H. Hall

H. Hall, A. Nobin, M. Bugge, 1989, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and (67/68Ga)-labeled haptens by pretargeting.

L. Påhlman, B. Långström, H. Hall, 2012, American journal of nuclear medicine and molecular imaging.

Synthesis and in vitro evaluation of 18F-labelled di- and tri(ethylene glycol) metomidate esters

B. Långström, H. Hall, M. Erlandsson, 2009 .

Biochemical pharmacology of the atypical neuroleptic remoxipride

C. Kohler, T. Lewander, H. Ericson, 1990, Schizophrenia Research.

Synthesis and biological evaluation of [carboxyl-11C]eprosartan

B. Långstrom, H. Hall, O. Åberg, 2009 .

Original Article In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multi

L. Påhlman, B. Långstrom, W. Mcbride, 2012 .

Development of radioligands for the dopamine transporter

C. Halldin, T. Suhara, N. Ginovart, 1996 .

Binding of a specific 5-HT uptake inhibitor, [3H]norzimelidine, to rat brain homogenates.

H. Hall, S. Ross, S. Ogren, 1982, European journal of pharmacology.

Preparation of [1-11C]dopamine, [1-11C]p-tyramine and [1-11C]m-tyramine. Autoradiography and PET examination of [1-11C]dopamine in primates.

K. Någren, C. Halldin, L. Farde, 1993, Nuclear medicine and biology.

PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain

B. Gulyás, C. Halldin, V. Pike, 2004, Synapse.

[11C] beta-CIT, a cocaine analogue. Preparation, autoradiography and preliminary PET investigations.

C. Halldin, L. Farde, C. Swahn, 1993, Nuclear medicine and biology.

Animal pharmacology of raclopride, a selective dopamine D2 antagonist.

H. Hall, C. Köhler, S. Ogren, 1989, Psychopharmacology series.

Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites.

S. Dahl, H. Hall, P. Hals, 1988, Life sciences.

Phenothiazine drug metabolites: Dopamine D2 receptor, α1-and α2-adrenoceptor binding

S. Dahl, H. Hall, P. Hals, 1986 .

Preparation of tritium labelled benzamide dopamine‐D2 lignads at high specific activity

H. Hall, C. Köhler, L. Gawell, 1985 .

Serotonin selective reuptake inhibitors — relationship between chemical structure and pharmacological effects

H. Hall, T. Högberg, S. Ögren, 1983 .

[11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding

G. Sedvall, C. Halldin, L. Farde, 1992, Psychopharmacology.

Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants onβ-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortex

H. Hall, S. Ross, M. Sällemark, 2005, Journal of Neural Transmission.

Characterization of the binding of 3H-norzimeldine, a 5-HT uptake inhibitor, to rat brain homogenates.

H. Hall, 2009, Acta pharmacologica et toxicologica.

Synthesis and binding properties of the fluorinated substituted benzamide [3H]NCQ 115, a new selective dopamine D2 receptor ligand.

C. Halldin, H. Hall, T. Högberg, 1991, European journal of pharmacology.

Potential antipsychotic agents. Part 8. Antidopaminergic properties of a potent series of 5-substituted (−)-(S)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybcnzaimides. Synthesis via common lithio intermediates†

H. Hall, T. Högberg, S. Ögren, 1990 .

Preparation of a potential positron emission tomographic radioligand for the dopamine transporter

C. Halldin, L. Farde, P. Suzdak, 1994, European Journal of Nuclear Medicine.

New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey.

H. Wikström, J. Sandell, C. Halldin, 2001, Nuclear medicine and biology.

“Specific” Binding of [3H]Imipramine to Protease‐Sensitive and Protease‐Resistant Sites

B. Winblad, J. Marcusson, H. Hall, 1985, Journal of neurochemistry.

PET scanning--a new tool in clinical psychopharmacology.

G. Sedvall, L. Farde, H. Hall, 1988, Psychopharmacology series.

Pet study of [11C] β‐CIT binding to monoamine transporters in the monkey and human brain

C. Halldin, T. Suhara, L. Farde, 1994, Synapse.

Synthesis of nor-β-CIT, β-CIT and trimethylstannyl-β-CT

C. Halldin, S. Ametamey, L. Farde, 1995 .

Autoradiographic studies of 5‐HT1A‐receptor‐stimulated [35S]GTPγS‐binding responses in the human and monkey brain

P. Pauwels, H. Hall, D. Radu, 1999, The European journal of neuroscience.

A comparative PET-study of five carbon-11 or fluorine-18 labelled salicylamides. Preparation and in vitro dopamine D-2 receptor binding.

C. Halldin, L. Farde, H. Hall, 1991, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Evaluation of a semiautomatic filtration technique for receptor binding studies.

H. Hall, L. Thor, Hȧkan Hall, 1979, Life sciences.

Autoradiographic comparison of [125I]epidepride and [125I]NCQ 298 binding to human brain extrastriated dopamine receptors.

G. Sedvall, C. Halldin, L. Farde, 1997, Nuclear medicine and biology.

Syntheses of [123I]-, [125I]- and unlabelled (S)-3-iodo-5,6-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]salicylamide (NCQ 298), selective ligands for the study of dopamine D-2 receptors.

C. Halldin, L. Farde, H. Hall, 1990, Acta pharmaceutica Nordica.

[Selective antidopaminergic properties of remoxiprid, a new potential antipsychotic agent].

H. Hall, C. Köhler, S. Ogren, 1985, Arzneimittel-Forschung.

Autoradiographic studies of the labelling of 5-HT1A receptors in the post-mortem human brain using [11C]NAD-299 and [3H]NAD-299

G. Sedvall, J. Sandell, C. Halldin, 1998, European Neuropsychopharmacology.

Carbon-11 epidepride: a suitable radioligand for PET investigation of striatal and extrastriatal dopamine D2 receptors.

C Crouzel, J Sandell, C. Crouzel, 1999, Nuclear medicine and biology.

Saturation Analysis in PET—Analysis of Errors Due to Imperfect Reference Regions

J. Litton, H. Hall, S. Pauli, 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Studies on the binding of [3H]flumazenil and [3H]sarmazenil in post‐mortem human brain

G. Sedvall, C. Halldin, J. Litton, 1992 .

Binding of [3H]SCH 39166 to human post mortem brain tissue.

G. Sedvall, C. Halldin, H. Hall, 1993, Pharmacology & toxicology.

Positron emission tomography--examination of chemical transmission in the living human brain. Development of radioligands.

L. Farde, H. Hall, 1992, Arzneimittel-Forschung.

Neuropharmacological and behavioural properties of remoxipride in the rat

H. Hall, S. Ögren, O. Magnusson, 1990, Acta psychiatrica Scandinavica. Supplementum.

Autoradiographic evaluation of [11C]vinpocetine binding in the human postmortem brain.

J Sandell, J. Sandell, C. Halldin, 2002, Acta Biologica Hungarica.

Effects of antidepressant drugs on histamine-H1 receptors in the brain.

H. Hall, S. Ogren, Sven Ove Ögren, 1984, Life sciences.

Autoradiographic localization of [3H]neurotensin-binding sites in the hippocampal region of the rat and primate brain

B. Winblad, H. Hall, C. Ko¨hler, 1985, Neuroscience.

Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER.

B. Gulyás, C. Halldin, V. Pike, 2003, Nuclear medicine and biology.

Autoradiographic localization of extrastriatal D2‐dopamine receptors in the human brain using [125I]epidepride

Christer Halldin, Lars Farde, Stefan Pauli, 1996, Synapse.

No D2 receptor increase in PET study of schizophrenia.

S. Stone-Elander, G. Sedvall, C. Halldin, 1987, Archives of general psychiatry.

Autoradiographic mapping of dopamine-D 2 ⁄D 3 receptor stimulated ( 35 S)GTPcS binding in the human brain

B. Gulyás, H. Hall, J. Sóvágó, 2005 .

Acute effects of atypical antidepressants on various receptors in the rat brain.

H. Hall, I. Wedel, M. Sällemark, 2009, Acta pharmacologica et toxicologica.

Relationships between receptor affinities of different antidepressants and their clinical profiles

H. Hall, 1983 .

The pharmacology of zimelidine: A 5‐HT selective reuptake inhibitor

H. Hall, A. Holm, S. Ögren, 1981, Acta psychiatrica Scandinavica. Supplementum.

Effects of zimelidine on various transmitter systems in the brain.

H. Hall, S. Ross, S. Ogren, 1982, Advances in biochemical psychopharmacology.

Effects of antidepressant drugs on different receptors in the brain.

H. Hall, S. Ogren, Ögren Sven-Ove, 1981, European journal of pharmacology.

Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer’s disease

G. Sedvall, C. Halldin, L. Farde, 2000, Psychopharmacology.

Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain.

S O Ogren, H. Hall, C. Köhler, 1985, Biochemical pharmacology.

Cortical beta- and alpha 2- adrenoceptor binding, hypothalamic noradrenaline and pineal melatonin concentrations measured at different times of the day after repeated treatment of rats with imipramine, zimeldine, alaproclate and amiflamine.

J. Sääf, H. Hall, C. Fowler, 2009, Acta pharmacologica et toxicologica.

Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia

H. Hall, A. Holm, S. Ögren, 2005, Journal of Neural Transmission.

Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.

H. Hall, C. Köhler, S. Ögren, 1984, European journal of pharmacology.

Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain.

H. Hall, C. Köhler, L. Gawell, 1985, European journal of pharmacology.

Binding affinity of levomepromazine and two of its major metabolites to central dopamine and α-adrenergic receptors in the rat

S. Dahl, H. Hall, 2004, Psychopharmacology.

Gpp(NH)p stimulates [3H]raclopride binding to homogenates from human putamen and accumbens

G. Sedvall, C. Halldin, H. Hall, 1992, Neuroscience Letters.

Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue

P. Greengard, G. Sedvall, N. Lindefors, 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain

Christer Halldin, Lars Farde, Göran Sedvall, 1994, Neuropsychopharmacology.

Distribution of messenger RNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey: Relationship to D1 dopamine receptors

G. Sedvall, C. Halldin, N. Lindefors, 1995, Neuroscience.

Studies on the role of central 5-HT neurons in avoidance learning: a behavioral and biochemical analysis.

K. Fuxe, T. Archer, H. Hall, 1981, Advances in experimental medicine and biology.

An overview on functional receptor autoradiography using [35S]GTPγS

B. Gulyás, H. Hall, J. Sóvágó, 2001, Brain Research Reviews.

Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT(1A) receptor and the alpha1-adrenergic receptor.

C. Halldin, K. Varnäs, H. Hall, 2002, Nuclear medicine and biology.

Visualization of the Dopamine Transporter in the Human Brain Postmortem with the New Selective Ligand [125I]PE2I

D. Guilloteau, L. Farde, G. Sedvall, 1999, NeuroImage.

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

G. Antoni, K. Magnusson, L. Lannfelt, 2013, Journal of Alzheimer's disease : JAD.

Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding

T. Hökfelt, H. Hall, S. Ceccatelli, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

GTP differentially affects antagonist radioligand binding to adenosine A1 and A2A receptors in human brain

Per Svenningsson, Håkan Hall, P. Svenningsson, 2000, Neuropharmacology.

Evidence for an exclusive localization of 3H-ADTN binding sites to postsynaptic nerve cells in the striatum of the rat.

K. Fuxe, H. Hall, C. Köhler, 1979, European journal of pharmacology.

Dopamine D2 receptors and transporters in type 1 and 2 alcoholics

J. Tiihonen, H. Hall, T. Särkioja, 2002, European Psychiatry.

Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease.

Obaidur Rahman, Håkan Hall, H. Hall, 2012, Nuclear medicine and biology.

Amyloid Imaging PET Ligands as Biomarkers for Alzheimer’s Disease, Preclinical Evaluation

Marie Svedberg, Obaidur Rahman, Håkan Hall, 2012 .

[(11)C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients

H. Hall, Hakan Hall, 2010, Alzheimer's & Dementia.

[11C]PIB-amyloid binding and levels of Aβ40 and Aβ42 in postmortem brain tissue from Alzheimer patients

Bengt Långström, Agneta Nordberg, Håkan Hall, 2009, Neurochemistry International.

Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

J. Tiihonen, H. Hall, K. Bergström, 2003 .

In vitro and in vivo characterisation of nor-β-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain

C. Halldin, N. Ginovart, L. Farde, 1997, European Journal of Nuclear Medicine.

Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635

H. Wikström, G. Sedvall, C. Halldin, 1997, Brain Research.

Whole hemisphere autoradiography of the postmortem human brain.

G. Sedvall, C. Halldin, L. Farde, 1998, Nuclear medicine and biology.

Development of a central nicotinic acetylcholine receptor radioligand, 5‐methyl‐A‐85380, and postmortem autoradiography in human brain

C. Crouzel, J. Sandell, C. Halldin, 2001 .

Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography

J. Tiihonen, H. Hall, P. Halonen, 2004, Synapse.

Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography☆

Pirkko Räsänen, Erkki Tupala, Håkan Hall, 2003, NeuroImage.

(68)Ga-Labeling of RGD peptides and biodistribution.

S. Estrada, B. Långström, H. Hall, 2012, International journal of clinical and experimental medicine.

Autoradiography screening of potential positron emission tomography tracers for asymptomatic abdominal aortic aneurysms

S. Estrada, G. Antoni, M. Björck, 2014, Upsala Journal of Medical Sciences.

Autoradiographic mapping of 5-HT1B and 5-HT1D receptors in the post mortem human brain using [3H]GR 125743

Katarina Varnäs, Göran Sedvall, Håkan Hall, 2001, Brain Research.

Pharmacological Characterization ofN,N-Dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a Ligand of the Serotonin Transporter with High Affinity and Selectivity

Denis Guilloteau, Christer Halldin, Lars Farde, 2003, Journal of Pharmacology and Experimental Therapeutics.

Human dopamine receptor subtypes—in vitro binding analysis using3H-SCH 23390 and3H-raclopride

L. Farde, G. Sedvall, L. Farde, 2005, Journal of Neural Transmission.

Temperature Dependence of [3H]Ro 15–1788 Binding to Benzodiazepine Receptors in Human Postmortem Brain Homogenates

G. Sedvall, H. Hall, A. Persson, 1990, Journal of neurochemistry.

Distribution of 5-HT4 receptors in the postmortem human brain—an autoradiographic study using [125I]SB 207710

Victor W. Pike, Christer Halldin, Katarina Varnäs, 2003, European Neuropsychopharmacology.

Mapping of serotonin 5‐HT4 receptor mRNA and ligand binding sites in the post‐mortem human brain

P. Bonaventure, M. Jurzak, J. Leysen, 2000, Synapse.

Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat

D. Westerlund, H. Hall, S. Ross, 2004, Psychopharmacology.

Central monoamine synapses as sites of action for ergot drugs.

K. Fuxe, L. Agnati, B. Fredholm, 1980, Advances in biochemical psychopharmacology.

Pharmacological characterization of 18F‐labeled vorozole analogs

S. Estrada, B. Långström, H. Hall, 2012 .

Synthesis and in vitro evaluation of 18F-β-carboline alkaloids as PET ligands

B. Långström, H. Hall, O. Eriksson, 2008 .

Imaging of dopamine receptors using PET and SPECT

G. Sedvall, C. Halldin, L. Farde, 1992, Neurochemistry International.

Synthesis and binding properties of [3H]NNC 12-0781, a new radioligand for the dopamine reuptake system.

C. Halldin, L. Farde, P. Suzdak, 1995, Nuclear medicine and biology.

Utilization of radioligands in schizophrenia research.

G. Sedvall, C. Halldin, L. Farde, 1995, Clinical neuroscience.

(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates.

S. Estrada, G. Antoni, K. Nilsson, 2016, ACS medicinal chemistry letters.

Measurement of the Striatal Dopamine Transporter Density and Heterogeneity in Type 1 Alcoholics Using Human Whole Hemisphere Autoradiography

J. Tiihonen, H. Hall, J. Kuikka, 2001, NeuroImage.

Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics

J. Tiihonen, H. Hall, K. Bergström, 2001, Molecular Psychiatry.

Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.

H. Hall, E. Jerning, M. Sällemark, 2009, Acta pharmacologica et toxicologica.

Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study.

J. Tiihonen, H. Hall, K. Bergström, 2002, The American journal of psychiatry.

Spatial Benzodiazepine Receptor Imaging in the Human Brain

G. Sedvall, C. Halldin, H. Hall, 1996 .

Raclopride, a new selective ligand for the dopamine-D2 receptors

G. Sedvall, L. Farde, H. Hall, 1988, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Phenothiazine drug metabolites: dopamine D2 receptor, alpha 1- and alpha 2-adrenoceptor binding.

S. Dahl, H. Hall, P. Hals, 1986, European journal of pharmacology.

Sedative/anxiolytic effects of antidepressants in animals

H. Hall, S. Ögren, J. Cott, 1981, Acta psychiatrica Scandinavica. Supplementum.

Effect of raclopride on dopamine D2 receptor mRNA expression in rat brain

G. Sedvall, N. Lindefors, H. Hall, 1992, Neuroscience.

An overview on functional receptor autoradiography using [35S]GTPgammaS.

B. Gulyás, H. Hall, J. Sóvágó, 2001, Brain research. Brain research reviews.

NCQ 298, a new selective iodinated salicylamide ligand for the labelling of dopamine D2 receptors

C. Halldin, L. Farde, H. Hall, 2005, Psychopharmacology.

Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [ 3 H ]SB-269970

Katarina Varnäs, Jari Tiihonen, Erkki Tupala, 2004, Neuroscience Letters.

Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907

Lars Farde, Stefan Pauli, Göran Sedvall, 1996, Psychopharmacology.

Pharmacological Characterization of (E)-N-(4-Fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane (LBT-999) as a Highly Promising Fluorinated Ligand for the Dopamine Transporter

C. Halldin, D. Guilloteau, H. Hall, 2006, Journal of Pharmacology and Experimental Therapeutics.

Serotonin receptors in the brain following total hepatectomy in rats treated with branched-chain amino acids.

H. Hall, A. Nobin, M. Bugge, 1989, JPEN. Journal of parenteral and enteral nutrition.

Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography.

Christer Halldin, Nicholas Seneca, Ivanka Savic, 2005, Nuclear medicine and biology.

Human brain imaging post-mortem - whole hemisphere technologies

Y. Hurd, G. Sedvall, C. Halldin, 2001 .

Regional expression of 5‐HT1B receptor mRNA in the human brain

Y. Hurd, K. Varnäs, H. Hall, 2005, Synapse.

Neuroimaging of mirtazapine enantiomers in humans

L. Minuzzi, Donald F. Smith, S. Hansen, 2008, Psychopharmacology.

Comparison of the In Vitro Receptor Binding Properties of N‐[3H]Methylspiperone and [3H]Raclopride to Rat and Human Brain Membranes

C. Halldin, L. Farde, H. Hall, 1990, Journal of neurochemistry.

Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2

C. Halldin, V. Pike, R. Innis, 2005, European Neuropsychopharmacology.

Effects of chronic treatment with l-sulpiride and haloperidol on central monoaminergic mechanisms.

K. Fuxe, L. Agnati, R. Schwarcz, 1980, Advances in biochemical psychopharmacology.

Clenbuterol, a Central β‐Adrenoceptor Agonist

H. Hall, S. Ross, M. Sällemark, 2009 .

Clenbuterol, a central beta-adrenoceptor agonist.

H. Hall, S. Ross, M. Sällemark, 1980, Acta pharmacologica et toxicologica.

Synthesis and evaluation of a 11C-labelled angiotensin II AT2 receptor ligand

Marc Y. Stevens, B. Långstrom, H. Hall, 2010 .

Regional in vivo binding of the substituted benzamide [3H]eticlopride in the rat brain: evidence for selective labelling of dopamine receptors.

H. Hall, C. Köhler, L. Gawell, 1986, European journal of pharmacology.

Maximal turnover number of the membranal serotonin carrier in rat brain synaptosomes in vitro.

H. Hall, S. Ross, 1983, Acta physiologica Scandinavica.

Cardiovascular and anticholinergic effects of zimelidine

H. Hall, S. Ögren, L. Lindbom, 1982, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Effects of chronic neuroleptic treatment on agonist affinity states of the dopamine-D2 receptor in the rat brain.

H. Hall, M. Sällemark, 1987, Pharmacology & toxicology.