A. Hershko

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Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

A. Ciechanover, A. Hershko, H. Heller, 1983, The Journal of biological chemistry.

The ubiquitin system.

A. Ciechanover, A. Hershko, 1998, Annual review of biochemistry.

The ubiquitin system.

Alexander Varshavsky, Aaron Ciechanover, Avram Hershko, 1998, Annual review of biochemistry.

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Michele Pagano, Daniele Guardavaccaro, Avram Hershko, 2003, Nature.

The Cyclin-Ubiquitin Ligase Activity of Cyclosome/APC Is Jointly Activated by Protein Kinases Cdk1-Cyclin B and Plk*

Avram Hershko, A. Hershko, Amnon Golan, 2002, The Journal of Biological Chemistry.

The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

Brett Larsen, Mike Tyers, Michele Pagano, 2001, Nature Cell Biology.

Inhibitors of the Ubiquitin-Proteasome System as Potential Therapeutic Agents for Cardiovascular Diseases

A. Ciechanover, A. Hershko, 2008 .

MODE OF DEGRADATION OF ABNORMAL GLOBIN CHAINS IN RABBIT RETICULOCYTES

A. Hershko, H. Heller, D. Ganoth, 1978 .

Basic Medical Research Award. The ubiquitin system.

A. Ciechanover, A. Varshavsky, A. Hershko, 2000, Nature medicine.

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.

A Ciechanover, A. Ciechanover, A. Hershko, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

A. Hershko, D. Ganoth, Gil Bornstein, 2006, Proceedings of the National Academy of Sciences of the United States of America.

"Covalent affinity" purification of ubiquitin-activating enzyme.

A. Ciechanover, A. Hershko, H. Heller, 1982, The Journal of biological chemistry.

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.

A. Ciechanover, A. Hershko, Avram HershkoS, 1982, The Journal of biological chemistry.

The ubiquitin pathway for the degradation of intracellular proteins.

A. Ciechanover, A. Hershko, 1986, Progress in nucleic acid research and molecular biology.

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway.

A. Ciechanover, S. Arfin, A. Hershko, 1988, The Journal of biological chemistry.

Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli.

A. Hershko, Y. Shechter, D. Rafaeli-Eshkol, 1973, Biochemical and biophysical research communications.

ATP-dependent degradation of ubiquitin-protein conjugates.

A. Hershko, H. Heller, D. Ganoth, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells.

A. Hershko, D. Epstein, S. Elias-Bishko, 1975, Biochemistry.

A high molecular weight protease in liver cytosol.

A. Hershko, I. A. Rose, J. V. Warms, 1979, The Journal of biological chemistry.

Protein turnover in senescent cultured chick embryo fibroblasts

A. Hershko, M. Fry, A. Kaftory, 1978, Journal of cellular physiology.

Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes.

A. Ciechanover, A. Hershko, H. Heller, 1980, The Journal of biological chemistry.

Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown.

A. Ciechanover, A. Hershko, I. A. Rose, 1981, The Journal of biological chemistry.

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet

A. Hershko, T. Yen, Kexi Wang, 2014, Proceedings of the National Academy of Sciences.

Mechanisms and regulation of ubiquitin-mediated cyclin degradation.

A. Hershko, 1996, Advances in experimental medicine and biology.

Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes

A. Hershko, S. Kaisari, Shirly Miniowitz-Shemtov, 2015, Proceedings of the National Academy of Sciences.

Hierarchical order of phosphorylation events commits Cdc25A to Beta-TrCP-dependent degradation

A. Hershko, M. Donzelli, Massimo Chiesa, 2004, Cell cycle.

The ubiquitin system for protein degradation.

A. Ciechanover, A. Hershko, 1992, Annual review of biochemistry.

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

A. Hershko, D. Ganoth, R. Palazzo, 1991, The Journal of biological chemistry.

"Pleiotypic response".

R. Shields, A. Hershko, G. Tomkins, 1971, Nature: New biology.

What history tells us XLI. Ubiquitin and proteolysis

A. Hershko, 2016 .

Preparation of clam oocyte extracts for cell cycle studies.

A. Hershko, J. Ruderman, V. Sudakin, 1997, Methods in enzymology.

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

A. Hershko, 1996 .

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.

A. Hershko, H. Heller, I. A. Rose, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

A. Hershko, I. Braunstein, E. Eytan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Roles of protein synthesis and tRNA aminoacylation in the regulation of intracellular protein breakdown in E. coli.

A. Hershko, D. Rafaeli-Eshkol, D. Epstein, 1974, Biochemical and biophysical research communications.

Influence of ATP depletion on the degradation of rapidly labeled RNA in cultured hepatoma cells.

A. Hershko, M. Aviram, 1975, Biochemical and biophysical research communications.

Past, Present, and Future Perspectives

Avram Hershko, A. Hershko, 1998 .

Studies on amino acid control of cellular function

A. Hershko, V. Morhenn, G. Tomkins, 1974 .

The pleiotypic response in mammalian cells: search for an intracellular mediator.

A. Hershko, J. Lust, G. Tomkins, 1972, Biochemical and biophysical research communications.

Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence.

A. Hershko, G. Tomkins, 1971, The Journal of biological chemistry.

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.

A. Hershko, F. Townsley, J. Ruderman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Post-translational cleavage of polypeptide chains: role in assembly.

A. Hershko, M. Fry, 1975, Annual review of biochemistry.

Ubiquitin-mediated protein degradation.

A. Hershko, 1988, The Journal of biological chemistry.

Mechanisms of intracellular protein breakdown.

A. Ciechanover, A. Hershko, 1982, Annual review of biochemistry.

Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells.

A. Hershko, Y. Hod, 1976, The Journal of biological chemistry.

Interconversion of multiple forms of tyrosine aminotransferase in vitro and in vivo in cultured hepatoma cells.

A. Hershko, M. Aviram, 1977, Biochimica et biophysica acta.

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

R. Annan, A. Hershko, T. Yen, 2008, The Journal of cell biology.

Roles of ubiquitin-mediated proteolysis in cell cycle control.

A. Hershko, 1997, Current opinion in cell biology.

Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation*

Michele Pagano, Laura S Itzhaki, Avram Hershko, 2002, The Journal of Biological Chemistry.

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

A Ciechanover, A. Ciechanover, A. Hershko, 1980, Proceedings of the National Academy of Sciences of the United States of America.

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

A Ciechanover, A. Ciechanover, A. Hershko, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts.

A. Ciechanover, A. Hershko, Aaron Ciechanover, 1976, Biochemical and biophysical research communications.

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle*

A. Hershko, A Hershko, 2005, Cell Death and Differentiation.

Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase*

M. Pagano, K. Nakayama, A. Hershko, 2003, Journal of Biological Chemistry.

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

M. Pagano, A. Hershko, J. Boulaire, 2004, Proceedings of the National Academy of Sciences of the United States of America.

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Michele Pagano, Avram Hershko, Andrea C. Carrano, 1999, Nature Cell Biology.

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

Andrea C. Carrano, M. Pagano, A. Montagnoli, 1999, Genes & development.

Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

Michele Pagano, Avram Hershko, Andrea C. Carrano, 2001, Cancer.

Ubiquitin: Roles in protein modification and breakdown

Avram Hershko, A. Hershko, 1983, Cell.

SKP 2 is required for ubiquitin-mediated degradation of the CDK inhibitor p 27

Andrea C. Carrano, M. Pagano, A. Hershko, 1999 .

Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes

A. Hershko, S. Kaisari, Shirly Miniowitz-Shemtov, 2017, Proceedings of the National Academy of Sciences.

Dual mode of degradation of Cdc25 A phosphatase

M. Pagano, A. Hershko, M. Donzelli, 2002, The EMBO journal.

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

Michele Pagano, Daniele Guardavaccaro, Avram Hershko, 2003, Nature.

E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.

A. Admon, A. Hershko, J. Ruderman, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates.

A. Hershko, H. Heller, 1985, Biochemical and biophysical research communications.

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

A. Hershko, H. Heller, D. Ganoth, 1995, Molecular biology of the cell.

Lessons from the discovery ofthe ubiquitin system

A. Hershko, 1996 .

Lessons from the discovery of the ubiquitin system.

A. Hershko, 1996, Trends in biochemical sciences.

From Rabbit Reticulocytes to Clam Oocytes: In Search of the System That Targets Mitotic Cyclins for Degradation

A. Hershko, 2010, Molecular biology of the cell.

Mechanisms and regulation of the degradation of cyclin B.

A. Hershko, 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Binding of Activated Cyclosome to p13 suc1

A. Hershko, D. Ganoth, V. Sudakin, 1997, The Journal of Biological Chemistry.

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes.

A. Hershko, Y. Hod, A. Ciehanover, 1978, Biochemical and biophysical research communications.

Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint.

A. Hershko, M. Brandeis, Y. Yudkovsky, 2000, Biochemical and biophysical research communications.

The ubiquitin pathway for protein degradation.

A. Hershko, 1991, Trends in biochemical sciences.

Selectivity of Ubiquitin-Mediated Protein Breakdown

A. Hershko, 1988 .

Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

Y. Protopopov, A. Hershko, M. Brandeis, 1999, Biochemical and biophysical research communications.

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

A. Hershko, J. Ruderman, V. Sudakin, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Ubiquitin-mediated protein degradation: The early days The ubiquitin system

A. Ciechanover, A. Varshavsky, A. Hershko, 2000 .

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

A. Hershko, D. Ganoth, J. Ruderman, 1994, The Journal of biological chemistry.

Regulation of the Action of Early Mitotic Inhibitor 1 on the Anaphase-promoting Complex/Cyclosome by Cyclin-dependent Kinases*

Avram Hershko, A. Hershko, D. Ganoth, 2011, The Journal of Biological Chemistry.

Early work on the ubiquitin proteasome system, an interview with Avram Hershko

A. Hershko, 2005, Cell Death and Differentiation.

Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B.

A. Hershko, M. Shteinberg, 1999, Biochemical and biophysical research communications.

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

A. Hershko, A. Haas, I. A. Rose, 1982, The Journal of biological chemistry.

Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system.

A Ciechanover, A. Ciechanover, A. Hershko, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint

A. Hershko, I. Braunstein, Yakir Moshe, 2007, Proceedings of the National Academy of Sciences.

Some Lessons from My Work on the Biochemistry of the Ubiquitin System

A. Hershko, 2009, Journal of Biological Chemistry.

The Ubiquitin System for Protein Degradation and Some of Its Roles in the Control of the Cell‐Division Cycle Nobel Lecture

Avram Hershko, A. Hershko, 2006 .

The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).

Avram Hershko, A. Hershko, 2005, Angewandte Chemie.

Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1.

A. Hershko, 2005, Methods in enzymology.

The Ubiquitin System and Some of Its Roles in Cell Cycle Control

A. Hershko, 2002 .

A ubiquitin-protein ligase specific for type III protein substrates.

A. Hershko, H. Heller, 1990, The Journal of biological chemistry.

Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme.

A. Hershko, Y. Reiss, 1990, The Journal of biological chemistry.

Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein.

A. Hershko, H. Heller, Y. Reiss, 1989, The Journal of biological chemistry.

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

A. Hershko, Y. Reiss, D. Kaim, 1988, The Journal of biological chemistry.

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

A. Hershko, I. A. Rose, Irwin A. ROSEt, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The protein substrate binding site of the ubiquitin-protein ligase system.

A. Hershko, H. Heller, Y. Reiss, 1986, The Journal of biological chemistry.

Regulation of APC/CCdh1 ubiquitin ligase in differentiation of human embryonic stem cells

K. Skorecki, A. Hershko, D. Hershko, 2010 .

Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.

K. Skorecki, A. Hershko, D. Hershko, 2010, Cell cycle.

p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

Avram Hershko, A. Hershko, Elena Dumin, 2011, Proceedings of the National Academy of Sciences.

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

A. Hershko, I. Braunstein, D. Ganoth, 2008, Proceedings of the National Academy of Sciences.

The mouse and human genes encoding the recognition component of the N-end rule pathway.

N. Copeland, N. Jenkins, A. Varshavsky, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis

A. Hershko, S. Kaisari, Shirly Miniowitz-Shemtov, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Role of phosphorylation of Cdc20 in p31comet-stimulated disassembly of the mitotic checkpoint complex

Avram Hershko, A. Hershko, D. Ganoth, 2012, Proceedings of the National Academy of Sciences.

ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint

A. Hershko, Shirly Miniowitz-Shemtov, Danielle Sitry-Shevah, 2010, Proceedings of the National Academy of Sciences.

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

A. Hershko, D. Ganoth, E. Leshinsky, 1988, The Journal of biological chemistry.

A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.

A. Hershko, I. A. Rose, Avram HershkoS, 1992, The Journal of biological chemistry.

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

A. Hershko, D. Ganoth, E. Eytan, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Role of Polo-like kinase 1 in the regulation of the action of p31comet in the disassembly of mitotic checkpoint complexes

T. Ziv, A. Hershko, S. Kaisari, 2019, Proceedings of the National Academy of Sciences.

Regulation of intracellular protein breakdown in stringent and relaxed strains of E. coli,.

A. Hershko, D. Rafaeli-Eshkol, 1974, Cell.

Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes

A. Hershko, G. Kozlov, K. Gehring, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

A. Hershko, S. Kaisari, Shirly Miniowitz-Shemtov, 2018, Proceedings of the National Academy of Sciences.

Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly

A. Hershko, E. Eytan, Danielle Sitry-Shevah, 2013, Proceedings of the National Academy of Sciences.

Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex

A. Hershko, S. Kaisari, Shirly Miniowitz-Shemtov, 2016, Proceedings of the National Academy of Sciences.

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

A. Hershko, D. Ganoth, T. Armon, 1990, The Journal of biological chemistry.

Ubiquitin-mediated proteolysis The Nobel Prize in Chemistry for 2004 is shared between three scientists who have made fundamental discoveries concerning how cells regulate the breakdown of intracellular proteins with extreme specificity as to target, time and space

A. Ciechanover, A. Hershko, 2004 .

Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex.

A. Hershko, H. Heller, Avram HershkoS, 1993, The Journal of biological chemistry.

The ubiquitin system

A. Ciechanover, A. Varshavsky, A. Hershko, 2000, Nature Medicine.

Ubiquitin Family Modifiers and the Proteasome

A. Ciechanover, M. Scheffner, A. Hershko, 2012, Methods in Molecular Biology.

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978.

A. Ciechanover, A. Hershko, Y. Hod, 2012, Biochemical and Biophysical Research Communications - BBRC.

Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

Avram Hershko, A. Hershko, I. Braunstein, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Relevance of protease "inhibitor" to the ATP-ubiquitin proteolytic system.

A. Hershko, E. Eytan, 1984, Biochemical and biophysical research communications.

Ubiquitin: Roles in protein modification and breakdown

A. Hershko, 1983, Cell.

Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia

A. Ciechanover, J. H. Schwartz, A. Goldberg, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.