P. Gros

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Testing the method of crystallographic refinement using molecular dynamics

W. V. Gunsteren, M. Fujinaga, P. Gros, 1989 .

Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

J. Sixma, P. Gros, P. D. de Groot, 2002, Science.

Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site

P Gros, P. Gros, M. Egmond, 2001, The EMBO journal.

Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies.

R. Ravelli, P. Gros, H. Leiros, 2005, Journal of synchrotron radiation.

Structure of the translocator domain of a bacterial autotransporter

Piet Gros, J. Tommassen, P. van Gelder, 2004, The EMBO journal.

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

P. Gros, F. Forneris, B. Burnley, 2014, Acta crystallographica. Section D, Biological crystallography.

Structures of complement component C3 provide insights into the function and evolution of immunity

Piet Gros, Bo Nilsson, B. Nilsson, 2005, Nature.

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Piet Gros, Deniz Ugurlar, Abraham J. Koster, 2014, Science.

Simple Geometry for Diffusion Limited Protein Crystal Growth: Harnessing Gravity to Suppress Convection

P. Gros, P. Poodt, E. Vlieg, 2009 .

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

P. Gros, N. Pearce, M. Lutz, 2020, Life Science Alliance.

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

P. Gros, N. Pearce, M. Lutz, 2020, Life Science Alliance.

Modelling dynamics in protein crystal structures by ensemble refinement

Paul D Adams, Pavel V Afonine, Piet Gros, 2012, eLife.

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

F. Förster, P. Gros, A. Mattevi, 2018, Nature Communications.

Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c.

P Gros, W G Hol, W. Hol, 1989, Acta crystallographica. Section B, Structural science.

Accounting for molecular mobility in structure determination based on nuclear magnetic resonance spectroscopic and X-ray diffraction data.

C. Schiffer, W. V. van Gunsteren, W. V. Gunsteren, 1994, Methods in enzymology.

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

P. Parren, A. Heck, P. Gros, 2016, Molecular cell.

Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT.

P. Gros, M. Egmond, K. Brandenburg, 2002, European journal of biochemistry.

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

M. Pangburn, P. Roversi, P. Gros, 2012, Cell reports.

Anti-LRP 5 / 6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

I. Jordens, Michaela A. Gold, P. Gros, 2019 .

Multifaceted Activities of Seven Nanobodies against Complement C4b

P. Gros, P. M. P. van Bergen en Henegouwen, J. Lorent, 2022, The Journal of Immunology.

Structures of platelet-receptor glycoprotein Ib and its complex with von Willebrand factor domain A1

J. Sixma, P. Gros, E. Huizinga, 2002 .

Staphylococcal Complement Inhibitor: Structure and Active Sites1

P. Gros, F. Milder, J. V. van Strijp, 2007, The Journal of Immunology.

Activation of phosphatidylinositol transfer protein α and β isoforms from inclusion bodies

K. Wirtz, P. Gros, N. Dekker, 2001 .

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

W. de Lau, H. Clevers, Weng Chuan Peng, 2013, Cell reports.

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

P. Gros, N. Pearce, J. Granneman, 2019, Front. Immunol..

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

John D Lambris, E. Volokhina, D. Ricklin, 2016, The EMBO journal.

A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1

P. Gros, J. de Kruif, T. Arvinte, 2017, The Journal of Biological Chemistry.

Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization.

J. Helms, P. Gros, E. N. Nolte-‘t Hoen, 2012, Biochimica et biophysica acta.

Crystallization and preliminary X-ray analysis of Drosophila glutathione S-transferase-2.

P. Tucker, B. Agianian, J. Clayton, 2001, Acta crystallographica. Section D, Biological crystallography.

Structural basis for targeting human cancer antigen STEAP1 with antibodies

P. Gros, W. Oosterheert, 2020, bioRxiv.

Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)

P. Gros, W. Oosterheert, 2020, The Journal of Biological Chemistry.

Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)*

A. Heck, P. Gros, K. Mertens, 2016, The Journal of Biological Chemistry.

CRYSTAL STRUCTURE OF OUTER MEMBRANE PROTEASE OMPT FROM ESCHERICHIA COLI

P. Gros, M. Egmond, L. Vandeputte-Rutten, 2001 .

Releasing Nonperipheral Subunits from Protein Complexes in the Gas Phase.

A. Heck, P. Gros, R. D. de Jong, 2020, Analytical chemistry.

Molecular Basis of Assem bly and Activation of Complement Component C 1 in Complex with Immunoglobulin G 1 and Antigen Graphical

P. Parren, A. Heck, P. Gros, 2016 .

Novel proteases: common themes and surprising features.

P. Gros, L. Vandeputte-Rutten, 2002, Current opinion in structural biology.

Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding

E. Volokhina, P. Gros, L. P. Van den Heuvel, 2012, Pediatric Nephrology.

Pax‐3 regulates neurogenesis in neural crest‐derived precursor cells

P. Gros, P. Gros, P. Bartlett, 1999, Journal of neuroscience research.

In self-defense

P. Gros, 2011, Nature Structural &Molecular Biology.

HYDROGEN-EXCHANGE OF INDIVIDUAL AMIDE PROTONS IN THE ESCHERICHIA-COLI LAC REPRESSOR DNA-BINDING DOMAIN - A NUCLEAR MAGNETIC-RESONANCE STUDY

R. Kaptein, R. Boelens, P. Gros, 1985 .

Influence of donor C3 allotype on late renal-transplantation outcome.

R. Vaughan, P. Gros, N. Sheerin, 2006, The New England journal of medicine.

Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense

John D Lambris, D. Ricklin, J. Lambris, 2016, Immunological reviews.

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

P. Gros, Evelien T. M. Berends, J. A. Soppe, 2015, BMC Biology.

Structural and functional implications of the complement convertase stabilized by a staphylococcal inhibitor

John D Lambris, D. Ricklin, J. Lambris, 2009, Nature Immunology.

Crystallography & NMR system: A new software suite for macromolecular structure determination.

R J Read, A T Brünger, P D Adams, 1998, Acta crystallographica. Section D, Biological crystallography.

Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products.

P. Tucker, B. Agianian, P. Gros, 2003, Journal of molecular biology.

Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids.

H. Dijkstra, G. van Koten, P. Gros, 2009, Chemistry.

Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content.

C. Betzel, W. Hol, Z. Dauter, 1989, Journal of molecular biology.

Electronic Reprint Synchrotron Radiation Evidence for the Formation of Disulfide Radicals in Protein Crystals upon X-ray Irradiation Radiation Damage Workshop Evidence for the Formation of Disul®de Radicals in Protein Crystals upon X-ray Irradiation²

J. Sussman, I. Silman, R. Ravelli, 2022 .

Specific protein dynamics near the solvent glass transition assayed by radiation‐induced structural changes

J. Sussman, I. Silman, R. Ravelli, 2001, Protein science : a publication of the Protein Society.

The structure of leech anti-platelet protein, an inhibitor of haemostasis.

J. Sixma, P. Gros, E. Huizinga, 2001, Acta crystallographica. Section D, Biological crystallography.

Specific chemical and structural damage to proteins produced by synchrotron radiation.

J L Sussman, P Gros, I Silman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.

P. Gros, T. Logtenberg, D. Maussang, 2018, Cancer cell.

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

P. Parren, D. Ricklin, P. Gros, 2021, Proceedings of the National Academy of Sciences.

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography.

Piet Gros, Abraham J Koster, A. Koster, 2016, Cell reports.

Phosphatidylinositol transfer proteins: from closed for transport to open for exchange.

K. Wirtz, P. Gros, A. Schouten, 2006, Advances in enzyme regulation.

The structure of phosphatidylinositol transfer protein α reveals sites for phospholipid binding and membrane association with major implications for its function

K. Wirtz, P. Gros, A. Schouten, 2002, FEBS letters.

Structure of apo‐phosphatidylinositol transfer protein α provides insight into membrane association

K. Wirtz, B. Agianian, P. Gros, 2002, The EMBO journal.

Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice.

K. Vogan, P. Gros, P. Gros, 1996, Development.

Accounting for partiality in serial crystallography using ray-tracing principles

R. Ravelli, P. Gros, A. Schreurs, 2015, Acta crystallographica. Section D, Biological crystallography.

Identification of the Collagen-binding Site of the von Willebrand Factor A3-domain*

Jan Kroon, Piet Gros, J. Sixma, 2001, The Journal of Biological Chemistry.

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

W. de Lau, H. Clevers, Weng Chuan Peng, 2013, PloS one.

Structure of complement component C2A: implications for convertase formation and substrate binding.

P. Gros, E. Huizinga, R. Romijn, 2006, Structure.

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

P. Gros, M. Meisterernst, J. Brandsen, 1997, Nature Structural Biology.

Complement driven by conformational changes

Piet Gros, P. Gros, F. Milder, 2008, Nature Reviews Immunology.

StructureFunction Studies on 2-glycoprotein I

P. Gros, M. Simmelink, R. Derksen, 2000 .

Adhesion mechanism of human β2‐glycoprotein I to phospholipids based on its crystal structure

R. Ravelli, P. Gros, P. D. de Groot, 1999, The EMBO journal.

Factor B structure provides insights into activation of the central protease of the complement system

P. Gros, E. Huizinga, R. Romijn, 2007, Nature Structural &Molecular Biology.

Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome

L. Vissers, J. Veltman, H. Brunner, 2014, European Journal of Human Genetics.

Insights into complement convertase formation based on the structure of the factor B‐cobra venom factor complex

A. Koster, D. Svergun, P. Gros, 2009, The EMBO journal.

An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes-Similar Vehicle, Different Destination.

P. Gros, A. Mattevi, J. Reis, 2020, Accounts of chemical research.

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

Piet Gros, Deniz Ugurlar, P. Parren, 2018, Science.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

W. de Lau, H. Clevers, Weng Chuan Peng, 2014, Genes & development.

Conformational complexity of complement component C3.

P. Gros, B. Janssen, 2006, Advances in experimental medicine and biology.

Channel properties of the translocator domain of the autotransporter Hbp of Escherichia coli

J. Tommassen, P. Gros, J. Luirink, 2011, Molecular membrane biology.

Crystallography: Crystallographic evidence for deviating C3b structure

Randy J. Read, Piet Gros, Axel T. Brünger, 2007, Nature.

Inclusion of thermal motion in crystallographic structures by restrained molecular dynamics.

P Gros, W G Hol, W F van Gunsteren, 1990, Science.

Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design.

P. Gros, G. Vidarsson, L. van Alphen, 2005, Journal of molecular biology.

Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations.

Alexandre M J J Bonvin, Piet Gros, A. Bonvin, 2003, Journal of molecular biology.

Structural insights into the central complement component C3.

P. Gros, B. Janssen, 2007, Molecular immunology.

Structure of C8α-MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense

Piet Gros, P. Gros, Dennis X Beringer, 2007, Science.

Structure of C3b reveals conformational changes that underlie complement activity

Piet Gros, John D Lambris, Andrew McCarthy, 2006, Nature.

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

I. Jordens, P. Gros, M. Maurice, 2019, Nature Communications.

Platelet Adhesion to Collagen: an Update

J. Sixma, P. Gros, P. D. de Groot, 1997, Thrombosis and Haemostasis.

Interaction of PC4 with melted DNA inhibits transcription

P. Gros, M. Meisterernst, H. Timmers, 1998, The EMBO journal.

Structural and functional implications of the alternative complement pathway C 3 convertase stabilized by a staphylococcal inhibitor

D. Ricklin, J. Lambris, P. Gros, 2009 .

Bactericidal Antibody Recognition of Meningococcal PorA by Induced Fit

P. Gros, J. Kroon, J. van den Elsen, 1999, The Journal of Biological Chemistry.

Activation of Human Platelets by Misfolded Proteins

P. Gros, T. V. van Berkel, E. Herczenik, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9

Inge M. N. Wortel, A. Heck, P. Gros, 2020, The FEBS journal.

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition*

John D Lambris, J. Lambris, P. Gros, 2007, Journal of Biological Chemistry.

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

D. Ricklin, J. Lambris, P. Gros, 2022, Nature Communications.

‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development

J. Ioannidis, B. Nilsson, A. Mantovani, 2019, Nature Immunology.

Complement component C3: A structural perspective and potential therapeutic implications.

John D Lambris, J. Lambris, P. Gros, 2022, Seminars in immunology.

Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss

J. Gris, A. Blom, P. Gros, 2018, Front. Immunol..

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

T. Sharp, D. Ricklin, J. Lambris, 2017, Nature Structural &Molecular Biology.

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

Jin Wu, Piet Gros, Federico Forneris, 2010, Science.

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

A. Heck, J. Snijder, P. Gros, 2017, Nature Communications.

The modular serine proteases of the complement cascade.

Piet Gros, Federico Forneris, P. Gros, 2012, Current opinion in structural biology.

Structure of complement fragment C 3 b – factor H and implications for host protection by complement regulators

John D Lambris, D. Ricklin, J. Lambris, 2009 .

Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.

J. Sussman, I. Silman, P. Gros, 2001, Acta crystallographica. Section D, Biological crystallography.

Effects of eglin‐c binding to thermitase: Three‐dimensional structure comparison of native thermitase and thermitase eglin‐c complexes

W. Hol, P. Gros, A. Teplyakov, 1992, Proteins.

The complement system

P. Gros, 2017 .

Proteolysis, Complex Formation and Conformational Changes Drive the Complement Pathways

P. Gros, F. Forneris, 2013 .

Deciphering complement mechanisms: the contributions of structural biology.

Christine Gaboriaud, Piet Gros, Gérard J Arlaud, 2007, Molecular immunology.

Structural insights into the Slit-Robo complex

S. Cusack, R. Ravelli, A. McCarthy, 2007, Proceedings of the National Academy of Sciences.

Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium.

W. Hol, K. H. Kalk, P. Gros, 1992, The Journal of biological chemistry.

Time-averaging crystallographic refinement: possibilities and limitations using alpha-cyclodextrin as a test system.

C. Schiffer, W. V. van Gunsteren, P. Gros, 1995, Acta crystallographica. Section D, Biological crystallography.

On deriving spatial protein structure from NMR or X-ray diffraction data.

H. Berendsen, W. V. van Gunsteren, P. Gros, 1991, Ciba Foundation symposium.

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

A. Heck, J. Snijder, P. Gros, 2017, Nature Communications.

Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa.

Piet Gros, J. Tommassen, A. Bonvin, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

A. Koster, A. Boyle, T. Sharp, 2019, Proceedings of the National Academy of Sciences.

A method for intuitively extracting macromolecular dynamics from structural disorder

P. Gros, N. Pearce, 2021, Nature Communications.

Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site

P. Gros, M. Egmond, L. Vandeputte-Rutten, 2001, FEBS letters.

Structure of C3b-factor H and implications for host protection by complement regulators

John D Lambris, D. Ricklin, J. Lambris, 2009, Nature Immunology.

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3.

S. Cusack, A. McCarthy, P. Gros, 2007, Acta crystallographica. Section D, Biological crystallography.

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

F. Förster, P. Gros, A. Mattevi, 2018, Nature Communications.

Crystal structure of SecB from Escherichia coli.

C. Dekker, P. Gros, B. de Kruijff, 2003, Journal of structural biology.

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

R. Rappuoli, P. Gros, D. Serruto, 2010, Nature Reviews Microbiology.

Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: Crystal structure of a Fab fragment in complex with a fluorescein‐conjugated peptide

P. Gros, T. Logtenberg, D. Crommelin, 1997, Proteins.

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

M. Goldflam, I. Jordens, P. Gros, 2019, Nature Communications.

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation.

A. Koster, T. Sharp, P. Gros, 2017, Journal of structural biology.

Abstract 33: The binding mode of the bispecific anti-HER2xHER3 antibody MCLA-128 is responsible for its potent inhibition of HRG-driven tumorigenesis

P. Gros, T. Logtenberg, M. Throsby, 2017 .

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

P. Gros, E. Dolk, D. A. Heesterbeek, 2023, bioRxiv.

Experiments in membrane protein crystallization

W. Hol, J. Drenth, P. Gros, 1988 .

Crystallographic Refinement and Structure-Factor Time-Averaging by Molecular Dynamics in the Absence of a Physical Force Field

W. F. Gunsteren, P. Gros, 1993 .

Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis

P. Gros, Dounia El Mazouni, 2022, Science advances.

Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium

Alexandre M J J Bonvin, Piet Gros, J. Tommassen, 2009, Proceedings of the National Academy of Sciences.

Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion.

M. Pangburn, P. Gros, B. Janssen, 2009, Developmental and comparative immunology.

Improving sampling of crystallographic disorder in ensemble refinement

P. Gros, N. Pearce, N. Ploscariu, 2021, Acta crystallographica. Section D, Structural biology.

Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.

J. Sussman, I. Silman, R. Ravelli, 2002, Journal of Synchrotron Radiation.

Crystal Structure of Neisserial Surface Protein A (NspA), a Conserved Outer Membrane Protein with Vaccine Potential*

Piet Gros, J. Tommassen, P. Gros, 2003, Journal of Biological Chemistry.

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1).

S. Cusack, A. McCarthy, P. Gros, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Modularity and conformational changes as key features of the complement system

Piet Gros, Federico Forneris, Michael A. Hadders, 2012 .