Zhong Chen

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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Benjamin J. Raphael, Joshua M. Stuart, Adam A. Margolin, 2014, Cell.

TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB c-REL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer

Joshua M. Stuart, P. Meltzer, W. Xiao, 2016, Oncogene.

A signal network involving coactivated NF‐κB and STAT3 and altered p53 modulates BAX/BCL‐XL expression and promotes cell survival of head and neck squamous cell carcinomas

Jay Friedman, C. Van Waes, Zhong Chen, 2008, International journal of cancer.

The structural network of Interleukin-10 and its implications in inflammation and cancer

Ozlem Keskin, Ruth Nussinov, Attila Gursoy, 2014, BMC Genomics.

Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle.

Zhong Chen, Liya Su, Guihua Xu, 2009, Oncology reports.

Resource Genomic , Pathway Networ k , and Immunologic Features Distinguishing Squamous Carcinomas Graphical

Joshua M. Stuart, Joshua D. Campbell, Christopher K. Wong, 2018 .

Integrated genomic and molecular characterization of cervical cancer

Steven J. M. Jones, Christopher A. Miller, Richard A. Moore, 2017, Nature.

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Steven J. M. Jones, Joshua M. Stuart, Thomas M. Harris, 2015, Nature.

Resource Reveals Molecular Classification Multiplatform Analysis of 12 Cancer Types within and across Tissues of Origin

Benjamin J. Raphael, Joshua M. Stuart, Adam A. Margolin, 2022 .

Emergence of protein kinase CK2 as a key target in cancer therapy

C. Van Waes, Zhong Chen, G. Unger, 2010, BioFactors.

CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides In vitro or In vivo via Sub–50-nm Nanocapsules

C. Van Waes, Zhong Chen, Hai Lu, 2010, Clinical Cancer Research.

Assessment of Gene Expression in Head and Neck Carcinoma Using Laser Capture Microdissection and Real‐Time Reverse Transcription Polymerase Chain Reaction

R. Bonner, C. Van Waes, Zhong Chen, 2004, The Laryngoscope.

Title Systems biology-defined NF-κ B regulons , interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p 53 status

Shane T. Jensen, C. Stoeckert, K. Saigal, 2015 .

Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma.

James B. Mitchell, E. Sausville, K. Camphausen, 2005, International journal of radiation oncology, biology, physics.

IL (Interleukin)-1α Promotes Nuclear Factor-κB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas

G. Dong, C. Waes, Zhong Chen, 2001 .

Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL‐1α, EGF and TGF‐β1 through NF‐κB dependent and independent mechanisms

C. Van Waes, G. Dong, Zhong Chen, 2001 .

Variation in cisplatinum sensitivity is not associated with Fanconi Anemia/BRCA pathway inactivation in head and neck squamous cell carcinoma cell lines.

C. Waes, Zhong Chen, J. Ricker, 2007, Cancer letters.

Early Tumor Progression Associated with Enhanced EGFR Signaling with Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer

N. Simone, Minyoung Jang, Seungwon Kim, 2011, Clinical Cancer Research.

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF‐κB and AP‐1 activation and IL‐8 and VEGF expression in human head and neck squamous cell carcinoma lines

C. Van Waes, Zhong Chen, J. Yeh, 2002, International journal of cancer.

Current status of clinical testing for human papillomavirus in oropharyngeal squamous cell carcinoma

Kelly Y. Kim, Zhong Chen, J. Lewis, 2018, The journal of pathology. Clinical research.

Head and Neck Cancers Promote an Inflammatory Transcriptome through Coactivation of Classic and Alternative NF-κB Pathways

R. Nussinov, O. Keskin, A. Gursoy, 2019, Cancer Immunology Research.

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers.

Scott E. Martin, Ramya Viswanathan, C. Van Waes, 2022, Molecular cancer research : MCR.

Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers

W. Xiao, R. Ferris, C. Van Waes, 2018, Cell reports.

YAP Dysregulation by Phosphorylation or ΔNp63-mediated Gene Repression Promotes Proliferation, Survival and Migration in Head and Neck Cancer Subsets

M. Brown, S. Feller, C. Van Waes, 2010, Oncogene.

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

James B. Mitchell, C. Van Waes, Zhong Chen, 2016, Cancer research.

Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

C. Van Waes, Zhong Chen, B. Yan, 2007, Clinical Cancer Research.

DeficientTP 53 Expression , Function , and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

C. Waes, Zhong Chen, J. Friedman, 2007 .

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

C. Van Waes, Zhong Chen, Xinping Yang, 2019, Clinical Cancer Research.

Combination therapy of anti-cancer bioactive peptide with Cisplatin decreases chemotherapy dosing and toxicity to improve the quality of life in xenograft nude mice bearing human gastric cancer

Zhong Chen, Liya Su, X. Su, 2014, Cell & Bioscience.

Dynamic Effect of Bortezomib on Nuclear Factor- (cid:1) B Activity and Gene Expression in Tumor Cells □ S

M. Sung, G. Hager, C. Waes, 2008 .

Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer research.

Erratum: Nuclear factor-κB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma (Cancer Research (September 2004) 64 (6511-6523)

James B. Mitchell, C. Waes, Zhong Chen, 2004 .

Expression of a Dominant-Negative Mutant Inhibitor-κBα of Nuclear Factor-κB in Human Head and Neck Squamous Cell Carcinoma Inhibits Survival, Proinflammatory Cytokine Expression, and Tumor Growth in Vivo

G. Dong, C. Waes, Zhong Chen, 1999 .

Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus

C. Van Waes, Zhong Chen, Jialing Zhang, 2017, Cancer.

Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism

G. Dong, C. Waes, Zhong Chen, 2000, Oncogene.

Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib.

J. Xie, B. Wood, King Li, 2008, Radiology.

The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth.

C. Van Waes, Zhong Chen, Hai Lu, 2008, Cancer research.

The p53 Homologue # Np63 A Interacts with the Nuclear Factor- K B Pathway to Modulate Epithelial Cell Growth

C. Waes, Zhong Chen, Hai Lu, 2008 .

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV (cid:1) and HPV þ Head and Neck Cancers to TNF a , TRAIL, and Radiation Therapy

C. Waes, Zhong Chen, X. Yang, 2019 .

The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC

C. Van Waes, G. Dong, Zhong Chen, 1998, Clinical & Experimental Metastasis.

Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma

C. Van Waes, G. Dong, Zhong Chen, 1997, Journal of cellular biochemistry. Supplement.

Cytokines IL-1α, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon γ

C. Waes, Zhong Chen, J. Wen, 2003, Cancer Immunology, Immunotherapy.

IL‐12‐ and IL‐2‐induced tumor regression in a new murine model of oral squamous‐cell carcinoma is promoted by expression of the CD80 co‐stimulatory molecule and interferon‐γ

C. Van Waes, Zhong Chen, I. Enamorado, 2000, International journal of cancer.

Hepatocyte Growth Factor / Scatter Factor-induced Activation of MEK and PI 3 K Signal Pathways Contributes to Expression of Proangiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor in Head and Neck Squamous Cell Carcinoma 1

G. Dong, C. Waes, Zhong Chen, 2001 .

Metastastic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction

C. Van Waes, Zhong Chen, Conrad W. Smith, 1997, Clinical & Experimental Metastasis.

IL (Interleukin)-1a Promotes Nuclear Factor-kB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas

G. Dong, C. Waes, Zhong Chen, 2001 .

Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer Research.

HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2013, Translational oncology.

Proinflammatory Signaling Pathways and Genomic Signatures in Head and Neck Cancers

Ramya Viswanathan, C. Waes, Zhong Chen, 2021 .

Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches

C. Van Waes, Zhong Chen, C. Allen, 2015, Cancers.

Epidermal overexpression of transgenic ΔNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF‐κB activation

C. Van Waes, S. Sinha, A. Mattox, 2014, The Journal of pathology.

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

Tumor and Stem Cell Biology D Np 63 Versatilely Regulates a Broad NFk B Gene Program and Promotes Squamous Epithelial Proliferation , Migration , and Inflammation

S. Sinha, C. Waes, Zhong Chen, 2011 .

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

C. Van Waes, Zhong Chen, Hai Lu, 2014, Neoplasia.

TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

C. Van Waes, Zhong Chen, Anthony D. Saleh, 2018, Oncoimmunology.

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ.

C. Van Waes, Zhong Chen, J. Friedman, 2017, Cancer research.

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

C. Van Waes, Zhong Chen, A. Derakhshan, 2016, Clinical Cancer Research.

Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma

C. Van Waes, Zhong Chen, Chengyu Liu, 2015, Scientific Reports.

Lipopolysaccharide-Mediated Chronic Inflammation Promotes Tobacco Carcinogen–Induced Lung Cancer and Determines the Efficacy of Immunotherapy

Zhong Chen, Xiaoping Liu, Kong Chen, 2020, Cancer Research.

Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous‐cell carcinoma

C. Van Waes, Zhong Chen, Z. Chen, 1999, International journal of cancer.

Current and potential inflammation targeted therapies in head and neck cancer.

Jay Friedman, Frederick Wang, C. Van Waes, 2009, Current opinion in pharmacology.

Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

C. Van Waes, Zhong Chen, C. Allen, 2007, Head & neck.

A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma

C. Van Waes, Zhong Chen, N. Yeh, 2005, Head & neck.

Lymphotoxin‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer

C. Van Waes, Zhong Chen, Anthony D. Saleh, 2018, Molecular carcinogenesis.

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

C. Van Waes, Zhong Chen, X. Yang, 2007, Genome Biology.

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-κB Subunits in Head and Neck Cancer

C. Van Waes, K. Saigal, Zhong Chen, 2008, Clinical Cancer Research.

Nuclear factor-κB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101

C. Van Waes, Zhong Chen, J. Friedman, 2007, Molecular Cancer Therapeutics.

Atlas of Genetics and Cytogenetics in Oncology and Haematology TP 63 ( tumor protein p 63 )

A. Mattox, C. Waes, Zhong Chen, 2022 .

Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

Christian J Stoeckert, Shane T. Jensen, Shane T Jensen, 2008, Genome Biology.

Title Integrated transcriptional profiling and genomic analyses revealRPN 2 and HMGB 1 as promising biomarkers in colorectal cancer

H. Qun, C. Waes, Zhong Chen, 2015 .

EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy

C. Van Waes, Zhong Chen, J. Friedman, 2011, Expert opinion on therapeutic targets.

Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancer.

Hai Lu, Oumou Diallo, Jonah Cohen, 2009, Cancer research.

Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor

G. Dong, C. Waes, Zhong Chen, 2004, Oncogene.

Nuclear Factor-κB–Related Serum Factors as Longitudinal Biomarkers of Response and Survival in Advanced Oropharyngeal Carcinoma

P. Albert, C. Van Waes, Zhong Chen, 2007, Clinical Cancer Research.

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

Christian Freudlsperger, C. Van Waes, Zhong Chen, 2012, Oncogene.

Aberrant Activation of HGF/c-MET Signaling and Targeted Therapy in Squamous Cancer

Zhong Chen, 2011 .

Nuclear Transcription Factors and Signaling Pathways in Oral Cancer Metastasis

C. Waes, Zhong Chen, R. Ehsanian, 2009 .

Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-κB and activator protein-1 related mechanisms

C. Van Waes, Zhong Chen, Tin-Lap Lee, 2008, Molecular Cancer Therapeutics.

Title Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p 53 , nuclear factor-κ B and other signal transcription factors in head and neck squamous cell carcinoma

C. Waes, Zhong Chen, X. Yang, 2015 .

A Novel Nuclear Factor-κB Gene Signature Is Differentially Expressed in Head and Neck Squamous Cell Carcinomas in Association with TP53 Status

A. Elkahloun, C. Van Waes, G. Dong, 2007, Clinical Cancer Research.

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

C. Van Waes, Zhong Chen, C. Allen, 2018, Oncoimmunology.

Constitutive activation of transcription factors NF‐κB, AP‐1, and NF‐IL6 in human head and neck squamous cell carcinoma cell lines that express pro‐inflammatory and pro‐angiogenic cytokines

C. Van Waes, G. Dong, Zhong Chen, 1999, Molecular carcinogenesis.

Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer.

Anurag K. Singh, J. Dancey, D. Citrin, 2010, International journal of radiation oncology, biology, physics.

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC

C. Van Waes, Zhong Chen, D. Eytan, 2015, The Laryngoscope.

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

L. Dang, C. Van Waes, Zhong Chen, 2013, Oncogene.

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

C. Van Waes, Zhong Chen, Tin-Lap Lee, 2006, Molecular Cancer Therapeutics.

Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.

C. Van Waes, Zhong Chen, R. Vander Broek, 2014, Oral oncology.

Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

C. Van Waes, Zhong Chen, Matthew S. Brown, 2009, Clinical Cancer Research.

Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine.

C. Van Waes, Zhong Chen, X. Jiao, 2006, Immunology letters.

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

C. Van Waes, Zhong Chen, J. Friedman, 2017, Oncotarget.

Regulation of NFκB Signalling by Ubiquitination: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma?

C. Van Waes, Zhong Chen, Ethan L. Morgan, 2020, Cancers.

Tumor and Stem Cell Biology TNF-a Promotes c-REL / D Np 63 a Interaction and TAp 73 Dissociation from Key Genes That Mediate Growth Arrest and Apoptosis in Head and Neck Cancer

S. Sinha, C. Waes, Zhong Chen, 2011 .

Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer

H. Qun, C. Van Waes, Zhong Chen, 2015, Cell & Bioscience.

NF-κB in carcinoma therapy and prevention

M. Brown, C. Waes, Zhong Chen, 2008 .

The Role of the NF-kappaB Transcriptome and Proteome as Biomarkers in Human Head and Neck Squamous Cell Carcinomas.

C. Van Waes, Zhong Chen, B. Yan, 2008, Biomarkers in medicine.

Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF‐κB

James B. Mitchell, C. Van Waes, G. Dong, 2000, Head & neck.

Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer

Steven J. M. Jones, Thomas M. Harris, Ludmila V. Danilova, 2019, Clinical Cancer Research.

2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

C. Van Waes, Zhong Chen, J. Ricker, 2004, Clinical Cancer Research.

Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancer.

F. Guadagni, J. Schlom, C. Van Waes, 2002, Cancer research.

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

C. Van Waes, Zhong Chen, D. Eytan, 2015, Clinical Cancer Research.

Signaling Networks of Activated Oncogenic and Altered Tumor Suppressor Genes in Head and Neck Cancer

C. Van Waes, Zhong Chen, B. Yan, 2013, Journal of carcinogenesis & mutagenesis.

Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL‐6: a general role for inflammation?

Z Chen, J. Mulshine, C. Van Waes, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer

Xiaojiang Xu, Jay Friedman, C. Van Waes, 2009, Clinical Cancer Research.

Abstract 4193: TNF-α dynamically modulates genome-wide cross-regulation of cRel, ΔNp63 and TAp73 promoter binding and gene expression in head and neck cancer: TP53 and NFκB ChIP-Seq in HNSCC

P. Meltzer, W. Xiao, S. Davis, 2012 .

NF-kappaB in carcinoma therapy and prevention.

M. Brown, C. Van Waes, Zhong Chen, 2008, Expert opinion on therapeutic targets.

The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers

Z. Chen, C. Van Waes, Zhong Chen, 2021, Cancer Research.

cDNA microarray and bioinformatic analysis of nuclear factor-kappaB related genes in squamous cell carcinoma.

C. Van Waes, G. Dong, Zhong Chen, 2007, Methods in molecular biology.

Unraveling Regulatory Programs for NF-kappaB, p53 and MicroRNAs in Head and Neck Squamous Cell Carcinoma

Ming Zhan, Huai Li, Sige Zou, 2013, PloS one.

Cytokines IL-1 alpha, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon gamma.

C. Van Waes, Zhong Chen, J. Wen, 2004, Cancer immunology, immunotherapy : CII.

Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma.

C. Van Waes, Zhong Chen, X. Yang, 2005, Cancer research.

Egr-1 in Head and Neck Squamous Cell Carcinoma Regulates Expression of Proangiogenic Factors through Hepatocyte Growth Factor / Scatter Factor Differentially

C. Waes, Zhong Chen, X. Yang, 2005 .

MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer

Zhong Chen, Y. Bian, J. Friedman, 2015, International journal of biological sciences.

Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC)

James B. Mitchell, C. Van Waes, Zhong Chen, 2023, Cell Death & Differentiation.

Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.

C. Van Waes, Zhong Chen, N. Issaeva, 2018, Cancer research.

Dynamic Effect of Bortezomib on Nuclear Factor-κB Activity and Gene Expression in Tumor Cells

J. McNally, C. Van Waes, M. Sung, 2008, Molecular Pharmacology.

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133+ Skin Cancer Stem Cells

P. Meltzer, C. Van Waes, Zhong Chen, 2018, Molecular Cancer Therapeutics.

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.

C. Smith, C. Van Waes, C. Waes, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

C. Van Waes, C. Waes, Zhong Chen, 2007 .

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

Z Chen, E. Sausville, P. Elliott, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Oncogenic Ras and ΔNp63α cooperate to recruit immunosuppressive polymorphonuclear myeloid-derived suppressor cells in a mouse model of squamous cancer pathogenesis

C. Van Waes, Zhong Chen, A. George, 2023, Frontiers in Immunology.

Characterization of HPV and host genome interactions in primary head and neck cancers

Chandra Sekhar Pedamallu, Angeliki Pantazi, Joshua M. Stuart, 2014, Proceedings of the National Academy of Sciences.

Abstract 2988: Proteasomal deubiquitinases represent an attractive therapeutic target in head and neck squamous cell carcinomas (HNSCC)

Ramya Viswanathan, C. Van Waes, Zhong Chen, 2022, Cancer Research.

The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

C. Van Waes, C. Waes, Zhong Chen, 2015, Oral diseases.

A human vascular endothelial cell model to study angiogenesis and tumorigenesis.

J. Lautenberger, J. Rhim, C. Van Waes, 1998, Carcinogenesis.

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma.

C. Van Waes, G. Dong, C. Waes, 2001, Cancer research.

Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.

C. Van Waes, G. Dong, C. Waes, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death

C. Van Waes, G. Dong, C. Waes, 2000, British Journal of Cancer.

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Joshua M. Stuart, Joshua D. Campbell, Christopher K. Wong, 2018, Cell reports.

Integrative modeling of transcriptional regulatory networks in head and neck cancer

Zhong Chen, B. Yan, Huai Li, 2012 .

BASIC SCIENCE REVIEW

R. Ferris, C. Waes, Zhong Chen, 2007 .

G. Dong, C. Waes, Zhong Chen, 1999 .

The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.

C. Van Waes, G. Dong, C. Waes, 1999, Cancer research.

Construction of an immune-related lncRNA signature pair for predicting oncologic outcomes and the sensitivity of drugs to treat adverse reactions to immunotherapy in lung adenocarcinoma

Zhong Chen, Zhijian Hu, Zhongwu Chen, 2021 .

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

Abstract 6042: TNFa co-activates IKK/NF-kB/RELA prosurvival and WEE1-CDC2 G2/M checkpoint signaling and is targetable by WEE1 antagonist AZD1775 in head and neck cancer

Ramya Viswanathan, C. Waes, Zhong Chen, 2020 .

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

C. Van Waes, Zhong Chen, X. Yang, 2021, Scientific Reports.

Abstract 3400: Integrated functional RNAi screening and structural genomics identifies inverse co-modulators of TP53 family and NF-kB transitional activation as potential therapeutic targets in head and neck squamous cell carcinoma

Zhong Chen, Anthony D. Saleh, Xinping Yang, 2014 .