C. Schroeder

发表

Fmoc-based synthesis of disulfide-rich cyclic peptides.

D. Craik, David A. Price, O. Cheneval, 2014, The Journal of organic chemistry.

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

D. Craik, C. Schroeder, T. Durek, 2016, Biopolymers.

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain.

C. Schroeder, R. Lewis, P. Alewood, 2009, Journal of medicinal chemistry.

Disulfide-rich macrocyclic peptides as templates in drug design.

D. Craik, C. Schroeder, T. Durek, 2014, European journal of medicinal chemistry.

Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel

C. Schroeder, R. Lewis, M. Smythe, 2004, Molecular Diversity.

The α2δ Auxiliary Subunit Reduces Affinity of ω-Conotoxins for Recombinant N-type (Cav2.2) Calcium Channels*

Aaron M. Beedle, David John Adams, C. Schroeder, 2004, Journal of Biological Chemistry.

Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers.

Jason S. Lewis, T. Reiner, C. Schroeder, 2021, Molecular pharmaceutics.

Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?

C. Schroeder, S. Henriques, A. Agwa, 2017, Neuropharmacology.

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

M. Ammirati, D. Craik, David A. Price, 2014, Chemistry & biology.

Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides.

D. Craik, C. Schroeder, Joakim E. Swedberg, 2013, Current protein & peptide science.

A novel (cid:1) 4/7-conotoxin LvIA from Conus lividus that selectively blocks (cid:1) 3 (cid:2) 2 vs . (cid:1) 6/ (cid:1) 3 (cid:2) 2 (cid:2) 3 nicotinic acetylcholine receptors

D. Craik, Q. Kaas, C. Schroeder, 2014 .

N‐ and c‐terminal extensions of μ‐conotoxins increase potency and selectivity for neuronal sodium channels

C. Schroeder, R. Lewis, P. Alewood, 2012, Biopolymers.

N-type calcium channel blockers: novel therapeutics for the treatment of pain.

C. Schroeder, R. Lewis, G. Zamponi, 2006, Medicinal chemistry (Shariqah (United Arab Emirates)).

Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?

C. Schroeder, J. Svenson, N. Molchanova, 2022, Frontiers in Immunology.

Peptides from mamba venom as pain killers.

D. Craik, C. Schroeder, 2013, Angewandte Chemie.

Enzymatic Ligation of Disulfide-Rich Animal Venom Peptides: Using Sortase A to Form Double-Knotted Peptides.

C. Schroeder, Poanna Tran, 2021, Methods in molecular biology.

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID.

D. Craik, C. Schroeder, R. Lewis, 2012, Biopolymers.

Synthesis and biological evaluation of nonpeptide mimetics of ω-conotoxin GVIA

J. Baell, C. Schroeder, R. Lewis, 2004 .

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.

D. Craik, P. Loria, David A. Price, 2015, European journal of medicinal chemistry.

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7

D. Craik, I. Vetter, C. Schroeder, 2022, Toxins.

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.

Brice A P Wilson, Y. Pommier, K. Gustafson, 2020, Journal of the American Chemical Society.

Isolation and Structure-Activity of (cid:1) -Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels

David John Adams, C. Schroeder, R. Lewis, 2007 .

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.

D. Craik, C. Schroeder, Jonathan M. Harris, 2016, Journal of medicinal chemistry.

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ -conotoxin KIIIA disul ﬁ de isomers

I. Vetter, C. Schroeder, J. Deuis, 2022 .

Development of a (cid:2) O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel Na V 1.8 *

D. Craik, I. Vetter, C. Schroeder, 2020 .

High‐Throughput Synthesis of Peptide α‐Thioesters: A Safety Catch Linker Approach Enabling Parallel Hydrogen Fluoride Cleavage

C. Schroeder, P. Alewood, A. Brust, 2014, ChemMedChem.

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

J. Baell, C. Schroeder, R. Lewis, 2004, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA

J. Baell, C. Schroeder, R. Lewis, 2006 .

Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant

I. Vetter, C. Schroeder, Vanessa Schendel, 2023, BMC Biology.

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

I. Vetter, C. Schroeder, S. Robinson, 2022, Scientific reports.

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed.

Martin J. Stoermer, D. Craik, David A. Price, 2014, ACS medicinal chemistry letters.

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods

D. Craik, Q. Kaas, C. Schroeder, 2018, Marine drugs.

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

C. Schroeder, Markus Muttenthaler, Alysha G. Elliott, 2020, Chemical communications.

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract.

C. Schroeder, S. Brierley, Markus Muttenthaler, 2020, ACS pharmacology & translational science.

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

C. Schroeder, Markus Muttenthaler, Alysha G. Elliott, 2020, Chemical communications.

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite

C. Schroeder, A. Beck‐Sickinger, Markus Muttenthaler, 2021, Journal of medicinal chemistry.

Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans

I. Vetter, C. Schroeder, D. Merritt, 2021, Proceedings of the National Academy of Sciences.

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7

D. Craik, I. Vetter, C. Schroeder, 2020, The Journal of Biological Chemistry.

Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease.

P. Dawson, C. Schroeder, G. Dawson, 2010, Biochemical and biophysical research communications.

Pharmacological Inhibition of the Voltage-Gated Sodium Channel NaV1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome.

T. Reiner, C. Schroeder, G. King, 2021, ACS pharmacology & translational science.

Isolation and Structure-Activity of μ-Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels

David John Adams, C. Schroeder, R. Lewis, 2007, Molecular Pharmacology.

Neuronally Selective μ-Conotoxins from Conus striatus Utilize an α-Helical Motif to Target Mammalian Sodium Channels*

David John Adams, C. Schroeder, R. Lewis, 2008, Journal of Biological Chemistry.

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

T. Sixma, A. Smit, C. Schroeder, 2007, The EMBO Journal.

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.

David John Adams, C. Schroeder, R. Lewis, 2007, Molecular pharmacology.

Identification of a Novel Class of Nicotinic Receptor Antagonists

David John Adams, C. Schroeder, R. Lewis, 2006, Journal of Biological Chemistry.

Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide.

T. Reiner, I. Ganly, C. Schroeder, 2019, Bioconjugate chemistry.

A novel α4/7‐conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors

D. Craik, Q. Kaas, C. Schroeder, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

C. Schroeder, R. Lewis, 2006, Marine Drugs.

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Philipp M. Cromm, A. Plowright, D. Craik, 2018, Journal of medicinal chemistry.

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A*

D. Craik, C. Schroeder, Yen‐Hua Huang, 2014, The Journal of Biological Chemistry.

Small cyclic sodium channel inhibitors.

D. Craik, I. Vetter, J. Tytgat, 2020, Biochemical pharmacology.

Efficient enzymatic cyclization of an inhibitory cystine knot‐containing peptide

D. Craik, O. Cheneval, Q. Kaas, 2016, Biotechnology and bioengineering.

Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition.

I. Vetter, C. Schroeder, J. Deuis, 2019, Bioconjugate chemistry.

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7*

A. Mark, D. Craik, I. Vetter, 2016, The Journal of Biological Chemistry.

Therapeutic potential of conopeptides.

David J Craik, D. Craik, C. Schroeder, 2012, Future medicinal chemistry.

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

I. Vetter, C. Schroeder, J. Deuis, 2022, The Journal of biological chemistry.

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

I. Vetter, C. Schroeder, R. Lewis, 2020, Biomedicines.

Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors

D. Craik, P. Herdewijn, S. Heinemann, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

D. Craik, C. Schroeder, Yen‐Hua Huang, 2017, Toxins.

Weaponisation 'on the fly': convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies.

C. Schroeder, G. King, G. Panyi, 2019, Insect biochemistry and molecular biology.

Development of a O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8

D. Craik, I. Vetter, C. Schroeder, 2016 .

Modelling the interactions between animal venom peptides and membrane proteins

Q. Kaas, C. Schroeder, S. Kuyucak, 2017, Neuropharmacology.

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

David J. Craik, David P. Fairlie, Spiros Liras, 2014, Proceedings of the National Academy of Sciences.

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

D. Craik, J. Tytgat, C. Schroeder, 2018, The Journal of Biological Chemistry.

Spinal actions of ω‐conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model

C. Schroeder, M. Christie, C. Vaughan, 2013, British journal of pharmacology.

Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.

David John Adams, C. Schroeder, R. Lewis, 2003, The Journal of biological chemistry.

Cyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site.

D. Craik, J. Tytgat, O. Cheneval, 2021, ACS pharmacology & translational science.

Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides.

D. Craik, I. Vetter, C. Schroeder, 2021, Bioconjugate chemistry.

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I.

S. Dib-Hajj, S. Waxman, I. Vetter, 2020, Biochemical pharmacology.

Three-Dimensional Structure Determination of Peptides Using Solution Nuclear Magnetic Resonance Spectroscopy.

C. Schroeder, K. Rosengren, 2019, Methods in molecular biology.

ω-Conotoxin CVID Inhibits a Pharmacologically Distinct Voltage-sensitive Calcium Channel Associated with Transmitter Release from Preganglionic Nerve Terminals*

David John Adams, C. Schroeder, R. Lewis, 2003, The Journal of Biological Chemistry.

Inhibition of the Norepinephrine Transporter by the Venom Peptide χ-MrIA

David John Adams, C. Schroeder, R. Lewis, 2003, Journal of Biological Chemistry.

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro*

D. Craik, P. Loria, David A. Price, 2016, The Journal of Biological Chemistry.

Block of Voltage-Gated Calcium Channels by Peptide Toxins

David John Adams, C. Schroeder, R. Lewis, 2005 .

Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities.

I. Vetter, C. Schroeder, G. King, 2021, Biochemical pharmacology.

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.

D. Craik, C. Schroeder, G. King, 2018, Bioconjugate chemistry.

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

D. Craik, O. Cheneval, C. Schroeder, 2017, Biochimica et biophysica acta. Biomembranes.

Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.

Andrew M. White, A. Plowright, D. Craik, 2021, Journal of medicinal chemistry.

Early development of Monoplex pilearis and Monoplex parthenopeus (Gastropoda: Cymatiidae): biology and morphology

D. Craik, Q. Kaas, C. Schroeder, 2020, Organisms Diversity & Evolution.

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.

D. Craik, C. Schroeder, T. Durek, 2014, Angewandte Chemie.

Targeted Delivery of Cyclotides via Conjugation to a Nanobody.

D. Craik, H. Ploegh, O. Cheneval, 2018, ACS chemical biology.

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.

D. Craik, C. Schroeder, S. D. de Veer, 2018, European journal of medicinal chemistry.

Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific.

I. Vetter, C. Schroeder, R. Payne, 2023, Bioconjugate chemistry.

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

D. Craik, C. Schroeder, Yen‐Hua Huang, 2017, Biopolymers.

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH

I. Vetter, C. Schroeder, M. Mobli, 2023, ACS omega.

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

I. Vetter, O. Cheneval, C. Schroeder, 2019, Pain.

Mapping the Molecular Surface of the Analgesic NaV1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions.

I. Vetter, Q. Kaas, C. Schroeder, 2020, ACS pharmacology & translational science.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.

D. Craik, O. Cheneval, C. Schroeder, 2018, ACS chemical biology.

Calcium-Mediated Allostery of the EGF Fold.

D. Craik, J. Weidmann, P. Harvey, 2018, ACS Chemical Biology.

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating.

A. Mark, D. Craik, Jennifer J. Smith, 2016, Biochimica et biophysica acta.

Cyclizing Disulfide-Rich Peptides Using Sortase A.

D. Craik, C. Schroeder, A. Agwa, 2019, Methods in molecular biology.

ω‐Conotoxin CVIB differentially inhibits native and recombinant N‐ and P/Q‐type calcium channels

David John Adams, C. Schroeder, R. Lewis, 2007 .

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

T. Sixma, C. Schroeder, C. Ulens, 2007, The EMBO Journal.

Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a.

I. Vetter, C. Schroeder, R. Payne, 2023, Organic letters.

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

D. Craik, O. Cheneval, C. Schroeder, 2017, Biochimica et biophysica acta. Biomembranes.

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

I. Vetter, Nina Brinkwirth, C. Schroeder, 2023, Nature communications.

Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels

I. Vetter, C. Schroeder, N. Daly, 2023, The FEBS journal.