G. Vigers

发表

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

M. Belvin, S. Seshagiri, B. Jaiswal, 2010, Nature.

Fluorescent microtubules break up under illumination

J. McIntosh, G. Vigers, M. Coué, 1988, The Journal of cell biology.

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.

E. Laird, S. Gloor, G. Vigers, 2014, Bioorganic & medicinal chemistry letters.

Regulation of nuclear envelope precursor functions during cell division.

G. Vigers, M. Lohka, 1992, Journal of cell science.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

J. Blake, J. Christensen, B. Brandhuber, 2018, ACS medicinal chemistry letters.

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Jun Liang, J. Blake, B. Brandhuber, 2012, Journal of medicinal chemistry.

Characterization of the microtubule movement produced by sea urchin egg kinesin.

J. McIntosh, D. Stemple, M. Sheetz, 1987, Journal of Biological Chemistry.

A distinct vesicle population targets membranes and pore complexes to the nuclear envelope in Xenopus eggs

G. Vigers, M. Lohka, G P Vigers, 1991, The Journal of cell biology.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

J. Blake, J. Christensen, G. Vigers, 2020 .

Arrangement of protofilaments in two forms of tubulin crystal induced by vinblastine.

R. Henderson, L. Amos, G. Vigers, 1984, Journal of molecular biology.

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.

Tyler T. Risom, J. Blake, B. Brandhuber, 2010, Bioorganic & medicinal chemistry letters.

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution.

B. Brandhuber, G. Vigers, R. Thompson, 1995, The Journal of biological chemistry.

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.

E. Laird, B. Brandhuber, G. Vigers, 2011, Bioorganic & medicinal chemistry letters.

Non-oxime inhibitors of B-Raf(V600E) kinase.

E. Laird, B. Brandhuber, G. Vigers, 2011, Bioorganic & medicinal chemistry letters.

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.

Bin Wang, G. Vigers, S. Seiwert, 2014, Journal of medicinal chemistry.

Discovery and SAR of spirochromane Akt inhibitors.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

B. Brandhuber, G. Vigers, W. Voegtli, 2010, PloS one.

Non-oxime pyrazole based inhibitors of B-Raf kinase.

E. Laird, B. Brandhuber, G. Vigers, 2011, Bioorganic & medicinal chemistry letters.

Potent and selective pyrazole-based inhibitors of B-Raf kinase.

Mike Welch, E. Laird, B. Brandhuber, 2008, Bioorganic & medicinal chemistry letters.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1β

B. Brandhuber, G. Vigers, L. Anderson, 1997, Nature.

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor.

J. Blake, J. Christensen, J. Lawson, 2021, Journal of medicinal chemistry.

The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.

J. Fernandez-Banet, A. Pavlícek, J. Christensen, 2019, Cancer discovery.

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

B. Brandhuber, S. Gloor, G. Vigers, 2012, Science Signaling.

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

N. Ahn, J. Rudolph, G. Vigers, 2019, Proceedings of the National Academy of Sciences.

Three‐dimensional structure of clathrin cages in ice.

R A Crowther, R. Crowther, G. Vigers, 1986, The EMBO journal.

Location of the 100 kd‐50 kd accessory proteins in clathrin coats.

R. Crowther, G. Vigers, B. Pearse, 1986, The EMBO journal.

Abstract 5753: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

M. Belvin, S. Seshagiri, B. Jaiswal, 2010 .

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.

M. Volgraf, G. Vigers, Xingrong Liu, 2014, Bioorganic & medicinal chemistry letters.

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.

K. Scearce-Levie, G. Vigers, Xingrong Liu, 2014, Journal of medicinal chemistry.

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

K. Scearce-Levie, M. Volgraf, G. Vigers, 2014, Journal of medicinal chemistry.

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.

G. Vigers, Xingrong Liu, Darin J. Smith, 2013, Journal of medicinal chemistry.

X-ray Crystal Structure of a Small Antagonist Peptide Bound to Interleukin-1 Receptor Type 1*

D. Dripps, B. Brandhuber, G. Vigers, 2000, The Journal of Biological Chemistry.

Electron microscopy of frozen-hydrated biological material

G. Vigers, M. Stewart, Murray Stewart, 1986, Nature.

Multiple active site corrections for docking and virtual screening.

G. Vigers, Guy P A Vigers, James P Rizzi, 2004, Journal of medicinal chemistry.

Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

G. Vigers, Darin J. Smith, Weiru Wang, 2013 .

Discovery of pyrrolopyrimidine inhibitors of Akt.

Tyler T. Risom, S. Gross, J. Blake, 2010, Bioorganic & medicinal chemistry letters.

Potent selective nonpeptidic inhibitors of human lung tryptase.

B. Brandhuber, G. Vigers, M. Kashem, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.

A side-entry cold holder for cryo-electron microscopy.

R. Henderson, G. Vigers, C. Raeburn, 1991, Ultramicroscopy.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.

G. Vigers, J. Gaudino, Jennifer N. Otten, 2020, Journal of medicinal chemistry.

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

B. Brandhuber, S. Gloor, G. Vigers, 2012, Science Signaling.