S. Hawley

发表

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Hardie, F. Ross, S. Hawley, 2012, Nature Reviews Molecular Cell Biology.

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

D. Hardie, S. Hawley, D. Hardie, 1999, The Biochemical journal.

AMP‐activated protein kinase: the energy charge hypothesis revisited

D. Hardie, S. Hawley, 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Jérôme Boudeau, Dario R Alessi, Tomi P Mäkelä, 2003, Journal of biology.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Jérôme Boudeau, Maria Deak, T. Mäkelä, 2004, The EMBO journal.

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

D. Hardie, S. Hawley, D. Norman, 2004, The Journal of clinical investigation.

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Sheng-Cai Lin, D. Hardie, S. Hawley, 2017, Nature.

Edinburgh Research Explorer Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Peter Donnelly, Robert Plomin, Elvira Bramon, 2022 .

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Sheng-Cai Lin, D. Hardie, S. Hawley, 2020, Cell Research.

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

D. Hardie, S. Hawley, D. Hardie, 1995, European journal of biochemistry.

Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

D. Befroy, G. Shulman, D. Hardie, 2007, Cell metabolism.

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

B. Viollet, D. Barron, B. Kemp, 2014, Chemistry & biology.

AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus

N. Dale, B. Frenguelli, S. Hawley, 2004, Journal of neurochemistry.

AMP-activated Protein Kinase α2 Subunit is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids Running title: n-3 fatty acids and hepatic AMPK

B. Viollet, S. Hawley, P. Flachs, 2010 .

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

D. Hardie, S. Hawley, W. Wilson, 1996, Current Biology.

Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.

D. Hardie, S. Hawley, D. Hardie, 1994, European journal of biochemistry.

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

D. Hardie, S. Hawley, G. S. Olsen, 2002, Diabetes.

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

F. Ross, S. Hawley, D. Hardie, 2017, Cell chemical biology.

University of Dundee Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU 6656 and

F. Ross, S. Hawley, D. Hardie, 2017 .

AMP-activated protein kinase : greater AMP dependence , and preferential nuclear localization , of complexes containing the α 2 isoform

A. Prescott, D. Hardie, S. Hawley, 1998 .

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

B. Kemp, D. Hardie, F. Ross, 2012, Science.

Mechanism of Activation of AMPK by Cordycepin

F. Ross, S. Hawley, D. Hardie, 2020, Cell chemical biology.

Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation.

S. Hawley, D. Grahame Hardie, G. Gowans, 2018, Methods in molecular biology.

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

D. Hardie, S. Hawley, A. Gray, 2018, Methods in molecular biology.

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

D. Hardie, S. Hawley, G. Gowans, 2016, Diabetes.

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

S. Hawley, D. Hardie, J. Corton, 1995, European journal of biochemistry.

AMP‐activated protein kinase – development of the energy sensor concept

D. Hardie, S. Hawley, J. Scott, 2006, The Journal of physiology.

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

F. Ross, S. Hawley, D. Hardie, 2022, Cell reports.

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*)

A. Edelman, D. Hardie, S. Hawley, 1995, The Journal of Biological Chemistry.

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

D. Hardie, S. Hawley, D. Cantrell, 2006, The Journal of experimental medicine.

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

A. Edelman, B. Frenguelli, D. Hardie, 2005, Cell metabolism.

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

D. Hardie, S. Hawley, K. J. Mustard, 2009, The Biochemical journal.

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

F. Ross, S. Hawley, N. Leslie, 2014, The Biochemical journal.

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

B. Furman, D. Hardie, S. Hawley, 2008, British journal of pharmacology.

Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation

S. Pirkmajer, F. Ross, S. Hawley, 2014, Diabetes.

AMP-activated protein kinase: a target for drugs both ancient and modern

D. Hardie, F. Ross, S. Hawley, 2012, Chemistry & biology.

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

F. Ross, S. Hawley, D. Hardie, 2010, Cell metabolism.

Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase*

B. Viollet, F. Ross, S. Hawley, 2007, Journal of Biological Chemistry.

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase*

S. Hawley, D. Carling, A. Woods, 1996, The Journal of Biological Chemistry.

Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

D. Hardie, S. Hawley, R. McCartney, 2003, Current Biology.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

B. Viollet, T. Palmer, G. Baillie, 2016, Science Signaling.

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

David M. A. Martin, A. Ashworth, D. Hardie, 2008, The Biochemical journal.

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

D. Hardie, S. Hawley, D. Norman, 2002, Journal of molecular biology.

A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias

J. James, D. Hardie, S. Hawley, 2003, Current Biology.

Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase*

D. Hardie, S. Hawley, M. Korbonits, 2005, Journal of Biological Chemistry.

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

D. Hardie, S. Hawley, Z. Ye, 2019, Cell Research.

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

T. Haystead, S. Hawley, D. Carling, 1994, European journal of biochemistry.

The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle

D. Hardie, S. Hawley, D. Carling, 1995 .

The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA.

J. Scott, S. Hawley, D. Carling, 1995, European journal of biochemistry.

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

D. Hardie, F. Ross, S. Hawley, 2013, Cell metabolism.

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Clint L. Miller, G. Christ, D. Hardie, 2021, Proceedings of the National Academy of Sciences.

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

A. Prescott, S. Hawley, D. Carling, 1998, The Biochemical journal.

Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

F. Ross, S. Hawley, D. Hardie, 2010 .

AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line*

D. Hardie, S. Hawley, C. Wolf, 2005, Journal of Biological Chemistry.

S. Hawley, D. Grahame Hardie, M. Jossier, 2009, The Plant journal : for cell and molecular biology.

Regulation of lipid metabolism by the AMP-activated protein kinase.

D. Hardie, S. Hawley, J. Corton, 1997, Biochemical Society transactions.

Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A1 Receptors

A. Doney, B. Frenguelli, S. Hawley, 2011, The Journal of Neuroscience.

AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

B. Viollet, S. Hawley, P. Flachs, 2010, Diabetes.

The Na + / glucose cotransporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

S. Hawley, G. Gowans, G. Steinberg, 2016 .

LKB 1 is a master kinase that activates 13 protein kinases of the AMPK subfamily , including the MARK / PAR-1 kinases

T. Mäkelä, Lina Udd, S. Hawley, 2004 .

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Spencer, C. Freeman, P. Deloukas, 2012 .

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Hardie, S. Hawley, Fiona A. Ross, 2012, Nature Reviews Molecular Cell Biology.

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

S. Hawley, Fiona A. Ross, Graeme J. Gowans, 2017, Cell chemical biology.

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

S. Hawley, D. Hardie, K. Green, 2010, Cell metabolism.

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

S. Hawley, D. Hardie, K. J. Mustard, 2006, The Journal of experimental medicine.

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

T. Mäkelä, Lina Udd, S. Hawley, 2003, Journal of biology.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Freeman, P. Deloukas, E. Bramon, 2010, Nature Genetics.

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation

S. Hawley, Fiona A. Ross, Fiona M. Russell, 2023, International journal of molecular sciences.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

C. Freeman, P. Deloukas, E. Bramon, 2012 .

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

D. Hardie, S. Hawley, Chen-Song Zhang, 2019, Cell Research.

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

S. Hawley, Fiona A. Ross, Fiona M Russell, 2022, The Biochemical journal.