleanthous, A. Leech, Renata Kaminska, 2015, Journal of the American Chemical Society.

Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding.

S. Radford, N. Ferguson, C. Kleanthous, 2001, Journal of molecular biology.

Analysis of nitroxide spin label motion in a protein-protein complex using multiple frequency EPR spectroscopy.

T. Georgiou, C. Kleanthous, G. Moore, 2007, Journal of magnetic resonance.

Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein.

C. Robinson, C. Kleanthous, N. Oldham, 2017, Angewandte Chemie.

Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9.

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