D. Rifkin

D. Rifkin, P. Gleizes, R. Shapiro, 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

D. Rifkin, L. Ossowski, J. Quigley, 1973, The Journal of experimental medicine.

Enamel and dental anomalies in latent‐transforming growth factor beta‐binding protein 3 mutant mice

P. Dollé, D. Rifkin, A. Bloch-Zupan, 2017, European journal of oral sciences.

Specificity of latent TGF‐β binding protein (LTBP) incorporation into matrix: Role of fibrillins and fibronectin

D. Rifkin, L. Sakai, B. Dabovic, 2012, Journal of cellular physiology.

Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation.

D. Rifkin, C. Colarossi, B. Dabovic, 2002, The Journal of endocrinology.

Experiments with normal and transformed cells : a laboratory manual for working with cells in culture

D. Rifkin, H. Ozer, R. Crowe, 1978 .

Aspirin inhibits vascular plasminogen activator activity in vivo. Studies utilizing a new assay to quantify plasminogen activator activity.

D. Rifkin, R. Levin, P. Harpel, 1984, The Journal of clinical investigation.

Overexpression of the 18 kDa and 22/24 kDa FGF‐2 isoforms results in differential drug resistance and amplification potential

L. Magnelli, E. Fanti, D. Rifkin, 2002, Journal of cellular physiology.

Cellular glycosylphosphatidylinositol‐specific phospholipase D regulates urokinase receptor shedding and cell surface expression

D. Rifkin, V. Magdolen, O. Wilhelm, 1999, Journal of cellular physiology.

Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-β and Potentiates Fibrosis

D. Rifkin, J. Buyon, R. Clancy, 2011, The Journal of Immunology.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5

H. von Melchner, D. Rifkin, L. Sakai, 2013, Proceedings of the National Academy of Sciences.

The Integrin avb6 Binds and Activates Latent TGFb1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

N. Kaminski, D. Sheppard, D. Rifkin, 1999 .

Growth Factors , Cytokines , Cell Cycle Molecules Lung Alveolar Septation Defects in Ltbp-3-Null Mice

D. Rifkin, C. Colarossi, Yan Chen, 2010 .

Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta

G. Mortier, P. Dollé, D. Rifkin, 2015, Human molecular genetics.

brachyolmia with amelogenesis imperfecta

G. Mortier, P. Dollé, D. Rifkin, 2015 .

Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1*

R. Beavis, D. Rifkin, P. Gleizes, 1996, The Journal of Biological Chemistry.

Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1.

R. Beavis, D. Rifkin, P. Gleizes, 1996, The Journal of biological chemistry.

Lipopolysaccharide inhibits activation of latent transforming growth factor‐β in bovine endothelial cells

D. Rifkin, S. Kojima, H. Amanuma, 1995, Journal of cellular physiology.

Amino Acid Requirements for Formation of the TGF-β-Latent TGF-β Binding Protein Complexes

A. Downing, D. Rifkin, Yan Chen, 2005 .

LTBPs, more than just an escort service

D. Rifkin, V. Todorovic, 2012, Journal of cellular biochemistry.

Long form of latent TGF‐β binding protein 1 (Ltbp1L) regulates cardiac valve development

D. Rifkin, L. Zilberberg, M. Ota, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.

D. Rifkin, Yan Chen, V. Todorovic, 2005, Journal of molecular biology.

Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.

D. Rifkin, R. Fässler, L. Sakai, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion

D. Rifkin, Yan Chen, B. Dabovic, 2002 .

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

D. Rifkin, Yan Chen, B. Dabovic, 2002, FEBS letters.

Cell density dependent effects of TGF‐β demonstrated by a plasminogen activator‐based assay for TGF‐β

D. Rifkin, R. Flaumenhaft, 1992 .

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.

A. Beaudet, D. Rifkin, B. Keller, 2010, The Journal of clinical investigation.

HL-60 Cells on Growth and Differentiation of Retinoic Acid-treated β Factor-Effects of Endogenously Activated Transforming Growth

D. Rifkin, S. Kojima, I. Nunes, 2006 .

Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells.

D. Rifkin, S. Kojima, I. Nunes, 1996, Cancer research.

Plasminogen is present in the basal layer of the epidermis.

R. Isseroff, D. Rifkin, Daniel B. Rifkin, 1983, The Journal of investigative dermatology.

Location of a gelatin-binding region of human plasma fibronectin.

D. Rifkin, A. Frey, M. Furie, 1980, The Journal of biological chemistry.

SV40 mutants with an altered small-t protein are tumorigenic in newborn hamsters.

D. Rifkin, M. Sleigh, W. Topp, 1981, Virology.

Transformation of Primary Hamster Brain Cells with JC Virus and Its DNA

D. Rifkin, R. Frisque, D. Walker, 1980, Journal of Virology.

The characterization of the tryptic peptides from the hemoglobin of the chimpanzee (Pan troglodytes).

D. Rifkin, W. Konigsberg, 1965, Biochimica et biophysica acta.

Hyperoxia stimulates endothelin-1 secretion from endothelial cells; modulation by captopril and nifedipine.

R. Higgins, D. Rifkin, K. Hendricks-Muñoz, 1998, Current eye research.

Isolation of the major serine protease inhibitor from the 5‐day serum‐free conditioned medium of human embryonic lung cells and demonstration that it is fetuin

D. Rifkin, S. T. Rohrlich, 1981, Journal of cellular physiology.

Phospholipid composition of Rous sarcoma virus, host cell membranes and other enveloped RNA viruses.

D. Rifkin, J. Quigley, E. Reich, 1971, Virology.

Determination of phospholipid composition of RNA tumor viruses by 32 P labeling of infected cell cultures.

D. Rifkin, J. Quigley, M. Einhorn, 1972, Analytical biochemistry.

Actin-containing cables within anchorage-dependent rat embryo cells are dissociated by plasmin and trypsin

D. Rifkin, R. Pollack, Daniel B. Rifkin, 1975, Cell.

TGF-beta latency: biological significance and mechanisms of activation.

D. Rifkin, P. Gleizes, R. Mazzieri, 1997, Stem cells.

The role of proteases in matrix breakdown during cellular invasion.

D. Rifkin, P. Mignatti, R. Tsuboi, 1989, The American review of respiratory disease.

Stimulation of motility in cultured bovine capillary endothelial cells by angiogenic preparations

D. Rifkin, D. Mullins, 1984, Journal of cellular physiology.

Production of Gastrointestinal Tumors in Mice by Modulating Latent Transforming Growth Factor Beta 1 Activation.

D. Rifkin, K. Yoshinaga, M. Ota, 2012 .

[Activation of latent TGF-beta. A required mechanism for vascular integrity].

D. Rifkin, P. Gleizes, 1999, Pathologie-biologie.

Requirement for receptor‐bound urokinase in plasmin‐dependent cellular conversion of latent TGF‐β to TGF‐β

D. Rifkin, F. Blasi, L. Odekon, 1994 .

Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells.

J. Gabrilove, D. Rifkin, Rifkin, 1993, Blood.

The effect of avian retroviruses on limb bud chondrogenesis in vitro

D. Rifkin, J. Gross, 1979, Cell.

Clonal sublines of rat neurotumor RT4 and cell differentiation. II. A conversion coupling of tumorigenicity and a glial property.

N. Sueoka, D. Rifkin, M. Imada, 1978, Developmental biology.

The preparation and use of pyridoxal [32P]phosphate as a labeling reagent for proteins on the outer surface of membranes.

D. Rifkin, R. Eger, 1977, Biochimica et biophysica acta.

Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles.

D. Rifkin, D. Roses, R. Shapiro, 1997, The American journal of pathology.

Both normal and tumor cells produce basic fibroblast growth factor

D. Rifkin, M. Presta, D. Moscatelli, 1986, Journal of cellular physiology.

Down-regulation of epidermal growth factor receptor correlates with plasminogen activator activity in human A431 epidermoid carcinoma cells.

D. Rifkin, M. Lane, J. Gross, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Endothelial Cell Growth Factors and the Vessel Wall

D. Rifkin, J. Joseph-Silverstein, J. Joseph‐Silverstein, 1987, Seminars in thrombosis and hemostasis.

Purification and biological activities of an angiogenesis factor from human placenta.

D. Rifkin, M. Presta, D. Moscatelli, 1986, Anticancer research.

Proteases and Angiogenesis: Production of Plasminogen Activator and Collagenase by Endothelial Cells

D. Rifkin, D. Moscatelli, J. Gross, 1982 .

A polypeptide secreted by transformed cells that modulates human plasminogen activator production.

R. Kucherlapati, D. Rifkin, R. Tepper, 1983, Science.

Proteolytic control of growth factor availability

D. Rifkin, D B Rifkin, R Mazzieri, 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Control of transforming growth factor-β activity: Latency vs. activation

D. Rifkin, S. Kojima, C. Metz, 1992 .

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

D. Rifkin, Y. Sato, Yasufumi Sato, 1989, The Journal of cell biology.

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

D. Rifkin, O. Saksela, 1990 .

Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart.

D. Rifkin, K. Hajjar, A. Deora, 2004, Developmental biology.

Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta.

D. Rifkin, F. Blasi, L. Odekon, 1994, Journal of cellular physiology.

Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor.

D. Rifkin, P. Dennis, O. Saksela, 1989, The Journal of biological chemistry.

Plasminogen activator in differentiating mouse keratinocytes.

R. Isseroff, N. Fusenig, D. Rifkin, 1983, Journal of Investigative Dermatology.

Proteolytically derived fragments of human plasma fibronectin and their localization within the intact molecule.

D. Rifkin, M. Furie, 1980, Journal of Biological Chemistry.

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

Wolfram Kress, Julie De Backer, Jan Hellemans, 2005, Nature Genetics.

Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan

D. Rifkin, A. Sommer, D B Rifkin, 1989, Journal of cellular physiology.

The extracellular regulation of growth factor action.

D. Rifkin, R. Flaumenhaft, D B Rifkin, 1992, Molecular biology of the cell.

Studies of Rous sarcoma virus. Effects of nucleoside analogues on virus synthesis.

D. Rifkin, E. Reich, B. Brdar, 1973, The Journal of biological chemistry.

II. MAMMALL~N FIBROBLAST CULTURES TRANSFORMED BY DNA AXD RNA TI;~IOR VIRUSES

D. Rifkin, L. Ossowski, J. Quigley, 1973 .

Isolation of a protease inhibitor from tissues resistant to tumor invasion.

D. Rifkin, R. M. Crowe, 1977, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation

D. Rifkin, N. Selvamurugan, B. Dabovic, 2017, Stem cells international.

Selective lysis of cells transformed by Rous Sarcoma virus.

D. Rifkin, E. Reich, 1971, Virology.

Proteases and biological control

D. Rifkin, E. Reich, E. Shaw, 1975 .

Plasminogen activators and matrix metalloproteinases in angiogenesis.

D. Rifkin, P. Mignatti, 1996, Enzyme & protein.

Plasma membrane alteration associated with malignant transformation in culture.

D. Rifkin, N. Gilula, R. Eger, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Biological roles of fibroblast growth factor-2.

D. Rifkin, A. Bikfalvi, D B Rifkin, 1997, Endocrine reviews.

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells

D. Rifkin, Y. Sato, R. Tsuboi, 1990, The Journal of cell biology.

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis

D. Rifkin, Y. Sato, Yasufumi Sato, 1988, The Journal of cell biology.

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

B. Hinz, J. Meister, D. Rifkin, 2007, The Journal of cell biology.

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.

D. Rifkin, Ian B Robertson, 2016, Cold Spring Harbor perspectives in biology.

Latent TGF-β-binding proteins.

D. Rifkin, K. Hadjiolova, B. Dabovic, 2015, Matrix biology : journal of the International Society for Matrix Biology.

TGF-β: Structure, Function, and Formation

D. Rifkin, S. Kojima, M. Abe, 1993, Thrombosis and Haemostasis.

PROPERTIES OF PLASMINOGEN ACTIVATORS FORMED BY NEOPLASTIC HUMAN CELL CULTURES

D. Rifkin, E. Reich, J. Loeb, 1974, The Journal of experimental medicine.

Isolation and amino acid composition of the tryptic peptides from the beta chain of C57BL-6 mouse hemoglobin.

D. Rifkin, M. Rifkin, W. Konigsberg, 1966, Archives of biochemistry and biophysics.

Tumor promoters induce changes in the chick embryo fibroblast cytoskeleton

D. Rifkin, R. Pollack, R. M. Crowe, 1979, Cell.

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

D. Rifkin, P. Mignatti, E. Robbins, 1986, Cell.

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

D. Rifkin, L. Ossowski, J. Quigley, 1973, The Journal of experimental medicine.

Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology.

D. Rifkin, P. Mignatti, 2000, Advances in cancer research.

Plasminogen activator production accompanies loss of anchorage regulation in transformation of primary rat embryo cells by simian virus 40.

D. Rifkin, R. Risser, R. Pollack, 1974, Proceedings of the National Academy of Sciences of the United States of America.

L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice

S. Friedman, D. Rifkin, S. Kojima, 2015, Fibrogenesis & tissue repair.

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

N. Kaminski, D. Sheppard, D. Rifkin, 1999, Cell.

Proteinases and Tissue Remodeling

D. Rifkin, W. Parks, P. Mignatti, 1988 .

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.

D. Rifkin, C. Metz, D. Loskutoff, 1994, Analytical biochemistry.

Fibronectin from chicken embryo fibroblasts contains covalently bound phosphate

D. Rifkin, M. Teng, 1979, The Journal of cell biology.

In vitro differentiation of teratomas and the distribution of creatine phosphokinase and plasminogen activator in teratocarcinoma-derived cells.

A. Levine, D. Rifkin, J. Hall, 1976, Cancer research.

Production of plasminogen activator by established cell lines of mouse origin

D. Rifkin, R. Pollack, 1977, The Journal of cell biology.

PROTEASES PRODUCED BY NORMAL AND MALIGNANT CELLS IN CULTURE

D. Rifkin, R. Pollack, 1976 .

Binding of developing mouse cerebellar cells to fibronectin: a possible mechanism for the formation of the external granular layer

M. Hatten, D. Rifkin, M. Furie, 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

An Endogenous Glycosylphosphatidylinositol-Specific Phospholipase D Releases Basic Fibroblast Growth Factor-Heparan Sulfate Proteoglycan Complexes From Human Bone Marrow Cultures

D. Rifkin, C. Metz, Rifkin, 2002 .

Control of transforming growth factor-beta activity: latency vs. activation.

D. Rifkin, S. Kojima, C. Metz, 1992, Progress in growth factor research.

Early mutants of polyoma virus (dl8 and dl23) with altered transformation properties: is polyoma virus middle T antigen a transforming gene product?

Y. Ito, D. Rifkin, U. Novak, 1980, Cold Spring Harbor Symposia on Quantitative Biology.

High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding.

N. Janjić, D. Rifkin, D. Jellinek, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Biology and biochemistry of proteinases in tumor invasion.

D. Rifkin, P. Mignatti, 1993, Physiological reviews.

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

D. Rifkin, P. Dennis, P. A. Dennis, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

D. Rifkin, Yan Chen, J. Munger, 2004, The Journal of cell biology.

The presence of two major hemoglobin components in an inbred strain of mice.

D. Rifkin, M. Rifkin, W. Konigsberg, 1966, Proceedings of the National Academy of Sciences of the United States of America.

Isoform-Specific Activation of Latent Transforming Growth Factor β (LTGF-β) by Reactive Oxygen Species

Mary Helen Barcellos-Hoff, Daniel B. Rifkin, J. Mott, 2006, Radiation research.

The integrin alphaVbeta6 binds and activates latent TGFbeta3.

D. Rifkin, J. Munger, J. Annes, 2002, FEBS letters.

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

N. Kaminski, D. Sheppard, D. Rifkin, 1999, Cell.

Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1

D. Rifkin, R. Fässler, L. Sakai, 2005 .

Function of Latent TGFβ Binding Protein 4 and Fibulin 5 in Elastogenesis and Lung Development

D. Rifkin, B. Dabovic, E. Davis, 2015, Journal of cellular physiology.

Making sense of latent TGFbeta activation.

D. Rifkin, J. Munger, Daniel B Rifkin, 2003, Journal of cell science.

Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms.

D. Rifkin, P. Cowin, A. Gualandris, 2003, Gene.

Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein*

D. Rifkin, S. Ushiro, D. Keene, 2003, The Journal of Biological Chemistry.

Making sense of latent TGFβ activation

Justin P. Annes, D. Rifkin, J. Munger, 2003, Journal of Cell Science.

Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability

D. Rifkin, C. Colarossi, Yan Chen, 2002, The Journal of cell biology.

Role of extracellular matrix in the action of basic fibroblast growth factor: Matrix as a source of growth factor for long‐term stimulation of plasminogen activator production and DNA synthesis

D. Rifkin, R. Flaumenhaft, D. Moscatelli, 1989, Journal of cellular physiology.

Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity

D. Rifkin, R. Tsuboi, Ryoji Tsuboi, 1990, International journal of cancer.

Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.

P. Handford, A. Downing, D. Rifkin, 2003, Journal of molecular biology.

The pituitary TGF b 1 system as a novel target for the treatment of resistant prolactinomas

D. Rifkin, M. V. Recouvreux, M. Camilletti, 2016 .

Transforming growth factor-beta 1 regulates axon/Schwann cell interactions

D. Rifkin, C. Metz, J. Salzer, 1995, The Journal of cell biology.

Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals.

D. Rifkin, Yan Chen, R. Florkiewicz, 1999, Molecular biology of the cell.

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms

D. Rifkin, A. Bikfalvi, N. Quarto, 1995, The Journal of cell biology.

Latent transforming growth factor-beta: structural features and mechanisms of activation.

D. Rifkin, P. Gleizes, R. Mazzieri, 1997, Kidney international.

Matrix control of transforming growth factor-β function.

D. Rifkin, M. Ota, Masahito Horiguchi, 2012, Journal of biochemistry.

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

D. Rifkin, T. Morimoto, P. Mignatti, 1992, Journal of cellular physiology.

Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation.

J. Melamed, D. Rifkin, K. Yoshinaga, 2013, Cancer research.

Tumor and Stem Cell Biology Production of Gastrointestinal Tumors inMice byModulating Latent TGF-b 1 Activation

J. Melamed, D. Rifkin, K. Yoshinaga, 2012 .

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome

J. Humphrey, D. Rifkin, C. Bellini, 2018, Biomechanics and Modeling in Mechanobiology.

The stable classes of transformed cells induced by SV40 infection of established 3T3 cells and primary rat embryonic cells.

D. Rifkin, R. Risser, R. Pollack, 1975, Cold Spring Harbor symposia on quantitative biology.

Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner.

D. Rifkin, T. Morimoto, P. Mignatti, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The characterization of SV40‐transformed cell lines derived from mouse teratocarcinoma: Growth properties and differentiated characteristics

A. Levine, D. Rifkin, J. Hall, 1977, Journal of cellular physiology.

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

D. Rifkin, P. Gleizes, C. Metz, 1997, The Journal of cell biology.

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

D. Rifkin, S. Kojima, K. Nara, 1993, The Journal of cell biology.

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells

K. Miyazono, C. Heldin, D. Rifkin, 1993, The Journal of cell biology.

Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue.

D. Rifkin, M. Cammer, C. Loomis, 2014, Cancer research.

Perturbation of transforming growth factor (TGF)-ß1 association with latent TGF-β binding protein yields inflammation and tumors

J. Melamed, D. Rifkin, D. Huso, 2008, Proceedings of the National Academy of Sciences.

Synthesis of collagenase and plasminogen activator by endothelial cells

D. Rifkin, E. Jaffe, D. Moscatelli, 1984 .

Integrin Regulation by Endogenous Expression of 18-kDa Fibroblast Growth Factor-2*

D. Rifkin, F. Giancotti, A. Bikfalvi, 1996, The Journal of Biological Chemistry.

Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells.

D. Rifkin, F. Giancotti, S. Albelda, 1993, Molecular biology of the cell.

Lipid studies of Rous sarcoma virus and host cell membranes.

D. Rifkin, J. Quigley, E. Reich, 1972, Virology.

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self- regulating system

D. Rifkin, R. Lyons, Y. Sato, 1990, The Journal of cell biology.

Extracellular matrix regulation of growth factor and protease activity.

D. Rifkin, R. Flaumenhaft, Daniel B. Rifkin, 1991, Current opinion in cell biology.

The organization of the proteins of vesicular stomatitis virions: labeling with pyridoxal phosphate.

D. Rifkin, R. Compans, R. Eger, 1975, Virology.

BEYOND CARRIER PROTEINS Bone defects in latent TGF- binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF- presentation

D. Rifkin, C. Colarossi, Yan Chen, 2002 .

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

D. Rifkin, P. Mignatti, 1991, Journal of cellular biochemistry.

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

D. Rifkin, B. Coller, K. Yoshinaga, 2008, Blood.

Tumor and Stem Cell Biology Genetic Suppression of In fl ammation Blocks the Tumor-Promoting Effects of TGF-b in Gastric Tissue

D. Rifkin, M. Cammer, C. Loomis, 2014 .

Studies on FGF‐2: Nuclear localization and function of high molecular weight forms and receptor binding in the absence of heparin

D. Rifkin, A. Bikfalvi, N. Quarto, 1994, Molecular reproduction and development.

Fibroblast growth factors as angiogenesis factors: new insights into their mechanism of action.

D. Rifkin, S. Klein, M. Roghani, 1997, EXS.

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.

D. Rifkin, P. Dell’Era, D. Moscatelli, 1994, The Journal of biological chemistry.

In Vitro Differentiationof Teratomas and the Distribution of Creatine Phosphokinase and Plasminogen Activator in Teratocarcinoma-derived Cells 1

A. Levine, D. Rifkin, A. Teresky, 2006 .

Plasminogen activator synthesis by cultured human embryonic lung cells: Characterization of the suppressive effect of corticosteroids

D. Rifkin, 1978, Journal of cellular physiology.

Activation of Latent Transforming Growth Factor ß

D. Rifkin, R. Flaumenhaft, S. Kojima, 1993 .

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity

D. Rifkin, R. Flaumenhaft, M. Abe, 1992, The Journal of cell biology.

Plasminogen activators and angiogenesis.

D. Rifkin, P. Mignatti, 1996, Current topics in microbiology and immunology.

Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation.

D. Rifkin, Ian B Robertson, 2013, Cytokine & growth factor reviews.

Pregnancy specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice

B. Klapp, G. Dveksler, D. Rifkin, 2013, Mucosal Immunology.

TGF‐β Latency: Biological Significance and Mechanisms of Activation

D. Rifkin, P. Gleizes, R. Mazzieri, 1997 .

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1

D. Rifkin, B. Coller, K. Yoshinaga, 2008 .

Oncogenic viruses. II. Mammalian fibroblast cultures transformed by dna and rna tumor viruses.

D. Reich, D. Rifkin, L. Ossowski, 1973 .

The integrin αVβ6 binds and activates latent TGFβ3

D. Rifkin, J. Munger, J. Annes, 2002 .

Latent Transforming Growth Factor β-binding Proteins and Fibulins Compete for Fibrillin-1 and Exhibit Exquisite Specificities in Binding Sites*

Takako Sasaki, D. Rifkin, N. Charbonneau, 2009, The Journal of Biological Chemistry.

Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability*

D. Rifkin, 2005, Journal of Biological Chemistry.

Microfibril Structure Masks Fibrillin-2 in Postnatal Tissues*

H. Dietz, D. Rifkin, D. Keene, 2010, The Journal of Biological Chemistry.

Methods for measuring TGF-b using antibodies, cells, and mice.

D. Rifkin, Yan Chen, B. Dabovic, 2005, Methods in molecular medicine.

Measurements of Active TGFβ Generated by Culture Cells

D. Rifkin, R. Mazzieri, J. Munger, 2000 .

LTBP-3 promotes early metastatic events during cancer cell dissemination

D. Rifkin, J. Quigley, B. Dabovic, 2017, Oncogene.

Expression of truncated latent TGF-β-binding protein modulates TGF-β signaling

D. Rifkin, P. Gleizes, R. Mazzieri, 2005, Journal of Cell Science.

TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins

D. Rifkin, V. Todorovic, 2008 .

LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis

S. Friedman, D. Rifkin, S. Kojima, 2014, SpringerPlus.

Characterization of latent TGF-beta activation by murine peritoneal macrophages.

D. Rifkin, R. Shapiro, I. Nunes, 1995, Journal of immunology.

Dual functions for LTBP in lung development: LTBP‐4 independently modulates elastogenesis and TGF‐β activity

H. von Melchner, H. Dietz, D. Rifkin, 2009, Journal of cellular physiology.

Purification and characterization of a low molecular mass cysteine proteinase inhibitor from human amniotic fluid.

D. Rifkin, S. T. Rohrlich, H. Levy, 1985, Progress in clinical and biological research.

Growth retardation as well as spleen and thymus involution in latent TGF‐β binding protein (Ltbp)‐3 null mice

D. Rifkin, C. Colarossi, Yan Chen, 2003, Journal of cellular physiology.

Isolation and cytokine analysis of lamina propria lymphocytes from mucosal biopsies of the human colon.

P. Loke, D. Rifkin, R. Bowcutt, 2015, Journal of immunological methods.

Angiogenesis and the Fibrinolytic System

D. Rifkin, A. Bikfalvi, G. Pintucci, 1996, Seminars in thrombosis and hemostasis.

The role of LTBPs in TGF beta signaling

D. Rifkin, G. Tellides, F. Ramirez, 2021, Developmental dynamics : an official publication of the American Association of Anatomists.

Studies on the control of plasminogen activator production by cultured human embryonic lung cells: Requirements for inhibition by corticosteroids

D. Rifkin, R. M. Crowe, 1980, Journal of cellular physiology.

Studies on the role of basic fibroblast growth factor in vivo: Inability of neutralizing antibodies to block tumor growth

D. Rifkin, P. Dennis, 1990, Journal of cellular physiology.

Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development.

K. Holland, D. Rifkin, M. Marble, 2009, American journal of human genetics.

Angiogenesis: Mechanisms and Pathobiology

M. Klagsbrun, D. Rifkin, 1987 .

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

D. Rifkin, J. Hagood, Yong Zhou, 2009, The American journal of pathology.

Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1).

D. Rifkin, D. Becu-Villalobos, M. V. Recouvreux, 2012, Endocrinology.

LTBPs in biology and medicine: LTBP diseases.

D. Rifkin, William J. Rifkin, L. Zilberberg, 2017, Matrix biology : journal of the International Society for Matrix Biology.

The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium.

D. Rifkin, A. Gualandris, M. Arese, 2000, Molecular biology of the cell.

A genetic screen to identify latent transforming growth factor β activators

D. Rifkin, J. Munger, M. Vassallo, 2004 .

Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal.

D. Rifkin, R. Weiskirchen, K. Hadjiolova, 2015, Matrix biology : journal of the International Society for Matrix Biology.

JB Review Matrix control of transforming growth factor-b function

D. Rifkin, M. Ota, Masahito Horiguchi, 2012 .

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.

D. Rifkin, Francesco Ramirez, F. Ramirez, 2009, Current opinion in cell biology.

Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling.

D. Rifkin, P. Gleizes, R. Mazzieri, 2005, Journal of cell science.

Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome.

J. Humphrey, D. Rifkin, C. Bellini, 2016, Journal of biomechanics.

Virus-induced modification of cellular membranes related to viral structure.

D. Rifkin, J. Quigley, 1974, Annual review of microbiology.

The small-t protein of SV40 is required for loss of actin cable networks and plasminogen activator synthesis in transformed rat cells.

D. Rifkin, W. Topp, 1980, Virology.

Identification of a pituitary factor responsible for enhancement of plasminogen activator activity in breast tumor cells.

D. Rifkin, L. Ossowski, R. Mira‐Y‐Lopez, 1986, Proceedings of the National Academy of Sciences of the United States of America.

New Observations on the Intracellular Localization and Release of bFGF a

D. Rifkin, N. Quarto, D. Moscatelli, 1991, Annals of the New York Academy of Sciences.

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous epithelial stem cell proliferation

J. McGrath, D. Rifkin, Raphael Ruppert, 2014, Nature Medicine.

TGF-beta: structure, function, and formation.

D. Rifkin, S. Kojima, M. Abe, 1993, Thrombosis and haemostasis.

Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

D. Fenyö, O. Kennedy, D. Rifkin, 2020, Scientific Reports.

Biochemistry of granule cell migration in developing mouse cerebellum.

M. Hatten, C. Mason, D. Rifkin, 1982, Progress in clinical and biological research.

Tumor cells secrete an Angiogenic factor that stimulates basic fibroblast growth factor and Urokinase expression in Vascular Endothelial cells

P. Quax, G. D. Valle, D. Rifkin, 1994, Journal of cellular physiology.

Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice.

D. Rifkin, D. Roses, R. Shapiro, 1998, The Journal of surgical research.

The Integrin (cid:97) v (cid:98) 6 Binds and Activates Latent TGF (cid:98) 1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

D. Sheppard, D. Rifkin, J. Pittet, 1999 .

Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy.

K. Yu, R. Higgins, D. Rifkin, 1999, Current eye research.

F-spondin , a neuroregulatory protein , is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-activation

S. Abramson, D. Rifkin, M. Attur, 2009 .

TGFβ−2 haploinsufficiency causes early death in mice with Marfan syndrome

G. Fishman, D. Rifkin, Sae-Il Murtada, 2023, Matrix biology : journal of the International Society for Matrix Biology.

Activation of latent transforming growth factor beta.

D. Rifkin, R. Flaumenhaft, S. Kojima, 1993, Advances in pharmacology.

and Potentiates Fibrosis b Receptor-Dependent Activation of TGF-Plasminogen Activator (uPA)/uPA Fetal Cardiocytes Stimulates Urokinase Binding of Anti-SSA Antibodies to Apoptotic

D. Rifkin, J. Buyon, R. Clancy, 2011 .

Collagen type VI regulates TGFβ bioavailability in skeletal muscle

T. Roberts, C. Bönnemann, D. Rifkin, 2023, bioRxiv.

A sensitive assay for elastase employing radioactive elastin coupled to sepharose.

D. Rifkin, R. M. Crowe, 1977, Analytical biochemistry.

A Wound Healing Model Using Healing‐impaired Diabetic Mice

D. Rifkin, R. Tsuboi, D. B. Rifkin, 1992, The Journal of dermatology.

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

D. Rifkin, T. Morimoto, N. Quarto, 1990, Journal of cellular physiology.

Measurement of active TGF-beta generated by cultured cells.

D. Rifkin, R. Mazzieri, J. Munger, 2000, Methods in molecular biology.

7 TGF-β Bioavailability: Latency, Targeting, and Activation

D. Rifkin, B. Dabovic, 2008 .

Recent developments in the cell biology of basic fibroblast growth factor

D. Rifkin, D. Moscatelli, D. Rifkin, 1989, The Journal of cell biology.

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor.

M. Hatten, D. Rifkin, D. Moscatelli, 1988, Developmental biology.

Immunohistochemical localization of basic fibroblast growth factor in astrocytomas.

Douglas C. Miller, D. Miller, D. Burstein, 1990, Cancer research.

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor

D. Rifkin, R. Flaumenhaft, D. Moscatelli, 1990, The Journal of cell biology.

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis.

D. Rifkin, D. Moscatelli, D. Rifkin, 1988, Biochimica et biophysica acta.

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation

D. Rifkin, A. Sommer, D. Moscatelli, 1988, The Journal of cell biology.

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice

D. Rifkin, D. B. Rifkin, R Tsuboi, 1990, The Journal of experimental medicine.

The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF.

D. Rifkin, M. Kuwano, J. Ono, 1991, Biochemical and biophysical research communications.

Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome.

D. Rifkin, J. Hansen, F. Ramirez, 2022, Human Molecular Genetics.

Adaptations of the Camel

Daniel B. Rifkin, D. Rifkin, 1961 .

Additional file 2 Figure S2

Mitsuko Hara, Soichi Kojima, Daniel B. Rifkin, 2013 .

Additional file 1 Figure S1

Shinji Ogawa, Mitsuko Hara, Soichi Kojima, 2013 .

Structure and activation of the large latent transforming growth factor-Beta complex.

D. Rifkin, P. Gleizes, R. Shapiro, 1996, Journal of the American Optometric Association.

Modulation of cell growth and transformation by doxycycline‐regulated FGF‐2 expression in NIH‐3T3 cells

D. Rifkin, A. Gualandris, M. Arese, 1999, Journal of cellular physiology.

Characterization of a temperature-sensitive membrane alteration in chick embryo fibroblasts infected with a temperature-sensitive mutant of Rous sarcoma virus.

D. Rifkin, R. Eger, 1980, Biochimica et Biophysica Acta.

Isolation and characterization of ribonucleoprotein substructures from Rous sarcoma virus.

D. Rifkin, R. Compans, J. Quigley, 1972, Virology.

Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice.

D. Rifkin, G. Karsenty, B. Dabovic, 2005, Bone.

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair.

D. Rifkin, J. Davidson, D. B. Rifkin, 1989, Laboratory investigation; a journal of technical methods and pathology.

Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome [Human Molecular Genetics (2010) 19,24, 4790-4798] DOI: 10.1093/hmg/ddq409

H. Dietz, D. Rifkin, L. Carta, 2014 .

LTBPS AND FIBULINS COMPETE FOR FIBRILLIN-1 AND EXHIBIT EXQUISITE SPECIFICITIES IN BINDING SITES*

Takako Sasaki, D. Rifkin, N. Charbonneau, 2009 .

Cell density dependent effects of TGF-beta demonstrated by a plasminogen activator-based assay for TGF-beta.

D. Rifkin, R. Flaumenhaft, 1992, Journal of cellular physiology.

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation

D. Rifkin, A. Sommer, D. Moscatelli, 1988, The Journal of cell biology.

Plasminogen activator expression and matrix degradation.

D. Rifkin, 1992, Matrix (Stuttgart, Germany). Supplement.

Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state.

D. Rifkin, R. Frisque, W. Topp, 1980, Cold Spring Harbor symposia on quantitative biology.

CELL SURFACE PROTEOLYSIS AND THE TRANSFORMED PHENOTYPE

D. Rifkin, 1978 .

Immunoreactive Basic Fibroblast Growth Factor‐Like Proteins in Chromaffin Granules

D. Rifkin, M. Presta, 1991, Journal of neurochemistry.

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.

D. Rifkin, D. Littman, I. Ivanov, 2008, Cell host & microbe.

The involvement of proteases and protease inhibitors in neovascularization.

D. Rifkin, D. Moscatelli, C. Gabrielides, 1981, Acta biologica et medica Germanica.

Function of Latent TGFβ Binding Protein 4 and Fibulin 5 in Elastogenesis and Lung Development

D. Rifkin, B. Dabovic, E. Davis, 2015, Journal of cellular physiology.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5

H. von Melchner, D. Rifkin, L. Sakai, 2013, Proceedings of the National Academy of Sciences.

Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development.

K. Holland, D. Rifkin, M. Marble, 2009, American journal of human genetics.

New aspects of blood vessel growth: tumor and tissue-derived angiogenesis factors.

D. Rifkin, M. Presta, 1988, Haemostasis.

The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling.

A. Brivanlou, M. Heke, D. Rifkin, 2002, Developmental biology.

Latent TGF-β-binding proteins.

D. Rifkin, K. Hadjiolova, B. Dabovic, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.

D. Rifkin, F. Ramirez, 2009, Current opinion in cell biology.

Long form of latent TGF‐β binding protein 1 (Ltbp1L) regulates cardiac valve development

D. Rifkin, L. Zilberberg, M. Ota, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

A rapid and sensitive bioassay to measure bone morphogenetic protein activity

D. Rifkin, L. Sakai, P. ten Dijke, 2007, BMC Cell Biology.

Transforming growth factor-beta 1 regulates axon/Schwann cell interactions

D. Rifkin, J. Salzer, M. Hannocks, 1995, The Journal of cell biology.

Mechanisms of tendon injury and repair

D. Rifkin, W. Parks, S. Thomopoulos, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

F‐spondin, a neuroregulatory protein, is up‐regulated in osteoarthritis and regulates cartilage metabolism via TGF‐β activation

S. Abramson, D. Rifkin, M. Attur, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PROPERTIES OF PLASMINOGEN ACTIVATORS FORMED BY NEOPLASTIC HUMAN CELL CULTURES

D. Rifkin, E. Reich, J. Loeb, 1974, The Journal of experimental medicine.

Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue.

D. Rifkin, M. Cammer, C. Loomis, 2014, Cancer research.

L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice

S. Friedman, D. Rifkin, S. Kojima, 2015, Fibrogenesis & tissue repair.

Regulation of plasminogen activator synthesis in chick embryo fibroblasts infected with avian retroviruses.

D. Rifkin, 1980, Cold Spring Harbor Symposia on Quantitative Biology.

Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds.

D. Rifkin, G. Powis, L. Zalkow, 1996, Anticancer research.