G. Drusano

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Population Pharmacokinetic Comparison and Pharmacodynamic Breakpoints of Ceftazidime in Cystic Fibrosis Patients and Healthy Volunteers

U. Holzgrabe, J. Bulitta, C. Landersdorfer, 2010, Antimicrobial Agents and Chemotherapy.

L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.

F. B. Davis, S. Mousa, P. Davis, 2009, American journal of physiology. Cell physiology.

Serum inhibitory and bactericidal activity against methicillin-resistant Staphylococcus aureus in volunteers receiving novobiocin and rifampin alone and in combination.

G. Drusano, H. Standiford, T. Walsh, 1993, Diagnostic microbiology and infectious disease.

Bactericidal activity of ciprofloxacin compared with that of cefotaxime in normal volunteers

G. Drusano, K. Plaisance, H. Standiford, 1987, Antimicrobial Agents and Chemotherapy.

Future Trends in Antimicrobial Chemotherapy: Expert Opinion on the 43rd ICAAC

A. P. Ball, J. Bartlett, L. Mandell, 2004, Journal of chemotherapy.

Efficacies of High-Dose Fluconazole plus Amphotericin B and High-Dose Fluconazole plus 5-Fluorocytosine versus Amphotericin B, Fluconazole, and 5-Fluorocytosine Monotherapies in Treatment of Experimental Endocarditis, Endophthalmitis, and Pyelonephritis Due to Candida albicans

Michael H. Miller, G. Drusano, A. Louie, 1999, Antimicrobial Agents and Chemotherapy.

Oseltamivir‐zanamivir combination therapy suppresses drug‐resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system

G. Drusano, Ashley N Brown, Camilly P Pires de Mello, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Antimicrobial Pharmacodynamics in Theory and Clinical Practice

G. Drusano, P. Ambrose, C. Nightingale, 2007 .

Pharmacodynamic profiling of cefepime in plasma and cerebrospinal fluid of hospitalized patients with external ventriculostomies.

V. Tam, G. Drusano, D. Rhoney, 2006, Diagnostic microbiology and infectious disease.

Optimizing antimicrobial pharmacodynamics: dosage strategies for meropenem.

G. Drusano, D. Nicolau, J. Kuti, 2004, Clinical therapeutics.

Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli

L. Cisneros, M. Levine, R. Black, 1981, Antimicrobial Agents and Chemotherapy.

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

G. Drusano, M. Salfinger, T. Gumbo, 2007, Antimicrobial Agents and Chemotherapy.

Explaining the Poor Bacteriologic Eradication Rate of Single-Dose Ceftriaxone in Group A Streptococcal Tonsillopharyngitis: A Reverse Engineering Solution Using Pharmacodynamic Modeling

E. Kaplan, G. Drusano, J. Blumer, 2005, Pediatrics.

Relationships between renal function and disposition of oral ciprofloxacin

G. Drusano, M. Weir, J. Leslie, 1988, Antimicrobial Agents and Chemotherapy.

Population Pharmacokinetics at Two Dose Levels and Pharmacodynamic Profiling of Flucloxacillin

U. Holzgrabe, C. Landersdorfer, G. Drusano, 2007, Antimicrobial Agents and Chemotherapy.

Penetration of Moxifloxacin into Bone Evaluated by Monte Carlo Simulation

U. Holzgrabe, C. Landersdorfer, M. Kinzig, 2009, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics-Pharmacodynamics of Gatifloxacin in a Lethal Murine Bacillus anthracis Inhalation Infection Model

G. Drusano, W. Craig, S. Bhavnani, 2007, Antimicrobial Agents and Chemotherapy.

Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Michael H. Miller, V. Tam, G. Drusano, 2006, Antimicrobial Agents and Chemotherapy.

Effects of sub-minimum inhibitory concentrations of ciprofloxacin on enteroaggregative Escherichia coli and the role of the surface protein dispersin.

G. Drusano, J. Nataro, J. Fowlkes, 2011, International journal of antimicrobial agents.

Role of pharmacokinetics in the outcome of infections

G. Drusano, 1988, Antimicrobial Agents and Chemotherapy.

Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β‑Lactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials

Brian T. Tsuji, R. Bonomo, G. Drusano, 2019, Antimicrobial Agents and Chemotherapy.

Appropriate antimicrobial treatment in nosocomial infections-the clinical challenges.

D. Paterson, G. Drusano, R. Masterton, 2003, The Journal of hospital infection.

Potential of imipenem as single-agent empiric antibiotic therapy of febrile neutropenic patients with cancer.

G. Drusano, D. Johnson, H. Standiford, 1985, The American journal of medicine.

Pharmacodynamics of cefepime in patients with Gram-negative infections.

V. Tam, G. Drusano, M. Rybak, 2002, The Journal of antimicrobial chemotherapy.

Pharmacokinetics and Pharmacodynamics of Cefepime in Patients with Various Degrees of Renal Function

V. Tam, G. Drusano, M. Rybak, 2003, Antimicrobial Agents and Chemotherapy.

Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia.

G. Drusano, J. Kahn, C. Fowler, 2004, The Journal of infectious diseases.

Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia

Ronald N. Jones, R. Wunderink, J. Rello, 2017, Antimicrobial Agents and Chemotherapy.

Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 1

G. Drusano, A. MacGowan, W. Hope, 2015, Antimicrobial Agents and Chemotherapy.

Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model.

G. Drusano, Dodge Baluya, R. Cirz, 2014, The Journal of infectious diseases.

Penetration of Vancomycin into Epithelial Lining Fluid in Healthy Volunteers

George L. Drusano, G. Drusano, K. Rodvold, 2011, Antimicrobial Agents and Chemotherapy.

Identifying Exposure Targets for Treatment of Staphylococcal Pneumonia with Ceftobiprole

G. Drusano, G. Noel, D. Nicolau, 2009, Antimicrobial Agents and Chemotherapy.

Relationship between initial vancomycin concentration-time profile and nephrotoxicity among hospitalized patients.

G. Drusano, K. Rodvold, B. Lomaestro, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)

J. Bilello, G. Drusano, D. Stein, 1996, AIDS.

Daptomycin: a novel agent for Gram-positive infections.

G. Drusano, M. Zeckel, F. Tally, 1999, Expert opinion on investigational drugs.

Comparative Pharmacokinetics and Pharmacodynamic Target Attainment of Ertapenem in Normal-Weight, Obese, and Extremely Obese Adults

G. Drusano, A. Nafziger, J. Bertino, 2006, Antimicrobial Agents and Chemotherapy.

Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growth.

G. Drusano, S. Bhavnani, P. Ambrose, 2007, The Journal of infectious diseases.

Isoniazid Bactericidal Activity and Resistance Emergence: Integrating Pharmacodynamics and Pharmacogenomics To Predict Efficacy in Different Ethnic Populations

G. Drusano, S. Bhavnani, P. Ambrose, 2007, Antimicrobial Agents and Chemotherapy.

The crisis of resistance: identifying drug exposures to suppress amplification of resistant mutant subpopulations.

G. Drusano, T. Gumbo, A. Louie, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

"One-two Punch": Synergistic β-lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes.

David C. Nguyen, S. Holland, R. Bonomo, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Tolerance and Pharmacokinetic Interactions of Rifabutin and Azithromycin

G. Drusano, S. Follansbee, L. Mole, 2001, Antimicrobial Agents and Chemotherapy.

2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases

R. Bonomo, G. Drusano, C. Banchio, 2021, Chemical science.

GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens

G. Drusano, H. Schweizer, Kelly L. Warfield, 2019, Antimicrobial Agents and Chemotherapy.

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

G. Drusano, K. Green, J. Bulitta, 2018, Antimicrobial Agents and Chemotherapy.

Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid

U. Holzgrabe, C. Landersdorfer, M. Kinzig, 2009, Antimicrobial Agents and Chemotherapy.

Determination of antibiotic dosage adjustments in patients with renal impairment: elements for success.

G. Drusano, M. Scheetz, N. Patel, 2010, The Journal of antimicrobial chemotherapy.

Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial

G. Drusano, F. Sörgel, S. Sakka, 2007, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of ceftaroline fosamil for complicated skin and skin structure infection: rationale for improved anti-methicillin-resistant Staphylococcus aureus activity.

G. Drusano, 2010, The Journal of antimicrobial chemotherapy.

Phenotypic Drug Susceptibility Assay for Influenza Virus Neuraminidase Inhibitors

G. Drusano, J. McSharry, Ann McDonough, 2004, Clinical Diagnostic Laboratory Immunology.

A 48-week duration of therapy with pegylated interferon alpha 2b plus ribavirin may be too short to maximize long-term response among patients infected with genotype-1 hepatitis C virus.

G. Drusano, S. Preston, 2004, The Journal of infectious diseases.

In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.

M. Unemo, M. Neely, G. Drusano, 2019, The Journal of antimicrobial chemotherapy.

Dosing Adjustment of 10 Antimicrobials for Patients with Renal Impairment

G. Drusano, G. Bailie, L. Briceland, 1995, The Annals of pharmacotherapy.

Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression

S. Rogers, W. Yamada, M. Neely, 2021, Antimicrobial Agents and Chemotherapy.

Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.

G. Drusano, H. Derendorf, K. Rand, 2019, International journal of antimicrobial agents.

Prevalence of drug-resistant and nonsubtype B HIV strains in antiretroviral-naïve, HIV-infected individuals in New York State.

Jill Taylor, G. Drusano, M. Parker, 2007, AIDS patient care and STDs.

High-Dose Continuous Infusion β-Lactam Antibiotics for the Treatment of Resistant Pseudomonas Aeruginosa Infections in Immunocompromised Patients

W. Wilson, S. Holland, G. Drusano, 2010, The Annals of pharmacotherapy.

Relevance of the Alexander Project: pharmacodynamic considerations.

G. Drusano, F. Goldstein, 1996, The Journal of antimicrobial chemotherapy.

Penetration of Meropenem into Epithelial Lining Fluid of Patients with Ventilator-Associated Pneumonia

M. Kinzig, F. Sorgel, G. Drusano, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic optimisation of β-lactams for the treatment of ventilator-associated pneumonia

G. Drusano, 2007, European Respiratory Review.

The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates.

G. Drusano, D. Benjamin, T. Walsh, 2008, The Journal of infectious diseases.

From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling.

G. Drusano, 2016, Bioorganic & medicinal chemistry.

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

G. Drusano, Ashley N Brown, Dodge Baluya, 2015, mBio.

Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents

G. Drusano, A. Eakin, A. Dane, 2019, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics of intravenous daptomycin during continuous ambulatory peritoneal dialysis.

G. Drusano, Katie E Cardone, H. Manley, 2011, Clinical journal of the American Society of Nephrology : CJASN.

In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae

G. Drusano, A. Louie, Weiguo Liu, 2007, Antimicrobial Agents and Chemotherapy.

Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation To Describe the Pharmacodynamic Profile of Cefditoren in Plasma and Epithelial Lining Fluid

G. Drusano, F. Sörgel, M. Hinder, 2007, Antimicrobial Agents and Chemotherapy.

Comparison of the probability of target attainment between ceftriaxone and cefepime in the cerebrospinal fluid and serum against Streptococcus pneumoniae.

Ronald N. Jones, M. Kinzig, G. Drusano, 2007, Diagnostic microbiology and infectious disease.

Treatment of Community-Acquired Respiratory Tract Infections with Penicillins and Cephalosporins

G. Drusano, S. Preston, 2003 .

Dosing Regimen Matters: the Importance of Early Intervention and Rapid Attainment of the Pharmacokinetic/Pharmacodynamic Target

G. Drusano, M. Papich, Marilyn N. Martinez, 2012, Antimicrobial Agents and Chemotherapy.

Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for Bacillus anthracis?

G. Drusano, F. Sörgel, A. Louie, 2008, Antimicrobial Agents and Chemotherapy.

A Model-Based PK/PD Antimicrobial Chemotherapy Drug Development Platform to Simultaneously Combat Infectious Diseases and Drug Resistance

G. Drusano, N. Jumbe, 2011 .

Human pharmacodynamics of beta-lactams, aminoglycosides and their combination.

G. Drusano, 1990, Scandinavian journal of infectious diseases. Supplementum.

Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

M. Unemo, F. Franceschi, G. Drusano, 2022, Frontiers in Pharmacology.

Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction.

M. Unemo, J. Hocking, G. Drusano, 2020, The Lancet. Infectious diseases.

Pharmacodynamics of Ceftazidime plus Avibactam against KPC-2-Bearing Isolates of Klebsiella pneumoniae in a Hollow Fiber Infection Model

G. Drusano, C. Clancy, M. Nguyen, 2019, Antimicrobial Agents and Chemotherapy.

Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?

W. Yamada, M. Neely, G. Drusano, 2020, Antimicrobial Agents and Chemotherapy.

Building Optimal Three-Drug Combination Chemotherapy Regimens

W. Yamada, M. Neely, G. Drusano, 2020, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae

R. Kolamunnage-Dona, G. Drusano, P. Knechtle, 2020, Antimicrobial Agents and Chemotherapy.

The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model

W. Yamada, M. Neely, G. Drusano, 2018, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of Fosfomycin: Insights into Clinical Use for Antimicrobial Resistance

G. Drusano, J. Rodríguez-Baño, Á. Pascual, 2015, Antimicrobial Agents and Chemotherapy.

Role of pharmacokinetics in the outcome of infections

G. Drusano, 1988, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic Evaluation of RWJ-270201, a Novel Neuraminidase Inhibitor, in a Lethal Murine Model of Influenza Predicts Efficacy for Once-Daily Dosing

D. Smee, K. Bush, G. Drusano, 2001, Antimicrobial Agents and Chemotherapy.

Saturability of Granulocyte Kill of Pseudomonas aeruginosa in a Murine Model of Pneumonia

G. Drusano, B. VanScoy, A. Louie, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic Studies of Fluconazole in Rabbits Characterizing Doses Which Achieve Peak Levels in Serum and Area under the Concentration-Time Curve Values Which Mimic Those of High-Dose Fluconazole in Humans

Michael H. Miller, G. Drusano, A. Louie, 1998, Antimicrobial Agents and Chemotherapy.

Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.

Ronald N. Jones, G. Drusano, J. Anon, 2008, Diagnostic microbiology and infectious disease.

Pharmacology Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis

Ronald N. Jones, G. Drusano, J. Anon, 2008 .

kinase and phosphatidylinositol 3-kinase proliferation: activation of mitogen-activated protein L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell

F. B. Davis, S. Mousa, G. Drusano, 2009 .

Infection Site Concentrations: Their Therapeutic Importance and the Macrolide and Macrolide‐Like Class of Antibiotics

G. Drusano, 2005, Pharmacotherapy.

Meropenem: clinical response in relation to in vitro susceptibility.

G. Drusano, H. Lode, J. R. Edwards, 2000, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype

W. Yamada, M. Neely, G. Drusano, 2022, Antimicrobial agents and chemotherapy.

The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance

V. Tam, G. Drusano, A. Louie, 2006, Antimicrobial Agents and Chemotherapy.

Differential Effects of Linezolid and Ciprofloxacin on Toxin Production by Bacillus anthracis in an In Vitro Pharmacodynamic System

G. Drusano, B. VanScoy, T. Abshire, 2011, Antimicrobial Agents and Chemotherapy.

Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efﬁcacies of Streptomycin and Levoﬂoxacin for Plague Therapy (cid:1)

G. Drusano, A. Louie, Weiguo Liu, 2007 .

Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response.

G. Drusano, H. Keyserling, C. Harro, 2003, Vaccine.

Evaluation of Imipenem for Prophylaxis and Therapy of Yersinia pestis Delivered by Aerosol in a Mouse Model of Pneumonic Plague

G. Drusano, F. Sörgel, S. Opal, 2014, Antimicrobial Agents and Chemotherapy.

A double beta-lactam combination versus an aminoglycoside-containing regimen as empiric antibiotic therapy for febrile granulocytopenic cancer patients.

J. Tenney, G. Drusano, R. Finley, 1986, The American journal of medicine.

Impact of Different Carbapenems and Regimens of Administration on Resistance Emergence for Three Isogenic Pseudomonas aeruginosa Strains with Differing Mechanisms of Resistance

Brian Van Scoy, K. Bush, G. Drusano, 2010, Antimicrobial Agents and Chemotherapy.

Emergence of resistance to imipenem in Pseudomonas aeruginosa

M. J. Lynch, G. Drusano, H. Mobley, 1987, Antimicrobial Agents and Chemotherapy.

Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity.

A. Heredia, R. Redfield, D. Margolis, 1999, Journal of acquired immune deficiency syndromes.

Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis.

G. Drusano, S. Bhavnani, P. Ambrose, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Emergence of resistance to carbapenem antibiotics in Pseudomonas aeruginosa.

G. Drusano, H. Standiford, B. Margaret, 1989, The Journal of antimicrobial chemotherapy.

A prospective randomized controlled trial of cefoxitin versus clindamycin-aminoglycoside in mixed anaerobic-aerobic infections.

J. Tenney, G. Drusano, A. Saah, 1982, Surgery, gynecology & obstetrics.

Soluble Tumor Necrosis Factor-α Receptor Type II (sTNFαRII) Correlates with Human Immunodeficiency Virus (HIV) RNA Copy Number in HIV-Infected Patients

J. Bilello, G. Drusano, K. Stellrecht, 1996 .

Soluble tumor necrosis factor-alpha receptor type II (sTNF alpha RII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients.

J. Bilello, G. Drusano, K. Stellrecht, 1996, The Journal of infectious diseases.

Population Pharmacokinetics of Micafungin in Pediatric Patients and Implications for Antifungal Dosing

A. Shad, G. Drusano, T. Walsh, 2007, Antimicrobial Agents and Chemotherapy.

Once-Weekly Micafungin Therapy Is as Effective as Daily Therapy for Disseminated Candidiasis in Mice with Persistent Neutropenia

G. Drusano, T. Gumbo, A. Louie, 2006, Antimicrobial Agents and Chemotherapy.

Effect of Neutropenia and Treatment Delay on the Response to Antifungal Agents in Experimental Disseminated Candidiasis

D. Denning, G. Drusano, T. Walsh, 2006, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and Absolute Bioavailability of Ribavirin in Healthy Volunteers as Determined by Stable-Isotope Methodology

P. McNamara, P. McNamara, G. Drusano, 1999, Antimicrobial Agents and Chemotherapy.

Population differences in ganciclovir clearance as determined by nonlinear mixed-effects modelling

G. Drusano, M. Jacobson, S. Follansbee, 1995, Antimicrobial agents and chemotherapy.

Use of Nonlinear, Mixed‐Effects Modeling for Population Analysis of Ofloxacin: Effects of Age on Oral Drug Pharmacokinetics

G. Drusano, J. Brooks, G. Yuen, 1992, Pharmacotherapy.

Commonly Used Methods of Estimating Creatinine Clearance Are Inadequate for Elderly Debilitated Nursing Home Patients

G. Drusano, H. Muncie, J. Warren, 1988, Journal of the American Geriatrics Society.

Pharmacokinetics of ceftazidime, alone or in combination with piperacillin or tobramycin, in the sera of cancer patients

G. Drusano, J. Leslie, H. Standiford, 1985, Antimicrobial Agents and Chemotherapy.

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

V. Tam, G. Drusano, A. Eakin, 2019, Antimicrobial Agents and Chemotherapy.

Impact of bioavailability on determination of the maximal tolerated dose of 2',3'-dideoxyinosine in phase I trials

J. Lambert, G. Drusano, F. Valentine, 1992, Antimicrobial Agents and Chemotherapy.

Relationship between Dideoxyinosine Exposure, CD4 Counts, and p24 Antigen Levels in Human Immunodeficiency Virus Infection

J. Lambert, G. Drusano, F. Valentine, 1992, Annals of Internal Medicine.

Population pharmacokinetic modeling and Monte Carlo simulation of varying doses of intravenous metronidazole.

G. Drusano, J. Rotschafer, L. Danziger, 2006, Diagnostic microbiology and infectious disease.

Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate.

G. Drusano, T. Lodise, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Evaluation of new anti-infective drugs for the treatment of infective endocarditis. Infectious Diseases Society of America and the Food and Drug Administration.

A. Bisno, G. Drusano, D. Gilbert, 1992, Clinical Infectious Diseases.

Rational design of a new antibiotic class for drug-resistant infections

S. McLeod, A. Ferguson, G. Drusano, 2021, Nature.

Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia

G. Drusano, S. Leone, S. Esposito, 2009, European Respiratory Journal.

Reply to Wallis et al. and Mitchison et al.

G. Drusano, T. Gumbo, 2007 .

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

G. Drusano, T. Gumbo, A. Louie, 2005, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic Considerations and Efficacy of Levofloxacin in an Inhalational Anthrax (Postexposure) Rhesus Monkey Model

K. Bush, G. Drusano, S. Chien, 2006, Antimicrobial Agents and Chemotherapy.

Comparative Pharmacokinetics and Renal Effects of Cyclosporin A and Cyclosporin G in Renal Allograft Recipients

S. Gruber, G. Drusano, D. Conti, 1997, Journal of clinical pharmacology.

Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy

J. Bilello, G. Drusano, H. Standiford, 1994, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation.

M. Kinzig, G. Drusano, F. Sörgel, 2007, The Journal of antimicrobial chemotherapy.

Population Pharmacokinetic Comparison and Pharmacodynamic Breakpoints of 1

U. Holzgrabe, J. Bulitta, C. Landersdorfer, 2010 .

Integration of selected pharmacologic and microbiologic properties of three new beta-lactam antibiotics: a hypothesis for rational comparison.

G. Drusano, H. Standiford, S. Schimpff, 1984, Reviews of infectious diseases.

Pharmacokinetics and pharmacodynamics of fluoroquinolones.

O. Cars, G. Drusano, F. Sörgel, 1998, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Individualized Patient Care Through Model-Informed Precision Dosing: Reflections on Training Future Practitioners

R. Jelliffe, G. Drusano, Marilyn N. Martinez, 2022, The AAPS Journal.

Use of Pharmacokinetic and Pharmacodynamic Principles To Determine Optimal Administration of Daptomycin in Patients Receiving Standardized Thrice-Weekly Hemodialysis

G. Drusano, Katie E Cardone, H. Manley, 2011, Antimicrobial Agents and Chemotherapy.

Antiviral Pharmacodynamics in Hollow Fibre Bioreactors

G. Drusano, J. McSharry, 2011, Antiviral chemistry & chemotherapy.

Back to the future: using aminoglycosides again and how to dose them optimally.

G. Drusano, S. Bhavnani, P. Ambrose, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Susceptibilities of Human Cytomegalovirus Clinical Isolates to BAY38-4766, BAY43-9695, and Ganciclovir

G. Drusano, S. Hallenberger, J. McSharry, 2001, Antimicrobial Agents and Chemotherapy.

Infection in the intensive care unit: beta-lactamase-mediated resistance among Enterobacteriaceae and optimal antimicrobial dosing.

G. Drusano, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Evaluation by Monte Carlo Simulation of the Pharmacokinetics of Two Doses of Meropenem Administered Intermittently or as a Continuous Infusion in Healthy Volunteers

U. Holzgrabe, C. Landersdorfer, G. Drusano, 2005, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic-pharmacodynamic considerations in the design of hospital-acquired or ventilator-associated bacterial pneumonia studies: look before you leap!

G. Drusano, S. Bhavnani, P. Ambrose, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Multiple‐dose ciprofloxacin dose ranging and kinetics

G. Drusano, B. Painter, M. A. González, 1985, Clinical pharmacology and therapeutics.

Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System

G. Drusano, M. Deziel, J. McSharry, 2008, Antimicrobial Agents and Chemotherapy.

Measurement of amikacin in serum by a latex agglutination inhibition test

R. Khabbaz, G. Drusano, H. Standiford, 1985, Journal of clinical microbiology.

Rational Dose Selection for a Nonnucleoside Reverse Transcriptase Inhibitor through Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation

G. Drusano, W. Prince, J. Kleim, 2002, Antimicrobial Agents and Chemotherapy.

Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy.

A. Francesconi, G. Drusano, J. Wingard, 2007, The Journal of infectious diseases.

Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside.

G. Drusano, W. Hope, W. Hope, 2009, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Vancomycin Area Under the Curve-Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First.

G. Drusano, T. Lodise, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Saving lives with optimal antimicrobial chemotherapy.

G. Drusano, T. Lodise, 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Lack of interference with creatinine assays by four cephalosporin-like antibiotics.

G. Drusano, M. Kroll, J. Warren, 1984, American journal of clinical pathology.

Bacterial Pathogens for the 1990s: A Case for New Drug Development

G. Drusano, 1992 .

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

Michael N Neely, Jason A Roberts, Jerome J. Schentag, 2014, The Lancet. Infectious diseases.

Pharmacodynamics of Caspofungin in a Murine Model of Systemic Candidiasis: Importance of Persistence of Caspofungin in Tissues to Understanding Drug Activity

George L. Drusano, Arnold Louie, G. Drusano, 2005, Antimicrobial Agents and Chemotherapy.

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.

O. Cars, G. Drusano, H. Derendorf, 2005, The Journal of antimicrobial chemotherapy.

Pharmacodynamics of Fluconazole in a Murine Model of Systemic Candidiasis

Michael H. Miller, George L. Drusano, Arnold Louie, 1998, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics for antifungal drug development: an approach for acceleration, risk minimization and demonstration of causality.

G. Drusano, J. Rex, W. Hope, 2016, The Journal of antimicrobial chemotherapy.

How many steps along the path is too far?

G. Drusano, 2010, Clinical Infectious Diseases.

Derivation of an In Vivo Drug Exposure Breakpoint for Flucytosine against Candida albicans and Impact of the MIC, Growth Rate, and Resistance Genotype on the Antifungal Effect

David W. Denning, Miki Kasai, Thomas J. Walsh, 2006, Antimicrobial Agents and Chemotherapy.

How does a patient maximally benefit from anti-infective chemotherapy?

G. Drusano, 2004, Clinical Infectious Diseases.

Multiple-dose pharmacokinetics of imipenem-cilastatin

G. Drusano, J. Leslie, H. Standiford, 1984, Antimicrobial Agents and Chemotherapy.

Effect of saturable clearance during high-dose mezlocillin therapy

G. Drusano, A. Forrest, F. Auger, 1984, Antimicrobial Agents and Chemotherapy.

Cefoxitin falsely elevates creatinine levels.

G. Drusano, A. Saah, T. Koch, 1982, JAMA.

Modeling amantadine treatment of influenza A virus in vitro.

Ruy M Ribeiro, Alan S Perelson, A. Perelson, 2008, Journal of theoretical biology.

Prediction of the Pharmacodynamically Linked Variable of Oseltamivir Carboxylate for Influenza A Virus Using an In Vitro Hollow-Fiber Infection Model System

G. Drusano, Ashley N Brown, R. Kulawy, 2009, Antimicrobial Agents and Chemotherapy.

Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.

D. Margolis, G. Drusano, M. Hossain, 2002, Antiviral research.

The plasma pharmacokinetics of high dose (1 g) imipenem coadministered with 1 g cilastatin in six normal volunteers

G. Drusano, H. Standiford, A. Forrest, 1984, European Journal of Clinical Microbiology.

Meropenem: laboratory and clinical data.

G. Drusano, 1997, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Pharmacokinetic profile of imipenem/cilastatin in normal volunteers.

G. Drusano, H. Standiford, Harold C. Standiford, 1985, The American journal of medicine.

Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers

G. Drusano, J. Leslie, H. Standiford, 1986, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic and pharmacokinetic considerations in antimicrobial selection: focus on telithromycin.

G. Drusano, 2001, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Telavancin Penetration into Human Epithelial Lining Fluid Determined by Population Pharmacokinetic Modeling and Monte Carlo Simulation

G. Drusano, S. Barriere, M. Gotfried, 2008, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials.

G L Drusano, G. Drusano, A. Chow, 1998, JAMA.

Frequentist and Bayesian Pharmacometric-Based Approaches To Facilitate Critically Needed New Antibiotic Development: Overcoming Lies, Damn Lies, and Statistics

Paul G. Ambrose, George L. Drusano, G. Drusano, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it's not just for mice anymore.

Alan Forrest, Arnold Louie, G. Drusano, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'

George L. Drusano, G. Drusano, 2004, Nature Reviews Microbiology.

Synergism of the combinations of imipenem plus ciprofloxacin and imipenem plus amikacin against Pseudomonas aeruginosa and other bacterial pathogens

G. Drusano, J. Wade, C. Bustamante, 1987, Antimicrobial Agents and Chemotherapy.

Interaction between Fluconazole and Amphotericin B in Mice with Systemic Infection Due to Fluconazole-Susceptible or -Resistant Strains of Candida albicans

Michael H. Miller, G. Drusano, M. Shayegani, 1999, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of ofloxacin in serum and vitreous humor of albino and pigmented rabbits

G. Drusano, A. Madu, M. Mayers, 1995, Antimicrobial agents and chemotherapy.

Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis.

B. Keevil, D. Denning, G. Drusano, 2005, The Journal of infectious diseases.

Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program

G. Drusano, A. Madu, M. Mayers, 1995, Antimicrobial agents and chemotherapy.

Model of Systemic Candidiasis Pharmacodynamics of Fluconazole in a Murine

Michael H. Miller, G. Drusano, H. Taber, 2013 .

A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study.

G L Drusano, S. Zolla-Pazner, P. Hartigan, 1992, The New England journal of medicine.

Effect of Carbon Dioxide and pH on Susceptibility of Bacteroides fragilis Group to Erythromycin

G. Drusano, S. L. Hansen, Patricia Swomley, 1981, Antimicrobial Agents and Chemotherapy.

Postantibiotic effect of imipenem on Pseudomonas aeruginosa

G. Drusano, H. Standiford, B. Tatem, 1984, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis

G. Drusano, D. Johnson, H. Standiford, 1993, Antimicrobial Agents and Chemotherapy.

The acylampicillins: mezlocillin, piperacillin, and azlocillin.

G. Drusano, W. Hewitt, S. Schimpff, 1984, Reviews of infectious diseases.

Quantifying the matrix of relationships between reduced vancomycin susceptibility phenotypes and outcomes among patients with MRSA bloodstream infections treated with vancomycin .

G. Drusano, L. Cosler, R. Jones, 2014, The Journal of antimicrobial chemotherapy.

Correlation of predicted serum bactericidal activities and values measured in volunteers

G. Drusano, H. Standiford, S. Schimpff, 1986, European Journal of Clinical Microbiology.

Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin.

G. Drusano, H. Standiford, S. Schimpff, 1985, The Journal of antimicrobial chemotherapy.

The serum bactericidal activity of latamoxef (moxalactam), cefoperazone and cefotaxime.

G. Drusano, H. Standiford, B. Tatem, 1984, The Journal of antimicrobial chemotherapy.

Comparison of the pharmacokinetics of ceftazidime and moxalactam and their microbiological correlates in volunteers

G. Drusano, J. Leslie, H. Standiford, 1984, Antimicrobial Agents and Chemotherapy.

Bactericidal activity of ceftazidime in serum compared with that of ticarcillin combined with amikacin

G. Drusano, H. Standiford, S. Schimpff, 1984, Antimicrobial Agents and Chemotherapy.

Comparative pharmacokinetics of moxalactam, cefoperazone, and cefotaxime in normal volunteers.

G. Drusano, H. Standiford, S. Schimpff, 1982, Reviews of infectious diseases.

Identification of Optimal Renal Dosage Adjustments for Traditional and Extended-Infusion Piperacillin-Tazobactam Dosing Regimens in Hospitalized Patients

G. Drusano, M. Scheetz, N. Patel, 2009, Antimicrobial Agents and Chemotherapy.

Absolute oral bioavailability of ciprofloxacin

G. Drusano, J. Caldwell, J. Leslie, 1986, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate

G. Drusano, K. Plaisance, H. Standiford, 1989, Antimicrobial Agents and Chemotherapy.

Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers

U. Holzgrabe, J. Bulitta, G. Drusano, 2007, Antimicrobial Agents and Chemotherapy.

Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective.

Stephan Harbarth, Johan W Mouton, John Turnidge, 2011, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Pharmacodynamics of Daptomycin in a Murine Thigh Model of Staphylococcus aureus Infection

Michael H. Miller, George L. Drusano, Arnold Louie, 2001, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics of antimicrobials.

G. Drusano, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

Michael H. Miller, G. Drusano, A. Madu, 1998, Antimicrobial Agents and Chemotherapy.

Population pharmacokinetics of micafungin in adult patients.

G. Drusano, J. Keirns, T. Gumbo, 2008, Diagnostic microbiology and infectious disease.

Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis

George L. Drusano, Arnold Louie, G. Drusano, 2006, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics: optimal antimicrobial therapy in the intensive care unit.

G. Drusano, T. Lodise, 2011, Critical care clinics.

Optimizing Aminoglycoside Therapy for Nosocomial Pneumonia Caused by Gram-Negative Bacteria

G. Drusano, A. Kashuba, A. Nafziger, 1999, Antimicrobial Agents and Chemotherapy.

Optimization of the Dosage of Flucytosine in Combination with Amphotericin B for Disseminated Candidiasis: a Pharmacodynamic Rationale for Reduced Dosing

B. Keevil, D. Denning, G. Drusano, 2007, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic Evaluation of the Activities of Six Parenteral Vancomycin Products Available in the United States

Vikram Patel, G. Drusano, Dodge Baluya, 2014, Antimicrobial Agents and Chemotherapy.

2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode.

R. Bonomo, G. Drusano, C. Banchio, 2021, ACS infectious diseases.

Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 2

G. Drusano, A. MacGowan, W. Hope, 2015, Antimicrobial Agents and Chemotherapy.

Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST)

Ronald N. Jones, G. Drusano, D. Andes, 2019, Antimicrobial Agents and Chemotherapy.

Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis

A. Schumitzky, G. Drusano, C. Peloquin, 2014, PloS one.

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.

Robert Leary, Michael H. Miller, Arnold Louie, 2003, The Journal of clinical investigation.

Integration of Population Pharmacokinetics, a Pharmacodynamic Target, and Microbiologic Surveillance Data to Generate a Rational Empiric Dosing Strategy for Cefepime against Pseudomonas aeruginosa

G. Drusano, A. Louie, B. Lomaestro, 2003, Pharmacotherapy.

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing?

Roger W. Jelliffe, George L. Drusano, R. Jelliffe, 2013, Antimicrobial Agents and Chemotherapy.

In Vitro System for Modeling Influenza A Virus Resistance under Drug Pressure

D. Engelthaler, P. Keim, G. Drusano, 2010, Antimicrobial Agents and Chemotherapy.

Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling

Brian T. Tsuji, Nirav R. Shah, R. Bonomo, 2021, Clinical pharmacology and therapeutics.

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

R. Bonomo, G. Drusano, H. Schweizer, 2020, mBio.

What are the properties that make an antibiotic acceptable for therapy of community-acquired pneumonia?

G. Drusano, 2011, The Journal of antimicrobial chemotherapy.

The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of Mycobacterium tuberculosis as Determined in a Hollow-Fiber Infection Model

G. Drusano, A. Louie, R. Kulawy, 2010, mBio.

Determination of the Dynamically Linked Indices of Fosfomycin for Pseudomonas aeruginosa in the Hollow Fiber Infection Model

G. Drusano, A. Louie, Michael Vicchiarelli, 2018, Antimicrobial Agents and Chemotherapy.

Vancomycin: we can't get there from here.

G. Drusano, K. Rodvold, M. Pai, 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A Population Pharmacokinetic Analysis of the Penetration of the Prostate by Levofloxacin

G. Drusano, J. Kahn, M. Oefelein, 2000, Antimicrobial Agents and Chemotherapy.

Practical Application of Pharmacodynamic Principles to Optimize Therapy and Treat Resistant Organisms: A Focus on Beta-Lactam Antibiotics

G. Drusano, B. Lomaestro, T. Lodise, 2007 .

Application of Antimicrobial Pharmacodynamic Concepts into Clinical Practice: Focus on β‐Lactam Antibiotics

G. Drusano, B. Lomaestro, T. Lodise, 2006 .

Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on beta-lactam antibiotics: insights from the Society of Infectious Diseases Pharmacists.

G. Drusano, B. Lomaestro, T. Lodise, 2006, Pharmacotherapy.

Use of Preclinical Data for Selection of a Phase II/III Dose for Evernimicin and Identification of a Preclinical MIC Breakpoint

G. Drusano, W. Craig, D. Andes, 2001, Antimicrobial Agents and Chemotherapy.

Fluoroquinolone pharmacodynamics. Authors' reply

Jerome J. Schentag, G. Drusano, R. Owens, 2001 .

Evaluation of Daptomycin Exposure and Efficacy and Safety Endpoints To Support Risk-versus-Benefit Considerations

G. Drusano, S. Bhavnani, P. Ambrose, 2015, Antimicrobial Agents and Chemotherapy.

Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis

A. Oliver, C. Landersdorfer, G. Drusano, 2018, Clinical Pharmacokinetics.

Population pharmacokinetics of zidovudine

Harold C. Standiford, George L. Drusano, Merrill J. Egorin, 1990 .

Preclinical evaluation of antiviral activity and toxicity of Abbott A77003, an inhibitor of the human immunodeficiency virus type 1 protease

J. Bilello, G. Drusano, G. Bauer, 1993, Antimicrobial Agents and Chemotherapy.

Quantitative relationships between zidovudine exposure and efficacy and toxicity

G. Drusano, F. Balis, P. Pizzo, 1994, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics and clinical use of anti-HIV drugs.

G. Drusano, P. Piliero, S. Preston, 2003, Infectious disease clinics of North America.

Methodological features of clinical pharmacokinetic-pharmacodynamic studies of antibacterials and antifungals: a systematic review.

J. Higgins, G. Drusano, A. MacGowan, 2020, The Journal of antimicrobial chemotherapy.

Prospective Evaluation of the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity

G. Drusano, S. Lerner, M. Rybak, 1999, Antimicrobial Agents and Chemotherapy.

Effect of dose size on bioavailability of ciprofloxacin

G. Drusano, K. Plaisance, H. Standiford, 1987, Antimicrobial Agents and Chemotherapy.

Dose ranging study and constant infusion evaluation of ciprofloxacin

G. Drusano, K. Plaisance, H. Standiford, 1986, Antimicrobial Agents and Chemotherapy.

Steady-state pharmacokinetics of imipenem in febrile neutropenic cancer patients

G. Drusano, K. Plaisance, H. Standiford, 1987, Antimicrobial Agents and Chemotherapy.

Efficacy of ciprofloxacin in the treatment of chronic typhoid carriers.

M. Levine, J. Morris, G. Drusano, 1988, The Journal of infectious diseases.

In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents

J. Morris, J. Tenney, G. Drusano, 1985, Antimicrobial Agents and Chemotherapy.

InVitro Susceptibility ofPathogenic Vibrio Species toNorfloxacin andSixOtherAntimicrobial Agents

J. Morris, J. Tenney, G. Drusano, 1985 .

Multiple-dose pharmacokinetics of ciprofloxacin administered intravenously to normal volunteers

G. Drusano, A. Forrest, B. Painter, 1985, Antimicrobial Agents and Chemotherapy.

Relationship between foscarnet exposure, baseline cytomegalovirus (CMV) blood culture and the time to progression of CMV retinitis in HIV‐positive patients

M. Polis, G. Drusano, M. Jacobson, 1996, AIDS.

Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System

J. Bilello, G. Drusano, W. Symonds, 2002, Antimicrobial Agents and Chemotherapy.

The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic

J. Bilello, O. Weislow, G. Drusano, 2000, Antimicrobial Agents and Chemotherapy.

Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein.

J. Bilello, G. Drusano, T. Robins, 1995, The Journal of infectious diseases.

The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial.

J. Bilello, G. Drusano, K. Melbourne, 1999, The Journal of infectious diseases.

The pharmacokinetics of meropenem.

G. Drusano, M. Hutchison, 1995, Scandinavian journal of infectious diseases. Supplementum.

Moxalactam and piperacillin: A study of in vitro characteristics and pharmacokinetics in cancer patients

G. Drusano, S. Schimpff, M. Moody, 2005, Infection.

Pharmacodynamics of Antiretroviral Chemotherapy

G. Drusano, 1993, Infection Control & Hospital Epidemiology.

Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulation: CME REVIEW ARTICLE

G. Drusano, M. Dudley, J. Bradley, 2003, The Pediatric infectious disease journal.

Rapid Ganciclovir Susceptibility Assay Using Flow Cytometry for Human Cytomegalovirus Clinical Isolates

C. Crumpacker, G. Drusano, H. Shapiro, 1998, Antimicrobial Agents and Chemotherapy.

Flow Cytometric Determination of Ganciclovir Susceptibilities of Human Cytomegalovirus Clinical Isolates

C. Crumpacker, G. Drusano, N. Lurain, 1998, Journal of Clinical Microbiology.

Pre‐clinical in vitro infection models

G. Drusano, 2017, Current opinion in pharmacology.

Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System

David Brown, Sharon Lin, Shaker A. Mousa, 2011, PLoS Comput. Biol..

Activities of Ceftazidime and Avibactam against β-Lactamase-Producing Enterobacteriaceae in a Hollow-Fiber Pharmacodynamic Model

G. Drusano, A. Girard, D. Shlaes, 2014, Antimicrobial Agents and Chemotherapy.

A prospective evaluation of optimal sampling theory in the determination of the steady‐state pharmacokinetics of piperacillin in febrile neutropenic cancer patients

A Forrest, G L Drusano, G. Drusano, 1989, Clinical pharmacology and therapeutics.

Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

J. Bilello, G. Drusano, M. Rogers, 2000, Antimicrobial Agents and Chemotherapy.

Prevention of resistance: a goal for dose selection for antimicrobial agents.

G L Drusano, G. Drusano, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Ertapenem Pharmacokinetics and Pharmacodynamics during Continuous Ambulatory Peritoneal Dialysis

G. Drusano, Katie E Cardone, D. Grabe, 2011, Antimicrobial Agents and Chemotherapy.

Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation

G. Drusano, J. Korth-Bradley, S. Bhavnani, 2007, Antimicrobial Agents and Chemotherapy.

Mathematical Modeling of the Interrelationship of CD4 Lymphocyte Count and Viral Load Changes Induced by the Protease Inhibitor Indinavir

G. Drusano, D. Stein, 1998, Antimicrobial Agents and Chemotherapy.

Zanamivir, at 600 Milligrams Twice Daily, Inhibits Oseltamivir-Resistant 2009 Pandemic H1N1 Influenza Virus in an In Vitro Hollow-Fiber Infection Model System

G. Drusano, Ashley N Brown, Jonathan R. Adams, 2011, Antimicrobial Agents and Chemotherapy.

The Combination of Meropenem and Levofloxacin Is Synergistic with Respect to both Pseudomonas aeruginosa Kill Rate and Resistance Suppression

Brian Van Scoy, G. Drusano, A. Louie, 2010, Antimicrobial Agents and Chemotherapy.

Sex differences in CYP3A activity using intravenous and oral midazolam

G. Drusano, A. Nafziger, J. Bertino, 2006, Clinical pharmacology and therapeutics.

Pharmacometrics of Viral Infections

G. Drusano, Ashley N Brown, Ashley N. Brown, 2014 .

Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection.

G. Drusano, C. Inderlied, R. Hafner, 1999, The Journal of infectious diseases.

Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases

Ronald N. Jones, M. Castanheira, G. Drusano, 2011, Antimicrobial Agents and Chemotherapy.

Bacterial-population responses to drug-selective pressure: examination of garenoxacin's effect on Pseudomonas aeruginosa.

Robert Leary, Arnold Louie, Vincent H Tam, 2005, The Journal of infectious diseases.

Tolerance and Pharmacokinetic Interactions of Rifabutin and Clarithromycin in Human Immunodeficiency Virus-Infected Volunteers

G. Drusano, B. Landry, S. Follansbee, 1998, Antimicrobial Agents and Chemotherapy.

Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy

G. Drusano, A. Louie, Weiguo Liu, 2007, Antimicrobial Agents and Chemotherapy.

Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.

Max Salfinger, Arnold Louie, G. Drusano, 2004, The Journal of infectious diseases.

Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacodynamic variable.

J. Bilello, G. Drusano, R. Echols, 2001, The Journal of infectious diseases.

Effect of 2',3'-didehydro-3'-deoxythymidine in an in vitro hollow-fiber pharmacodynamic model system correlates with results of dose-ranging clinical studies

J A Bilello, G L Drusano, J. Bilello, 1994, Antimicrobial Agents and Chemotherapy.

Population Pharmacokinetics of Extended-Infusion Piperacillin-Tazobactam in Hospitalized Patients with Nosocomial Infections

G. Drusano, W. Hope, A. Kwa, 2012, Antimicrobial Agents and Chemotherapy.

Patients with Nosocomial Infections 2

G. Drusano, W. Hope, T. Felton, 2012 .

Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment: Report of a Veterans Affairs Cooperative Study

P. Hartigan, W. O'brien, G. Drusano, 1996 .

Chikungunya Virus: In Vitro Response to Combination Therapy With Ribavirin and Interferon Alfa 2a.

G. Drusano, Ashley N Brown, K. Gallegos, 2016, The Journal of infectious diseases.

Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa.

G. Sutton, D. Fouts, R. Bonomo, 2019, The Journal of infectious diseases.

Antiviral Effects of Clinically-Relevant Interferon-α and Ribavirin Regimens against Dengue Virus in the Hollow Fiber Infection Model (HFIM)

G. Drusano, Ashley N Brown, A. Kaushik, 2018, Viruses.

Pharmacokinetic Determinants of Virological Response to Raltegravir in the In Vitro Pharmacodynamic Hollow-Fiber Infection Model System

G. Drusano, Ashley N Brown, Dodge Baluya, 2015, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic Analysis of a Serine Protease Inhibitor, MK-4519, against Hepatitis C Virus Using a Novel In Vitro Pharmacodynamic System

D. Hazuda, G. Drusano, Ashley N Brown, 2011, Antimicrobial Agents and Chemotherapy.

False elevation in serum creatinine levels.

G. Drusano, D. Herrington, H. Standiford, 1984, JAMA.

Prospective use of optimal sampling theory: Steady‐state ciprofloxacin pharmacokinetics in critically ill trauma patients

A Forrest, G L Drusano, G. Drusano, 1989, Clinical pharmacology and therapeutics.

Pharmacodynamic Evaluation of Extending the Administration Time of Meropenem using a Monte Carlo Simulation

G. Drusano, G. L. Drusano, Ben M. Lomaestro, 2005, Antimicrobial Agents and Chemotherapy.

Optimization of Aminoglycoside Therapy

G. Drusano, A. Louie, 2011, Antimicrobial Agents and Chemotherapy.

Impact of Burden on Granulocyte Clearance of Bacteria in a Mouse Thigh Infection Model

G. Drusano, A. Louie, Weiguo Liu, 2010, Antimicrobial Agents and Chemotherapy.

Impact of short-course quinolone therapy on susceptible and resistant populations of Staphylococcus aureus.

L. Rice, G. Drusano, A. Louie, 2009, The Journal of infectious diseases.

Erratum: Pharmacokinetics-pharmacodynamics of antimicrobial therapy: It's not just for mice anymore (Clinical Infectious Diseases (2007) 44, (79-86))

Alan Forrest, Paul G. Ambrose, George L. Drusano, 2007 .

Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy.

G. Drusano, B. Lomaestro, T. Lodise, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease

J. Leonard, J. Bilello, D. Norbeck, 1996, Antimicrobial agents and chemotherapy.

Steady-state serum pharmacokinetics of novobiocin and rifampin alone and in combination

G. Drusano, E. Antal, H. Standiford, 1986, Antimicrobial Agents and Chemotherapy.

Genes and spectrum : The theoretical limits. Discussion

J. Quinn, I. Phillips, F. Baquero, 1998 .

Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis.

G. Drusano, Y. Tanigawara, K. Sunakawa, 2019, International journal of antimicrobial agents.

Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections

M. Unemo, F. Franceschi, G. Drusano, 2022, Frontiers in Pharmacology.

Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

M. Unemo, F. Franceschi, G. Drusano, 2021, Frontiers in Pharmacology.

Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea - challenges and opportunities.

M. Unemo, F. Franceschi, G. Drusano, 2020, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Development of New Antimicrobials for Urogenital Gonorrhea Therapy: Clinical Trial Design Considerations.

H. Handsfield, C. Deal, G. Drusano, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Meropenem Pharmacokinetics in the Newborn

F. Sorgel, G. Drusano, J. N. van den Anker, 2009, Antimicrobial Agents and Chemotherapy.

Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation

J. Bilello, G. Drusano, P. Bilello, 1996, Antimicrobial agents and chemotherapy.

Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.

U. Holzgrabe, C. Landersdorfer, M. Kinzig, 2009, Diagnostic microbiology and infectious disease.

Soluble Tumor Necrosis Factor-a Receptor Type II ( sTNFaRII ) Correlates with Human Immunodeficiency Virus ( HIV ) RNA Copy Number in HIV-Infected Patients

J. Bilello, G. Drusano, K. Stellrecht, 2010 .

Population Pharmacokinetics of Piperacillin at Two Dose Levels: Influence of Nonlinear Pharmacokinetics on the Pharmacodynamic Profile

U. Holzgrabe, C. Landersdorfer, M. Kinzig, 2012, Antimicrobial Agents and Chemotherapy.

Women and Children Postexposure Prophylaxis in Pregnant Efficacy of Amoxicillin for Anthrax and Mathematical Modeling To Predict the Hollow-Fiber Pharmacodynamic Studies

G. Drusano, B. VanScoy, A. Louie, 2014 .

Hollow-Fiber Pharmacodynamic Studies and Mathematical Modeling To Predict the Efficacy of Amoxicillin for Anthrax Postexposure Prophylaxis in Pregnant Women and Children

Robert Kulawy, Arnold Louie, G. Drusano, 2013, Antimicrobial Agents and Chemotherapy.

Probability of Target Attainment for Ceftobiprole as Derived from a Population Pharmacokinetic Analysis of 150 Subjects

K. Bush, G. Drusano, G. Noel, 2007, Antimicrobial Agents and Chemotherapy.

Emergence of resistance to ceftazidime-avibactam in a derepressed bla PDC producing Pseudomonas aeruginosa isolate in a Hollow Fiber Infection Model.

M. Adams, R. Bonomo, G. Drusano, 2021, Antimicrobial Agents and Chemotherapy.

Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone antimicrobial.

G L Drusano, R Leary, V H Tam, 2007, The Journal of infectious diseases.

Vancomycin exposure in patients with methicillin-resistant Staphylococcus aureus bloodstream infections: how much is enough?

G. Drusano, L. Cosler, L. McNutt, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Larger Vancomycin Doses (= 4 grams/day) are Associated with an Increased Incidence of

G. Drusano, B. Lomaestro, Lodise Tp, 2008 .

Characterization of enterococcal strains exhibiting a novel glycopeptide susceptibility pattern

G. Drusano, T. Walsh, R. Schwalbe, 1991 .

Levofloxacin Penetration into Epithelial Lining Fluid as Determined by Population Pharmacokinetic Modeling and Monte Carlo Simulation

G. Drusano, L. Danziger, K. Rodvold, 2002, Antimicrobial Agents and Chemotherapy.

Modeling of the change in CD4 lymphocyte counts in patients before and after administration of the human immunodeficiency virus protease inhibitor indinavir

G. Drusano, D. Stein, 1997, Antimicrobial agents and chemotherapy.

Evaluating the effect of clofazimine against Mycobacterium tuberculosis when given alone or in combination with pretomanid, bedaquiline or linezolid

W. Yamada, M. Neely, G. Drusano, 2021, International Journal of Antimicrobial Agents.

Serum bactericidal test in volunteers — A review

G. Drusano, H. Standiford, S. Schimpff, 1986, European Journal of Clinical Microbiology.

Evaluation of an antiseptic triple‐lumen catheter in an intensive care unit

R. Venezia, G. Drusano, Abigail V Veeder, 2000, Critical care medicine.

Pharmacodynamics of an 800-mg dose of telithromycin in patients with community-acquired pneumonia caused by extracellular pathogens.

G. Drusano, A. Bryskier, R. Nusrat, 2005, Diagnostic microbiology and infectious disease.

Improved micromethod for mezlocillin quantitation in serum and urine by high-pressure liquid chromatography

L. Lesko, G. Drusano, F. Auger, 1984, Antimicrobial Agents and Chemotherapy.

Meropenem Penetration into Epithelial Lining Fluid in Mice and Humans and Delineation of Exposure Targets

A. Oliver, G. Drusano, B. VanScoy, 2011, Antimicrobial Agents and Chemotherapy.

An overview of the pharmacology of intravenously administered ciprofloxacin.

G. Drusano, 1987, The American journal of medicine.

Impact of Different Factors on the Probability of Clinical Response in Tigecycline-Treated Patients with Intra-Abdominal Infections

G. Drusano, J. Korth-Bradley, S. Bhavnani, 2009, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics-Pharmacodynamics of Gatiﬂoxacin in a Lethal Murine Bacillus anthracis Inhalation Infection Model (cid:1)

G. Drusano, W. Craig, S. Bhavnani, 2007 .

In vivo activity of oritavancin in animal infection models and rationale for a new dosing regimen in humans.

G. Drusano, W. Craig, P. Ambrose, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Double-blind, prospective, multicenter trial comparing ceftazidime with moxalactam in the treatment of serious gram-negative infections

W. Anthony, J. Tenney, G. Drusano, 1986, Antimicrobial Agents and Chemotherapy.

Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

R. Bonomo, G. Drusano, B. Spellberg, 2023, Antimicrobial agents and chemotherapy.

Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase

S. Rogers, W. Yamada, M. Neely, 2021, Antimicrobial agents and chemotherapy.

Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model

M. Neely, G. Drusano, S. Schmidt, 2018, Antimicrobial Agents and Chemotherapy.

Effect of Administration of Moxifloxacin plus Rifampin against Mycobacterium tuberculosis for 7 of 7 Days versus 5 of 7 Days in an In Vitro Pharmacodynamic System

G. Drusano, A. Louie, R. Kulawy, 2011, mBio.

Natural history of Acinetobacter baumannii infection in mice

R. Bonomo, G. Drusano, B. Spellberg, 2019, PloS one.

Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis

K. Bush, G. Drusano, W. Byrne, 2005, Antimicrobial Agents and Chemotherapy.

Comparative Efficacies of Candidate Antibiotics against Yersinia pestis in an In Vitro Pharmacodynamic Model

G. Drusano, B. VanScoy, A. Louie, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacodynamics of Antivirals

G. Drusano, 2007 .

Pharmacokinetics-pharmacodynamics of quinolones against Streptococcus pneumoniae in patients with community-acquired pneumonia.

G. Drusano, S. Bhavnani, P. Ambrose, 2008, Diagnostic microbiology and infectious disease.

Levofloxacin Population Pharmacokinetics and Creation of a Demographic Model for Prediction of Individual Drug Clearance in Patients with Serious Community-Acquired Infection

G. Drusano, A. Chow, J. Natarajan, 1998, Antimicrobial Agents and Chemotherapy.

Introduction to Drug Interactions

G. Drusano, K. Gallicano, 2005 .

Impact of Spores on the Comparative Efficacies of Five Antibiotics for Treatment of Bacillus anthracis in an In Vitro Hollow Fiber Pharmacodynamic Model

George L. Drusano, Arnold Louie, G. Drusano, 2011, Antimicrobial Agents and Chemotherapy.

First Penicillin-Binding Protein Occupancy Patterns for 15 β-Lactams and β-Lactamase Inhibitors in Mycobacterium abscessus

Nirav R. Shah, G. Drusano, J. Bulitta, 2020, Antimicrobial Agents and Chemotherapy.

Searching for synergy: Identifying optimal antiviral combination therapy using Hepatitis C virus (HCV) agents in a replicon system.

G. Drusano, J. Rodriquez, Justin J Pomeroy, 2017, Antiviral research.

Ciprofloxacin pharmacokinetics in critically ill trauma patients.

G. Drusano, K. Plaisance, A. Forrest, 1989, The American journal of medicine.

Cefoxitin-resistant facultative or aerobic gram-negative bacilli in infections associated with the gastrointestinal tract.

J. Tenney, G. Drusano, A. Saah, 1981, Annals of internal medicine.

Why Molnupiravir Fails in Hospitalized Patients

G. Drusano, Yinzhi Lang, Jieqiang Zhou, 2022, mBio.

Efficacy of constant infusion of A-77003, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, in limiting acute HIV-1 infection in vitro

J. Leonard, J. Bilello, G. Drusano, 1995, Antimicrobial agents and chemotherapy.

Use of an In Vitro Pharmacodynamic Model To Derive a Moxifloxacin Regimen That Optimizes Kill of Yersinia pestis and Prevents Emergence of Resistance

G. Drusano, F. Sörgel, B. VanScoy, 2010, Antimicrobial Agents and Chemotherapy.

The case for precision dosing: medical conservatism does not justify inaction.

M. Neely, G. Drusano, K. Downes, 2021, The Journal of antimicrobial chemotherapy.

Human Pharmacodynamics of Anti-infectives: Determination from Clinical Trial Data

G. Drusano, 2007 .

Refining Vancomycin Protein Binding Estimates: Identification of Clinical Factors That Influence Protein Binding

Nimish Patel, George L. Drusano, G. Drusano, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacodynamic Profiling of Piperacillin in the Presence of Tazobactam in Patients through the Use of Population Pharmacokinetic Models and Monte Carlo Simulation

G. Drusano, L. Danziger, K. Rodvold, 2004, Antimicrobial Agents and Chemotherapy.

Individualized Patient Care Through Model-Informed Precision Dosing: Reflections on Training Future Practitioners

R. Jelliffe, G. Drusano, Jiang Liu, 2022, The AAPS Journal.

Pharmacokinetics of intravenously administered ciprofloxacin in patients with various degrees of renal function

G. Drusano, M. Weir, K. Plaisance, 1987, Antimicrobial Agents and Chemotherapy.

Evaluation of Once-Daily Vancomycin against Methicillin-Resistant Staphylococcus aureus in a Hollow-Fiber Infection Model

G. Drusano, J. Bulitta, A. Louie, 2011, Antimicrobial Agents and Chemotherapy.

Optimal Sampling Theory and Population Modelling: Application to Determination of the Influence of the Microgravity Environment on Drug Distribution and Elimination

G L Drusano, G. Drusano, 1991, Journal of clinical pharmacology.

Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model

G. Drusano, J. Barr, S. Shadomy, 2017, Antimicrobial Agents and Chemotherapy.

Dose Range Evaluation of Mycograb C28Y Variant, a Human Recombinant Antibody Fragment to Heat Shock Protein 90, in Combination with Amphotericin B-Desoxycholate for Treatment of Murine Systemic Candidiasis

G. Drusano, D. Stein, B. VanScoy, 2011, Antimicrobial Agents and Chemotherapy.

A five-day treatment course of zanamivir for the flu with a single, self-administered, painless microneedle array patch: Revolutionizing delivery of poorly membrane-permeable therapeutics.

G. Drusano, J. Westover, R. Donnelly, 2023, International journal of pharmaceutics.

Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model

G. Drusano, J. Bulitta, Jonathan R. Adams, 2011, Antimicrobial Agents and Chemotherapy.

In Vitro-In Vivo Model for Evaluating the Antiviral Activity of Amprenavir in Combination with Ritonavir Administered at 600 and 100 Milligrams, Respectively, Every 12 Hours

J. Bilello, G. Drusano, W. Symonds, 2003, Antimicrobial Agents and Chemotherapy.

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.

O. Cars, G. Drusano, H. Derendorf, 2002, International journal of antimicrobial agents.

Optimizing the Use of Beta-Lactam Antibiotics in Clinical Practice: A Test of Time

G. Drusano, A. Tilanus, Alwin Tilanus, 2023, Open forum infectious diseases.

Differing Effects of Combination Chemotherapy with Meropenem and Tobramycin on Cell Kill and Suppression of Resistance of Wild-Type Pseudomonas aeruginosa PAO1 and Its Isogenic MexAB Efflux Pump-Overexpressed Mutant

G. Drusano, A. Louie, Weiguo Liu, 2009, Antimicrobial Agents and Chemotherapy.

Factors influencing the emergence of resistance to indinavir: role of virologic, immunologic, and pharmacologic variables.

J. Bilello, J. Condra, P. Deutsch, 1998, The Journal of infectious diseases.

Fluoroquinolone Pharmacodynamics: Prospective Determination of Relationships Between Exposure and Outcome

G. Drusano, 2000, Journal of chemotherapy.

In memoriam: John P. Quinn, MD.

L. Rice, R. Weinstein, R. Bonomo, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Combination Therapy with UV-4B and Molnupiravir Enhances SARS-CoV-2 Suppression

G. Drusano, Kelly L. Warfield, Ashley N. Brown, 2023, Viruses.

Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.

Ronald N. Jones, G. Drusano, F. Sörgel, 2010, Diagnostic microbiology and infectious disease.

An overview of the pharmacology of imipenem/cilastatin.

G. Drusano, 1986, The Journal of antimicrobial chemotherapy.

Nucleoside Analog 1592U89 and Human Immunodeficiency Virus Protease Inhibitor 141W94 Are Synergistic In Vitro

J. Bilello, G. Drusano, B. Sadler, 1998, Antimicrobial Agents and Chemotherapy.

Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment; report of a Veterans Affairs Cooperative Study. VA Cooperative Study Group on AIDS Treatment.

P. Hartigan, W. O'brien, G. Drusano, 1996, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Population Pharmacokinetics and Pharmacodynamics of Piperacillin : Systematic Comparison of Cystic Fibrosis Patients and Healthy Volunteers

U. Holzgrabe, J. Bulitta, G. Drusano, 2007 .

Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration.

G. Drusano, A. Madu, M. Mayers, 1996, Experimental eye research.

Impact of Meropenem in Combination with Tobramycin in a Murine Model of Pseudomonas aeruginosa Pneumonia

G. Drusano, A. Louie, Weiguo Liu, 2013, Antimicrobial Agents and Chemotherapy.

Effect of Moxifloxacin plus Pretomanid against Mycobacterium tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in an In Vitro Assay

G. Drusano, A. Hajihosseini, S. Schmidt, 2018, Antimicrobial Agents and Chemotherapy.

Guillain-Barré syndrome associated with immune reconstitution.

G. Drusano, T. Kinchelow, M. Salgo, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacodynamics of Levofloxacin in a Murine Pneumonia Model of Pseudomonas aeruginosa Infection: Determination of Epithelial Lining Fluid Targets

Robert Kulawy, Arnold Louie, G. Drusano, 2009, Antimicrobial Agents and Chemotherapy.

Relevance of pharmacokinetics and pharmacodynamics in the selection of antibiotics for respiratory tract infections.

G. Drusano, W. Craig, 1997, Journal of chemotherapy.

Optimal Sampling Schedule Design for Populations of Patients

V. Tam, G. Drusano, S. Preston, 2003, Antimicrobial Agents and Chemotherapy.

An evaluation of optimal sampling strategy and adaptive study design

A Forrest, G L Drusano, M D Reed, 1988, Clinical pharmacology and therapeutics.

Larger Vancomycin Doses (at Least Four Grams per Day) Are Associated with an Increased Incidence of Nephrotoxicity

G. Drusano, T. Lodise, G. Drusano, 2008, Antimicrobial Agents and Chemotherapy.

Pharmacokinetic-Pharmacodynamic Analysis for Efficacy of Ceftaroline Fosamil in Patients with Acute Bacterial Skin and Skin Structure Infections

G. Drusano, T. Riccobene, S. Bhavnani, 2014, Antimicrobial Agents and Chemotherapy.

The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens

W. Yamada, M. Neely, G. Drusano, 2020, Antimicrobial Agents and Chemotherapy.

Natural History of Yersinia pestis Pneumonia in Aerosol-Challenged BALB/c Mice

G. Drusano, G. Hurteau, R. Cirz, 2013, Antimicrobial Agents and Chemotherapy.

Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague.

F. Sorgel, G. Drusano, L. J. Sullivan, 2007, The Journal of infectious diseases.

Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model

M. Neely, G. Drusano, S. Schmidt, 2018, Antimicrobial Agents and Chemotherapy.

Effect of Linezolid plus Bedaquiline against Mycobacterium tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in an In Vitro Assay

G. Drusano, A. Hajihosseini, S. Schmidt, 2018, Antimicrobial Agents and Chemotherapy.

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

Jerome J. Schentag, M. Neely, G. Drusano, 2014, The Lancet. Infectious diseases.

Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia.

A. Schumitzky, R. Jelliffe, M. Neely, 2015, The Journal of infectious diseases.

Quantifying the matrix of relationships between reduced vancomycin susceptibility phenotypes and outcomes among patients with MRSA bloodstream infections treated with vancomycin .

G. Drusano, L. Cosler, L. McNutt, 2014, The Journal of antimicrobial chemotherapy.

How many steps along the path is too far?

G. Drusano, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacodynamics of Caspofungin in a Murine Model of Systemic Candidiasis: Importance of Persistence of Caspofungin in Tissues to Understanding Drug Activity

G. Drusano, Michael Drusano, T. Gumbo, 2005, Antimicrobial Agents and Chemotherapy.

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.

Michael H. Miller, V. Tam, K. Bush, 2003, The Journal of clinical investigation.

A New Paradigm for Early Clinical Trials

G. Drusano, A. Chow, J. Natarajan, 2013 .

Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.

J. S. Daly, A. Casadevall, I. Sia, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Zanamivir, at 600 Milligrams Twice Daily, Inhibits Oseltamivir-Resistant 2009 Pandemic H1N1 Influenza Virus in an In Vitro Hollow-Fiber Infection Model System

G. Drusano, Jonathan R. Adams, R. Kulawy, 2011, Antimicrobial Agents and Chemotherapy.

Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV)

W. Yamada, M. Neely, G. Drusano, 2017, Scientific Reports.

Pharmacokinetic-pharmacodynamic considerations in the design of hospital-acquired or ventilator-associated bacterial pneumonia studies: look before you leap!

G. Drusano, S. Bhavnani, P. Ambrose, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Relationship between initial vancomycin concentration-time profile and nephrotoxicity among hospitalized patients.

G. Drusano, K. Rodvold, B. Lomaestro, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Reply to Shenoy et al

G. Drusano, 2005 .

A preliminary pharmacokinetic and pharmacodynamic evaluation of the HIV protease inhibitor BMS-232632 in a protease inhibitor-naive HIV+ population

G. Drusano, A. Schuster, P. Piliero, 2000 .

Stepping Off the Resistance Treadmill.

G. Drusano, 2017, The Journal of infectious diseases.

Impact of Spore Biology on the Rate of Kill and Suppression of Resistance in Bacillus anthracis

O. O. Okusanya, A. O. Okusanya, M. Kinzig, 2009, Antimicrobial Agents and Chemotherapy.

Use of an In Vitro Pharmacodynamic Model To Derive a Linezolid Regimen That Optimizes Bacterial Kill and Prevents Emergence of Resistance in Bacillus anthracis

G. Drusano, F. Sörgel, B. VanScoy, 2008, Antimicrobial Agents and Chemotherapy.