S. Gloor

发表

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

M. Belvin, S. Seshagiri, B. Jaiswal, 2010, Nature.

Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation.

S. Gloor, J. Falke, 2009, Biochemistry.

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.

E. Laird, S. Gloor, G. Vigers, 2014, Bioorganic & medicinal chemistry letters.

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.

Tyler T. Risom, E. Laird, S. Gloor, 2012, Bioorganic & medicinal chemistry letters.

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Jun Liang, J. Blake, B. Brandhuber, 2012, Journal of medicinal chemistry.

Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.

E. Laird, Y. Ran, G. Hatzivassiliou, 2012, Journal of medicinal chemistry.

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.

Tyler T. Risom, J. Blake, B. Brandhuber, 2010, Bioorganic & medicinal chemistry letters.

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

B. Strahl, S. Gloor, M. Keogh, 2022, bioRxiv.

Optimization of globomycin analogs as novel gram-negative antibiotics.

S. Gloor, Min Xu, Richard M Pastor, 2020, Bioorganic & medicinal chemistry letters.

Discovery and SAR of spirochromane Akt inhibitors.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.

Tyler Risom, Zhaoyang Wen, Ignacio Aliagas, 2011, ACS medicinal chemistry letters.

Potent and selective pyrazole-based inhibitors of B-Raf kinase.

Mike Welch, E. Laird, B. Brandhuber, 2008, Bioorganic & medicinal chemistry letters.

Inhibition of Escherichia coli Lipoprotein Diacylglyceryl Transferase Is Insensitive to Resistance Caused by Deletion of Braun’s Lipoprotein

Christian N. Cunningham, Peter S Liu, W. Sandoval, 2021, Journal of bacteriology.

Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase

Michele D. Kattke, S. Gloor, D. Yan, 2017, Proceedings of the National Academy of Sciences.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

Christian N. Cunningham, S. Gloor, D. Yan, 2020 .

Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase

Z. Modrušan, L. Komuves, S. Gloor, 2020, mBio.

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

B. Brandhuber, S. Gloor, G. Vigers, 2012, Science Signaling.

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

Matthew J. Meiners, Chao Lu, E. Nudler, 2023, bioRxiv.

Abstract 5753: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

M. Belvin, S. Seshagiri, B. Jaiswal, 2010 .

Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis.

S. Chervitz, S. Gloor, J. Falke, 2007, Methods in enzymology.

Cytochrome P450-Mediated Resistance to Isoquinoline Alkaloids and Susceptibility to Synthetic Insecticides inDrosophila

S. Gloor, R. Roush, P. Danielson, 1996 .

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

Matthew J. Meiners, B. Strahl, Geoffrey Fox, 2023, bioRxiv.

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.

Zhaoyang Wen, Joachim Rudolph, E. Laird, 2013, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.

Ellen R. Laird, Tyler Risom, Zhaoyang Wen, 2011, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.

Tyler T. Risom, E. Laird, S. Gloor, 2012, Bioorganic & medicinal chemistry letters.

Discovery of pyrrolopyrimidine inhibitors of Akt.

Tyler T. Risom, S. Gross, J. Blake, 2010, Bioorganic & medicinal chemistry letters.

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.

E. Laird, S. Gloor, Jonas Grina, 2012, Bioorganic & medicinal chemistry letters.

The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis.

S. Gloor, J. Falke, R. Bass, 2007, Methods in enzymology.

Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.

Y. Ran, S. Gloor, J. Rudolph, 2012, Bioorganic & medicinal chemistry letters.