J. O’Neill

F. Perera, R. Albertini, J. O’Neill, 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

The effect of folate deficiency on the cytotoxic and mutagenic responses to ethyl methanesulfonate in human lymphoblastoid cell lines that differ in p53 status.

R. Branda, J. Nicklas, J. O’Neill, 2001, Mutation research.

Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites

J. O’Neill, P. Vacek, T. Messier, 2005, Environmental and molecular mutagenesis.

Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children.

J. O’Neill, J. Pape, C. Sears, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Correlation between changes in intracellular level of cyclic AMP, activation of cyclic AMP-dependent protein kinase, and the morphology of Chinese hamster ovary cells in culture.

A. Li, J. O’Neill, A. Hsie, 1977, Archives of biochemistry and biophysics.

Lesch-Nyhan disease in a female with a clinically normal monozygotic twin.

D. Schretlen, H. Jinnah, J. O’Neill, 2005, Molecular genetics and metabolism.

Factors influencing mutation at the hprt locus in T-lymphocytes: women treated for breast cancer.

R. Branda, R. Albertini, J. O’Neill, 1991, Cancer research.

The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents.

R. Branda, J. Nicklas, J. O’Neill, 1999, Mutation research.

The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.

J. O’Neill, B. Kirkpatrick, Z. Hindle, 2005, The Journal of infectious diseases.

Southern-blot analyses of human T-lymphocyte mutants induced in vitro by γ-irradiation

R. Albertini, J. Nicklas, J. O’Neill, 1990 .

9 – Mutation at the hprt Locus in Human T-lymphocytes: In Vivo and In Vitro Studies

R. Albertini, J. Nicklas, J. O’Neill, 1989 .

Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes

R. Albertini, J. Nicklas, J. O’Neill, 1985, Nature.

Mammalian cell mutagenesis : the maturation of test systems

J. O’Neill, A. Hsie, V. Mcelheny, 1979 .

Phenotypic expression time of mutagen-induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system).

J. O’Neill, A. Hsie, J. O'neill, 1979, Mutation research.

The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans.

R. Branda, R. Albertini, J. Nicklas, 1994, Mutation research.

Cytosine arabinoside enhancement of gamma irradiation induced mutations in human t‐lymphocytes

J. Nicklas, J. O’Neill, G. Hoffman, 1991, Environmental and molecular mutagenesis.

Use of T-cell receptor gene probes to quantify the in vivo hprt mutations in human T-lymphocytes.

R. Albertini, J. Nicklas, J. O’Neill, 1986, Mutation research.

Molecular description of three macro-deletions and an Alu-Alu recombination-mediated duplication in the HPRT gene in four patients with Lesch-Nyhan disease.

R. Branda, J. Nicklas, J. O’Neill, 2001, Mutation research.

In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients

H. Liber, K. Kelsey, J. O’Neill, 1991, Environmental and molecular mutagenesis.

Molecular bases of hprt mutations in malathion-treated human T-lymphocytes.

R. Albertini, J. Nicklas, J. O’Neill, 1998, Mutation research.

In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

T. Skopek, J. Fuscoe, R. Branda, 1993, Environmental health perspectives.

Relationship between DNA alkylation and specific-locus mutation induction by N-methyl- and N-ethyl-N-nitrosourea in cultured Chinese hamster ovary cells (CHO/HGPRT system).

J. O’Neill, H. Thielmann, A. Hsie, 1979, Chemico-biological interactions.

Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents

R. Branda, J. Nicklas, J. O’Neill, 1998, Environmental and molecular mutagenesis.

Phenotypic expression time of mutagen-induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system): expression in division-arrested cell cultures.

J. O’Neill, A. Hsie, R. Machanoff, 1982, Environmental mutagenesis.

The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program.

J. O’Neill, D. Casciano, A. Hsie, 1981, Mutation research.

Mutagenicity of alkaline constituents of a coal-liquified crude oil in mammalian cells.

J. O’Neill, A. Hsie, J. Epler, 1980, Mutation research.

Cytotoxicity and mutagenicity of alkylating agents in cultured mammalian cells (CHO/HGPRT system): mutagen treatment in the presence or absence of serum.

J. O’Neill, A. Hsie, R. L. Schenley, 1979, Mutation research.

Quantitative analyses of radiation- and chemical-induced lethality and mutagenesis in Chinese hamster ovary cells.

J. Fuscoe, A. Li, J. O’Neill, 1978, Radiation research.

Fluctuation analyses of spontaneous mutations to 6-thioguanine resistance in Chinese hamster ovary cells in culture.

J. O’Neill, A. Hsie, P. Brimer, 1981, Mutation research.

Quantitative mammalian cell genetic toxicology: study of the cytotoxicity and mutagenicity of 70 individual environmental agents related to energy technologies and 3 subfractions of a crude synthetic oil in the CHO/HGPRT system. [Hamsters]

J. Fuscoe, J. O’Neill, A. Hsie, 1978 .

Hudrolysis of butyryl derivatives of adenosine cyclic 3':5'-monophosphate by Chinese hamster ovary cell extracts and characterization fo the products.

J. O’Neill, C. Schröder, C. Schröder, 1975, The Journal of biological chemistry.

Mutagenicity, cytotoxicity, and DNA binding of platinum(II)-chloroammines in Chinese hamster ovary cells.

J. O’Neill, J. Hoeschele, A. Hsie, 1980, Cancer research.

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations.

R. Branda, R. Albertini, J. Nicklas, 1993, Mutation research.

Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system).

J. O’Neill, A. Hsie, N. L. Forbes, 1981, Environmental mutagenesis.

DNA damage, DNA repair, cell proliferation, and DNA replication: how do gene mutations result?

J. O’Neill, J. O'neill, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mutagenicity and cytotoxicity of nineteen heterocyclic mustards (ICR compounds) in cultured mammalian cells.

J. Fuscoe, J. O’Neill, A. Hsie, 1979, Cancer research.

X-ray induction of 6-thioguanine-resistant mutants in division arrested, G0/G1 phase Chinese hamster ovary cells.

J. O’Neill, K. B. Flint, J. O'neill, 1985, Mutation research.

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system.

J. O’Neill, A. Hsie, A W Hsie, 1977, Mutation research.

Plasma and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs

J. O’Neill, W. Bigbee, M. Poirier, 2007, Environmental and molecular mutagenesis.

Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir

K. Nagashima, J. O’Neill, S. Seilkop, 2004, AIDS.

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT.

J. O’Neill, M. Poirier, V. Walker, 1999, Mutation research.

Effect of folate deficiency on mutations at the hprt locus in Chinese hamster ovary cells exposed to monofunctional alkylating agents.

R. Branda, J. Nicklas, J. O’Neill, 1997, Cancer research.

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother–child pairs to AZT or AZT‐3TC

R. Ness, J. O’Neill, W. Bigbee, 2007, Environmental and molecular mutagenesis.

NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

J. O’Neill, W. Nyhan, H. Jinnah, 2004 .

Suggestions concerning the relationship between mutant frequency and mutation rate at the hprt locus in human peripheral T-lymphocytes.

J. O’Neill, M. Green, J. Cole, 1995, Mutation research.

V(D)J recombinase-like activity mediates hprt gene deletion in human fetal T-lymphocytes.

J. Fuscoe, R. Albertini, J. Nicklas, 1991, Cancer research.

Molecular analyses of in vivo hprt mutations in human T-lymphocytes. III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins.

R. Albertini, J. Nicklas, J. O’Neill, 1989, Mutation research.

V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development1

L. Cowell, J. O’Neill, G. Kelsoe, 2006, The Journal of Immunology.

In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

T. Skopek, J. Fuscoe, R. Branda, 1993, Environmental health perspectives.

Recombinase-like Activity Mediates hprt Gene Deletion in Human Fetal T-Lymphocytes 1

J. Fuscoe, R. Albertini, J. Nicklas, 2006 .

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

J. Nicklas, J. O’Neill, T. Messier, 2003, The EMBO journal.

DNA sequence analysis of interlocus recombination between the human T‐cell receptor gamma variable (GV) and beta diversity‐joining (BD/BJ) sequences on chromosome 7 (inversion 7)

R. Albertini, J. Nicklas, J. O’Neill, 2002, Environmental and molecular mutagenesis.

Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke

R. Albertini, J. O’Neill, P. Vacek, 1998, Nature Medicine.

V(D)J recombinase-mediated deletion of the hprt gene in T-lymphocytes from adult humans.

J. Fuscoe, R. Albertini, J. Nicklas, 1992, Mutation research.

HPRT mutations in vivo in human CD 34+ hematopoietic stem cells.

R. Albertini, J. Nicklas, J. O’Neill, 1999, Mutation research.

Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum.

J. Nicklas, J. O’Neill, P. Rogan, 1998, Mutation research.

Fine structure mapping of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene region of the human X chromosome (Xq26).

R. Albertini, J. Nicklas, J. O’Neill, 1991, American journal of human genetics.

Development of long PCR techniques to analyze deletion mutations of the human hprt gene.

B. Van Houten, J. Nicklas, J. O’Neill, 1998, Mutation research.

DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.

T. Skopek, R. Albertini, J. Nicklas, 1990, Mutagenesis.

Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age.

R. Albertini, J. Nicklas, J. O’Neill, 1994, Mutation research.

An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets.

A. Tates, D. Beare, D. Robinson, 1994, Mutation research.

Mutagenicity monitoring in humans by autoradiographic assay for mutant T lymphocytes.

R. Albertini, J. O’Neill, J. Stewart, 1988, Mutation research.

Cytotoxicity and mutagenicity of dimethylnitrosamine in mammalian cells (CHO/HGPRT system); enhancement by calcium phosphate.

J. O’Neill, A. Hsie, R. Machanoff, 1982, Environmental mutagenesis.

Chemical mutagenesis of mammalian cells can be quantified

J. O’Neill, A. Hsie, J. O'neill, 1977, Nature.

Molecular analyses of in vivo hypoxanthine-guanine phosphoribosyltransferase mutations in human T-lymphocytes: II. Demonstration of a clonal amplification of hprt mutant T-lymphocytes in vivo.

R. Albertini, J. Nicklas, J. O’Neill, 1988, Environmental and molecular mutagenesis.

Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA.

J. O’Neill, R. J. Preston, M. Heartlein, 1983, Mutation research.

V(D)J recombinase mediated inter‐chromosomal HPRT alterations at cryptic recombination signal sequences in peripheral human T cells

J. O’Neill, T. Messier, B. Finette, 2006, Human mutation.

Possible role of adenosine cyclic 3':5'-monophosphate phosphodiesterase in the morphological transformation of Chinese hamster ovary cells mediated by N6,O2-dibutyryl adenosine cyclic 3':5"-monophosphate.

J. O’Neill, C. Schröder, K. Kawashima, 1975, The Journal of biological chemistry.

Induction of chromosomes aberrations, sister chromatid exchanges, and specific locus mutations in Chinese hamster ovary cells by 5-bromodeoxyuridine.

J. O’Neill, A. Hsie, J. S. San Sebastian, 1980, Cytogenetics and cell genetics.

The replication of unsubstituted and 5-bromodeoxyuridine- or 5-chlorodeoxyuridine-substituted DNA regulates the rate of induction of sister chromatid exchanges.

J. O’Neill, R. J. Preston, M. Heartlein, 1984, Basic life sciences.

SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU.

J. O’Neill, R. J. Preston, M. Heartlein, 1983, Mutation research.

The cytotoxic and mutagenic effects of 5-bromodeoxyuridine-plus-black-light treatment in cultured mammalian cells.

J. O’Neill, L. A. Lynn, J. O'neill, 1982, Mutation research.

The induction of specific-locus mutations and sister-chromatid exchanges by 5-bromo- and 5-chloro-deoxyuridine.

J. O’Neill, R. J. Preston, M. Heartlein, 1982, Mutation research.

Genotoxic Markers among Butadiene Polymer Workers in China Long-term Measures, but Did Not Show Specific Genotoxic Effects, at the Chromosomal or Gene Levels, Related to That

R. Hayes, W. Bechtold, M. Dosemeci, 2022 .

Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans.

R. Albertini, J. Nicklas, J. O’Neill, 1987, Mutagenesis.

Quantitative analysis of cytotoxicity and mutagenicity of benzo[a]pyrene in mammalian cells (CHO/HGPRT system).

J. O’Neill, A. Hsie, R. Machanoff, 1981, Chemico-biological interactions.

Quantitative mammalian cell mutagenesis and a preliminary study of the mutagenic potential of metallic compounds. [Cell system used was CHO/HGPRT]

J. O’Neill, A. Hsie, D. B. Couch, 1978 .

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): utilization with a variety of mutagenic agents.

J. O’Neill, A. Hsie, R. Machanoff, 1977, Mutation research.

Radiation quality affects the efficiency of induction and the molecular spectrum of HPRT mutations in human T cells.

R. Albertini, J. Nicklas, J. O’Neill, 1997, Radiation research.

Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.

J. O’Neill, David N. Taylor, A. L. Bourgeois, 2006, Vaccine.

In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes.

R. Albertini, J. O’Neill, L. Sullivan, 1990, Mutation research.

Transition mutations at CpG dinucleotides are the most frequent in vivo spontaneous single‐base substitution mutation in the human HPRT gene

J. O’Neill, Barry A. Finette, 1998, Environmental and molecular mutagenesis.

Markers for carcinogenicity among butadiene-polymer workers in China.

R. Hayes, W. Bechtold, M. Dosemeci, 2001, Chemico-biological interactions.

Prostaglandin E1 induced changes in cyclic AMP levels in WI-38 human fibroblasts. Two different effects of cell density.

J. O’Neill, A. Hsie, 1975, Biochimica et biophysica acta.

Detection of DNA damage and repair by alkaline elution using human lymphocytes.

J. O’Neill, S. Robison, J. S. Munzer, 1988, Mutation research.

hprt mutant frequencies, nonpulmonary malignancies, and domestic radon exposure: “Postmortem” analysis of an interesting hypothesis

A. Baron, J. O’Neill, J. Glanz, 2001, Environmental and molecular mutagenesis.

Quantification of the induction of SCE due to the replication of unsubstituted and BrdU- or CldU-substituted DNA in CHO cells.

J. O’Neill, 1984, Mutation research.

Longitudinal study of the in vivo hprt mutant frequency in human T‐lymphocytes as determined by a cell cloning assay

R. Albertini, J. O’Neill, J. Booker, 1989, Environmental and molecular mutagenesis.

Analysis of point mutations in the hprt gene of cancer patients treated with radioimmunoglobulin therapy

R. Albertini, J. Nicklas, J. O’Neill, 1995, Environmental and molecular mutagenesis.

Induction and expression of mutations in mammalian cells in the absence of DNA synthesis and cell division.

J. O’Neill, J. O'neill, 1982, Mutation research.

In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes.

R. Albertini, J. Nicklas, J. O’Neill, 1991, Mutation research.

hprt mutation frequency among workers exposed to 1,3-butadiene in China.

R. Hayes, R. Henderson, W. Bechtold, 1996, Toxicology.

Studies of DNA alterations in in vivo somatic cell mutations in humans.

R. Albertini, J. Nicklas, J. O’Neill, 1990, Basic life sciences.

Induction and Persistence of Chromosome Aberrations in Human Lymphocytes Exposed to Neutrons In vitro or In vivo: Implications of Findings in 'Retrospective' Biological Dosimetry

J. O’Neill, L. Littlefield, M. Maor, 2000 .

Genetic instability in human T-lymphocytes.

T. Skopek, R. Albertini, J. Nicklas, 1998, Mutation research.

Enumeration of 6‐thioguanine‐resistant T‐lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys)

R. Albertini, J. O’Neill, G. Hoffman, 1991, Environmental and molecular mutagenesis.

Molecular analyses of in vivo hprt mutations in human T-lymphocytes. I. Studies of low frequency 'spontaneous' mutants by Southern blots.

R. Albertini, J. Nicklas, J. O’Neill, 1987, Mutagenesis.

V(D)J Recombinase-Mediated TCR β Locus Gene Usage and Coding Joint Processing in Peripheral T Cells during Perinatal and Pediatric Development

J. O’Neill, P. Vacek, J. Murray, 2012, The Journal of Immunology.

hprt mutations in vivo in human T-lymphocytes: frequencies, spectra and clonality.

T. Skopek, R. Albertini, J. Nicklas, 1990, Progress in clinical and biological research.

The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice.

R. Branda, J. Nicklas, J. O’Neill, 2007, Mutation research.

Increased frequency of specific genomic deletions resulting from in vitro malathion exposure.

R. Albertini, J. Nicklas, J. O’Neill, 1996, Cancer research.

Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures

T. Skopek, R. Albertini, J. Nicklas, 1990, Human Genetics.

Mutations in the hypoxanthine-guanine phosphoribosyltransferase gene in Spanish HPRT deficient families.

J. O’Neill, R. Torres, J. Puig, 2000, Advances in experimental medicine and biology.

Utilization of a quantitative mammalian cell mutation system, CHO/HGPRT, in experimental mutagenesis and genetic toxicology

J. O’Neill, A. Hsie, D. B. Couch, 1977 .

IN VIVO MUTATIONS IN HUMAN T-CELLS AFTER IONIZING RADIATION EXPOSURES

R. Albertini, J. Nicklas, J. O’Neill, 1992 .

Factors influencing mutation at the hprt locus in T‐lymphocytes: Studies in normal women and women with benign and malignant breast masses

R. Branda, R. Albertini, J. O’Neill, 1992, Environmental and molecular mutagenesis.

A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay.

A. Li, W. Choy, J. O’Neill, 1987, Mutation research.

High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.

J. Tischfield, R. Albertini, J. O’Neill, 1997, Cancer research.

Action of cyclic nucleotide analogues in Chinese hamster ovary cells.

A. Li, J. O’Neill, A. Hsie, 1977, Biochimica et biophysica acta.

Mutagenicity of heterocyclic nitrogen mustards (ICR compounds) in cultured mammalian cells.

J. Fuscoe, J. O’Neill, A. Hsie, 1978, Cancer research.

Quantification and analysis of reverse mutations at the hgprt locus in Chinese hamster ovary cells.

J. Fuscoe, J. O’Neill, A. Hsie, 1982, Mutation research.

The cell cycle specificity of the morphological conversion of chinese hamster ovary cells by N6, O2'-dibutyryl cyclic adenosine 3',5'-phosphate.

J. O’Neill, A. Hsie, C. Schröder, 1976, Experimental cell research.

Induction of chromosome aberrations and specific locus mutation but not sister chromatid exchanges in Chinese hamster ovary cells by neocarzinostatin.

J. O’Neill, R. J. Preston, W. Au, 1984, Teratogenesis, carcinogenesis, and mutagenesis.

Effect of pentachlorophenol on the activation of 2,6‐dinitrotoluene to genotoxic urinary metabolites in CD‐1 mice: A comparison of GI enzyme activities and urine mutagenicity

J. Creason, J. O’Neill, J. Dekker, 1991, Environmental and molecular mutagenesis.

HPRT deficiency in a two-month-old child presenting acute renal failure and gout with a new deletion of two bases in exon 3 of the HPRT gene.

J. O’Neill, R. O. Escárcega, R. Vazquez, 2007, Archives of medical research.

Sensitivity of somatic mutations in human umbilical cord blood to maternal environments

R. Albertini, J. Nicklas, J. O’Neill, 1995, Environmental and molecular mutagenesis.

Melanin photosensitizes ultraviolet light (uvc) dna damage in pigmented cells

J. O’Neill, C. Huselton, H. Hill, 1990, Environmental and molecular mutagenesis.

Somatic cell gene mutations in humans: biomarkers for genotoxicity.

R. Albertini, J. Nicklas, J. O’Neill, 1993, Environmental health perspectives.