D. Ng

发表

Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway

Chengchao Xu, Songyu Wang, Guillaume Thibault, 2013, Science.

Modularity of the Hrd1 ERAD complex underlies its diverse client range

D. Ng, K. Kanehara, W. Xie, 2010, The Journal of cell biology.

Glycosylation-directed quality control of protein folding

Chengchao Xu, D. Ng, Chengchao Xu, 2015, Nature Reviews Molecular Cell Biology.

ER membrane protein complex required for nuclear fusion

P. Walter, D. Ng, Peter Walter, 1996, The Journal of cell biology.

Yos9p detects and targets misfolded glycoproteins for ER-associated degradation.

Woong Kim, Eric D. Spear, E. Spear, 2005, Molecular cell.

The signal for clathrin-mediated endocytosis of the paramyxovirus SV5 HN protein resides at the transmembrane domain-ectodomain boundary region.

R. Lamb, D. Ng, G. Leser, 1999, Virology.

ERAD substrate recognition in budding yeast.

D. Ng, W. Xie, 2010, Seminars in cell & developmental biology.

The EDEM and Yos9p families of lectin-like ERAD factors.

D. Ng, K. Kanehara, S. Kawaguchi, 2007, Seminars in cell & developmental biology.

Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

Eric D. Spear, E. Spear, D. Ng, 2005, The Journal of cell biology.

Biosynthetic mode can determine the mechanism of protein quality control.

D. Ng, S. Kawaguchi, Rupali Prasad, 2012, Biochemical and biophysical research communications.

Targeting pathways to the endoplasmic reticulum membrane.

J. D. Brown, P. Walter, D. Ng, 1995, Cold Spring Harbor symposia on quantitative biology.

Lectins sweet-talk proteins into ERAD

Songyu Wang, D. Ng, 2008, Nature Cell Biology.

Heat/Stress Responses

Guillaume Thibault, D. Ng, 2013 .

The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control

D. Ng, P. Matsudaira, Ian Cheong, 2020, bioRxiv.

Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface

R. Lamb, D. Ng, R. Randall, 1989, The Journal of cell biology.

SnapShot: ER-Associated Protein Degradation Pathways

D. Ng, S. Kawaguchi, 2007, Cell.

Different roles of individual N-linked oligosaccharide chains in folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase

R. Lamb, D. Ng, S. Hiebert, 1990, Molecular and cellular biology.

Interplay of Substrate Retention and Export Signals in Endoplasmic Reticulum Quality Control

D. Ng, S. Kawaguchi, Chia-Ling Hsu, 2010, PloS one.

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

David W. Reid, D. Ng, Katherine E. Larrimore, 2020, BMC biology.

Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein

Peter Walter, Jonne Helenius, Markus Aebi, 2002, Nature.

Routing Misfolded Proteins through the Multivesicular Body (MVB) Pathway Protects against Proteotoxicity*

Songyu Wang, Guillaume Thibault, D. Ng, 2011, The Journal of Biological Chemistry.

O-mannosylation: The other glycan player of ER quality control.

Chengchao Xu, D. Ng, 2015, Seminars in cell & developmental biology.

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

D. Ng, Shilpa Vashist, Davis T.W. Ng, 2004, The Journal of cell biology.

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

Eric D. Spear, D. Ng, Woong Kim, 2001, The Journal of cell biology.

The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control

Eric D. Spear, P. Walter, D. Ng, 2000, The Journal of cell biology.

Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene.

R. Lamb, D. Ng, S. Watowich, 1992, Molecular biology of the cell.

The endoplasmic reticulum-associated degradation pathways of budding yeast.

Guillaume Thibault, D. Ng, 2012, Cold Spring Harbor perspectives in biology.

The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network.

S. Gygi, G. McAlister, Guillaume Thibault, 2012, Molecular cell.

Endoplasmic reticulum stress regulation of the Kar2p/BiP chaperone alleviates proteotoxicity via dual degradation pathways

D. Ng, Rupali Prasad, Chia-Ling Hsu, 2012, Molecular biology of the cell.

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

Guillaume Thibault, Guillaume Thibault, D. Ng, 2011, Proceedings of the National Academy of Sciences.

A complex of Pdi1p and the mannosidase Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum.

Pedro Carvalho, M. Aebi, D. Ng, 2011, Molecular cell.

ER stress regulation of the Kar 2 p / BiP chaperone alleviates proteotoxicity via dual degradation pathways

D. Ng, Rupali Prasad, Chia-Ling Hsu, 2011 .

A screen for mutants requiring activation of the unfolded protein response for viability.

Guillaume Thibault, D. Ng, 2011, Methods in enzymology.

Screening for mutants defective in secretory protein maturation and ER quality control.

D. Ng, 2005, Methods.

Search and Destroy: ER Quality Control and ER-Associated Protein Degradation

D. Ng, Ayaz Sayeed, 2005, Critical reviews in biochemistry and molecular biology.

Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways.

Eric D. Spear, D. Ng, 2003, Molecular biology of the cell.

Two distinctly localized p-type ATPases collaborate to maintain organelle homeostasis required for glycoprotein processing and quality control.

D. Ng, Shilpa Vashist, Davis T W Ng, 2002, Molecular biology of the cell.

Interorganellar signal transduction: the arrest of secretion response.

D. Ng, 2001, Developmental cell.

The Unfolded Protein Response: No Longer Just a Special Teams Player

Eric D. Spear, D. Ng, 2001, Traffic.

Signal sequences specify the targeting route to the endoplasmic reticulum membrane

P. Walter, D. Ng, Jeremy D. Brown, 1996, The Journal of cell biology.

Evasion of Endoplasmic Reticulum Surveillance Makes Wsc1p an Obligate Substrate of Golgi Quality Control

Songyu Wang, D. Ng, 2010, Molecular biology of the cell.

Hsp40/70/110 chaperones adapt nuclear protein quality control to serve cytosolic clients

Chengchao Xu, D. Ng, Rupali Prasad, 2018, The Journal of cell biology.

A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

D. Ng, S. Kawaguchi, Rupali Prasad, 2010, Molecular biology of the cell.

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system.

D. Ng, K. Kanehara, W. Xie, 2009, Molecular biology of the cell.

Concepts | Heat/Stress Responses

Guillaume Thibault, D. Ng, Vikash Verma, 2021, Encyclopedia of Biological Chemistry III.

Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation

Chengchao Xu, D. Ng, Shan Zhang, 2017, Cell.

Sensing ER Stress

Shinichi Kawaguchi, D. Ng, S. Kawaguchi, 2011, Science.

Helenius et al. reply

M. Aebi, P. Walter, D. Ng, 2008, Nature.