J. Telliez

发表

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

LRDD, a novel leucine rich repeat and death domain containing protein.

J. Telliez, K. Bean, L. L. Lin, 2000, Biochimica et biophysica acta.

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.

Mark E Flanagan, J. D. Clark, J. Telliez, 2014, Journal of medicinal chemistry.

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

M. Gaestel, J. Arthur, J. Telliez, 2010, Nucleic acids research.

Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood*

K. Seidl, J. D. Clark, J. Telliez, 2007, Journal of Biological Chemistry.

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

J. Telliez, J. Cuozzo, Lih-Ling Lin, 2006, Bioorganic & medicinal chemistry letters.

Engagement of Tumor Necrosis Factor (TNF) Receptor 1 Leads to ATF-2- and p38 Mitogen-activated Protein Kinase-dependent TNF-α Gene Expression*

J. Telliez, B. Brinkman, L. L. Lin, 1999, The Journal of Biological Chemistry.

Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.

Y. Ni, R. Denny, J. Telliez, 2011, Bioorganic & medicinal chemistry letters.

Jak3 deficiency blocks innate lymphoid cell development

L. Notarangelo, Tyler K Ulland, M. Colonna, 2017, Mucosal Immunology.

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.

R. Everley, J. Telliez, Liang Xue, 2019, ACS chemical biology.

Regulatory elements in the first intron of the mouse ha‐ras gene

A. Balmain, J. Telliez, M. Plumb, 1995, Molecular carcinogenesis.

JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines.

J. Telliez, S. Danese, M. Grisham, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

J. Bauman, J. D. Clark, M. Hegen, 2016, ACS chemical biology.

The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.

J. D. Clark, J. Telliez, M. Dowty, 2016, Clinical and experimental rheumatology.

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

M. Hegen, J. Telliez, M. Dowty, 2019, Pharmacology research & perspectives.

Resistant to Collagen-Induced Arthritis MAPKAP Kinase 2-Deficient Mice Are

M. Gaestel, M. Hegen, J. Telliez, 2013 .

MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

M. Gaestel, M. Hegen, J. Telliez, 2006, The Journal of Immunology.

The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium

R. Buchsbaum, J. Telliez, L. Feig, 1996, Molecular and cellular biology.

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.

J. Telliez, Lih-Ling Lin, Junjun Wu, 2009, Bioorganic & medicinal chemistry letters.

Discovery of indazoles as inhibitors of Tpl2 kinase.

David R. Anderson, Y. Ni, R. Denny, 2011, Bioorganic & medicinal chemistry letters.

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.

J. Telliez, D. Powell, J. Cuozzo, 2007, Bioorganic & medicinal chemistry.

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

J. Telliez, A. Gopalsamy, G. Ciszewski, 2005, Bioorganic & medicinal chemistry letters.

Janus Kinase Inhibitors

J. Telliez, 2016 .

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Mark J. Mitton-Fry, J. D. Clark, M. Hegen, 2018, Journal of medicinal chemistry.

Therapeutic Drug Monitoring for Current and Investigational Inflammatory Bowel Disease Treatments

J. Telliez, E. Loftus, R. Shivashankar, 2020, Journal of clinical gastroenterology.

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis

J. Telliez, I. McInnes, D. Veale, 2018, Rheumatology.

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK (cid:1)

M. Gaestel, J. Telliez, O. Dittrich‐Breiholz, 2006 .

The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization.

T. Maurer, J. Telliez, M. Kuhn, 2020, Bioorganic & medicinal chemistry.

OP0147 Lack of Differentiation of Janus Kinase Inhibitors in Rheumatoid Arthritis Based on Janus Kinase Pharmacology and Clinically Meaningful Concentrations

J. Telliez, M. Dowty, J. Jussif, 2014 .

Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)

Alcino J. Silva, J. Telliez, K. Giese, 2001, Neuropharmacology.

Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp.

David E. Williams, R. Andersen, J. Telliez, 2004, Journal of natural products.

Structural analysis of the mouse c‐HA‐ras gene promoter

A. Balmain, J. Telliez, M. Plumb, 1991, Molecular carcinogenesis.

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

K. Parris, J. Telliez, F. Lovering, 2009, Bioorganic & medicinal chemistry.

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.

K. Parris, L. Mosyak, J. Telliez, 2003, Structure.

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

M. Gaestel, J. Telliez, O. Dittrich‐Breiholz, 2006, Molecular and Cellular Biology.

Distinct Cellular Functions of MK2

M. Gaestel, J. Telliez, K. Laass, 2002, Molecular and Cellular Biology.

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.

J. Bauman, J. Telliez, J. Chrencik, 2018, Journal of medicinal chemistry.

Phaeochromycins A-E, anti-inflammatory polyketides isolated from the soil actinomycete Streptomyces phaeochromogenes LL-P018.

J. Telliez, E. Graziani, V. Bernan, 2005, Journal of natural products.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Li Xing, Eddine Saiah, David Lin, 2018, Journal of medicinal chemistry.

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

M. Hegen, J. Telliez, J. Chrencik, 2017, Journal of medicinal chemistry.

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

D. Joseph-McCarthy, J. Telliez, J. Cuozzo, 2007, Journal of medicinal chemistry.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

ATP-mediated kinome selectivity: the missing link in understanding the contribution of individual JAK Kinase isoforms to cellular signaling.

J. Telliez, A. Thorarensen, A. Casimiro-Garcia, 2014, ACS chemical biology.

Mutational analysis and NMR studies of the death domain of the tumor necrosis factor receptor-1.

R. Powers, J. Telliez, S. Sukits, 2000, Journal of molecular biology.

Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.

D H Tsao, J. Telliez, D. Tsao, 2000, Molecular cell.

Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.

F. Bibollet-Ruche, J. Telliez, B. Wasylyk, 1992, Nucleic acids research.

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

G. S. Walker, J. Bauman, J. Telliez, 2022, Drug Metabolism and Disposition.

Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.

M. Bunnage, J. Telliez, Betsy S. Pierce, 2017, ACS chemical biology.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

Inhibition of T-cell activity in alopecia areata: recent developments and new directions

J. Telliez, M. Steinhoff, Desmond J. Tobin, 2023, Frontiers in immunology.