J. Mecklin

J. Mecklin, H. Kautiainen, M. Kairaluoma, 2014, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

Predictive genetic testing for hereditary non‐polyposis colorectal cancer: Uptake and long‐term satisfaction

A. de la Chapelle, P. Peltomäki, J. Mecklin, 2000, International journal of cancer.

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

T. Kuopio, A. Ristimäki, J. Mecklin, 2015, British Journal of Cancer.

No Support for Endoscopic Surveillance for Gastric Cancer in Hereditary Non-Polyposis Colorectal Cancer

L. Aaltonen, J. Mecklin, H. Järvinen, 2002, Scandinavian journal of gastroenterology.

Recurrent groin hernia surgery after primary open inguinal procedures: a reappraisal of the open preperitoneal (Ugahary) technique

J. Mecklin, M. Aarnio, M. Tuuliranta, 2018, Hernia.

E-Posters

Justin K Scheer, Allan R. Martin, Munish C. Gupta, 2017, Hematological Oncology.

EXO 1 Variants Occur Commonly in Normal Population : Evidence against a Role in Hereditary Nonpolyposis Colorectal Cancer 1

L. Aaltonen, P. Møller, R. Houlston, 2002 .

Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

E. Dermitzakis, L. Aaltonen, E. Pitkänen, 2018, EMBO molecular medicine.

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Aung Ko Win, I. Deary, M. Nöthen, 2019, Nature Communications.

Edinburgh Research Explorer Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer

D. Bishop, R. Scott, A. Lindblom, 2022 .

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

P. Møller, E. Hovig, S. Nakken, 2017, Gut.

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

M. Kloor, M. von Knebel Doeberitz, A. Riemer, 2020, Nature Communications.

The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution

M. Kloor, M. von Knebel Doeberitz, A. Riemer, 2019, bioRxiv.

The value of a follow-up programme after radical surgery for colorectal carcinoma.

J. Mecklin, H. Järvinen, J. Ovaska, 1989, Scandinavian journal of gastroenterology.

Follow-up of patients operated on for colorectal carcinoma.

J. Mecklin, H. Järvinen, J. Ovaska, 1990, American journal of surgery.

Guidelines for the clinical management of Lynch

P. Møller, G. Capellá, J. Mecklin, 2007 .

Treatment and follow-up strategies in hereditary nonpolyposis colorectal carcinoma

J. Mecklin, H. Järvinen, 1993, Diseases of the colon and rectum.

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies.

M. Kloor, M. von Knebel Doeberitz, C. Strassburg, 2018, Gastroenterology.

Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database

B. Bonanni, P. Møller, E. Hovig, 2020, Journal of clinical medicine.

Spinopelvic Changes Based on the Simplified SRS-Schwab Adult Spinal Deformity Classification: Relationships With Disability and Health-Related Quality of Life in Adult Patients With Prolonged Degenerative Spinal Disorders

J. Mecklin, H. Kautiainen, A. Häkkinen, 2017, Spine.

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability.

L. Aaltonen, E. Pitkänen, Kimmo Palin, 2013, Gastroenterology.

Immunoscore in mismatch repair‐proficient and ‐deficient colon cancer

T. Kuopio, J. Mecklin, H. Kautiainen, 2017, The journal of pathology. Clinical research.

Surveillance in Lynch Syndrome

J. Mecklin, H. Järvinen, 2005, Familial Cancer.

The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer.

J. Mecklin, H. Järvinen, I. Bernstein, 2001, Gynecologic oncology.

Quantitative Analysis of &ggr;-H2AX and p53 Nuclear Expression Levels in Ovarian and Fallopian Tube Epithelium from Risk-reducing Salpingo-Oophorectomies in BRCA1 and BRCA2 Mutation Carriers

T. Tolonen, J. Isola, J. Mecklin, 2014, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

Evaluation of a counselling protocol for predictive genetic testing for hereditary non-polyposis colorectal cancer

A. de la Chapelle, P. Peltomäki, J. Mecklin, 2000, Journal of medical genetics.

Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer.

J. Mecklin, H. Järvinen, L. Renkonen-Sinisalo, 2000, Cancer detection and prevention.

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome.

D. Bishop, R. Scott, D. Evans, 2008, The New England journal of medicine.

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer

R. Scott, A. Lindblom, J. Lubiński, 2016 .

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer

David Evans, R. Scott, D. Evans, 2016 .

Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women with lynch syndrome

J. Mecklin, T. Seppälä, S. Staff, 2021, Hereditary cancer in clinical practice.

Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma.

A. Ristimäki, J. Mecklin, M. Härkönen, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

The impact of upper GI endoscopy referral volume on the diagnosis of gastroesophageal reflux disease and its complications: a 1-year cross-sectional study in a referral area with 260,000 inhabitants.

I. Kunnamo, J. Mecklin, M. Färkkilä, 2002 .

The impact of upper GI endoscopy referral volume on the diagnosis of gastroesophageal reflux disease and its complications: a 1-year cross-sectional study in a referral area with 260,000 inhabitants

I. Kunnamo, J. Mecklin, M. Färkkilä, 2002, American Journal of Gastroenterology.

NOD2 3020insC Alone Is Not Sufficient for Colorectal Cancer Predisposition

L. Aaltonen, J. Mecklin, H. Järvinen, 2004, Cancer Research.

Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases

K. Aittomäki, T. Kuopio, P. Peltomäki, 2012, Breast Cancer Research.

Gastroesophageal Reflux Disease: Prevalence, Clinical, Endoscopic and Histopathological Findings in 1,128 Consecutive Patients Referred for Endoscopy due to Dyspeptic and Reflux Symptoms

J. Mecklin, M. Färkkilä, P. Sipponen, 2000, Digestion.

Classical Barrett Esophagus Contrasted with Barrett-Type Epithelium at Normal-Appearing Esophagogastric Junction: Comparison of Demographic, Endoscopic, and Histologic Features

J. Mecklin, M. Färkkilä, P. Sipponen, 2000 .

Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease

J. Mecklin, M. Färkkilä, P. Sipponen, 1999, American Journal of Gastroenterology.

Complete and incomplete intestinal metaplasia at the oesophagogastric junction: prevalences and associations with endoscopic erosive oesophagitis and gastritis

J. Mecklin, M. Färkkilä, P. Sipponen, 1999, Gut.

Specialized columnar epithelium of the esophagogastric junction: prevalence and associations

I. Kunnamo, J. Mecklin, M. Färkkilä, 1999, American Journal of Gastroenterology.

The International Collaborative Group on HNPCC.

J. Mecklin, H. Lynch, H. Vasen, 1994, Anticancer research.

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases

T. Kuopio, J. Mecklin, J. Väyrynen, 2021, Cancers.

Advances in Brief No Evidence of Peutz-Jeghers Syndrome Gene LKB 1 Involvement in Left-sided Colorectal Carcinomas 1

L. Aaltonen, P. Laiho, J. Kim, 2000 .

Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation

L. Aaltonen, P. Laiho, J. Mecklin, 2003, Journal of medical genetics.

Short Communication Proportion and Phenotype of MYH-Associated Colorectal Neoplasia in a Population-Based Series of Finnish Colorectal Cancer Patients

L. Lipton, L. Aaltonen, I. Tomlinson, 2003 .

No evidence for association of NOD2 R702W and G908R with colorectal cancer

L. Aaltonen, J. Mecklin, H. Järvinen, 2007, International journal of cancer.

Contribution of allelic imbalance to colorectal cancer

T. Ørntoft, E. Dermitzakis, L. Aaltonen, 2018, Nature Communications.

Endo-ultrasonography for preoperative staging of rectal cancer.

J. Mecklin, H. Järvinen, J. Salo, 1988, Annales chirurgiae et gynaecologiae.

Psychological consequences of predictive genetic testing for hereditary non‐polyposis colorectal cancer (HNPCC): A prospective follow‐up study

J. Mecklin, A. Uutela, A. Haukkala, 2001, International journal of cancer.

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

L. Aaltonen, E. Pitkänen, T. Kuopio, 2018, Nature Communications.

Genome-wide asociation study and meta-analysis in Northrn European populations replicate multiple colorectal cancer risk

Johanna, François G. Meyer, Ripatti, 2017 .

Appendiceal neoplasm risk associated with complicated acute appendicitis—a population based study

J. Mecklin, P. Salminen, A. Kaljonen, 2018, International Journal of Colorectal Disease.

Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Aung Ko Win, M. von Knebel Doeberitz, B. Bonanni, 2021, European journal of cancer.

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Aung Ko Win, P. Møller, E. Hovig, 2019, Genetics in Medicine.

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Aung Ko Win, M. von Knebel Doeberitz, B. Bonanni, 2020, Genetics in Medicine.

Letter to the Editor-Recent advances in Lynch syndrome

P. Møller, J. Mecklin, J. Burn, 2020, Familial Cancer.

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study

J. Mecklin, H. Huhtala, T. Seppälä, 2020, Familial Cancer.

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.

M. Kloor, M. von Knebel Doeberitz, A. Stenzinger, 2020, Gastroenterology.

Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report

M. Kloor, P. Møller, E. Hovig, 2019, Hereditary Cancer in Clinical Practice.

Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

P. Møller, E. Hovig, S. Nakken, 2017, Hereditary cancer in clinical practice.

Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations

J. Mecklin, T. Seppälä, K. Pylvänäinen, 2017, European Journal of Human Genetics.

Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome

J. Mecklin, H. Järvinen, T. Seppälä, 2017, Diseases of the colon and rectum.

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

P. Møller, E. Hovig, S. Nakken, 2016, Gut.

Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

P. Møller, E. Hovig, S. Nakken, 2017, Hereditary Cancer in Clinical Practice.

Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study

J. Mecklin, H. Huhtala, S. Staff, 2016, British Journal of Cancer.

Causes of death of mutation carriers in Finnish Lynch syndrome families

J. Mecklin, H. Järvinen, T. Lehtinen, 2012, Familial Cancer.

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Aung Ko Win, P. Møller, E. Hovig, 2020, Genetics in Medicine.

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Aung Ko Win, M. Kloor, B. Bonanni, 2022, Hereditary Cancer in Clinical Practice.

Outcome of Temporary Stomas

J. Mecklin, M. Kairaluoma, I. Kellokumpu, 2002, Digestive Surgery.

Molecular Analysis of Endometrial Tumorigenesis: Importance of Complex Hyperplasia Regardless of Atypia

P. Peltomäki, J. Mecklin, H. Järvinen, 2009, Clinical Cancer Research.

Carcinoma of the stomach and its heredity in young patients.

J. Mecklin, I. Saario, S. Nordling, 1988, Scandinavian journal of gastroenterology.

Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases.

O. Mäkelä, P. Roberts, J. Mecklin, 1984, British Journal of Cancer.

Hereditary non-polyposis colorectal cancer

J. Mecklin, H. Lynch, H. Vasen, 1991, The Lancet.

Endometrial carcinoma in the cancer family syndrome

J. Mecklin, H. Järvinen, P. Lehtovirta, 1991, Cancer.

Screening for colorectal carcinoma in cancer family syndrome kindreds.

J. Mecklin, H. Järvinen, I. Elomaa, 1987, Scandinavian journal of gastroenterology.

Cancer family syndrome. Genetic analysis of 22 Finnish kindreds.

J. Mecklin, H. Järvinen, P. Peltokallio, 1986, Gastroenterology.

Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance

P. Møller, E. Hovig, S. Nakken, 2018 .

Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations

P. Peltomäki, J. Mecklin, Xin Gao, 2004, Familial Cancer.

Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma

J. Mecklin, H. Järvinen, H. Lynch, 1998, Cancer.

Hereditary aspects of endometrial adenocarcinoma

J. Mecklin, A. Leminen, P. Lehtovirta, 1995, International journal of cancer.

The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer.

J. Jass, J. Mecklin, H. Lynch, 1994, Anticancer research.

Cancer occurrence during follow-up of the CAPP2 study -aspirin use for up to four years significantly reduces Lynch syndrome cancers for up to several years after completion of therapy

A. Lindblom, G. Evans, J. Mathers, 2010, Hereditary Cancer in Clinical Practice.

Features of gastric cancer in hereditary non‐polyposis colorectal cancer syndrome

L. Aaltonen, J. Mecklin, H. Järvinen, 1997, International journal of cancer.

Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer

A. de la Chapelle, P. Peltomäki, J. Mecklin, 1998, Human mutation.

Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.

J. Weissenbach, L. Aaltonen, A. de la Chapelle, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Improvements in the treatment and prognosis of colorectal carcinoma

J. Mecklin, H. Järvinen, J. Ovaska, 1988, The British journal of surgery.

The Role of Surgery in Crohn's Disease: A Retrospective Analysis from a Single Hospital

J. Mecklin, M. Voutilainen, M. Aarnio, 2010, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden.

L. Aaltonen, A. de la Chapelle, R. Sankila, 1994, Cancer detection and prevention.

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer

P. Møller, E. Hovig, S. Nakken, 2022 .

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome

J. Mecklin, H. Järvinen, A. Leminen, 2007, International journal of cancer.

Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.

P. Peltomäki, J. Mecklin, H. Järvinen, 1998 .

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

P. Møller, G. Capellá, A. Lindblom, 2013, Gut.

Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study

P. Peltomäki, J. Mecklin, H. Järvinen, 2007, Gut.

p53 Codon 72 and MDM2 SNP309 Polymorphisms and Age of Colorectal Cancer Onset in Lynch Syndrome

Sandya Liyanarachchi, Jukka-Pekka Mecklin, L. Aaltonen, 2005, Clinical Cancer Research.

Saving the Kidneys by Sparing Intravenous Chloride

J. Mecklin, A. Uutela, A. Haukkala, 2017 .

Uroepithelial and kidney carcinoma in Lynch syndrome

P. Peltomäki, J. Mecklin, H. Järvinen, 2012, Familial Cancer.

Screening for hereditary colorectal carcinoma.

J. Mecklin, H. Järvinen, Mecklin Jp, 1989, Scandinavian journal of gastroenterology.

Blood transfusion and prognosis in colorectal carcinoma.

J. Mecklin, H. Järvinen, J. Ovaska, 1989, Scandinavian journal of gastroenterology.

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study

J. Mecklin, T. Seppälä, J. Mäenpää, 2020, Familial Cancer.

The association between appendicitis severity and patient age with appendiceal neoplasm histology—a population-based study

J. Mecklin, P. Salminen, J. Sand, 2022, International Journal of Colorectal Disease.

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study.

J. Mecklin, S. Staff, J. Mäenpää, 2017, Molecular and clinical oncology.

Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer.

A. Lindblom, J. Mecklin, R. Salovaara, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The association between cholangiooaroinoma and hereditary nonpolyposis colorectal carcinoma

J. Mecklin, H. Järvinen, M. Virolainen, 2010, Cancer.

CTCF/cohesin-binding sites are frequently mutated in cancer

Niko Välimäki, Esa Pitkänen, Kashyap Dave, 2015, Nature Genetics.

Genetic mapping of a locus predisposing to human colorectal cancer.

J. Weber, B. Vogelstein, L. Aaltonen, 1993, Science.

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.

W F Bodmer, P Rozen, L. Aaltonen, 2001, American journal of human genetics.

SMAD genes in juvenile polyposis

L. Aaltonen, C. Amos, P. Sistonen, 1999, Genes, chromosomes & cancer.

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency

S. Scherer, A. Paterson, P. Peltomäki, 2014, Gastroenterology.

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

P. Møller, G. Capellá, S. Tejpar, 2008, Gut.

Hereditary nonpolyposis colorectal cancer.

P. Peltomäki, J. Mecklin, H. Vasen, 1994, Scandinavian journal of gastroenterology.

Peutz–Jeghers syndrome: a systematic review and recommendations for management

P. Møller, G. Capellá, S. Tejpar, 2010, Gut.

Gene expression signatures for colorectal cancer microsatellite status and HNPCC

T. Ørntoft, L. Aaltonen, D. Arango, 2005, British Journal of Cancer.

Unregulated smooth-muscle myosin in human intestinal neoplasia

Darryl Shibata, Charis Eng, Jukka-Pekka Mecklin, 2008, Proceedings of the National Academy of Sciences.

Novel splicing associations of hereditary colon cancer related DNA mismatch repair gene mutations

P. Peltomäki, J. Mecklin, H. Järvinen, 2004, Journal of Medical Genetics.

Hereditary Nonpolyposis Colorectal Cancer Patients Replication Errors in Benign and Malignant Tumors from

H T Lynch, K. Kinzler, B. Vogelstein, 2006 .

Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families

J. Mecklin, M. Kairaluoma, K. Pylvänäinen, 2005, Familial Cancer.

Genetic and epigenetic characteristics of inflammatory bowel disease associated colorectal cancer.

M. Nykter, L. Aaltonen, Kimmo Palin, 2021, Gastroenterology.

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Steven Gallinger, Yusuke Nakamura, Graeme Grimes, 2012, Nature Genetics.

Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.

J. Kere, L. Aaltonen, G. Petersen, 1992, Cancer research.

Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds.

B. Vogelstein, A. de la Chapelle, P. Peltomäki, 1991, Cancer research.

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers

Jukka-Pekka Mecklin, Auli Karhu, L. Aaltonen, 2006, International journal of cancer.

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.

J. Astola, L. Aaltonen, D. Arango, 2005, Gastroenterology.

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.

L. Aaltonen, S. Vanharanta, J. Isola, 2004, The American journal of pathology.

The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome

J. Mecklin, H. Järvinen, I. Bernstein, 2008, International journal of cancer.

Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors.

P. Peltomäki, J. Mecklin, H. Järvinen, 2008, Carcinogenesis.

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

H T Lynch, J. Mecklin, H. Lynch, 1999, Gastroenterology.

Cancer risk in mutation carriers of DNA‐mismatch‐repair genes

L. Aaltonen, A. de la Chapelle, R. Sankila, 1999, International journal of cancer.

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population‐based study

J. Mecklin, E. Sihvo, T. Seppälä, 2020, BJS open.

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms

Min Ju Park, T. Visakorpi, H. Nevanlinna, 2016, The Prostate.

Founding mutations and Alu-mediated recombination in hereditary colon cancer

K. Kinzler, B. Vogelstein, L. Aaltonen, 1995, Nature Medicine.

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

L. Aaltonen, E. Pitkänen, Kimmo Palin, 2019, British Journal of Cancer.

Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance

M. Kloor, M. von Knebel Doeberitz, A. Stenzinger, 2020, medRxiv.

The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

M. Kloor, M. von Knebel Doeberitz, H. Brenner, 2020, International journal of cancer.

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.

Kyoung-Mee Kim, Darryl Shibata, Jukka-Pekka Mecklin, 2002, The American journal of pathology.

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

V. Salomaa, D. Kerr, L. Aaltonen, 2016, Human molecular genetics.

The genetics of HNPCC: application to diagnosis and screening.

P. Peltomäki, J. Mecklin, W. Abdel-Rahman, 2006, Critical reviews in oncology/hematology.

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis

Rainer Lehtonen, Jukka-Pekka Mecklin, James R Eshleman, 2005, Human mutation.

No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer

L. Aaltonen, J. Mecklin, H. Järvinen, 2007, Oncogene.

Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC).

L. Aaltonen, P. Laiho, J. Mecklin, 2001, Cancer research.

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

D. Bishop, R. Scott, D. Evans, 2020, The Lancet.

SMAD4 as a Prognostic Marker in Colorectal Cancer

Jukka-Pekka Mecklin, Lauri A. Aaltonen, L. Aaltonen, 2005, Clinical Cancer Research.

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

P. Peltomäki, J. Mecklin, S. Eldfors, 2020, Cancers.

DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer.

A. de la Chapelle, J. Osinga, R. Hofstra, 1996, Human molecular genetics.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Esko Ukkonen, Jussi Taipale, Mikko Turunen, 2009, Nature Genetics.

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

L. Aaltonen, J. Schleutker, P. Laiho, 2006, BMC Cancer.

Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer

L. Aaltonen, E. Pitkänen, J. Taipale, 2013, PLoS genetics.

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Aung Ko Win, V. Salomaa, D. Kerr, 2017, International journal of cancer.

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study.

D. Bishop, R. Scott, D. Evans, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Little evidence for involvement of MLH3 in colorectal cancer predisposition

L. Aaltonen, P. Laiho, P. Peltomäki, 2003, International journal of cancer.

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study

Aung Ko Win, M. von Knebel Doeberitz, B. Bonanni, 2021, Journal of clinical medicine.

Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas

Min Ju Park, I. Tomlinson, P. Vahteristo, 2014, Human mutation.

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

L. Aaltonen, O. Abdel-Wahab, H. Nevanlinna, 2012, British Journal of Cancer.

Numbers of mutations to different types of colorectal cancer

Darryl Shibata, Simon Tavaré, Jukka-Pekka Mecklin, 2005, BMC Cancer.

Colorectal pretumor progression before and after loss of DNA mismatch repair.

S. Tavaré, L. Aaltonen, D. Shibata, 2004, The American journal of pathology.

The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription

S. Knuutila, P. Peltomäki, J. Mecklin, 2016, Gastroenterology research and practice.

Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry

K. Franssila, J. Mecklin, H. Järvinen, 1990, Cancer.

Growth of human colorectal carcinoma implants in the mouse subrenal capsule assay.

K. Franssila, J. Mecklin, L. Kangas, 1989, Annales chirurgiae et gynaecologiae.

Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.

J. Mecklin, P. Salminen, J. Sand, 2015, JAMA.

Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation

P. Peltomäki, J. Mecklin, H. Järvinen, 2014, Epigenetics.

Reply: To PMID 24941021.

P. Peltomäki, J. Mecklin, H. Järvinen, 2015, Gastroenterology.

Is preoperative distinction between complicated and uncomplicated acute appendicitis feasible without imaging?

J. Mecklin, P. Salminen, P. Ohtonen, 2016, Surgery.

Distinct molecular profiles in Lynch syndrome‐associated and sporadic ovarian carcinomas

P. Peltomäki, J. Mecklin, H. Järvinen, 2013, International journal of cancer.

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases

T. Ørntoft, L. Lipton, L. Aaltonen, 2003, Oncogene.

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.

L. Aaltonen, P. Laiho, J. Mecklin, 2000, Cancer research.

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome

L. Aaltonen, K. Aittomäki, I. Tomlinson, 2005, Journal of Medical Genetics.

Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.

P. Peltomäki, P. Sistonen, J. Mecklin, 1998, Gastroenterology.

No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers

Samantha L. Martin, L. Aaltonen, Kimmo Palin, 2021, Genes, chromosomes & cancer.

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

J. Mecklin, P. Salminen, J. Sand, 2018, JAMA.

Genetic reconstruction of individual colorectal tumor histories.

S. Tavaré, L. Aaltonen, D. Shibata, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Low-level microsatellite instability in most colorectal carcinomas.

J. Herman, L. Aaltonen, M. Esteller, 2002, Cancer research.

Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.

L. Aaltonen, A. de la Chapelle, J. Mecklin, 1999, The American journal of pathology.

Short Communication Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal Cancer

L. Aaltonen, J. Mecklin, M. Eskelinen, 1999 .

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.

L. Aaltonen, D. Shibata, J. Mecklin, 1998, The American journal of pathology.

Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases

K. Aittomäki, T. Kuopio, P. Peltomäki, 2012, Breast Cancer Research.

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer.

J. Mecklin, H. Järvinen, H. Lynch, 1994, The American journal of medicine.

Frequency of hereditary colorectal carcinoma.

J. Mecklin, 1987, Gastroenterology.

The MDM2 promoter polymorphism SNP309T→G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

L. Aaltonen, P. Vahteristo, A. Mäkitie, 2005, Journal of Medical Genetics.

Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status

T. Kuopio, J. Rantala, J. Mecklin, 2019, Modern Pathology.

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy.

L. Aaltonen, H. Joensuu, J. Mecklin, 2000, Gastroenterology.

Population-based molecular detection of hereditary nonpolyposis colorectal cancer.

L. Aaltonen, A. de la Chapelle, J. Mecklin, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer.

L. Aaltonen, A. de la Chapelle, P. Peltomäki, 2000, Gastroenterology.

Population-Based M olecular D etection o f H ereditary Nonpolyposis C olorectal C ancer

L. Aaltonen, J. Mecklin, M. Eskelinen, 2000 .

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.

L. Aaltonen, R. Chadwick, A. de la Chapelle, 1998, The New England journal of medicine.

Somatic mutations and germline sequence variants in patients with familial colorectal cancer

Jukka-Pekka Mecklin, Auli Karhu, L. Aaltonen, 2010, International journal of cancer.

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

J. Mecklin, M. Tammi, J. Väyrynen, 2021, Scientific Reports.

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.

L. Aaltonen, C. Morrison, S. Vanharanta, 2004, American journal of human genetics.

Biofeedback therapy in rectal prolapse patients

J. Mecklin, A. Palmu, P. Raivio, 1996, Diseases of the colon and rectum.

Life‐time risk of different cancers in hereditary non‐polyposis colorectal cancer (hnpcc) syndrome

L. Aaltonen, J. Mecklin, H. Järvinen, 1995, International journal of cancer.

Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer.

P. Sistonen, J. Mecklin, H. Järvinen, 1995, Gastroenterology.

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations

S. Knuutila, P. Peltomäki, J. Mecklin, 2005, Oncogene.

MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.

H. Grönberg, F. Wright, R. Chadwick, 2001, Cancer research.

Systematic search for rare variants in Finnish early-onset colorectal cancer patients.

L. Aaltonen, E. Pitkänen, Kimmo Palin, 2015, Cancer genetics.

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

S. Knuutila, A. Ristimäki, P. Peltomäki, 2018, EBioMedicine.

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

Jukka-Pekka Mecklin, L. Aaltonen, P. Peltomäki, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

P. Møller, G. Capellá, J. Mecklin, 2007, Journal of Medical Genetics.

Better survival rates in patients with MLH1-associated hereditary colorectal cancer.

L. Aaltonen, R. Sankila, J. Mecklin, 1996, Gastroenterology.

Frequency of hereditary nonpolyposis colorectal cancer

J. Mecklin, H. Järvinen, J. Ovaska, 1995, Diseases of the colon and rectum.

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients

L. Aaltonen, P. Vahteristo, O. Kilpivaara, 2013, Scandinavian journal of gastroenterology.

Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer

A. Ristimäki, P. Peltomäki, J. Mecklin, 2021, International journal of cancer.

A Comparative Pan-Genome Perspective of Niche-Adaptable Cell-Surface Protein Phenotypes in Lactobacillus rhamnosus

Maria Saarela, Jukka-Pekka Mecklin, Lars Paulin, 2014, PloS one.

Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

L. Aaltonen, P. Peltomäki, J. Mecklin, 2007, Journal of Medical Genetics.

Sharing genetic risk with next generation: mutation-positive parents’ communication with their offspring in Lynch Syndrome

J. Mecklin, H. Järvinen, A. Haukkala, 2011, Familial Cancer.

BRAF mutation in sporadic colorectal cancer and Lynch syndrome

A. Ristimäki, P. Peltomäki, J. Mecklin, 2013, Virchows Archiv.

The MDM 2 promoter polymorphism SNP 309 T R G and the risk of uterine leiomyosarcoma , colorectal cancer , and squamous cell carcinoma of the head and neck

L. Aaltonen, P. Vahteristo, A. Mäkitie, 2005 .

Is HLA type a possible cancer risk modifier in Lynch syndrome?

M. Kloor, M. von Knebel Doeberitz, P. Møller, 2022, International journal of cancer.

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

A. Chapelle, L. Aaltonen, P. Peltomäki, 1994, Nature Genetics.

Prognosis of colorectal cancer varies in different high-risk conditions.

J. Mecklin, H. Järvinen, H. Mustonen, 1998, Annals of medicine.

The C/C−13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

I Tomlinson, L. Aaltonen, R. Houlston, 2005, Gut.

Candidate driver genes in microsatellite‐unstable colorectal cancer

Sampsa Hautaniemi, Raquel Seruca, Juha Saharinen, 2012, International journal of cancer.

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

P. Møller, G. Capellá, A. Lindblom, 2010, Familial Cancer.

Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up

D. Bishop, J. Rashbass, A. Lindblom, 2022, Cancer prevention research.

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.

Katherine M. Tucker, Aung Ko Win, Swati G. Patel, 2021, The Lancet. Oncology.

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Aung Ko Win, P. Møller, E. Hovig, 2019, Genetics in Medicine.

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer

Esa Pitkänen, Jussi Taipale, Jukka-Pekka Mecklin, 2014, International journal of cancer.

Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis

P. Peltomäki, J. Mecklin, P. Alhopuro, 2022, Cancers.

Incident colorectal cancer in Lynch syndrome is usually not preceded by compromised quality of colonoscopy

J. Mecklin, T. Seppälä, A. Lepistö, 2019, Scandinavian journal of gastroenterology.

Colorectal surveillance in Lynch syndrome families

J. Mecklin, H. Järvinen, C. Engel, 2013, Familial Cancer.

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

Esa Läärä, Jukka-Pekka Mecklin, L. Aaltonen, 2007, Gastroenterology.

Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset.

Eero Pukkala, Jukka-Pekka Mecklin, Heather Hampel, 2005, Gastroenterology.

Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry

J. Mecklin, T. Seppälä, Kristina Zalevskaja, 2023, Frontiers in Oncology.

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas.

P. Peltomäki, J. Mecklin, S. Eldfors, 2018, Gynecologic oncology.

Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance

P. Peltomäki, J. Mecklin, S. Kaur, 2018, Modern Pathology.

Large genomic rearrangements and germline epimutations in Lynch syndrome

M. Ridanpää, K. Aittomäki, C. Wallgren‐Pettersson, 2009, International journal of cancer.

Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis

A. Ristimäki, P. Peltomäki, J. Mecklin, 2021, Biomolecules.

Arthroplasty-CervicalP001 - Double Crush Syndrome of the Vertebral Artery Loop and Foraminal Stenosis Causing Monoparesis

Justin K Scheer, Allan R. Martin, Munish C. Gupta, 2017, Global Spine Journal.

Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30

J. Mecklin, A. Häkkinen, J. Ylinen, 2016, Spine.

Comprehension of cancer risk one and 12 months after predictive genetic testing for hereditary non-polyposis colorectal cancer

J. Mecklin, A. Uutela, A. Haukkala, 2001, Journal of medical genetics.

Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study

T. Kuopio, P. Peltomäki, J. Mecklin, 2019, International journal of cancer.

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

A. Ristimäki, P. Peltomäki, J. Mecklin, 2015, Clinical Epigenetics.

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

Sampsa Hautaniemi, Jukka-Pekka Mecklin, Sari Tuupanen, 2008, Cancer research.

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

Sampsa Hautaniemi, Jussi Taipale, Mikko Turunen, 2010, Molecular Cancer Research.

Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer.

L. Aaltonen, E. Pitkänen, Kimmo Palin, 2017, Cancer research.

Clinical and laboratory findings in the diagnosis of right lower quadrant abdominal pain: outcome analysis of the APPAC trial

T. Kauko, J. Mecklin, P. Salminen, 2016, Clinical chemistry and laboratory medicine.

Carbonic Anhydrase IX Is Highly Expressed in Hereditary Nonpolyposis Colorectal Cancer

Abdul Waheed, Jukka-Pekka Mecklin, Torben F. Ørntoft, 2007, Cancer Epidemiology Biomarkers & Prevention.

Genome‐wide association study and meta‐analysis in Northern European populations replicate multiple colorectal cancer risk loci

Aung Ko Win, V. Salomaa, D. Kerr, 2017, International journal of cancer.

Systemic circulating microRNA landscape in Lynch syndrome

T. Kuopio, J. Mecklin, E. Sillanpää, 2022, bioRxiv.

Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer)

J. Mecklin, H. Järvinen, 1991, Cancer.

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

M. Kloor, P. Møller, E. Hovig, 2019, Hereditary Cancer in Clinical Practice.

Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study

T. Kuopio, J. Mecklin, E. Sihvo, 2021, Journal of clinical medicine.

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer

T. Kuopio, S. Jalkanen, J. Mecklin, 2020, British Journal of Cancer.

Background mutation frequency in microsatellite-unstable colorectal cancer.

Rainer Lehtonen, Jukka-Pekka Mecklin, Jarno Tuimala, 2007, Cancer research.

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.

L. Lipton, L. Aaltonen, I. Tomlinson, 2003, The American journal of pathology.

Pro-inflammatory fatty acid profile and colorectal cancer risk : A Mendelian randomisation analysis

Aung Ko Win, V. Salomaa, D. Kerr, 2017 .

Outcome of temporary stomas. A prospective study of temporary intestinal stomas constructed between 1989 and 1996.

J. Mecklin, M. Kairaluoma, I. Kellokumpu, 2002, Digestive surgery.

Expertise and Skill in Minimally Invasive Surgery

P. Saariluoma, J. Mecklin, P. Saariluoma, 2009, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

History of the International Collaborative Group on Hereditary NonPolyposis Colorectal Cancer

J. Mecklin, H. Lynch, H. Vasen, 2005, Familial Cancer.

Histopathology of colorectal carcinomas and adenomas in cancer family syndrome

J. Mecklin, H. Järvinen, P. Sipponen, 1986, Diseases of the colon and rectum.

Clinical features of colorectal carcinoma in cancer family syndrome

J. Mecklin, H. Järvinen, 1986, Diseases of the colon and rectum.

Cancer family syndrome

Jukka-Pekka Mecklin, J. Mecklin, H. Järvinen, 1986 .

Hereditary nonpolyposis colorectal carcinoma: cancer family syndrome.

J. Mecklin, 1989, Annals of medicine.

The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.

K. Franssila, S. Nordling, J. Mecklin, 1990, British Journal of Cancer.

Causes of death of mutation carriers in Finnish Lynch syndrome families

J. Mecklin, H. Järvinen, T. Lehtinen, 2012, Familial Cancer.

Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report

M. Kloor, P. Møller, E. Hovig, 2019, Hereditary cancer in clinical practice.

Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity

P. Peltomäki, J. Mecklin, H. Järvinen, 2023, Cancer research communications.

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

T. Törmäkangas, S. Sipilä, P. Peltomäki, 2021, Cancers.

The implications of genetics in colorectal cancer.

J. Mecklin, 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

Surveillance in hereditary nonpolyposis colorectal cancer: An international cooperative study of 165 families

J. Mecklin, J. Utsunomiya, H. Lynch, 1993, Diseases of the colon and rectum.

High immune cell score predicts improved survival in pancreatic cancer

J. Mecklin, O. Helminen, Maarit Ahtiainen, 2018, Virchows Archiv.

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.

L. Aaltonen, P. Møller, R. Houlston, 2003, Cancer research.

Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer

S. Ogino, T. Kuopio, J. Mecklin, 2023, British Journal of Cancer.

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database

Aung Ko Win, M. von Knebel Doeberitz, B. Bonanni, 2023, EClinicalMedicine.

P. Peltomäki, J. Mecklin, H. Järvinen, 2004 .

Mutation analysis of SMAD2,SMAD3, andSMAD4 genes in hereditary non-polyposis colorectal cancer

L. Aaltonen, P. Peltomäki, J. Mecklin, 2000, Journal of medical genetics.

Identification of 33 candidate oncogenes by screening for base-specific mutations

L. Aaltonen, C. Andersen, E. Pitkänen, 2014, British Journal of Cancer.

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

L. Aaltonen, R. Houlston, I. Tomlinson, 2011, BMC Medical Genetics.

Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial.

J. Mecklin, P. Salminen, J. Sand, 2020, JAMA surgery.

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).

Kristiina Aittomäki, Rainer Lehtonen, Jukka-Pekka Mecklin, 2010, Human molecular genetics.

Psychosocial consequences of predictive genetic testing for lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study

P. Peltomäki, J. Mecklin, H. Järvinen, 2013, Familial Cancer.

Lynch syndrome genetics and clinical implications.

P. Peltomäki, J. Mecklin, M. Nyström, 2023, Gastroenterology.

Primary gastrointestinal non-Hodgkin's lymphoma. A population based study in central Finland in 1975-1993.

J. Mecklin, A. Palmu, M. Juhola, 1997, Acta oncologica.

Serum carcinoembryonic antigen and DNA ploidy in colorectal carcinoma. A prospective study.

K. Franssila, S. Nordling, J. Mecklin, 1991, Scandinavian journal of gastroenterology.

Impact of Clinical Symptoms and Referral Volume on Endoscopy for Detecting Peptic Ulcer and Gastric Neoplasms

I. Kunnamo, J. Mecklin, M. Färkkilä, 2003, Scandinavian journal of gastroenterology.

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

L. Aaltonen, J. Taipale, P. Vahteristo, 2021, Human molecular genetics.

The different immune profiles of normal colonic mucosa in cancer-free Lynch syndrome carriers and Lynch syndrome colorectal cancer patients.

M. Kloor, M. von Knebel Doeberitz, D. Bishop, 2021, Gastroenterology.

3′-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity

L. Aaltonen, C. Andersen, E. Pitkänen, 2015, Familial Cancer.

CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer

T. Kuopio, J. Mecklin, J. Väyrynen, 2022, Cancers.

Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions

L. Aaltonen, J. Mecklin, U. Hänninen, 2020, Cancers.

MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer

A. Mannermaa, V. Kosma, J. Hartikainen, 2020, AntiCancer Research.

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.

Rainer Lehtonen, Bert Vogelstein, Jukka-Pekka Mecklin, 2005, Cancer research.

Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer

S. Jalkanen, J. Mecklin, J. Laukkarinen, 2020, Virchows Archiv.

Classical Barrett esophagus contrasted with Barrett-type epithelium at normal-appearing esophagogastric junction. Central Finland Endoscopy Study Group.

J. Mecklin, M. Färkkilä, P. Sipponen, 2000, Scandinavian journal of gastroenterology.

The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinoma.

T. Kuopio, J. Mecklin, J. Väyrynen, 2023, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Immunological and prognostic significance of tumour necrosis in colorectal cancer

T. Kuopio, J. Mecklin, J. Väyrynen, 2023, British Journal of Cancer.

LKB 1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome

L. Aaltonen, K. Aittomäki, J. Mecklin, 2006 .

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer

Joan E Bailey-Wilson, Heli Nevanlinna, Rainer Fagerholm, 2008, European Journal of Human Genetics.

BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.

A. Ristimäki, P. Peltomäki, J. Mecklin, 2011, Gastroenterology.

Colorectal surveillance in Lynch syndrome families

J. Mecklin, H. Järvinen, C. Engel, 2013, Familial Cancer.

Aalborg Universitet Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by overdiagnosis ; A prospective Lynch syndrome database report

M. Kloor, P. Møller, E. Hovig, 2019 .

Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer

T. Kuopio, J. Mecklin, J. Väyrynen, 2023, Virchows Archiv.

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas

T. Kuopio, P. Peltomäki, J. Mecklin, 2020, Oncotarget.

Mutation of a mutL homolog in hereditary colon cancer.

R. Fleischmann, M. Adams, J. Venter, 1994, Science.

Screening for hereditary colorectal cancer

J. Mecklin, H. Lynch, H. Vasen, 1994, The Lancet.

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

D. Bishop, R. Scott, D. Evans, 2013 .

Contribution of allelic imbalance to colorectal cancer

T. Ørntoft, E. Dermitzakis, L. Aaltonen, 2018, Nature Communications.

[A breakthrough in solving the genetic background of colon cancer].

A. de la Chapelle, P. Peltomäki, J. Mecklin, 1993, Duodecim; laaketieteellinen aikakauskirja.

ONCOGENOMICS Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

L. Aaltonen, S. Vanharanta, P. Laiho, 2006 .

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.

L. Aaltonen, D. Arango, S. Vanharanta, 2007, Oncogene.

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

K. D. Sørensen, Aung Ko Win, I. Deary, 2019, Nature Communications.

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

Aung Ko Win, V. Salomaa, L. Aaltonen, 2017, European journal of cancer.

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

K. D. Sørensen, Aung Ko Win, I. Deary, 2019, Nature Communications.

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

L. Aaltonen, E. Pitkänen, Kimmo Palin, 2019, British Journal of Cancer.

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

D. Bishop, A. Lindblom, J. Lubiński, 2011 .

Video-assisted surgery: suggestions for failure prevention in laparoscopic cholecystectomy

Minna Silvennoinen, Teuvo Antikainen, Jukka-Pekka Mecklin, 2014, Cognition, Technology & Work.

Comprehension of cancer risk one and 12 months after predictive genetic testing for hereditary non-polyposis colorectal cancer

J. Mecklin, A. Haukkala, A. Uutela, 2001 .

Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer

Jukka-Pekka Mecklin, Richard S. Houlston, Lauri A. Aaltonen, 2010, Cancer Epidemiology, Biomarkers & Prevention.

History of the International Collaborative Group on Hereditary NonPolyposis Colorectal Cancer

J. Mecklin, H. Lynch, H. Vasen, 2005, Familial Cancer.

Serrated Carcinomas Form a Subclass of Colorectal Cancer with Distinct Molecular Basis

L. Aaltonen, S. Vanharanta, P. Laiho, 2022 .

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer

David Evans, A. Lindblom, J. Lubiński, 2016 .

The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome

J. Mecklin, H. Järvinen, I. Bernstein, 2008, International journal of cancer.

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

V. Salomaa, L. Aaltonen, S. Ripatti, 2016, Human molecular genetics.

Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas

Min Ju Park, I. Tomlinson, P. Vahteristo, 2014, Human mutation.

S25. Results of the CAPP-2-trial (Aspirin and resistant starch) in HNPCC gene carriers

D. Bishop, J. Mathers, J. Mecklin, 2008 .

Is preoperative distinction between complicated and uncomplicated acute appendicitis feasible without imaging?

J. Mecklin, P. Salminen, P. Ohtonen, 2016, Surgery.

Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia

O. Kilpivaara, H. Järvinen, P. Peltomäki, 2023, Leukemia.

Psychosocial consequences of predictive genetic testing for lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study

P. Peltomäki, J. Mecklin, H. Järvinen, 2013, Familial Cancer.

Quantitative Analysis of &ggr;-H2AX and p53 Nuclear Expression Levels in Ovarian and Fallopian Tube Epithelium from Risk-reducing Salpingo-Oophorectomies in BRCA1 and BRCA2 Mutation Carriers

T. Tolonen, J. Isola, J. Mecklin, 2014, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

Large genomic rearrangements and germline epimutations in Lynch syndrome

M. Ridanpää, K. Aittomäki, C. Wallgren‐Pettersson, 2009, International journal of cancer.

Identification of cancer family syndrome.

J. Mecklin, H. Järvinen, P. Peltokallio, 1986, Gastroenterology.

Dominantly inherited micro-satellite instable cancer – the four Lynch syndromes - an EHTG, PLSD position statement

B. Bonanni, E. Hovig, S. Nakken, 2023, Hereditary Cancer in Clinical Practice.

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

P. Törönen, P. Peltomäki, J. Mecklin, 2024, EBioMedicine.

A "two-in-one hit" model of shortcut carcinogenesis in MLH1 Lynch syndrome carriers.

M. Kloor, M. von Knebel Doeberitz, G. Kristiansen, 2023, Gastroenterology.

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

L. Aaltonen, D. Arango, S. Hautaniemi, 2010, Molecular Cancer Research.

Molecular Analysis of Endometrial Tumorigenesis: Importance of Complex Hyperplasia Regardless of Atypia

P. Peltomäki, J. Mecklin, H. Järvinen, 2009, Clinical Cancer Research.

The Accuracy of the Computed Tomography Diagnosis of Acute Appendicitis: Does the Experience of the Radiologist Matter?

J. Mecklin, A. Jartti, T. Rantanen, 2018, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.