Y. Le

发表

Transcriptional code and disease map for adult retinal cell types

Michael B. Stadler, B. Roska, S. Siegert, 2012, Nature Neuroscience.

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

Michael H. Elliott, Y. Le, Xuelian Xu, 2010, Diabetes.

Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice*

K. Palczewski, M. Griswold, Y. Le, 2015, The Journal of Biological Chemistry.

Significance of outer blood-retina barrier breakdown in diabetes and ischemia.

Y. Le, Hui-Zhuo Xu, 2011, Investigative ophthalmology & visual science.

Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.

Y. Le, A. Lewin, Haoyu Mao, 2016, Advances in experimental medicine and biology.

7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.

Y. Le, Qilong Wang, Huaiping Zhu, 2013, The American journal of pathology.

Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes

T. McLaughlin, Y. Le, Yaqin Wang, 2019, Diabetologia.

Critical Role of Trophic Factors in Protecting Müller Glia: Implications to Neuroprotection in Age-Related Macular Degeneration, Diabetic Retinopathy, and Anti-VEGF Therapies.

Y. Le, Meili Zhu, Huiru Zhang, 2019, Advances in experimental medicine and biology.

Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia‐inducible factor‐1α expression in photoreceptors

C. Grimm, M. Samardzija, Y. Le, 2009, The European journal of neuroscience.

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

Dean Y. Li, W. Hauswirth, M. Shibuya, 2013, eLife.

Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration.

Y. Le, A. Lewin, Haoyu Mao, 2014, Investigative ophthalmology & visual science.

VASCULAR BIOLOGY , ATHEROSCLEROSIS , AND ENDOTHELIUM BIOLOGY 7-Ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox 4 and Atg 4 B

Y. Le, Qilong Wang, Huaiping Zhu, 2013 .

Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats.

Y. Le, J. Kusari, Meili Zhu, 2011, Investigative ophthalmology & visual science.

Computer-assisted semi-quantitative analysis of mouse choroidal density.

Y. Le, 2010, Advances in experimental medicine and biology.

Intravitreous high expression level of netrin-1 in patients with proliferative diabetic retinopathy.

Y. Le, X. Xia, Siqi Xiong, 2011, Eye science.

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells*

C. Kahn, Y. Le, M. Tanito, 2008, Journal of Biological Chemistry.

RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors

F. Schmitz, Y. Le, C. Grabner, 2015, The Journal of Neuroscience.

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

Y. Le, J. Pi, G. Fong, 2022, Investigative ophthalmology & visual science.

Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes

Y. Le, J. Haigh, Meili Zhu, 2015, Diabetes.

Unexpected transcriptional activity of the human VMD2 promoter in retinal development.

Y. Le, J. Ash, Meili Zhu, 2010, Advances in experimental medicine and biology.

Role of BCL-XL in photoreceptor survival.

Y. Le, Robert E Anderson, E. Rucker, 2008, Advances in experimental medicine and biology.

Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II

Y. Le, M. Elliott, D. Carr, 2018, Investigative ophthalmology & visual science.

Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency

Hongwei Ma, Y. Le, Xi-Qin Ding, 2019, eNeuro.

G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases

Y. Le, Qiang Wu, Xin-hua Du, 2017, Vision Research.

Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis

D. Zack, A. Swaroop, Y. Le, 2013, Development.

Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium in mammalian photoreceptor differentiation

D. Zack, A. Swaroop, Y. Le, 2013 .

Trafficking of Membrane Proteins to Cone But Not Rod Outer Segments Is Dependent on Heterotrimeric Kinesin-II

C. Watt, R. Marc, David S. Williams, 2009, The Journal of Neuroscience.

Conditional gene knockout system in cone photoreceptors.

Y. Le, Ying Chen, Jian-xing Ma, 2006, Advances in experimental medicine and biology.

Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice.

Y. Le, Ying Chen, Jian-xing Ma, 2004, Molecular vision.

RPE barrier breakdown in diabetic retinopathy: seeing is believing

Y. Le, Meili Zhu, Hui-Zhuo Xu, 2011, Journal of ocular biology, diseases, and informatics.

Müller cell‐derived VEGF is a significant contributor to retinal neovascularization

Y. Le, Ying Chen, Jian-xing Ma, 2009, The Journal of pathology.

Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function

P. Sieving, Y. Le, M. Haruta, 2009, Proceedings of the National Academy of Sciences.

DHA does not protect ELOVL4 transgenic mice from retinal degeneration

Kang Zhang, Y. Le, R. Brush, 2009, Molecular vision.

Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.

C. Punzo, Y. Le, M. Rüegg, 2015, Experimental eye research.

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

C. Punzo, Y. Le, M. Rüegg, 2015, The Journal of clinical investigation.

Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.

Y. Le, R. V. Rajala, S. Fliesler, 2011, Investigative ophthalmology & visual science.

VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes

Y. Le, Meili Zhu, Huiru Zhang, 2021, Biomolecules.

Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy.

Y. Le, Meili Zhu, Juan-Juan Wang, 2015, World journal of diabetes.

Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells

Y. Le, K. Zhou, R. S. Johnson, 2011, Diabetologia.

Numb Regulates the Polarized Delivery of Cyclic Nucleotide-Gated Ion Channels in Rod Photoreceptor Cilia

W. Hauswirth, Y. Le, M. Cayouette, 2014, The Journal of Neuroscience.

Loss of BCL-XL in rod photoreceptors: Increased susceptibility to bright light stress.

Y. Le, M. Agbaga, E. Rucker, 2006, Investigative ophthalmology & visual science.

Mouse opsin promoter-directed Cre recombinase expression in transgenic mice.

Y. Le, M. Agbaga, J. Ash, 2006, Molecular vision.

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7

Y. Le, A. Marmorstein, L. Marmorstein, 2017, Molecular vision.

Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium*

K. Palczewski, Y. Le, Bhubanananda Sahu, 2015, The Journal of Biological Chemistry.

Conditional Gene Targeting: Dissecting the Cellular Mechanisms of Retinal Degenerations

Y. Le, 2010, Journal of ophthalmology.

Expression of Cre recombinase in retinal Müller cells

Y. Le, J. Ash, Meili Zhu, 2009, Vision Research.

Inducible expression of cre recombinase in the retinal pigmented epithelium.

D. Zack, Y. Le, Wei Zheng, 2008, Investigative ophthalmology & visual science.

Temporal requirement of RPE‐derived VEGF in the development of choroidal vasculature

Y. Le, Meili Zhu, Yanyan Bai, 2010, Journal of neurochemistry.

Loss of a single VEGF allele prevents angiogenic growth of new blood vessels and leads to embryonic lethality in mice

Y. Le, Meili Zhu, Yanyan Bai, 2010 .

Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium

Y. Le, Meili Zhu, Chang-yun Wang, 2014, Molecular vision.

X-Box Binding Protein 1 Is Essential for the Anti-Oxidant Defense and Cell Survival in the Retinal Pigment Epithelium

Y. Le, M. A. Mandal, J. Wang, 2012, PloS one.

Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.

Y. Le, R. V. Rajala, D. Allen, 2011, Investigative ophthalmology & visual science.

Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.

Y. Le, Ying Chen, Yang Hu, 2012, Investigative ophthalmology & visual science.

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration

B. Humbel, Y. Le, S. Meloche, 2017, Molecular and Cellular Biology.

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells*

C. Kahn, Y. Le, M. Tanito, 2008, Journal of Biological Chemistry.

Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors

Y. Le, J. Ash, Werner Müller, 2009, Proceedings of the National Academy of Sciences.

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

K. Mikoshiba, Hongwei Ma, M. Biel, 2017, The Journal of Biological Chemistry.

Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.

C. Grimm, M. Samardzija, N. Tanimoto, 2011, Investigative ophthalmology & visual science.

Autophagy Protects the Retina from Light-induced Degeneration*

Y. Le, T. Maeda, A. Maeda, 2013, The Journal of Biological Chemistry.

VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases

Y. Le, 2017, Vision Research.

Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development.

Y. Le, Meili Zhu, Yanyan Bai, 2012, Advances in experimental medicine and biology.

The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity

Y. Le, G. Tosini, Kenkichi Baba, 2020, bioRxiv.

Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG

C. Ribelayga, Y. Le, J. Sellers, 2020, Investigative ophthalmology & visual science.

Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA

Y. Le, X. Xia, Siqi Xiong, 2011, Ophthalmic Research.

Diabetic retinopathy, an overview

Y. Le, W. Baehr, M. Hartnett, 2017, Vision Research.

Simplified system to investigate alteration of retinal neurons in diabetes.

Y. Le, Xuelian Xu, Meili Zhu, 2014, Advances in experimental medicine and biology.

VEGF as a Direct Functional Regulator of Photoreceptors and Contributing Factor to Diabetes-Induced Alteration of Photoreceptor Function

Y. Le, Qiang Wu, Meili Zhu, 2021, Biomolecules.

Noninvasive Diagnosis of Regional Alteration of Retinal Morphology and Structure with Optical Coherence Tomography in Rodents.

Y. Le, Meili Zhu, F. Qiu, 2019, Advances in experimental medicine and biology.

VEGF as a Trophic Factor for Müller Glia in Hypoxic Retinal Diseases.

Y. Le, Meili Zhu, Shuhua Fu, 2018, Advances in experimental medicine and biology.

gp130 activation in Müller cells is not essential for photoreceptor protection from light damage.

Y. Le, J. Ash, S. Chollangi, 2010, Advances in experimental medicine and biology.

IFT20 is required for opsin trafficking and photoreceptor outer segment development

G. Pazour, Y. Le, Brian T. Keady, 2011, Molecular biology of the cell.

The Role of Retinal Müller Cell-Produced VEGF in Ischemia Induced Vascular Leakage

Y. Le, Jian-xing Ma, Yanyan Bai, 2009 .

Interruption of Wnt Signaling in Müller Cells Ameliorates Ischemia-Induced Retinal Neovascularization

Y. Le, Jian-xing Ma, S. Benyajati, 2014, PloS one.