A. Ward

发表

The brain ’ s functional network architecture reveals human motives

D. Burton, K. Reimann, M. Klempner, 2022 .

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

Computational design of trimeric influenza neutralizing proteins targeting the hemagglutinin receptor binding site

David Baker, William Sheffler, Paul Yager, 2017, Nature Biotechnology.

Visualization of the HIV-1 Env glycan shield across scales

J. Diedrich, J. Yates, S. Gnanakaran, 2019, Proceedings of the National Academy of Sciences.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

S. Christley, John P. Moore, D. Burton, 2020, bioRxiv.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

S. Christley, John P. Moore, D. Burton, 2020, PLoS pathogens.

Visualization of the HIV-1 Env glycan shield across scales

Srirupa Chakraborty, S Gnanakaran, John R. Yates, 2019, Proceedings of the National Academy of Sciences.

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

Robyn L. Stanfield, Andrew B. Ward, Dennis R. Burton, 2013, Science.

SOSIP Envelope Glycoprotein Aggregation of Soluble, Cleaved HIV-1 Influences on Trimerization and

John P. Moore, I. Wilson, A. Ward, 2014 .

Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein

John P. Moore, I. Wilson, A. Ward, 2013, Journal of Virology.

Rational immunogen design to target specific germline B cell receptors

David Nemazee, Oleksandr Kalyuzhniy, Skye MacPherson, 2012, Retrovirology.

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

John P. Moore, I. Wilson, T. Ketas, 2013, PLoS pathogens.

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

John P. Moore, D. Burton, I. Wilson, 2013, Science.

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

John P. Moore, D. Burton, I. Wilson, 2013, Science.

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

A. Ward, L. Sewall, R. Kirchdoerfer, 2020, bioRxiv.

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

J. Pallesen, B. Graham, H. Turner, 2018, bioRxiv.

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Daniel Wrapp, Jesper Pallesen, Jason S McLellan, 2018, Scientific Reports.

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

I. Wilson, S. Kent, J. Crowe, 2018, Nature Communications.

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

R. Lerner, I. Wilson, N. Wu, 2017, Nature Communications.

A common solution to group 2 influenza virus neutralization

Gira Bhabha, Damian C. Ekiert, Andrew B. Ward, 2013, Proceedings of the National Academy of Sciences.

Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics

H. Turner, A. Ward, S. Khurana, 2019, Proceedings of the National Academy of Sciences.

The HIV‐1 envelope glycoprotein structure: nailing down a moving target

Ian A Wilson, I. Wilson, A. Ward, 2017, Immunological reviews.

Flexibility in the ABC transporter MsbA: Alternating access with a twist

Geoffrey Chang, C. B. Roth, G. Chang, 2007, Proceedings of the National Academy of Sciences.

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Yue Weng, Geoffrey Chang, G. Chang, 2009, Science.

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Adrian Apetri, Liesbeth Dekking, Andrew B. Ward, 2015, Science.

Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E

Bjoern Peters, L. Hsieh‐Wilson, A. Ward, 2014, PLoS pathogens.

Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses

H. Turner, A. Ward, M. Crispin, 2018, Cell reports.

Glycosylation of Human Ig A Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses Graphical Abstract Highlights

H. Turner, A. Ward, M. Crispin, 2018 .

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

M. V. van Breemen, N. Kootstra, A. Ward, 2020, Science.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

A. Ward, R. Kirchdoerfer, Andrew B Ward, 2019, Nature Communications.

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

I. Wilson, A. Ward, J. Glanville, 2017, Proceedings of the National Academy of Sciences.

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Robyn L Stanfield, Ian A Wilson, Dennis R Burton, 2015, Immunity.

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

Bryan Briney, Ian A Wilson, Dennis R Burton, 2016, Cell reports.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Daniel W. Kulp, D. Irvine, D. Burton, 2018, Cell.

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers

Q. Sattentau, D. Montefiori, A. Ward, 2022, npj Vaccines.

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

John P. Moore, D. Montefiori, Rashmi Ravichandran, 2021, NPJ vaccines.

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

D. Baker, John P. Moore, T. Ketas, 2020, bioRxiv.

HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite

D. Burton, H. Turner, A. Ward, 2019, Science Advances.

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

D. Baker, J. Bale, John P. Moore, 2019, Nature Communications.

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

John P. Moore, I. Wilson, M. Nussenzweig, 2019, Journal of Virology.

HIV-1 vaccine design through minimizing envelope metastability

D. Burton, I. Wilson, D. Nemazee, 2018, bioRxiv.

HIV-1 vaccine design through minimizing envelope metastability

D. Burton, I. Wilson, D. Nemazee, 2018, Science Advances.

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

R. Wyatt, S. Sharma, A. Ward, 2018, Front. Immunol..

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

R. Wyatt, I. Wilson, A. Ward, 2017, Immunity.

HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates

J. Mascola, R. Wyatt, N. Doria-Rose, 2017, Journal of Virology.

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

Richard Wilson, Richard T. Wyatt, Robyn L. Stanfield, 2014, Proceedings of the National Academy of Sciences.

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

R. Wyatt, S. Sharma, A. Ward, 2015, Journal of Virology.

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

William R. Schief, Andrew B. Ward, Louise Royle, 2015, Nature Communications.

Cross-neutralization of influenza A viruses mediated by a single antibody loop

John Steel, Gira Bhabha, Damian C. Ekiert, 2012, Nature.

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

D. Burton, I. Wilson, A. Ward, 2017, Nature.

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody.

D. Burton, I. Wilson, A. Ward, 2020, Science advances.

The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans.

Oliver C. Grant, C. Robinson, R. Woods, 2017, Structure.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

J. Diedrich, J. Yates, D. Nemazee, 2020, Science.

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

U. Dietrich, I. Wilson, A. Ward, 2017, Scientific Reports.

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

John P. Moore, D. Burton, I. Wilson, 2014, Cell.

Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice.

I. Wilson, J. Crowe, K. Edwards, 2019, Cell host & microbe.

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

I. Wilson, A. Ward, J. Torres, 2019, Journal of molecular biology.

Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase.

A. Ward, H. Young, J. Glaves, 2010, Methods in enzymology.

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

John P. Moore, I. Wilson, N. Wu, 2019, Cell host & microbe.

Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells

H. Turner, A. Ward, R. D. de Vries, 2020, Protein science : a publication of the Protein Society.

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.

I. Wilson, J. Crowe, H. Turner, 2019, Cell host & microbe.

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Daniel W. Kulp, D. Irvine, R. Wyatt, 2019, Immunity.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

Daniel W. Kulp, D. Irvine, R. Wyatt, 2018 .

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

D. Baker, D. Irvine, N. King, 2020, npj Vaccines.

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

D. Irvine, David Baker, N. King, 2020, npj Vaccines.

Playing Chess with HIV.

A. Ward, 2019, Immunity.

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

D. Burton, A. Ward, Jiang Zhu, 2017, Front. Immunol..

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

D. Burton, I. Wilson, A. Ward, 2016, Nature Communications.

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

A. Ward, R. Sanders, M. V. van Gils, 2020, bioRxiv.

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

A. Ward, R. Sanders, M. V. van Gils, 2020, Structure.

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

D. Burton, I. Wilson, D. Nemazee, 2016, Nature Communications.

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

R. Wyatt, A. Ward, Richard Wilson, 2016, PLoS pathogens.

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

D. Baker, P. Zwart, M. J. Bick, 2020, eLife.

A Network-based approach for Quantifying the Resilience and Vulnerability of HIV-1 Native Glycan Shield

N. Hengartner, S. Gnanakaran, A. Ward, 2019, bioRxiv.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2020, Cell reports.

Discoveries in structure and physiology of mechanically activated ion channels

A. Patapoutian, A. Ward, J. Kefauver, 2020, Nature.

Structures of the Otopetrin Proton Channels Otop1 and Otop3

A. Ward, M. Sansom, E. Liman, 2019, Nature Structural & Molecular Biology.

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

Peter D. Crompton, J. Mascola, I. Wilson, 2021, bioRxiv.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

D. Irvine, D. Burton, D. Montefiori, 2021, bioRxiv.

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

John P. Moore, D. Montefiori, H. Schuitemaker, 2020, Journal of Virology.

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

D. Burton, K. Reimann, M. Klempner, 2016, Science.

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

D. Fremont, H. Turner, A. Ward, 2020, bioRxiv.

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Karlynn E. Neu, Linda Yu-Ling Lan, Christopher T. Stamper, 2020, Immunity.

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties.

Oliver C. Grant, R. Woods, H. Turner, 2019, Journal of molecular biology.

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

A. Ward, C. Cottrell, J. Torres, 2018, bioRxiv.

Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.

I. Wilson, A. Ward, C. Cottrell, 2018 .

Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

I. Wilson, A. Ward, C. Cottrell, 2018, Science Advances.

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

I. Wilson, A. Ward, C. Cottrell, 2018, bioRxiv.

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein

J. Moore, D. Burton, A. Ward, 2021, Journal of virology.

Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

D. Burton, I. Wilson, H. Turner, 2020, Journal of Virology.

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

John P. Moore, M. V. van Breemen, I. Wilson, 2019, Nature Communications.

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

D. Burton, I. Wilson, H. Turner, 2019 .

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C

John P. Moore, I. Wilson, D. Montefiori, 2016, PLoS pathogens.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Daniel W. Kulp, D. Irvine, R. Wyatt, 2017, Immunity.

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

A. Bradley, I. Wilson, P. Kellam, 2020, PLoS pathogens.

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

R. Wyatt, I. Wilson, S. Sharma, 2018, Nature Communications.

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.

C. D. Murin, A. Ward, R. Stanfield, 2018, Cell reports.

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

J. Dye, A. Kuehne, K. Chandran, 2017, Cell.

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

D. Kim, K. Whaley, L. Zeitlin, 2015, PLoS pathogens.

A helical processing pipeline for EM structure determination of membrane proteins.

B. Carragher, C. Potter, N. Unwin, 2011, Methods.

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

John P. Moore, I. Wilson, A. Ward, 2019, Nature Communications.

Open and Closed Structures Reveal Allostery and Pliability in the HIV-1 Envelope Spike

John P. Moore, J. Pallesen, A. Ward, 2017, Nature.

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

John P. Moore, I. Wilson, C. D. Murin, 2013, Proceedings of the National Academy of Sciences.

Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies

L. Zeitlin, J. Pallesen, J. Crowe, 2016, Nature Microbiology.

Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy

John P. Moore, D. Burton, I. Wilson, 2014, Journal of Virology.

Resource Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches Graphical Abstract Highlights

Daniel W. Kulp, D. Irvine, R. Wyatt, 2022 .

Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity

I. Wilson, N. Wu, A. Ward, 2020, Immunity.

Engineered immunogen binding to alum adjuvant enhances humoral immunity

Daniel W. Kulp, D. Irvine, D. Burton, 2020, Nature Medicine.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Benjamin P. Kellman, S. Chanda, C. Glass, 2020, Cell.

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

Lisa E. Gralinski, Yana Safonova, D. Burton, 2022, Nature Immunology.

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

D. Baker, John P. Moore, D. Burton, 2021, Nature Communications.

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate

E. Go, H. Desaire, John P. Moore, 2017, Biotechnology and bioengineering.

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

D. Burton, H. Turner, A. Ward, 2019, bioRxiv.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

Ashish, A. Ward, Lauren G. Holden, 2020, bioRxiv.

Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein

A. Ward, G. Ozorowski, B. Chakrabarti, 2017, The Journal of Biological Chemistry.

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

John P. Moore, A. Ward, R. Sanders, 2017, Journal of Virology.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

I. Wilson, A. Ward, R. De Francesco, 2021, bioRxiv.

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

J. Crowe, E. Saphire, B. Gunn, 2020, Immunity.

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

H. Turner, A. Ward, B. Haagmans, 2020, bioRxiv.

Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level

A. Ward, Charles A. Bowman, B. Nogal, 2017, The Journal of Biological Chemistry.

Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

Karlynn E. Neu, Min Huang, P. Wilson, 2021, Proceedings of the National Academy of Sciences.

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Karlynn E. Neu, Linda Yu-Ling Lan, Henry A. Utset, 2020, Immunity.

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

B. Pulendran, D. Fremont, M. McCausland, 2020, Proceedings of the National Academy of Sciences.

A Blueprint for HIV Vaccine Discovery.

Adam Godzik, Hendrik Streeck, M Juliana McElrath, 2012, Cell host & microbe.

Structural Constraints Det ermine the Glycosylation of HIV-1 Envelope Trimers Graphical

John P. Moore, D. Burton, I. Wilson, 2015 .

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

A. Patapoutian, A. Dubin, A. Ward, 2018, bioRxiv.

OSCA / TMEM 63 are an Evolutionarily Conserved Family of Mechanically Activated Ion 1 Channels 2

A. Patapoutian, A. Dubin, M. Cahalan, 2022 .

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

J. Crowe, E. Saphire, B. Gunn, 2018, Immunity.

Human antibody recognition of H7N9 influenza virus HA following natural infection

H. Turner, A. Ward, S. Bangaru, 2021, JCI insight.

Isolation and Characterization of Cross-Neutralizing COVID-19+ Subjects

J. Mascola, L. Stamatatos, A. McGuire, 2021 .

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

D. Burton, R. Ahmed, A. Ward, 2020, Frontiers in Immunology.

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

John P. Moore, D. Burton, D. Montefiori, 2021, PLoS pathogens.

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

W. Schief, A. Ward, S. Crotty, 2021, bioRxiv.

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Jordan R. Willis, J. Diedrich, J. Yates, 2022, Immunity.

Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

D. Burton, D. Montefiori, A. V. van Kampen, 2022, Nature Communications.

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

John P. Moore, I. Wilson, D. Montefiori, 2017, Journal of Virology.

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

D. Burton, I. Wilson, A. Ward, 2021, bioRxiv.

Designing facial amphiphiles for the stabilization of integral membrane proteins.

R. Stevens, V. Jaakola, G. Chang, 2007, Angewandte Chemie.

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

J. Dye, A. Herbert, A. Kuehne, 2017, Cell Reports.

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

Jordan R. Willis, W. Schief, A. Ward, 2022, Immunity.

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

A. Walls, D. Veesler, Rashmi Ravichandran, 2022, Cell reports. Medicine.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

R. Fuller, R. Wyatt, D. Burton, 2018, Cell reports.

1 Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV- 2 2 and endemic coronavirus infection 3

D. Burton, D. Nemazee, A. Ward, 2020 .

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Larissa B. Thackray, Rebecca S. Brown, J. Dye, 2019, PLoS pathogens.

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

A. Heck, Rashmi Ravichandran, N. King, 2022, iScience.

Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection

A. Ward, R. Sanders, M. V. van Gils, 2022, Cell host & microbe.

Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

D. Burton, K. Kirsch, W. Schief, 2022, Immunity.

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B env Gene

John P. Moore, D. Burton, I. Wilson, 2015, Journal of Virology.

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

John P. Moore, T. Ketas, Helen J Kim, 2014, Retrovirology.

Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoEM

A. Ward, D. Lyumkis, Jeong Hyun Lee, 2015 .

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

John P. Moore, A. Ward, A. Cupo, 2019, Journal of Virology.

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

Barney S. Graham, Kwanyee Leung, Andrew B. Ward, 2019, Cell Reports.

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Barney S. Graham, Wei Shi, Andrew B. Ward, 2017, Proceedings of the National Academy of Sciences.

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Peter D. Crompton, J. Mascola, I. Wilson, 2021, Science Translational Medicine.

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

I. Wilson, N. Wu, A. Ward, 2020, Cell Reports.

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

I. Wilson, N. Wu, A. Ward, 2020, bioRxiv.

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

I. Wilson, N. Wu, A. Ward, 2020, bioRxiv.

One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization

A. Ward, Yuxing Li, J. Torres, 2021, Emerging microbes & infections.

Chapter 9 An HIV elite neutralizer as a blueprint for the induction of neutralizing antibodies

John P. Moore, D. Burton, D. Montefiori, 2016 .

Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers*

John P. Moore, I. Wilson, A. Ward, 2012, The Journal of Biological Chemistry.

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

G. Chang, A. Ward, Brigitte Gasser, 2011, PloS one.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Daniel W. Kulp, D. Irvine, D. Burton, 2018, Cell.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Benjamin P. Kellman, C. Glass, J. Esko, 2020, bioRxiv.

HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

Ben Murrell, Terri Wrin, Sergei L. Kosakovsky Pond, 2017, Immunity.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

Yana Safonova, D. Irvine, D. Burton, 2021, bioRxiv.

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

D. Burton, D. Nemazee, A. Ward, 2021, Nature Communications.

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

D. Burton, D. Nemazee, A. Ward, 2020, bioRxiv.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

J. Diedrich, J. Yates, D. Nemazee, 2020, bioRxiv.

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro

John P. Moore, A. Ward, A. Cupo, 2018, Journal of Virology.

Structure of the hepatitis C virus E1E2 glycoprotein complex

A. Ward, R. Sanders, M. Crispin, 2021, bioRxiv.

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

B. Haynes, D. Burton, I. Wilson, 2019, Cell reports.

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

I. Wilson, J. Pallesen, J. Crowe, 2018, bioRxiv.

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

B. Haynes, D. Burton, I. Wilson, 2018, bioRxiv.

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The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization

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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

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