T. Bickle

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A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.

J. Heitman, J. V. Van Etten, B. Stoddard, 2003, Nucleic acids research.

Phage introns on the hop: an alternative view

T. Bickle, 1992, Current Biology.

The McrBC restriction endonuclease assembles into a ring structure in the presence of G nucleotides

S. Müller, A. Engel, T. Bickle, 2001, The EMBO journal.

A single gene coding for resistance to both fusidic acid and chloramphenicol.

S. Iida, T. Bickle, T. A. Völker, 1982, Journal of molecular biology.

Mapping and characterization of the promoter elements of the regulatory nif genes rpoN, nifA1 and nifA2 in Rhodobacter capsulatus

T. Bickle, P. Preker, M. Schmehl, 1992, Molecular microbiology.

S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme.

M. Antognozzi, T. Bickle, M. Szczelkun, 2003, Journal of molecular biology.

DNA translocation blockage, a general mechanism of cleavage site selection by type I restriction enzymes

T. Bickle, V. Nagaraja, P. Janscak, 1999, The EMBO journal.

T. Bickle, R. Traut, T. Sun, 1972, Journal of bacteriology.

Complex restriction enzymes: NTP-driven molecular motors.

T. Bickle, Aude A Bourniquel, 2002, Biochimie.

ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.

T. Bickle, R. Yuan, C. Brack, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Macroevolution by transposition: drastic modification of DNA recognition by a type I restriction enzyme following Tn5 transposition.

E. Skrzypek, T. Bickle, A. Piekarowicz, 1993, The EMBO journal.

DNA methylation of bacterial viruses T3 and T7 by different DNA methylases in Escherichia coli K12 cells.

T. Bickle, D. Krüger, M. Reuter, 1985, European journal of biochemistry.

Structural homologies among type I restriction‐modification systems.

T. Bickle, N. Murray, J. Gough, 1982, The EMBO journal.

EcoA: the first member of a new family of type I restriction modification systems. Gene organization and enzymatic activities.

T. Bickle, B. Suri, 1985, Journal of molecular biology.

ATPase activity of the type IC restriction-modification system EcoR124II.

T. Bickle, J. Dreier, 1996, Journal of molecular biology.

Chemical Restriction: Strand Cleavage by Ammonia Treatment at 8‐Oxoguanine Yields Biologically Active DNA

T. Bickle, B. Giese, C. Meyer, 2003, ChemBioChem.

Purification and characterisation of a small DNA-binding protein, HB, from Bacillus globigii.

T. Bickle, H. Bächinger, R. Imber, 2005, European journal of biochemistry.

DNA recognition and cleavage by the EcoP15 restriction endonuclease.

T. Bickle, K. Ineichen, R. Yuan, 1979, Journal of molecular biology.

Separation of large quantities of ribosomal subunits by zonal ultracentrifugation.

E. Eikenberry, T. Bickle, R. Traut, 1970, European journal of biochemistry.

Generation of new DNA binding specificity by truncation of the type IC EcoDXXI hsdS gene.

T. Bickle, M. MacWilliams, 1996, The EMBO journal.

Characterization of mutations of the bacteriophage P1 mod gene encoding the recognition subunit of the EcoP1 restriction and modification system

T. Bickle, D. Rao, H. Eberle, 1989, Journal of bacteriology.

New Light‐Sensitive Nucleosides for Caged DNA Strand Breaks

T. Bickle, B. Giese, A. Marx, 2002, Chembiochem : a European journal of chemical biology.

A simple, general procedure for purifying restriction endonucleases.

V. Pirrotta, T. Bickle, R. Imber, 1977, Nucleic acids research.

The Escherichia coli prr region encodes a functional type IC DNA restriction system closely integrated with an anticodon nuclease gene.

T. Bickle, J. Meister, C. Tyndall, 1994, Journal of molecular biology.

A possible role for DNA restriction in bacterial evolution.

T. Bickle, C. Price, 1986, Microbiological sciences.

Bacterial DNA modification.

T. Bickle, V. Nagaraja, B. Suri, 1984, Current topics in microbiology and immunology.

Deletion analysis of a bacteriophage T4 late promoter.

T. Bickle, B. Keller, T. A. Völker, 1985, Gene.

New Variations on an Old Theme: Type I Restriction Enzymes and their Recognition Sequences

T. Bickle, V. Nagaraja, B. Suri, 1985 .

4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase.

T. Bickle, M. Amacker, U. Hübscher, 1998, Nucleic acids research.

Two DNA antirestriction systems of bacteriophage P1, darA, and darB: characterization of darA- phages.

S. Iida, T. Bickle, M. Streiff, 1987, Virology.

Ribosome heterogenecity. The nonuniform distribution of specific ribosomal proteins among different functional classes of ribosomes.

T. Bickle, R. Traut, G. Howard, 1973, The Journal of biological chemistry.

Purification and properties of the restriction endonuclease BglII from Bacillus globigii.

T. Bickle, R. Imber, 1981, European journal of biochemistry.

Correlation of 30S ribosomal proteins ofEscherichia coli isolated in different laboratories

C. Kurland, T. Bickle, R. Traut, 2004, Molecular and General Genetics MGG.

Methyl-specific DNA binding by McrBC, a modification-dependent restriction enzyme.

T. Bickle, E. Raleigh, D. Panne, 2000, Journal of molecular biology.

Ribosomal proteins of E. Coli: stoichiometry and implications for ribosome structure.

T. Bickle, R. Traut, H. Delius, 1969, Cold Spring Harbor symposia on quantitative biology.

Differences in size and number of 80 S and 70 S ribosomal proteins by dodecyl sulfate gel electrophoresis.

T. Bickle, R. Traut, 1971, The Journal of biological chemistry.

4‘-Acylated Thymidines: A New Class of DNA Chain Terminators and Photocleavable DNA Building Blocks

T. Bickle, B. Giese, A. Marx, 1997 .

Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.

G. Maga, T. Bickle, M. Amacker, 1999, Chemistry & biology.

The DNA sequence recognised by the HinfIII restriction endonuclease.

T. Bickle, K. Ineichen, A. Piekarowicz, 1981, Journal of molecular biology.

The DNA sequence recognised by BglI.

T. Bickle, K. Ineichen, 1980, Gene.

Cloning, over-expression and the catalytic properties of the EcoP15 modification methylase from Escherichia coli.

M. Page, T. Bickle, D. Rao, 1989, Journal of molecular biology.

Biology of DNA restriction.

T. Bickle, D. Krüger, T A Bickle, 1993, Microbiological reviews.

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.

T. Bickle, K. Shiraishi, P. Janscak, 2003, Journal of Molecular Biology.

DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI.

T. Bickle, P. Janscak, 2000, Journal of molecular biology.

Bacteriophage survival: multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts.

T. Bickle, D. Krüger, D. Kruger, 1983, Microbiological reviews.

Determination of the cleavage site of the phage T4 prohead protease in gene product 68. Influence of protein secondary structure on cleavage specificity.

A. Tsugita, T. Bickle, E. Kellenberger, 1985, Journal of molecular biology.

T. Bickle, R. Traut, 1972 .

Gene 68, a new bacteriophage T4 gene which codes for the 17K prohead core protein is involved in head size determination.

T. Bickle, E. Kellenberger, C. Sengstag, 1984, Journal of molecular biology.

Expression of regulatory nif genes in Rhodobacter capsulatus

J. Willison, T. Bickle, P. Vignais, 1991, Journal of bacteriology.

Host-controlled restriction and modification of filamentous 1- and F-specific bacteriophages.

T. Bickle, W. Arber, 1969, Virology.

Bacteriophage survival: multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts

T. Bickle, D. Krüger, 1983 .

Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes.

T. Bickle, K. Firman, J. Lingner, 1989, Journal of molecular biology.

EcoR124 and EcoR124/3: the first members of a new family of type I restriction and modification systems.

T. Bickle, C. Price, C. Price, 1987, European journal of biochemistry.

Biology of DNA restriction

T. Bickle, D. Krüger, 1993 .

Biology ofDNA Restriction

T. Bickle, 1993 .

Multiple steps in DNA recognition by restriction endonuclease from E. coli K

T. Bickle, R. Yuan, C. Brack, 1975, Nature.

A map of the sites on bacteriophage PM2 DNA for the restriction endonucleases HindIII and HpaII.

T. Bickle, R. Yuan, H. Eberle, 1976, Journal of molecular biology.

Variant insertion element IS1 generates 8-base pair duplications of the target sequence

S. Iida, T. Bickle, R. Marcoli, 1981, Nature.

DNA restriction--modification genes of phage P1 and plasmid p15B. Structure and in vitro transcription.

S. Iida, T. Bickle, W. Arber, 1983, Journal of molecular biology.

Gene 67, a new, essential bacteriophage T4 head gene codes for a prehead core component, PIP. II. The construction in vitro of unconditionally lethal mutants and their maintenance.

T. Bickle, A. Kuhn, M. Showe, 1982, Journal of molecular biology.

Gene 67, a new, essential bacteriophage T4 head gene codes for a prehead core component, PIP. I. Genetic mapping and DNA sequence.

T. Bickle, M. Showe, T. A. Völker, 1982, Journal of molecular biology.

A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity

T. Bickle, V. Nagaraja, J. Shepherd, 1985, Nature.

The McrBC endonuclease translocates DNA in a reaction dependent on GTP hydrolysis.

T. Bickle, E. Raleigh, D. Panne, 1999, Journal of molecular biology.

A novel bacteriophage defence mechanism: the anti-restriction protein

P. Herrlich, T. Bickle, N. Spoerel, 1979, Nature.

Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I.

T. Bickle, M. Szczelkun, P. Janscak, 2001, Journal of molecular biology.

Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants.

T. Bickle, D. Hornby, D. Rao, 1988, Journal of molecular biology.

Expression and proteolytic processing of the darA antirestriction gene product of bacteriophage P1.

S. Iida, T. Bickle, M. Streiff, 1987, Virology.

A mutational analysis of the bacteriophage P1 cin recombinase gene: Intragenic complementation

T. Bickle, P. Haffter, T. Pripfl, 2004, Molecular and General Genetics MGG.

Purification and DNA-binding properties of FIS and Cin, two proteins required for the bacteriophage P1 site-specific recombination system, cin.

T. Bickle, P. Haffter, Pascal Haffter, 1987, Journal of molecular biology.

Single amino acid substitutions in the HsdR subunit of the type IB restriction enzyme EcoAI uncouple the DNA translocation and DNA cleavage activities of the enzyme

Pavel Janscak, Ursula Sandmeier, Thomas A. Bickle, 1999, Nucleic Acids Res..

High level expression of the EcoP1 modification methylase gene and characterisation of the gene product.

T. Bickle, D. Hornby, M. Müller, 1987, Gene.

Two type I restriction enzymes from Salmonella species. Purification and DNA recognition sequences.

T. Bickle, V. Nagaraja, J. Shepherd, 1985, Journal of molecular biology.

The bacteriophage P1 site-specific recombinase cin: recombination events and DNA recognition sequences.

S. Iida, T. Bickle, W. Arber, 1984, Cold Spring Harbor symposia on quantitative biology.

Type III restriction endonucleases translocate DNA in a reaction driven by recognition site‐specific ATP hydrolysis.

T. Bickle, D. Krüger, C. Schroeder, 1995, The EMBO journal.

Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage

T. Bickle, C. Schroeder, A. Meisel, 1992, Nature.

Lack of Regulation of the Modification-Dependent Restriction Enzyme McrBC in Escherichia coli

T. Bickle, M. Murphy, S. Schmid Nuoffer, 2002, Journal of bacteriology.

Purification and properties of the Bg1I and II endonucleases.

V. Pirrotta, T. Bickle, R. Imber, 1980, Methods in enzymology.

The DNA sequence of an IS1‐flanked transposon coding for resistance to chloramphenicol and fusidic acid

S. Iida, T. Bickle, R. Marcoli, 1980, FEBS letters.

The EcoA restriction and modification system of Escherichia coli 15T‐: enzyme structure and DNA recognition sequence.

T. Bickle, B. Suri, J. Shepherd, 1984, The EMBO journal.

Role of ATP in the cleavage mechanism of the EcoP15 restriction endonuclease.

T. Bickle, R. Yuan, D. Hamilton, 1980, Journal of molecular biology.

Restricting restriction

T. Bickle, Thomas A. Bickle, 2003, Molecular microbiology.

DNA restriction--modification enzymes of phage P1 and plasmid p15B. Subunit functions and structural homologies.

S. Iida, T. Bickle, B. Bächi, 1983, Journal of molecular biology.

The DNA recognition subunit of the type IB restriction-modification enzyme EcoAI tolerates circular permutions of its polypeptide chain.

T. Bickle, P. Janscak, 1998, Journal of molecular biology.

On the DNA cleavage mechanism of Type I restriction enzymes

T. Bickle, P. Janscak, F. Hamburger, 2005, Nucleic acids research.

Regulation of the activity of the type IC EcoR124I restriction enzyme.

T. Bickle, E. Kulik, Eva M. Kulik, 1996, Journal of molecular biology.

Mapping of recognition sites for the restriction endonuclease from Escherichia coli K12 on bacteriophage PM2 DNA.

T. Bickle, R. Yuan, H. Eberle, 1976, Journal of molecular biology.

The role of S-adenosylmethionine in the cleavage of deoxyribonucleic acid by the restriction endonuclease from Escherichia coli K.

T. Bickle, R. Yuan, S. M. Hadi, 1975, Journal of Biological Chemistry.

Abortive infection of Escherichia coli F+ cells by bacteriophage T7 requires ribosomal misreading.

T. Bickle, D. Krüger, 1987, Journal of molecular biology.

The ATP-dependent Restriction Endonucleases

T. Bickle, 1982 .

Amber mutants in gene 67 of phage T4. Effects on formation and shape determination of the head.

T. Bickle, E. Kellenberger, B. Keller, 1986, Journal of molecular biology.

The nucleotide sequence of gene 21 of bacteriophage T4 coding for the prohead protease.

T. Bickle, B. Keller, 1986, Gene.

The relation of single-stranded regions in bacteriophage PM2 supercoiled DNA to the early melting sequences.

T. Bickle, R. Yuan, C. Brack, 1975, Journal of molecular biology.

Use of bacterial virus T7 as a tool for the study of DNA methylation.

T. Bickle, D. Krüger, M. Reuter, 1988, Gene.

Site-specific DNA inversion isenhanced byaDNA sequence element incis (site-specific recombination/recombinational enhancer/BAL-31 deletion analysis)

T. Bickle, H. Huber, 1985 .

Expression of the bacteriophage P1 cin recombinase gene from its own and heterologous promoters.

S. Iida, T. Bickle, H. Huber, 1985, Gene.

Determination of ribosomal protein molecular weight distributions from stained dodecyl sulfate gels.

T. Bickle, R. Traut, 1974, Methods in Enzymology.

Recombination of constant and variable modules alters DNA sequence recognition by type IC restriction‐modification enzymes.

T. Bickle, A. Piekarowicz, M. Gubler, 1992, The EMBO journal.

DNA cleavage by the type IC restriction-modification enzyme EcoR124II.

T. Bickle, J. Dreier, M. MacWilliams, 1996, Journal of molecular biology.

Spatial arrangement of ribosomal proteins: reaction of the Escherichia coli 30S subunit with bis-imidoesters.

T. Bickle, R. Traut, J. Hershey, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Enhancer‐independent mutants of the Cin recombinase have a relaxed topological specificity.

T. Bickle, P. Haffter, P. Haffter, 1988, The EMBO journal.

McrBs, a modulator peptide for McrBC activity

T. Bickle, E. Raleigh, D. Panne, 1998, The EMBO journal.

The type IC hsd loci of the enterobacteria are flanked by DNA with high homology to the phage P1 genome: implications for the evolution and spread of DNA restriction systems

T. Bickle, H. Lehnherr, U. Sandmeier, 1997, Molecular microbiology.

Site-specific DNA inversion is enhanced by a DNA sequence element in cis.

S. Iida, T. Bickle, W. Arber, 1985, Proceedings of the National Academy of Sciences of the United States of America.

General purification schemes for restriction endonucleases.

V. Pirrotta, T. Bickle, 1980, Methods in enzymology.