D. Hardie

发表

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Hardie, F. Ross, S. Hawley, 2012, Nature Reviews Molecular Cell Biology.

The AMP-activated protein kinase pathway – new players upstream and downstream

D. Hardie, 2004, Journal of Cell Science.

Key roles for AMP-activated protein kinase in the function of the carotid body?

D. Hardie, C. Wyatt, Selina A Pearson, 2008, Advances in experimental medicine and biology.

AMP-activated protein kinase as a drug target.

D. Hardie, D. Hardie, D Grahame Hardie, 2007, Annual review of pharmacology and toxicology.

Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?

D. Hardie, C. Wyatt, C. Peers, 2006, Advances in experimental medicine and biology.

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

D. Hardie, D. Carling, D. Hardie, 2005, Cell metabolism.

Involvement of AMP‐activated protein kinase in fat depot‐specific metabolic changes during starvation

D. Hardie, P. Flachs, M. Rossmeisl, 2005, FEBS letters.

Role of the AMP-activated protein kinase in the cellular stress response

D. Hardie, D. Hardie, J. Corton, 1994, Current Biology.

Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase.

D. Hardie, W. Winder, C. A. Hutber, 1997, The American journal of physiology.

The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1

David Carling, D. Hardie, D. Carling, 1999, FEBS letters.

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

D. Hardie, S. Hawley, D. Hardie, 1999, The Biochemical journal.

AMP‐activated protein kinase: the energy charge hypothesis revisited

D. Hardie, S. Hawley, 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.

Y. Hellsten, D. Hardie, J. Wojtaszewski, 2002, Diabetes.

Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle.

Y. Hellsten, B. Kemp, D. Hardie, 2003, American journal of physiology. Endocrinology and metabolism.

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Jérôme Boudeau, Dario R Alessi, Tomi P Mäkelä, 2003, Journal of biology.

Management of cellular energy by the AMP‐activated protein kinase system

D. Hardie, J. W. Scott, D. A. Pan, 2003, FEBS letters.

AMP-activated protein kinase: a key system mediating metabolic responses to exercise.

D. Hardie, D. Hardie, 2004, Medicine and science in sports and exercise.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Jérôme Boudeau, Maria Deak, T. Mäkelä, 2004, The EMBO journal.

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

D. Hardie, D. Alessi, K. Sakamoto, 2004, American journal of physiology. Endocrinology and metabolism.

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

D. Hardie, S. Hawley, D. Norman, 2004, The Journal of clinical investigation.

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Sheng-Cai Lin, D. Hardie, S. Hawley, 2017, Nature.

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

J. Padbury, D. Hardie, C. Phornphutkul, 2017, American journal of physiology. Heart and circulatory physiology.

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

J. Friedman, M. Miyazaki, A. Dobrzyń, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Reply…The sugar sensing story

D. Hardie, P. Purcell, Nigel G Halford, 1999 .

Edinburgh Research Explorer Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Peter Donnelly, Robert Plomin, Elvira Bramon, 2022 .

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.

D. Hardie, K. Sakamoto, H. S. Hundal, 2011, The Biochemical journal.

Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues.

T. Soderling, P. Kelly, S. Shenolikar, 1986, European journal of biochemistry.

Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle.

Y. Hellsten, D. Hardie, H. Galbo, 2002, American journal of physiology. Endocrinology and metabolism.

Cell-cycle dependence of two nuclear histone kinase enzyme activities.

D. Hardie, E. Bradbury, H. Matthews, 1976, European journal of biochemistry.

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Sheng-Cai Lin, D. Hardie, S. Hawley, 2020, Cell Research.

Protein phosphorylation: a practical approach

D. Hardie, 1993 .

Metabolic control: A new solution to an old problem

D. Hardie, 2000, Current Biology.

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

D. Hardie, D. Grahame Hardie, 2013, Diabetes.

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

D. Hardie, S. Hawley, D. Hardie, 1995, European journal of biochemistry.

Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase.

D. Hardie, S. Davies, G. Lopaschuk, 1999, European journal of biochemistry.

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase.

D. Hardie, D. Hardie, 1992, Biochimica et biophysica acta.

Phosphorylation and inactivation of HMG‐CoA reductase at the AMP‐activated protein kinase site in response to fructose treatment of isolated rat hepatocytes

D. Hardie, J. Gillespie, 1992, FEBS letters.

AMP‐activated protein kinase ‐ An archetypal protein kinase cascade?

D. Hardie, R. Mackintosh, 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

Running Title: AICAR stimulation of human glucose uptake

J. Babraj, D. Hardie, M. Rennie, 2007 .

AICAR acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

J. Babraj, D. Hardie, M. Rennie, 2007 .

Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.

D. Hardie, K. Højlund, H. Beck-Nielsen, 2003, Diabetes.

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

J. Babraj, G. Leese, D. Hardie, 2009, American journal of physiology. Endocrinology and metabolism.

AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.

D. Hardie, K. Højlund, H. Beck-Nielsen, 2004, American journal of physiology. Endocrinology and metabolism.

University of Dundee A novel , de novo mutation in PRKAG 2 gene

D. Hardie, C. Phornphutkul, Y. Tseng, 2017 .

AMP-ACTIVATED PROTEIN KINASE – A UBIQUITOUS SIGNALLING

D. Hardie, I. Salt, 2017 .

Advance of mitosis by histone phosphokinase.

D. Hardie, E. Bradbury, R. J. Inglis, 1976, Experimental cell research.

Organismal carbohydrate and lipid homeostasis.

D. Hardie, 2012, Cold Spring Harbor perspectives in biology.

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest*

D. Hardie, D. Hardie, S. Fogarty, 2009, Journal of Biological Chemistry.

Normal hypertrophy accompanied by phosphoryation and activation of AMP‐activated protein kinase α1 following overload in LKB1 knockout mice

D. Hardie, D. Hardie, K. J. Mustard, 2008, The Journal of physiology.

Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

D. Befroy, G. Shulman, D. Hardie, 2007, Cell metabolism.

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

B. Viollet, D. Barron, B. Kemp, 2014, Chemistry & biology.

Mapping of catalytic domains and phosphorylation sites in the multifunctional pyrimidine-biosynthetic protein CAD.

D. Hardie, E. Carrey, 1988, European journal of biochemistry.

University of Dundee The mechanisms of action of metformin

D. Hardie, G. Rena, E. Pearson, 2017 .

AMPK and Raptor: matching cell growth to energy supply.

D. Hardie, D. Grahame Hardie, 2008, Molecular cell.

Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise.

G. Shulman, D. Hardie, L. Cong, 2003, American journal of physiology. Endocrinology and metabolism.

Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet.

M. E. Kooi, K. Nicolay, W. Saris, 2005, Obesity research.

Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.

D. Hardie, S. Davies, I. Salt, 2000, Methods in molecular biology.

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

D. Hardie, D. Carling, L. Fryer, 2000, Diabetes.

Balancing Cellular Energy

D. Hardie, 2007, Science.

Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A.

D. Hardie, B. Rasmussen, W. Winder, 1997, Journal of applied physiology.

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.

D. Hardie, D. Campbell, D. Carling, 1988, European journal of biochemistry.

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase.

D. Hardie, D. Carling, 1989, Biochimica et biophysica acta.

Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism.

R. Colbran, D. Hardie, D. Campbell, 1989, European journal of biochemistry.

Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.

W. Saris, D. Hardie, L. V. van Loon, 2005, American journal of physiology. Endocrinology and metabolism.

Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase.

D. Hardie, 1989, Progress in lipid research.

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

D. Hardie, S. Hawley, W. Wilson, 1996, Current Biology.

AMP-activated protein kinase – not just an energy sensor

Sheng-Cai Lin, D. Hardie, 2017, F1000Research.

AMP-activated protein kinase – not just an energy sensor

Sheng-Cai Lin, D. Hardie, 2017, F1000Research.

AMPK and SNF1: Snuffing Out Stress

D. Hardie, 2007, Cell metabolism.

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

B. Viollet, D. Hardie, P. Schjerling, 2004, Diabetes.

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

D. Hardie, D. Carling, A. Woods, 1996 .

Identification of Raf‐1 Ser621 kinase activity from NIH 3T3 cells as AMP‐activated protein kinase

D. Hardie, T. Sturgill, D. Carling, 1997, FEBS letters.

Hot stuff: thyroid hormones and AMPK

D. Hardie, 2010, Cell Research.

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression.

G. Rutter, D. Hardie, G. da Silva Xavier, 2000, Proceedings of the National Academy of Sciences of the United States of America.

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.

D. Hardie, W. Winder, 1999, The American journal of physiology.

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

D. Hardie, P. Lochhead, C. Sutherland, 2000, Diabetes.

Glucose Starvation Blocks Translation at Multiple Levels.

Sheng-Cai Lin, D. Hardie, Chen-Song Zhang, 2020, Cell metabolism.

AMPK and autophagy get connected

D. Hardie, 2011, The EMBO journal.

Protein phosphorylation and dephosphorylation.

D. Hardie, 1989, Current opinion in cell biology.

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion.

D. Hardie, D. Hardie, F. Moore, 1991, European journal of biochemistry.

Distinct type‐2A protein phosphatases activate HMGCoA reductase and acetyl‐CoA carboxylase in liver

D. Hardie, L. Hue, V. Gaussin, 1997, FEBS letters.

Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.

D. Hardie, S. Hawley, D. Hardie, 1994, European journal of biochemistry.

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase.

D. Hardie, P. Cohen, 1991, Biochimica et biophysica acta.

Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase.

D. Hardie, L. Witters, R. Holland, 1984, European journal of biochemistry.

Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle.

D. Hardie, W. Winder, K. J. Mustard, 2002, Journal of applied physiology.

Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle.

D. Hardie, E. Taylor, W. Winder, 2001, Biochemical Society transactions.

Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

E. Hill, G. Rutter, D. Hardie, 2010, Biochemical Society transactions.

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

D. Hardie, S. Hawley, G. S. Olsen, 2002, Diabetes.

Targeting the Core of Transcription

D. Hardie, 2010, Science.

Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-∂ (PPAR-∂) Activity in Rat Skeletal Muscle

D. Hardie, K. Baar, A. Philp, 2013, PloS one.

Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity.

D. Hardie, M. Munday, 1984, European journal of biochemistry.

Regulation of mammalian acetyl‐CoA carboxylase

D. Hardie, P. Guy, 1981, FEBS letters.

Reversible phosphorylation and inactivation of acetyl-CoA carboxylase from lactating rat mammary gland by cyclic AMP-dependent protein kinase.

D. Hardie, P. Guy, 1980, European journal of biochemistry.

Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland

P. Cohen, D. Hardie, P. Cohen, 1979, FEBS letters.

Purification and physicochemical properties of fatty acid synthetase and acetyl-CoA carboxylase from lactating rabbit mammary gland.

D. Hardie, P. Cohen, 1978, European journal of biochemistry.

Purification and physicochemical properties of ATP citrate (pro-3S) lyase from lactating rat mammary gland and studies of its reversible phosphorylation.

D. Hardie, D. Hardie, P. Cohen, 1981, European journal of biochemistry.

Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-α1), and immunological analysis of multiple forms of the kinase, in spinach leaf

D. Hardie, Nigel G Halford, R. M. Crawford, 2001, Plant Molecular Biology.

Amino acid sequence around the reactive serine residue of the thioesterase domain of rabbit fatty acid synthase.

A. Aitken, D. Hardie, K. B. Dewart, 1985, Biochimica et biophysica acta.

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production

D. Hardie, D. Hardie, I. Salt, 2007, Biochemical and biophysical research communications.

Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP‐dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.

D. Hardie, D. Campbell, E. Carrey, 1985, The EMBO journal.

AMP-activated protein kinase : greater AMP dependence , and preferential nuclear localization , of complexes containing the α 2 isoform

A. Prescott, D. Hardie, S. Hawley, 1998 .

Ways of coping with stress

D. Hardie, 1994, Nature.

The First Messengers — Hormones, Neurotransmitters and Local Mediators

D. Hardie, 1991 .

Cloning of cDNA to rat mammary-gland fatty acid synthase mRNA. Evidence for the expression of two mRNA species during lactation.

M. Braddock, D. Hardie, 1988, The Biochemical journal.

Molecular pathways

D. Hardie, 2016 .

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

B. Kemp, D. Hardie, F. Ross, 2012, Science.

AMPK as a direct sensor of long-chain fatty acyl–CoA esters

D. Hardie, 2020, Nature Metabolism.

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

D. Hardie, S. Hawley, A. Gray, 2018, Methods in molecular biology.

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

D. Hardie, S. Hawley, G. Gowans, 2016, Diabetes.

Multidomain proteins : structure and evolution

J. Coggins, D. Hardie, 1986 .

Phosphorylation-dependent Translocation of Glycogen Synthase to a Novel Structure during Glycogen Resynthesis*

D. Hardie, B. Hansen, J. Nielsen, 2005, Journal of Biological Chemistry.

Peptide assay of protein kinases and use of variant peptides to determine recognition motifs.

D. Hardie, 2000, Methods in molecular biology.

Cell Surface Receptors — Signal Transduction

D. Hardie, 1991 .

Faculty Opinions recommendation of Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits.

D. Hardie, 2006 .

New insights into activation and function of the AMPK

D. Hardie, G. Steinberg, 2022, Nature Reviews Molecular Cell Biology.

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology

F. Polleux, D. Hardie, J. Prudent, 2022, Science advances.

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion.

D. Hardie, D. Hardie, D. A. Pan, 2002, The Biochemical journal.

Signal transduction: How cells sense energy

D. Hardie, 2011, Nature.

Reactin' with activin

D. Hardie, 1991, Current Biology.

AMP‐activated protein kinase – development of the energy sensor concept

D. Hardie, S. Hawley, J. Scott, 2006, The Journal of physiology.

AMPK: Sensing Glucose as well as Cellular Energy Status.

Sheng-Cai Lin, D. Hardie, D. Hardie, 2017, Cell metabolism.

Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia).

D. Hardie, K. Ball, J. Weekes, 1994, European journal of biochemistry.

Structure and Biosynthesis of First Messengers

D. Hardie, 1991 .

Negative interactions between phosphorylation of acetyl‐CoA carboxylase by the cyclic AMP‐dependent and AMP‐activated protein kinases

D. Hardie, D. Carling, M. Munday, 1988, FEBS letters.

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase.

D. Hardie, D. A. Pan, 2001, Biochemical Society transactions.

100 years of the Warburg effect: a historical perspective.

D. Hardie, 2022, Endocrine-related cancer.

Yeast carbamoyl-phosphate-synthetase--aspartate-transcarbamylase multidomain protein is phosphorylated in vitro by cAMP-dependent protein kinase.

D. Hardie, D. Hardie, E. Carrey, 1990, European journal of biochemistry.

D. Hardie, Nigel G Halford, F. Beaudoin, 2004, Plant physiology and biochemistry : PPB.

AMPK: a key regulator of energy balance in the single cell and the whole organism

D. Hardie, D. Hardie, 2008, International Journal of Obesity.

Metabolism of inflammation limited by AMPK and pseudo-starvation

D. Hardie, D. Hardie, L. O’Neill, 2013, Nature.

AMP-Activated Protein Kinase

D. Hardie, D. Carling, D. Hardie, 2017, Encyclopedia of Molecular Pharmacology.

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*)

A. Edelman, D. Hardie, S. Hawley, 1995, The Journal of Biological Chemistry.

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

D. Hardie, S. Hawley, D. Cantrell, 2006, The Journal of experimental medicine.

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

A. Edelman, B. Frenguelli, D. Hardie, 2005, Cell metabolism.

Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase

D. Hardie, R. Brownsey, 1980, FEBS letters.

Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid‐dependent protein kinase, calmodulin‐dependent multiprotein kinase and cyclic AMP‐dependent protein kinase

J. Woodgett, D. Hardie, S. Ferrari, 1985, FEBS letters.

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

D. Hardie, S. Hawley, K. J. Mustard, 2009, The Biochemical journal.

Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets.

D. Hardie, D. Carling, D. Hardie, 1992, European journal of biochemistry.

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

T. Haystead, A. Sim, D. Hardie, 1989, Nature.

Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.

D. Hardie, D. Campbell, D. Hardie, 1986, The Journal of biological chemistry.

A new assay procedure to study the induction of β-ketoacyl-ACP synthase I and II, and the complete purification of β-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus)

D. Hardie, A. Slabas, R. Mackintosh, 1989 .

The multifunctional polypeptide chain of rabbit mammary fatty acid synthase contains a domain homologous with the acyl carrier protein of Escherichia coli.

A. Aitken, D. Hardie, A. D. McCarthy, 1983, European journal of biochemistry.

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis.

D. Hardie, D Grahame Hardie, D. G. Hardie, 2015, Current opinion in cell biology.

5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside*

D. Hardie, N. Morrice, D. Hardie, 2001, The Journal of Biological Chemistry.

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.

D. Hardie, 2011, Genes & development.

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

B. Furman, D. Hardie, S. Hawley, 2008, British journal of pharmacology.

Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver.

D. Hardie, P. Clarke, 1990, The EMBO journal.

AMPK: mediating the metabolic effects of salicylate-based drugs?

D. Hardie, G. Steinberg, M. Dandapani, 2013, Trends in Endocrinology & Metabolism.

University of Dundee LKB 1 and AMPK and the cancer-metabolism link-ten years after

D. Hardie, D. Alessi, 2013 .

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

M. Carlson, D. Hardie, D. Carling, 1998, Annual review of biochemistry.

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

B. Viollet, D. Hardie, L. Fajas, 2017, Molecular cell.

Plant protein-serine/threonine kinases: Classification into subfamilies and overview of function

D. Hardie, 2000 .

PLANT PROTEIN SERINE/THREONINE KINASES: Classification and Functions.

D. Hardie, 1999, Annual review of plant physiology and plant molecular biology.

The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits

D. Hardie, D. Hardie, E. Knecht, 2010, Molecular biology of the cell.

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

D. Hardie, D. Hardie, M. Dandapani, 2013, Biochemical Society transactions.

LKB1 and AMPK and the cancer-metabolism link - ten years after

D. Hardie, D. Alessi, D. Hardie, 2013, BMC Biology.

Histological evaluation of AMPK signalling in primary breast cancer

Philip R Quinlan, Lee Baker, Alastair M Thompson, 2009, BMC Cancer.

AMP-Activated Protein Kinase: Friend or Foe in Cancer?

D. Hardie, M. Dandapani, Diana Vara-Ciruelos, 2020, Annual Review of Cancer Biology.

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?†

D. Hardie, Fiona M. Russell, Diana Vara-Ciruelos, 2019, Open Biology.

An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation.

D. Hardie, 2017, Cancer cell.

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

D. Hardie, D Grahame Hardie, 2015, Clinical Cancer Research.

AMP-activated protein kinase: a target for drugs both ancient and modern

D. Hardie, F. Ross, S. Hawley, 2012, Chemistry & biology.

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

D. Hardie, Fiona M. Russell, Fiona M Russell, 2020, International journal of molecular sciences.

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

D. Hardie, D. Hardie, D. Hodson, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

D. Hardie, F. Ross, D. Hardie, 2014, FEBS letters.

Keeping the home fires burning†: AMP-activated protein kinase

D. Hardie, D. Grahame Hardie, 2018, Journal of The Royal Society Interface.

AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours

D. Hardie, F. Ross, C. MacKintosh, 2016, The FEBS journal.

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

D. Richardson, D. Hardie, J. J. Cabrera, 2011, Biochemical Society transactions.

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

D. Hardie, D. Hardie, D. Grahame Hardie, 2007, Nature Reviews Molecular Cell Biology.

AMP‐activated protein kinase: a key regulator of energy balance with many roles in human disease

D. Hardie, 2014 .

AMP-Activated Kinase Regulates Cytoplasmic HuR

M. Gorospe, Jinshui Fan, Xiaoling Yang, 2002, Molecular and Cellular Biology.

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

D. Hardie, S. Fogarty, D G Hardie, 2010, Biochimica et biophysica acta.

Neither LKB1 nor AMPK are the direct targets of metformin.

D. Hardie, 2006, Gastroenterology.

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

D. Hardie, D. Carling, 1997, European journal of biochemistry.

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

B. Kemp, D. Hardie, D. Grahame Hardie, 2007, Circulation research.

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

D. Hardie, G. Moorhead, C. MacKintosh, 2007, The Biochemical journal.

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to insulin-like growth factor 1, EGF, PMA and AICAR

D. Hardie, G. Moorhead, C. MacKintosh, 2007 .

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes.

D. Hardie, W. Winder, W W Winder, 1999, American journal of physiology. Endocrinology and metabolism.

Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress.

D. Hardie, D G Hardie, 1999, Biochemical Society symposium.

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2Ac

D. Hardie, S. Davies, P. Cohen, 1995, FEBS letters.

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

L. Pusztai, A. Thompson, J. Dewar, 2011, Breast Cancer Research and Treatment.

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.

Sheng-Cai Lin, D. Hardie, D. Hardie, 2020, Cell metabolism.

AMPK in cancer: Tumor friend or foe?

D. Hardie, 2014 .

The LKB1-AMPK pathway-friend or foe in cancer?

D. Hardie, 2013, Cancer cell.

aspects of cell function an energy sensor that regulates all -- AMP-activated protein kinase

D. Hardie, 2012 .

Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection.

D. Hardie, 2011, Cold Spring Harbor symposia on quantitative biology.

New roles for the LKB1-->AMPK pathway.

D. Hardie, D. Hardie, 2005, Current opinion in cell biology.

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

D. Hardie, R. Holland, 1985, FEBS letters.

Evidence that amiloride antagonises insulin‐stimulated protein phosphorylation by inhibiting protein kinase activity

J. Woodgett, D. Hardie, R. Holland, 1983, FEBS letters.

Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

D. Hardie, S. Hawley, R. McCartney, 2003, Current Biology.

The mechanisms of action of metformin

D. Hardie, G. Rena, D. Hardie, 2017, Diabetologia.

A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.

D. Hardie, D. Hardie, Emma R Hudson, 2002, Developmental biology.

AMPK: a key sensor of fuel and energy status in skeletal muscle.

D. Hardie, K. Sakamoto, 2006, Physiology.

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

D. Hardie, D. Hardie, I. Salt, 2017, Circulation research.

5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.

D. Hardie, J. Wojtaszewski, S. Jørgensen, 2004, American journal of physiology. Endocrinology and metabolism.

5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle.

Henriette Pilegaard, D. Hardie, H. Pilegaard, 2003, Journal of applied physiology.

D. Hardie, 2022 .

Analysis of the LKB1-STRAD-MO25 complex

A. Prescott, D. V. van Aalten, D. Hardie, 2004, Journal of Cell Science.

AMP-activated protein kinase: also regulated by ADP?

S. Gamblin, D. Hardie, D. Carling, 2011, Trends in biochemical sciences.

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

David M. A. Martin, A. Ashworth, D. Hardie, 2008, The Biochemical journal.

1 1 2 3 4 AMPK and TOR : the Yin and Yang of cellular nutrient sensing and growth control 5 6

Sheng-Cai Lin, D. Hardie, A. González, 2020 .

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

B. Viollet, D. Hardie, K. Grzes, 2019, Cell reports.

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

D. Hardie, S. Hawley, D. Norman, 2002, Journal of molecular biology.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

D. Hardie, J. Tavaré, D. Carling, 2018, The Biochemical journal.

University of Dundee Isoform-specific AMPK association with TBC 1 D 1 is reduced by a mutation associated with severe obesity

D. Hardie, J. Tavaré, D. Carling, 2018 .

AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.

D. Hardie, 2014, Annual review of nutrition.

AMP-Activated Protein Kinase: A Master Switch in Glucose and Lipid Metabolism

D. Hardie, D. Hardie, 2004, Reviews in Endocrine and Metabolic Disorders.

A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias

J. James, D. Hardie, S. Hawley, 2003, Current Biology.

Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.

D. Hardie, D. Grahame, Soo-Hyun Park, 2002, American journal of physiology. Endocrinology and metabolism.

Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.

D. Hardie, P. Clarke, D. Carling, 1989, European journal of biochemistry.

Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise.

D. Hardie, P. Schjerling, B. Kiens, 2006, American journal of physiology. Endocrinology and metabolism.

Control of carbohydrase formation by gibberellic acid in barley endosperm

D. Hardie, D.Grahame Hardie, 1975 .

Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase.

D. Hardie, P. Clarke, D. Hardie, 1992, European journal of biochemistry.

Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase*

D. Hardie, S. Hawley, M. Korbonits, 2005, Journal of Biological Chemistry.

Edinburgh Research Explorer The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor

D. Hardie, D. Hardie, A. Mcbride, 2008 .

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Sheng-Cai Lin, D. Hardie, Z. Ye, 2019, Cell metabolism.

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

D. Hardie, S. Hawley, Z. Ye, 2019, Cell Research.

Prevention of high-fat diet-induced muscular lipid accumulation in rats by α lipoic acid is not mediated by AMPK activation[S]

D. Hardie, R. Mensink, D. Hardie, 2010, Journal of Lipid Research.

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

J. Dyck, B. Kemp, D. Hardie, 2013, Nature Medicine.

Rat mammary gland ATP‐citrate lyase is phosphorylated by cyclic AMP‐dependent protein kinase

P. Cohen, D. Hardie, P. Guy, 1980, FEBS letters.

Conference on ‘ Nutrition and health : cell to community ’ Plenary Lecture Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism

D. Hardie, D. G. Hardie, 2011 .

Chapter 11 The AMP-activated/SNF1 protein kinases: Key players in the response of eukaryotic cells to metabolic stress

D. Hardie, D. Hardie, 2001 .

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.

D. Hardie, W. Winder, 1996, The American journal of physiology.

Regulation of AMP-activated protein kinase by natural and synthetic activators

D. Hardie, D. Grahame Hardie, G. Hardie, 2015, Acta pharmaceutica Sinica. B.

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells*

B. Viollet, A. Marette, D. Hardie, 2012, The Journal of Biological Chemistry.

Sensing of energy and nutrients by AMP-activated protein kinase.

D. Hardie, D. Hardie, 2011, The American journal of clinical nutrition.

Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease

D. Hardie, 2008, FEBS letters.

5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men

J. Babraj, D. Hardie, M. Rennie, 2007, Diabetes.

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.

D. Hardie, G. Merrill, W. Winder, 1997, American journal of physiology. Endocrinology and metabolism.

Pharmacological activators of AMP‐activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells

D. Hardie, K. Kalsi, K. J. Mustard, 2007, British journal of pharmacology.

AMPK-and SNF 1-Related Kinases : Roles in Lower Eukaryotes

D. Hardie, M. Ashford, Grahame Hardie, 2014 .

The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle

D. Hardie, S. Hawley, D. Carling, 1995 .

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

D. Hardie, F. Ross, S. Hawley, 2013, Cell metabolism.

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.

A. Brunet, D. Hardie, B. Schaffer, 2016, Trends in cell biology.

Cell Surface Receptors — Protein Phosphorylation and Other Intracellular Events

D. Hardie, 1991 .

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Clint L. Miller, G. Christ, D. Hardie, 2021, Proceedings of the National Academy of Sciences.

Cellular Functions of Protein Kinases

D. Hardie, 1995 .

Ion Channel Regulation by AMPK

B. Viollet, M. Dallas, D. Hardie, 2009, Annals of the New York Academy of Sciences.

Effect of fiber type and nutritional state on AICAR and contraction stimulated glucose transport in rat skeletal muscle

Y. Hellsten, D. Hardie, H. Galbo, 2002 .

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.

D. Hardie, G. Merrill, W. Winder, 1997, The American journal of physiology.

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

D. Hardie, G. Johnson, D. Hardie, 1998, The Biochemical journal.

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

A. Sim, D. Hardie, D. Carling, 1989 .

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

M. Dallas, D. Hardie, J. Mankouri, 2010, Proceedings of the National Academy of Sciences.

A. Edelman, D. Hardie, W. Wilson, 1995, FEBS letters.

Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method.

D. Hardie, S. Davies, Y. Ching, 1996, European journal of biochemistry.

Fatty acid synthase — an example of protein evolution by gene fusion

D. Hardie, A. D. McCarthy, A. McCarthy, 1984 .

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.

D. Hardie, C. MacKintosh, J. Wojtaszewski, 2009, American journal of physiology. Endocrinology and metabolism.

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

D. Hardie, J. Zierath, H. Pilegaard, 2009, Diabetologia.

Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

J. Friedman, M. Miyazaki, A. Dobrzyń, 2005, American journal of physiology. Endocrinology and metabolism.

The multifunctional polypeptide chains of rabbit-mammary fatty-acid synthase. Stoichiometry of active sites and active-site mapping using limited proteolysis.

D. Hardie, A. D. McCarthy, A. McCarthy, 2005, European journal of biochemistry.

Reaction of chloroacetyl‐CoA with rabbit fatty acid synthase

D. Hardie, A. D. McCarthy, 1982, FEBS Letters.

Regulation of hormone‐sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise

Bente Kiens, D. Hardie, J. Wojtaszewski, 2004, The Journal of physiology.

Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP.

D. Hardie, Nigel G Halford, R. M. Crawford, 1999, The Plant journal : for cell and molecular biology.

Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase.

D. Hardie, N. Morrice, A. Ferrer, 1995, European journal of biochemistry.

AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line*

D. Hardie, S. Hawley, C. Wolf, 2005, Journal of Biological Chemistry.

Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

M. Dallas, D. Hardie, F. Ross, 2011, Proceedings of the National Academy of Sciences.

A Conserved Sequence Immediately N-terminal to the Bateman Domains in AMP-activated Protein Kinase γ Subunits Is Required for the Interaction with the β Subunits*

B. Viollet, D. Hardie, D. Carling, 2007, Journal of Biological Chemistry.

PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.

D. Hardie, H. Pilegaard, J. Wojtaszewski, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

PGC-1 (cid:1) increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

D. Hardie, H. Pilegaard, J. Wojtaszewski, 2010 .

Cell Biology of First Messenger Synthesis and Secretion

D. Hardie, 1991 .

Signal Transduction by Nuclear Receptors

D. Hardie, 1991 .

Regulation of lipid metabolism by the AMP-activated protein kinase.

D. Hardie, S. Hawley, J. Corton, 1997, Biochemical Society transactions.

Fatal Infantile Cardiac Glycogenosis with Phosphorylase Kinase Deficiency and a Mutation in the γ2-Subunit of AMP-Activated Protein Kinase

S. Dimauro, D. Hardie, F. Ross, 2007, Pediatric Research.

AMP-activated protein kinase (AMPK)

D. Hardie, 2014 .

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

G. Rutter, D. Hardie, I. Leclerc, 2009, Islets.

A Neural Protection Racket: AMPK and the GABAB Receptor

B. Frenguelli, D. Hardie, 2007, Neuron.

Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3':5'-cyclic monophosphate.

D. Hardie, D. Stansfield, 1977, The Biochemical journal.

Immunological evidence that HMG‐CoA reductase kinase‐A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases

D. Hardie, Nigel G Halford, K. Ball, 1995, FEBS letters.

Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.

D. Hardie, Nigel G Halford, D. Carling, 1994, Seminars in cell biology.

Site-specific phosphorylation of tyrosine hydroxylase after KCl depolarization and nerve growth factor treatment of PC12 cells.

D. Hardie, J. P. Mitchell, P R Vulliet, 1990, The Journal of biological chemistry.

Molecular cloning of higher-plant 3-oxoacyl-(acyl carrier protein) reductase. Sequence identities with the nodG-gene product of the nitrogen-fixing soil bacterium Rhizobium meliloti.

D. Hardie, C. Sidebottom, R. Safford, 1992, The Biochemical journal.

Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases‐1 and ‐2A

D. Hardie, P. Cohen, R. Mackintosh, 1990, FEBS letters.

Regulation of Cell Proliferation and Cancer

D. Hardie, 1991 .

Phosphorylation Sites on Tyrosine Hydroxylase

D. Hardie, P. Vulliet, 1987 .

Mammalian fatty acid synthase: a chimeric protein which has evolved by gene fusion.

M. Braddock, D. Hardie, A. D. McCarthy, 1986, Biochemical Society transactions.

Post-Translational Modifications in Plants: Roles of protein phosphorylation in animal cells

D. Hardie, 1993 .

AMP-activated protein kinase: the guardian of cardiac energy status.

D. Hardie, D Grahame Hardie, Lam, 2004, The Journal of clinical investigation.

Targeting an energy sensor to treat diabetes

D. Hardie, D. Hardie, D. Grahame Hardie, 2017, Science.

Why Starving Cells Eat Themselves

D. Hardie, 2011, Science.

Biochemical Messengers: Hormones, Neurotransmitters and Growth Factors

D. Hardie, 1991 .

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

J. Vaughan, P. Kelly, J. Seckl, 2011, Diabetologia.

Introduction: Cell—Cell Signalling by Cytoplasmic Bridges

D. Hardie, 1991 .

A new protein kinase cascade

D. Hardie, 2014, Nature reviews. Molecular cell biology.

Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.

M. Dallas, D. Hardie, F. Ross, 2009, Advances in experimental medicine and biology.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Spencer, C. Freeman, P. Deloukas, 2012 .

AMPK : an energy-sensing pathway with multiple inputs and outputs 3 4

A. Brunet, D. Hardie, Bethany E. Schaffer, 2015 .

Signaling by AMP‐activated Protein Kinase

D. Hardie, T. Wallimann, D. Neumann, 2007 .

The limit dextrinase from malted sorghum (Sorghum vulgare).

D. Manners, D. Hardie, D. Yellowlees, 1976, Carbohydrate Research.

A viscometric assay for pullulanase-type, debranching enzymes.

D. Manners, D. Hardie, 1974, Carbohydrate research.

Observations of the action of limit dextrinases on amylopectin-like polysaccharides.

D. Manners, D. Hardie, G. Dunn, 1973, The Biochemical journal.

Metformin-acting through cyclic AMP as well as AMP?

D. Hardie, D. Hardie, 2013, Cell metabolism.

Small molecules can have big effects on endurance.

D. Hardie, K. Baar, 2008, Nature chemical biology.

D. Hardie, K. J. Mustard, V. Pallottini, 2007, Mechanisms of Ageing and Development.

Ionic Homeostasis and Nervous Conduction

D. Hardie, 1991 .

CHAPTER 88 – AMP-Activated Protein Kinase

D. Hardie, D. G. Hardie, 2003 .

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Hardie, S. Hawley, Fiona A. Ross, 2012, Nature Reviews Molecular Cell Biology.

The regulation of enzyme activity by reversible phosphorylation.

D. Hardie, P. Guy, 1982, Progress in brain research.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Freeman, P. Deloukas, E. Bramon, 2010, Nature Genetics.

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

D. Hardie, R. Holland, 1985, FEBS letters.

How I Became a Biochemist

D. Hardie, P. Ascenzi, 2007, IUBMB life.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Freeman, P. Deloukas, E. Bramon, 2012 .