H. Wijma

发表

Computationally designed libraries for rapid enzyme stabilization

Hein J. Wijma, David Baker, D. Janssen, 2014, Protein engineering, design & selection : PEDS.

Stabilizing AqdC, a Pseudomonas Quinolone Signal‐Cleaving Dioxygenase from Mycobacteria, by FRESCO‐Based Protein Engineering

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

Creating Flavin Reductase Variants with Thermostable and Solvent‐Tolerant Properties by Rational‐Design Engineering

H. Wijma, S. Maenpuen, Vinutsada Pongsupasa, 2020, ChemBioChem.

A robust cosolvent-compatible halohydrin dehalogenase by computational library design

Hein J. Wijma, D. Janssen, H. Wijma, 2016, Protein engineering, design & selection : PEDS.

Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue

Marco W. Fraaije, Hein J. Wijma, Dick B. Janssen, 2014, FEBS open bio.

Computational Library Design for Increasing Haloalkane Dehalogenase Stability

Hein J. Wijma, B. Feringa, D. Janssen, 2014, Chembiochem : a European journal of chemical biology.

Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor

Hein J. Wijma, Matthias Heinemann, A. Schmidt, 2019, bioRxiv.

Measuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor

Matthias Heinemann, A. Schmidt, H. Wijma, 2019, Molecular systems biology.

Assessment of the interaction between the flux‐signaling metabolite fructose‐1,6‐bisphosphate and the bacterial transcription factors CggR and Cra

Matthias Heinemann, A. Milias-Argeitis, H. Wijma, 2018, Molecular microbiology.

In silico screening of enzyme variants by molecular dynamics simulation

Hein J. Wijma, H. Wijma, 2016 .

Metabolism of β-valine via a CoA-dependent ammonia lyase pathway

Hein J. Wijma, D. Janssen, H. Wijma, 2015, Applied Microbiology and Biotechnology.

Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation.

Hein J. Wijma, H. Wijma, F. Armstrong, 2007, Journal of the American Chemical Society.

Sensing nitrite through a pseudoazurin-nitrite reductase electron transfer relay.

Jason J. Davis, H. Wijma, H. Hill, 2005, Chemphyschem : a European journal of chemical physics and physical chemistry.

Directed Evolution Strategies for Enantiocomplementary Haloalkane Dehalogenases: From Chemical Waste to Enantiopure Building Blocks

Hein J Wijma, Dick B Janssen, Hein J. Wijma, 2012, Chembiochem : a European journal of chemical biology.

Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

Thermal stability effects of removing the type-2 copper ligand His306 at the interface of nitrite reductase subunits

H. Wijma, R. Guzzi, L. Sportelli, 2007, European Biophysics Journal.

BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B

Hein J. Wijma, H. Wijma, M. Fraaije, 2012 .

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

Hein J. Wijma, D. Janssen, B. Dijkstra, 2013, Chembiochem : a European journal of chemical biology.

Computational redesign of enzymes for regio- and enantioselective hydroamination

Hein J. Wijma, D. Janssen, H. Wijma, 2018, Nature Chemical Biology.

Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase.

M. Murphy, H. Wijma, E. Tocheva, 2007, Journal of the American Chemical Society.

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering**

Hein J. Wijma, D. Janssen, H. Wijma, 2020, Chembiochem : a European journal of chemical biology.

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

Hein J. Wijma, D. Janssen, H. Wijma, 2020, ACS catalysis.

Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus

Hein J. Wijma, B. Feringa, D. Janssen, 2012, Applied and Environmental Microbiology.

Peptide C-terminal modification using a computationally stabilized peptide amidase

Hein J. Wijma, B. Feringa, D. Janssen, 2018 .

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate and Protein Engineering

Hein J. Wijma, D. Janssen, H. Wijma, 2020, bioRxiv.

A conserved sequence motif in the Escherichia coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency

Hein J. Wijma, H. Wijma, M. Fraaije, 2022, The Journal of biological chemistry.

Bidirectional catalysis by copper-containing nitrite reductase.

Hein J. Wijma, S. de Vries, H. Wijma, 2004, Biochemistry.

A Random-sequential Mechanism for Nitrite Binding and Active Site Reduction in Copper-containing Nitrite Reductase*

Hein J. Wijma, H. Wijma, F. Armstrong, 2006, Journal of Biological Chemistry.

Electronic structure of the two copper sites in nitrite reductase by 9 and 95 GHz EPR on cavity mutants

H. Wijma, M. Huber, M. Verbeet, 2006 .

The substrate-bound type 2 copper site of nitrite reductase: the nitrogen hyperfine coupling of nitrite revealed by pulsed EPR.

H. Wijma, M. Huber, E. Groenen, 2005, Biochemistry.

A photo-switchable yeast isocitrate dehydrogenase to control metabolic flux through the citric acid cycle

Hein J. Wijma, Matthias Heinemann, H. Wijma, 2021, bioRxiv.

Catalytic and structural properties of ATP‐dependent caprolactamase from Pseudomonas jessenii

Hein J. Wijma, Clemens Mayer, D. Janssen, 2020, Proteins.

Enantioselective enzymes by computational design and in silico screening.

David Baker, Siewert J Marrink, Hein J Wijma, 2015, Angewandte Chemie.

Calorimetric and spectroscopic investigations of the thermal denaturation of wild type nitrite reductase.

H. Wijma, R. Guzzi, L. Sportelli, 2005, Biochimica et biophysica acta.

Protein engineering of amine transaminases

Hein J. Wijma, D. Janssen, H. Wijma, 2022, Frontiers in Catalysis.

Computational Prediction of ω-Transaminase Specificity by a Combination of Docking and Molecular Dynamics Simulations

D. Janssen, S. Marrink, H. Wijma, 2021, Journal of chemical information and modeling.

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Hein J. Wijma, D. Janssen, S. Marrink, 2021, ACS catalysis.

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.

Hein J. Wijma, D. Janssen, H. Wijma, 2018, Organic & biomolecular chemistry.

Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

Hein J. Wijma, A. Casini, H. Wijma, 2016, Molecular bioSystems.

Structure- and sequence-analysis inspired engineering of proteins for enhanced thermostability.

Hein J Wijma, Dick B Janssen, D. Janssen, 2013, Current opinion in structural biology.

Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion.

Hein J. Wijma, M. Murphy, H. Wijma, 2003, Biochemistry.

Rational-design engineering to create the flavin reductase variants with thermostable and solvent-tolerant properties.

H. Wijma, S. Maenpuen, Vinutsada Pongsupasa, 2019, Chembiochem : a European journal of chemical biology.

University of Groningen Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus Crismaru,

Hein J. Wijma, B. Feringa, D. Janssen, 2013 .

Computational design gains momentum in enzyme catalysis engineering

Hein J Wijma, Dick B Janssen, Hein J. Wijma, 2013, The FEBS journal.

Computationally Efficient and Accurate Enantioselectivity Modeling by Clusters of Molecular Dynamics Simulations

Siewert J. Marrink, Hein J. Wijma, Dick B. Janssen, 2014, J. Chem. Inf. Model..

Kinetic Resolution of α-Bromoamides: Experimental and Theoretical Investigation of Highly Enantioselective Reactions Catalyzed by Haloalkane Dehalogenases

Hein J. Wijma, B. Feringa, D. Janssen, 2011 .

From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase

Hein J. Wijma, D. Janssen, H. Wijma, 2021, Computational and structural biotechnology journal.

Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase.

Hein J. Wijma, B. Feringa, D. Janssen, 2010, Chemical communications.

Aminoacyl‐coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum

Hein J. Wijma, D. Janssen, H. Wijma, 2011, FEBS letters.

Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design

Hein J. Wijma, H. Wijma, M. Fraaije, 2018, Biotechnology for Biofuels.

Thermodynamics Determine the Diastereochemical Outcome of Catalytic Reactions

Hein J. Wijma, H. Wijma, L. Mestrom, 2021, ChemCatChem.

A Computational Library Design Protocol for Rapid Improvement of Protein Stability: FRESCO.

Hein J Wijma, Maximilian J L J Fürst, Dick B Janssen, 2017, Methods in molecular biology.

Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase

Ben L. Feringa, Hein J. Wijma, Dick B. Janssen, 2016 .

Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B

H. Wijma, M. Fraaije, R. T. Winter, 2012, Applied Microbiology and Biotechnology.

Peptide esterification by SbPam: studies on organic solvent stability and thermostability

Hein J. Wijma, D. Janssen, H. Wijma, 2018 .

A rearranging ligand enables allosteric control of catalytic activity in copper-containing nitrite reductase.

Hein J. Wijma, M. Murphy, H. Wijma, 2006, Journal of molecular biology.

Characterization of two bacterial multi-flavinylated proteins harboring multiple covalent flavin cofactors

Hein J. Wijma, H. Wijma, H. Rozeboom, 2023, BBA advances.

Real-Time Conformational Changes and Controlled Orientation of Native Proteins Inside a Protein Nanoreactor

Hein J. Wijma, B. Poolman, H. Wijma, 2017, Journal of the American Chemical Society.

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.

Hein J. Wijma, D. Janssen, H. Wijma, 2023, The FEBS journal.

Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin

Hein J. Wijma, D. Janssen, H. Wijma, 2022, ACS catalysis.