J. Pouysségur

发表

Hypoxia signalling in cancer and approaches to enforce tumour regression

J. Pouysségur, F. Dayan, N. Mazure, 2006, Nature.

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

J. Pouysségur, S. Meloche, K. Seuwen, 1992, Molecular endocrinology.

The Mouse p44 Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase 1) Gene

A. Brunet, J. Pouysségur, G. Pagès, 1995, The Journal of Biological Chemistry.

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6

P. Heutink, J. Pouysségur, G. Pagès, 2010, Cell Death and Differentiation.

MEK1-ERK2 Signaling Pathway Protects Myocardium From Ischemic Injury In Vivo

P. Doevendans, J. Pouysségur, S. Meloche, 2004, Circulation.

Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.

A. Brunet, J. Pouysségur, G. Pagès, 1994, Oncogene.

Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability*

J. Pouysségur, G. Pagès, E. Berra, 2000, The Journal of Biological Chemistry.

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.

J. Pouysségur, J. Brondello, F. McKenzie, 1999, Science.

Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.

J. Pouysségur, Raquel García-Medina, J. Shama, 2008, Biochemical and biophysical research communications.

Abrogation of p27Kip1 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts*

J. Bartek, J. Pouysségur, N. Rivard, 1996, The Journal of Biological Chemistry.

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

J. Pouysségur, S. Meloche, J Pouysségur, 2007, Oncogene.

Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory

David P Wolfer, Olga Valverde, Hans-Peter Lipp, 2002, Neuron.

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation*♦

J. Post, J. Wilsbacher, B. Rieger, 2009, The Journal of Biological Chemistry.

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice.

J. Pouysségur, G. Pagès, P. Auberger, 1999, Science.

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

J. Pouysségur, E. Berra, E. Benizri, 2003, The EMBO journal.

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

P Barbry, J. Pouysségur, N. Mazure, 2011, Cell Death and Differentiation.

The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites.

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1994, The Journal of biological chemistry.

HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome

Emmanuel Chamorey, A. Ramaioli, J. Pouysségur, 2007 .

Tumor cell metabolism: cancer's Achilles' heel.

Guido Kroemer, G. Kroemer, J. Pouysségur, 2008, Cancer cell.

Physical Interactions and Functional Coupling between Daxx and Sodium Hydrogen Exchanger 1 in Ischemic Cell Death*

J. Pouysségur, Yong-Sam Jung, Hyeyong Kim, 2008, Journal of Biological Chemistry.

Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis.

P. Cozzone, J. Pouysségur, Y. le Fur, 2013, Cancer research.

Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs.

J. Pouysségur, M. Kohno, Michiaki Kohno, 2003, Progress in cell cycle research.

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide‐specific phospholipase C.

J. Pouysségur, K. Seuwen, A. Lagarde, 1988, The EMBO journal.

Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown.

M. Roussel, J. Pouysségur, K. Seuwen, 1990, Growth factors.

A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment

J. Pouysségur, F. Dayan, N. Mazure, 2008, Cancer Microenvironment.

PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis

J. Pouysségur, E. Berra, A. Ginouvès, 2008, Proceedings of the National Academy of Sciences.

The silencing approach of the hypoxia-signaling pathway.

J. Pouysségur, E. Berra, 2007, Methods in enzymology.

The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling

J. Pouysségur, E. Berra, A. Ginouvès, 2006, EMBO reports.

Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS

P. Oefner, J. Pouysségur, Xueni Sun, 2020, Metabolites.

Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.

C. Sardet, J. Pouysségur, L. Counillon, 1990, Science.

ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB

M. Ravier, J. Pouysségur, J. Tanti, 2017, Diabetologia.

Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport.

J. Pouysségur, G. l'Allemain, S. Paris, 1984, The Journal of biological chemistry.

Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts.

J. Pouysségur, J. Chambard, 1986, Experimental cell research.

The role of intracellular pH in ligand internalization

I. Pastan, M. Willingham, J. Pouysségur, 1986, Journal of cellular physiology.

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

J. Pouysségur, Sandy Giuliano, H. Endou, 2018, The Journal of Biological Chemistry.

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

P. Lambin, L. Dubois, A. Harris, 2015, Journal of enzyme inhibition and medicinal chemistry.

Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis

I. Pastan, J. Pouysségur, W. Anderson, 1978, Nature.

The growth factor-activatable Na+/H+ exchange system: a genetic approach

J. Pouysségur, 1985 .

Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist.

E. Van Obberghen, J. Pouysségur, E. Van Obberghen-Schilling, 1993, The Biochemical journal.

Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1.

J. Pouysségur, R. Reithmeier, L. Counillon, 1997, Biochemistry.

Post-translational and Activation-dependent Modifications of the G Protein-coupled Thrombin Receptor (*)

J. Pouysségur, J. Chambard, D. Grall, 1995, The Journal of Biological Chemistry.

Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging

Mickael Tanter, Mathieu Pernot, Anikitos Garofalakis, 2018, Nature Biomedical Engineering.

Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting.

S. Clemenceau, J. Pouysségur, N. Mazure, 2012, International journal of radiation oncology, biology, physics.

Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.

J. Pouysségur, S. Paris, 1990, The Journal of biological chemistry.

SubsetsOpposites: Erk Direction of CD4 T Cell

Irene L. Ch, J. Pouysségur, S. Hedrick, 2012 .

ERK2 but not ERK1 plays a key role in hepatocyte replication: An RNAi‐mediated ERK2 knockdown approach in wild‐type and ERK1 null hepatocytes

J. Pouysségur, G. Pagès, G. Baffet, 2007, Hepatology.

Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation.

H. Bourne, J. Pouysségur, Y. Wong, 1991, Nature.

Structure of the 5'-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1.

C. Sardet, R. T. Miller, J. Pouysségur, 1991, The Journal of biological chemistry.

cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells.

C. Sardet, C. Slayman, P. Igarashi, 1991, The American journal of physiology.

Na+/H+ antiporter gene expression increases during retinoic acid‐induced granulocytic differentiation of HL60 cells

C. Sardet, J. Pouysségur, G. Rao, 1992, Journal of cellular physiology.

Focal localization of the NHE‐1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.

S. Grinstein, G. Downey, J. Pouysségur, 1993, The EMBO journal.

Cytoplasmic Domain of the Ubiquitous Na+/H+ Exchanger NHE1 Can Confer Ca2+ Responsiveness to the Apical Isoform NHE3 (*)

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1995, The Journal of Biological Chemistry.

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

J. Pouysségur, S. Meloche, G. Pagès, 1992, Molecular biology of the cell.

Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene Promoter*

J. Pouysségur, S. Hauguel-de Mouzon, E. Berra, 2002, The Journal of Biological Chemistry.

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

J. Pouysségur, C. Brahimi-Horn, 2006, Bulletin du cancer.

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.

J. Pouysségur, E. Berra, D. Roux, 2001, EMBO reports.

Angiogenesis: how a tumor adapts to hypoxia.

J. Pouysségur, E. Berra, D. Richard, 1999, Biochemical and biophysical research communications.

Total ERK1/2 activity regulates cell proliferation

J. Pouysségur, P. Lenormand, R. Lefloch, 2009, Cell cycle.

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.

S. Roy, S. Reddy, L. Platanias, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1

J. Pouysségur, M. Simon, R. Tournaire, 2008, Journal of cellular physiology.

Enhanced phosphorylation of the C‐terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases.

J. Pouysségur, O. Bensaude, G. Pagès, 1994, The EMBO journal.

Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1

S. Cook, J. Pouysségur, M. Ashcroft, 2007, Oncogene.

Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase.

J. Pouysségur, H. Kalckar, A. Franchi, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

J. Pouysségur, G. l'Allemain, E. Cragoe, 1984, The Journal of biological chemistry.

Growth factors activate the Na+/H+ antiporter in quiescent fibroblasts by increasing its affinity for intracellular H+.

J. Pouysségur, S. Paris, 1984, The Journal of biological chemistry.

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells.

J. Pouysségur, Y. Wang, M. Dunn, 1992, The Biochemical journal.

Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

J. Pouysségur, C. Gaggioli, S. Granja, 2015, Oncotarget.

Oxygen Tension Regulates Pancreatic β-Cell Differentiation Through Hypoxia-Inducible Factor 1α

R. Scharfmann, J. Pouysségur, N. Mazure, 2009, Diabetes.

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

S. Haferkamp, P. Oefner, B. Seliger, 2016, Cell metabolism.

Lactate and Acidity in the Cancer Microenvironment

J. Pouysségur, W. Mueller‐Klieser, S. Parks, 2020, Annual Review of Cancer Biology.

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

S. Richard, A. Baruchel, R. Wenger, 2012, Haematologica.

Glucose-induced O ( 2 ) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells . "

J. Pouysségur, D. R. Laybutt, C. Magnan, 2019 .

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

J. Pouysségur, D. R. Laybutt, C. Magnan, 2012, PloS one.

Enzyme-Linked Immunosorbent Assay for Pharmacological Studies Targeting Hypoxia-Inducible Factor 1α

N. Magné, J. Pouysségur, J. Formento, 2005, Clinical Diagnostic Laboratory Immunology.

HIF‐Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell‐Based Therapies for the Treatment of Critical Limb Ischemia

B. Lévy, J. Pouysségur, P. Bruneval, 2014, Stem cells.

Co‐culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia

J. Pouysségur, N. Mazure, F. Bost, 2020, Journal of cellular and molecular medicine.

HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation

J. Pouysségur, E. Berra, D. Richard, 2001, FEBS letters.

Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

S. Brant, J. Pouysségur, M. Donowitz, 1992, The Journal of biological chemistry.

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

I. Pastan, J. Pouysségur, R. Shiu, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation

I. Pastan, J. Pouysségur, R. Shiu, 1977, Cell.

Isolation and immunological characterization of a glucose-regulated fibroblast cell surface glycoprotein and its nonglycosylated precursor

Kenneth M. Yamada, J. Pouysségur, K. Yamada, 1978, Cell.

Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins.

I. Pastan, J. Pouysségur, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Signaling Pathways of the Thrombin Receptor

J. Pouysségur, E. Van Obberghen-Schilling, 1993, Thrombosis and Haemostasis.

Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli.

C. Sardet, J. Pouysségur, G. Rao, 1990, The Journal of biological chemistry.

Growth factor activation and "H(+)-sensing" of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation.

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1994, The Journal of biological chemistry.

Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective.

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1994, The Journal of biological chemistry.

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

S. Grinstein, C. Sardet, J. Pouysségur, 1992, The Journal of biological chemistry.

Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites.

C. Sardet, J. Pouysségur, P. Fafournoux, 1991, The Journal of biological chemistry.

ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.

S. Grinstein, G. Downey, J. Pouysségur, 1994, The Journal of biological chemistry.

The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors*

J. Pouysségur, G. l'Allemain, L. Bianchini, 1997, The Journal of Biological Chemistry.

Functional expression of the human growth factor activatable Na+/H+ antiporter (NHE-1) in baculovirus-infected cells.

C. Sardet, J. Pouysségur, J. Ghysdael, 1991, Biochemistry.

TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation*

D. Green, J. Pouysségur, G. Pagès, 2011, The Journal of Biological Chemistry.

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

J. Pouysségur, J. Durivault, Yann Cormerais, 2016, Oncotarget.

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

W. Fiers, B. Vanhaesebroeck, F. van Roy, 1990, FEBS letters.

Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability.

J. Pouysségur, G. Pagès, K. Essafi-Benkhadir, 2010, Methods in molecular biology.

Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.

K. Alitalo, K. Iljin, J. Pouysségur, 2002, Journal of cell science.

Complete Structure of an Increasing Capillary Permeability Protein (ICPP) Purified from Vipera lebetina Venom

J. Pouysségur, S. Wedge, S. Marchetti, 2002, Journal of Biological Chemistry.

cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition

J. Pouysségur, F. McKenzie, F. Mckenzie, 1996, The Journal of Biological Chemistry.

ERK1 is important for Th2 differentiation and development of experimental asthma

Hua Huang, E. Gelfand, J. Pouysségur, 2012, The FASEB Journal.

Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells1

J. Pouysségur, G. Pagès, S. Hedrick, 2009, The Journal of Immunology.

Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells.

C. Sardet, J. Pouysségur, G. Rao, 1993, The American journal of physiology.

Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

J. Pouysségur, G. Pagès, Clara Savary, 2020 .

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

J. Pouysségur, N. Mazure, 2009, Autophagy.

Identification of the protein and cDNA of the cardiac Na+ /H+ exchanger

C. Sardet, J. Pouysségur, L. Fliegel, 1991, FEBS letters.

Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript.

C. Sardet, C. Slayman, P. Igarashi, 1991, Biochimica et biophysica acta.

Cloning of the human genomic amiloride-sensitive Na+/H+ antiporter gene, identification of genetic polymorphisms, and localization on the genetic map of chromosome 1p.

C. Sardet, J. Lalouel, J. Pouysségur, 1990, Genomics.

Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts.

J. Pouysségur, S. Paris, 1983, The Journal of biological chemistry.

An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression

J. Pouysségur, M. Gall, J. Chambard, 1998, Oncogene.

Na/H Exchange activities in NHE1-transfected OK-cells: cell polarity and regulation

J. Pouysségur, C. Helmle‐Kolb, D. Roux, 1993, Pflügers Archiv.

Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype.

J. Pouysségur, J. Chambard, E. Van Obberghen-Schilling, 1991, Molecular endocrinology.

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein‐coupled thrombin receptor.

J. Pouysségur, D. Grall, E. Van Obberghen-Schilling, 1996, The EMBO journal.

Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

J. Pouysségur, E. Van Obberghen-Schilling, S. Courtneidge, 1994, The Journal of biological chemistry.

p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.

J. Pouysségur, G. Pagès, P. Angel, 2006, Cancer research.

Growth factors activate the bumetanide-sensitive Na+/K+/Cl-cotransport in hamster fibroblasts.

J. Pouysségur, S. Paris, 1986, The Journal of biological chemistry.

EGF and insulin action in fibroblasts

J. Pouysségur, G. l'Allemain, 1986, FEBS letters.

Transcriptional regulation of VCAM‐1 expression by tumor necrosis factor‐α in human tracheal smooth muscle cells: Involvement of MAPKs, NF‐κB, p300, and histone acetylation

J. Pouysségur, Chih‐Chung Lin, Chuen-Mao Yang, 2006 .

Thrombin-induced protein phosphorylation in resting platelets and fibroblasts: evidence for common post-receptor molecular events.

J. Pouysségur, J. Chambard, 1983, Biochemical and biophysical research communications.

ERK1 plays a critical protective role against N‐methyl‐D‐aspartate‐induced retinal injury

S. Endo, T. Nakazawa, K. Nishida, 2008, Journal of neuroscience research.

PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation*

A. Brunet, J. Pouysségur, M. H. Werner, 2003, Journal of Biological Chemistry.

Molecular physiology of vertebrate Na+/H+ exchangers.

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1997, Physiological reviews.

The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors (*)

J. Pouysségur, N. Rivard, J. Brondello, 1995, The Journal of Biological Chemistry.

Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

J. Pouysségur, H. Lang, L. Counillon, 1993, Molecular pharmacology.

Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts

J. Pouysségur, G. l'Allemain, A. Franchi, 1985, FEBS letters.

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

J. Nielsen, J. Pouysségur, E. Cummins, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Genetic Disruption of the γ-Glutamylcysteine Ligase in PDAC Cells Induces Ferroptosis-Independent Cell Death In Vitro without Affecting In Vivo Tumor Growth

J. Pouysségur, J. Durivault, M. Vucetic, 2022, Cancers.

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.

J. Pouysségur, M. Weber, G. l'Allemain, 1991, Cell regulation.

Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts.

J. Pouysségur, M. Kohno, 1986, The Biochemical journal.

Independent activation of endogenous p21‐activated protein kinase‐3 (PAK3) and JNK by thrombin in CCL39 fibroblasts

J. Pouysségur, K. Malcolm, J. Chambard, 2000, Journal of cellular physiology.

Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis.

J. Pouysségur, D. Pearce, X. Xi, 1991, The Journal of clinical investigation.

'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives.

J. Pouysségur, J. Durivault, M. Vucetic, 2022, Seminars in cancer biology.

Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction.

J. Pouysségur, T. Iwamoto, M. Shigekawa, 1997, Biochemistry.

Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.

J. Pouysségur, P. Fafournoux, J. Noël, 1994, The Journal of biological chemistry.

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

J. Pouysségur, P. Little, M. Donowitz, 1993, The Journal of biological chemistry.

A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.

J. Pouysségur, L. Counillon, A. Franchi, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation.

C. Sardet, J. Pouysségur, H. Ives, 1993, The Journal of biological chemistry.

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

C. Sardet, J. Pouysségur, M. Donowitz, 1991, The EMBO journal.

Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter.

J. Pouysségur, E. Cragoe, A. Franchi, 1986, The Journal of biological chemistry.

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

J. Pouysségur, S. Meloche, K. Seuwen, 1992, Molecular endocrinology.

A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.

J. Pouysségur, G. Pagès, Tomoaki Koga, 2007, Journal of immunology.

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteins in Rous sarcoma virus-transformed chick embryo fibroblasts ( glucose starvation / membrane proteins )

J. Pouysségur, R. Shiu, 2022 .

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

J. Pouysségur, J. Chambard, G. l'Allemain, 1986, The Journal of biological chemistry.

Functional Expression and Growth Factor Activation of an Epitope-Tagged p 44 Mitogen-Activated Protein Kinase , p 44 mapk

J. Pouysségur, S. Meloche, G. Pagès, 2022 .

Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.

J. Pouysségur, F. Viñals, 2001, Molecular and cellular biology.

Analysis of growth factor “relaxation” in chinese hamster lung fibroblasts required for tumoral expression

J. Pouysségur, J. Chambard, E. Van Obberghen-Schilling, 1983, Journal of cellular physiology.

ERK1 and ERK2 are required for radial glial maintenance and cortical lamination

S. Endo, K. Takishima, J. Pouysségur, 2010, Genes to cells : devoted to molecular & cellular mechanisms.

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

J. Pouysségur, G. Pagès, E. Van Obberghen-Schilling, 1991, FEBS letters.

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

P. Oefner, J. Cleveland, S. Ong, 2019, Cell reports.

Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1).

J. Pouysségur, L. Counillon, Jacques Pouysségur, 1995, Cardiovascular research.

Functional expression of Ca2+ ‐mobilizing α‐thrombin receptors in mRNA‐injected Xenopus oocytes

P. Lory, J. Pouysségur, J. Chambard, 1990 .

Affinity labeling of high-affinity alpha-thrombin binding sites on the surface of hamster fibroblasts.

J. Pouysségur, E. Van Obberghen-Schilling, 1985, Biochimica et biophysica acta.

Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms.

J. Pouysségur, L. Counillon, 1994, Society of General Physiologists series.

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

H. Bourne, J. Pouysségur, Y. Wong, 1991, Nature.

Sugar transport in chick embryo cardiac cells in culture: analysis by countertransport, relationship to phosphorylation and effect of glucose starvation.

G. Ailhaud, J. Pouysségur, S. Paris, 1980, Biochimica et biophysica acta.

Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa

J. Pouysségur, S. Paris, 1991 .

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin

J. Pouysségur, D. Rotin, Avinash K. Persaud, 2018, Journal of Cell Science.

Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained activity of PC-phospholipase C.

J. Pouysségur, K. Seuwen, F. McKenzie, 1992, The Journal of biological chemistry.

Growth factor-stimulated protein synthesis is inhibited by sodium orthovanadate.

J. Pouysségur, F. Viñals, F. McKenzie, 2001, European journal of biochemistry.

Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells.

C. Sardet, J. Pouysségur, G. Rao, 1991, The Journal of biological chemistry.

Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.

J. Pouysségur, D. Roux, J. Noel, 1996, Journal of cell science.

Chapter 16 The vertebrate Na+/H+ exchangers structure, expression and hormonal regulation

J. Pouysségur, P. Fafournoux, 1996 .

Regulation of the Na7H exchanger isoform NHE1: Role of phosphorylation

J. Pouysségur, Laurence BIicHINI, 2010 .

Molecular Studies of Members of the Mammalian Na+/H+ Exchanger Gene Family

S. Brant, J. Pouysségur, M. Donowitz, 1996 .

Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE‐1 isoform via Gi‐mediated mitogen activated protein kinase signaling transduction pathways

P. Casellas, J. Pouysségur, F. McKenzie, 1999, FEBS letters.

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress.

S. Grinstein, G. Lukács, J. Pouysségur, 1995, The American journal of physiology.

Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.

S. Brant, J. Pouysségur, M. Donowitz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Okadaic acid, a phosphatase inhibitor, induces activation and phosphorylation of the Na+/H+ antiport.

S. Grinstein, C. Sardet, J. Pouysségur, 1991, The Journal of biological chemistry.

Molecular Properties, Kinetics and Regulation of Mammalian Na+/H+ Exchangers

S. Brant, J. Pouysségur, M. Donowitz, 1994 .

The Na+/H+ exchanger is phosphorylated in human platelets in response to activating agents

C. Sardet, J. Pouysségur, A. Livne, 1991, FEBS letters.

Phosphorylation of the Growth-Factor Activatable Na+/H+ Antiporter: A Mechanism of Regulation

C. Sardet, J. Pouysségur, P. Fafournoux, 1991 .

Low cytoplasmic pH inhibits endocytosis and transport from the trans- Golgi network to the cell surface

J. Davoust, J. Pouysségur, G. Griffiths, 1989, The Journal of cell biology.

Chapter 12 Na+-H+ Exchange and Growth Control in Fibroblasts: A Genetic Approach

J. Pouysségur, M. Kohno, G. l'Allemain, 1986 .

SubsetsPolar Opposites: Erk Direction of CD4 T Cell

J. Pouysségur, G. Pagès, Warren N D'Souza, 2012 .

SubsetsPolar Opposites: Erk Direction of CD4 T Cell

J. Pouysségur, G. Pagès, S. Hedrick, 2012 .

Cyclic AMP inhibits mitogen‐induced DNA synthesis in hamster fibroblasts, regardless of the signalling pathway involved

J. Pouysségur, I. Magnaldo, S. Paris, 1989, FEBS letters.

Endothelin stimulates mitogen-activated protein kinase activity in mesangial cells through ETA.

J. Pouysségur, Y. Wang, M. Dunn, 1994, Journal of the American Society of Nephrology : JASN.

Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms*

J. Pouysségur, E. Pagé, D. Richard, 2002, The Journal of Biological Chemistry.

An Arresting Start for MAPK

J. Pouysségur, 2000, Science.

ERK1 Regulates the Hematopoietic Stem Cell Niches

J. Pouysségur, G. Pagès, X. Holy, 2012, PloS one.

Disrupting proton dynamics and energy metabolism for cancer therapy

J. Pouysségur, J. Chiche, S. Parks, 2013, Nature Reviews Cancer.

Abstract 3225: Growth inhibition of glycolytic tumors by targeting basigin/lactate-H+ symporters (MCTs): Metformin sensitizes MCT inhibition

J. Pouysségur, D. Roux, J. Chiche, 2012 .

The mammalian Na+/H+ exchanger gene family--initial structure/function studies.

S. Brant, J. Pouysségur, M. Donowitz, 1993, Journal of the American Society of Nephrology : JASN.

Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice

J. Pouysségur, G. Pagès, Yasunobu Miyake, 2017, International immunology.

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

J. Pouysségur, S. Critchlow, D. Roux, 2011, Proceedings of the National Academy of Sciences.

Gene disruption using zinc finger nuclease technology.

J. Pouysségur, F. Baltazar, S. Granja, 2014, Methods in molecular biology.

The monocarboxylate transporter 1 (MCT1) and Hypoxia-induced MCT4 are key targets promoting tumor cell survival

J. Pouysségur, D. Roux, J. Chiche, 2008 .

Oxygen tension regulates pancreatic beta-cell differentiation through HIF1 

R. Scharfmann, J. Pouysségur, N. Mazure, 2009 .

Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.

J. Pouysségur, I. Magnaldo, S. Paris, 1989, Cellular signalling.

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

J. Pouysségur, S. Meloche, K. Seuwen, 1992, The Journal of biological chemistry.

Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.

J. Pouysségur, Y. Bouret, L. Counillon, 2016, Biochimica et biophysica acta.

Mitogen-potentiating action and binding characteristics of insulin and insulin-like growth factors in Chinese hamster fibroblasts.

J. Pouysségur, E. Van Obberghen-Schilling, 1983, Experimental cell research.

Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa.

C. Sardet, J. Pouysségur, M. Schwartz, 1994, The American journal of physiology.

Evidence for a GTP‐binding protein coupling thrombin receptor to PIP2‐phospholipase C in membranes of hamster fibroblasts

J. Pouysségur, W. Anderson, H. Talwar, 1987, FEBS letters.

α‐Thrombin‐induced inositol phosphate formation in go‐arrested and cycling hamster lung fibroblasts: Evidence for a protein kinase C‐mediated desensitization response

J. Pouysségur, G. l'Allemain, I. Magnaldo, 1986 .

MAP kinases: activation, subcellular localization and role in the control of cell proliferation.

C. Sardet, J. Pouysségur, S. Meloche, 1993, Advances in second messenger and phosphoprotein research.

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.

J. Pouysségur, D. Roux, I. Marchiq, 2015, Cancer research.

Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts

J. Pouysségur, V. Baldin, N. Rivard, 1997, Oncogene.

Multiple division cycles and long‐term survival of hepatocytes are distinctly regulated by extracellular signal‐regulated kinases ERK1 and ERK2

D. Gilot, J. Pouysségur, G. Pagès, 2009, Hepatology.

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

J. Pouysségur, J. Iovanna, J. Neira, 2021, Cell death discovery.

Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform.

S. Brant, J. Pouysségur, M. Donowitz, 1993, The Journal of biological chemistry.

Signal transduction in hamster fibroblasts overexpressing the human EGF receptor.

J. Pouysségur, K. Seuwen, G. l'Allemain, 1989, Growth factors.

Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis.

J. Pouysségur, N. Mazure, M. Brahimi-Horn, 2003, Current pharmaceutical design.

Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors.

J. Pouysségur, G. Pagès, Jacques Pouysségur, 2005, Cardiovascular research.

Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin.

J. Pouysségur, S. Paris, 1987, The Journal of biological chemistry.

Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin.

J. Pouysségur, J. Chambard, S. Paris, 1987, The Journal of biological chemistry.

Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.

J. Pouysségur, P. Auberger, V. Imbert, 1994, The Journal of biological chemistry.

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

J. Pouysségur, I. Magnaldo, S. Paris, 1988, The Journal of biological chemistry.

Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3.

J. McPherson, S. Brant, J. Wasmuth, 1993, Genomics.

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

J. Pouysségur, J. Chiche, M. Brahimi-Horn, 2009, Journal of cellular and molecular medicine.

Hypoxia in cancer cell metabolism and pH regulation.

J. Pouysségur, M. Brahimi-Horn, 2007, Essays in biochemistry.

Oxygen, a source of life and stress

J. Pouysségur, Jacques Pouysségur, M Christiane Brahimi-Horn, 2007, FEBS letters.

Hypoxia signalling controls metabolic demand.

J. Pouysségur, Jacques Pouysségur, M Christiane Brahimi-Horn, 2007, Current opinion in cell biology.

Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system

S. Endo, Y. Satoh, T. Kazama, 2012, PAIN®.

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.

C. Supuran, J. Pouysségur, Marie Lopez, 2011, Journal of medicinal chemistry.

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

J. Pouysségur, F. Dayan, N. Mazure, 2009, Cancer research.

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

J. Pouysségur, M. Palacín, Sandy Giuliano, 2016, Cancer research.

The Expanding Family of Eucaryotic Na+/H+Exchangers*

J. Pouysségur, L. Counillon, 2000, The Journal of Biological Chemistry.

A Novel Role for IκB Kinase (IKK) α and IKKβ in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae1

J. Pouysségur, G. Pagès, Tomoaki Koga, 2007, The Journal of Immunology.

Hypoxia and cancer

J. Pouysségur, Jacques Pouysségur, Johanna Chiche, 2007, Journal of Molecular Medicine.

Cyclin D1 Expression Is Regulated Positively by the p42/p44MAPK and Negatively by the p38/HOGMAPK Pathway*

J. Pouysségur, G. l'Allemain, J. Lavoie, 1996, The Journal of Biological Chemistry.

A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry.

J. Pouysségur, N. Rivard, G. l'Allemain, 1996, Progress in cell cycle research.

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

S. Endo, J. Pouysségur, M. Huber, 2018, Nature Immunology.

Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation.

C. Sardet, J. Pouysségur, R. Motais, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

J. Pouysségur, M. Vucetic, Willian Meira, 2020, Cell Death & Disease.

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and −2 Are Induced by the p42/p44MAPK Cascade*

J. Pouysségur, J. Brondello, F. McKenzie, 1997, The Journal of Biological Chemistry.

Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells

M. Khaled, R. Buscà, K. Bille, 2005, The Journal of cell biology.

TGF‐β inhibits growth factor‐induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events

J. Pouysségur, J. Chambard, 1988 .

Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant.

I. Pastan, M. Willingham, J. Pouysségur, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Cell surface glycoproteins and malignant transformation.

J. Pouysségur, K. Yamada, K. Yamada, 1979, Biochimie.

Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family

S. Brant, J. Pouysségur, M. Donowitz, 1993, The Journal of Membrane Biology.

Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts

I. Pastan, M. Willingham, J. Pouysségur, 1977, Cell.

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

J. Pouysségur, Shamir Cassim, S. Cassim, 2019, International journal of molecular sciences.

Hypoxia-induced autophagy: cell death or cell survival?

J. Pouysségur, N. Mazure, 2010, Current opinion in cell biology.

Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

J. Pouysségur, M. Vucetic, M. Ždralević, 2020, Cancers.

Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate.

I. Pastan, J. Pouysségur, 1977, The Journal of biological chemistry.

Evidence that hamster fibroblast tumors emerge in nude mice through the process of two in vivo selections leading to growth factor “relaxation” and to immune resistance

J. Pouysségur, A. Franchi, B. F. Deys, 1982, International journal of cancer.

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

C. Sardet, J. Pouysségur, S. Wakabayashi, 1992, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca2+ mobilization

J. Pouysségur, G. Pagès, E. Van Obberghen-Schilling, 1991 .

"Carrier activation" and glucose transport in Chinese hamster fibroblasts.

J. Pouysségur, A. Franchi, P. Silvestre, 1978, Biochemical and biophysical research communications.

A genetic approach to the role of energy metabolism in the growth of tumor cells: Tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration

J. Pouysségur, A. Franchi, P. Silvestre, 1981, International journal of cancer.

From Malignant Progression to Therapeutic Targeting: Current Insights of Mesothelin in Pancreatic Ductal Adenocarcinoma

J. Pouysségur, G. Pagès, A. Broisat, 2020, International journal of molecular sciences.

ERK implication in cell cycle regulation.

J. Pouysségur, J. Chambard, P. Lenormand, 2007, Biochimica et biophysica acta.

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

R. Buscà, J. Pouysségur, P. Lenormand, 2016, Front. Cell Dev. Biol..

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

Jonathan LaMarre, Sabine Bailly, J. Pouysségur, 2004, Oncogene.

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

J. Pouysségur, N. Mazure, Raquel García-Medina, 2009, Molecular and Cellular Biology.

Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses.

J. Pouysségur, J. Durivault, E. Tambutté, 2019, Cancer research.

Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms.

J. Pouysségur, J. Noël, 1995, The American journal of physiology.

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

J. Pouysségur, M. Vucetic, Boutaina Daher, 2020, Frontiers in Oncology.

A functional role for the p62–ERK1 axis in the control of energy homeostasis and adipogenesis

P. Pfluger, M. Tschöp, J. Pouysségur, 2010, EMBO reports.

Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+

C. Sardet, J. Pouysségur, A. Franchi, 1989, Cell.

PHD2 mutation and congenital erythrocytosis with paraganglioma.

F. Galateau-Sallé, S. Richard, J. Pouysségur, 2008, The New England journal of medicine.

ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1

Jia-Xing Yue, R. Buscà, J. Pouysségur, 2015, BMC Evolutionary Biology.

ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1

Jia-Xing Yue, R. Buscà, J. Pouysségur, 2015, BMC Evolutionary Biology.

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

J. Pouysségur, I. Marchiq, 2015, Journal of Molecular Medicine.

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

P. Oefner, J. Pouysségur, G. Koehl, 2018, The Journal of Biological Chemistry.

Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.

J. Pouysségur, M. Vucetic, I. Marchiq, 2017, Advances in biological regulation.

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

C. Dani, J. Pouysségur, J. Chambard, 1985, Nature.

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

Erik Sahai, E. Sahai, J. Pouysségur, 2007, The Journal of cell biology.

Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma Protuberans (DP)

J. Pouysségur, D. Roux, M. Navarro, 2001, Oncogene.

[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells].

R. Buscà, R. Ballotti, J. Pouysségur, 2006, Medecine sciences : M/S.

The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain.

J. Pouysségur, R. Reithmeier, L. Counillon, 1994, Biochemistry.

The cytoplasmic domain of the Na+/H+ exchangers (NHEs) dictates the nature of the hormonal response: behavior of a chimeric human NHE1/trout beta NHE antiporter.

J. Pouysségur, B. Fiévet, R. Motais, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

C. Sardet, J. Pouysségur, G. l'Allemain, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells

J. Pouysségur, J. Durivault, M. Vucetic, 2022, Antioxidants.

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code

J. Pouysségur, M. Vucetic, Yann Cormerais, 2017, Front. Oncol..

Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases

J. Pouysségur, G. Pagès, Julie Milanini-Mongiat, 2002, The Journal of Biological Chemistry.

Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry

A. Brunet, J. Pouysségur, S. Keyse, 1999, The EMBO journal.

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

A. Brunet, J. Pouysségur, 1996, Science.

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1*

J. Pouysségur, E. Berra, D. Roux, 1999, The Journal of Biological Chemistry.

Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior

N. Tronson, J. Pouysségur, G. Pagès, 2008, Neuropsychopharmacology.

Confluence of Vascular Endothelial Cells Induces Cell Cycle Exit by Inhibiting p42/p44 Mitogen-Activated Protein Kinase Activity

J. Pouysségur, F. Viñals, 1999, Molecular and Cellular Biology.

Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4

J. Pouysségur, J. Deitmer, H. Becker, 2017, The FEBS journal.

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect.

Benoît Vanderperre, Nicola Zamboni, J. Martinou, 2015, Molecular cell.

pH control mechanisms of tumor survival and growth

J. Pouysségur, Jacques Pouyssegur, Johanna Chiche, 2011, Journal of cellular physiology.

Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype.

D. Julius, J. Pouysségur, K. Seuwen, 1992, Experimental cell research.

The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.

J. Pouysségur, M. Gall, M. le Gall, 2000, Molecular biology of the cell.

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

A. Brunet, J. Pouysségur, G. Pagès, 1994, The EMBO journal.

Activation of HIF‐1α in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway

J. Pouysségur, F. Dayan, N. Mazure, 2009, Journal of cellular physiology.

Harnessing the hypoxia-inducible factor in cancer and ischemic disease.

J. Pouysségur, Jacques Pouysségur, M Christiane Brahimi-Horn, 2007, Biochemical pharmacology.

Inducible expression of a MAP kinase phosphatase‐3‐GFP chimera specifically blunts fibroblast growth and ras‐dependent tumor formation in nude mice

J. Pouysségur, G. Pagès, S. Marchetti, 2004, Journal of cellular physiology.

Transforming Growth Factor 1 (TGF- 1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF- Signaling

J. Pouysségur, F. Viñals, Jacques Pouysségur, 2001 .

Redox regulation of the hypoxia-inducible factor

Fatima Mechta-Grigoriou, J. Pouysségur, F. Mechta-Grigoriou, 2006, Biological chemistry.

Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs

J. Pouysségur, I. Marchiq, S. Parks, 2017, Front. Oncol..

Spatiotemporal regulation of the p42/p44 MAPK pathway

J. Pouysségur, V. Volmat, Véronique Volmat, 2001, Biology of the cell.

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3*

A. Brunet, J. Wilsbacher, M. Camps, 2000, The Journal of Biological Chemistry.

The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma

N. Rioux-Leclercq, J. Pouysségur, N. Mazure, 2018, PloS one.

Mammalian MAP kinase modules: how to transduce specific signals.

A. Brunet, J. Pouysségur, 1997, Essays in biochemistry.

MAP Kinases and Hypoxia in the Control of VEGF Expression

J. Pouysségur, G. Pagès, E. Berra, 2004, Cancer and Metastasis Reviews.

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.

J. Pouysségur, G. Pagès, M. Gall, 2000, Biochemical pharmacology.

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

J. Pouysségur, S. Meloche, G. Pagès, 1993, Proceedings of the National Academy of Sciences of the United States of America.

MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

A. Noël, J. Pouysségur, N. Mazure, 2013, Cell Death and Disease.

Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels

J. Pouysségur, P. Lenormand, R. Lefloch, 2007, Molecular and Cellular Biology.

Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis

N. Ahn, J. Pouysségur, G. Pagès, 2002, Molecular and Cellular Biology.

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

Emmanuel Chamorey, A. Ramaioli, J. Pouysségur, 2007, International journal of cancer.

HIF‐1α mediates the induction of IL‐8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT‐like behaviour

R. Buscà, J. Pouysségur, E. Berra, 2010, Cellular microbiology.

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells.

J. Pouysségur, E. Berra, D. Richard, 2000, The Journal of biological chemistry.

Targeting the ERK signaling pathway in cancer therapy

J. Pouysségur, M. Kohno, 2006, Annals of medicine.

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Fatima Mechta-Grigoriou, A. Giaccia, D. Mansuy, 2004, Cell.

Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging

M. Tanter, B. Tavitian, J. Provost, 2018, Nature Biomedical Engineering.

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.

J. Pouysségur, F. Ettore, J. Ferrero, 2014, Biochemical and biophysical research communications.

pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

J. Pouysségur, G. Pagès, A. Franchi, 2001, Novartis Foundation symposium.

Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype.

J. Salomon, J. Pouysségur, A. Franchi, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth.

Frédéric Dayan, P. Sommer, J. Pouysségur, 2011, Cancer research.

MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ

S. Roy, S. Reddy, L. Platanias, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

A. Brunet, C. Sardet, J. Pouysségur, 1993, The Journal of cell biology.

MAP Kinase Cascade and the Control of Cell Proliferation

A. Brunet, J. Pouysségur, G. Pagès, 1993 .

Targeting pH regulating proteins for cancer therapy-Progress and limitations.

J. Pouysségur, S. Parks, 2017, Seminars in cancer biology.

Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins

A. Brunet, J. Pouysségur, J. Brondello, 1998, The Journal of cell biology.

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

J. Nielsen, J. Pouysségur, E. Cummins, 2006, Proceedings of the National Academy of Sciences.

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.

J. Pouysségur, F. Dayan, N. Mazure, 2006, Cancer research.

HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration

R. Buscà, J. Pouysségur, T. Virolle, 2008, Journal of Cell Science.

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

L. Meijer, N. Gray, J. Pouysségur, 2002, Oncogene.

Biomarkers in cancer management: a crucial bridge toward personalized medicine

J. Pouysségur, J. Borg, A. Gonçalves, 2004 .

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap

J. Pouysségur, V. Vouret-Craviari, D. Richard, 2001, Oncogene.

Signaling Angiogenesis via p42/p44 MAP Kinase Cascade

J. Pouysségur, G. Pagès, F. Viñals, 2000, Annals of the New York Academy of Sciences.

p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts*

J. Pouysségur, G. Pagès, F. Viñals, 1998, The Journal of Biological Chemistry.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis.

P. Opolon, J. Pouysségur, G. Pagès, 2010, Blood.

Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors.

J. Pouysségur, M. Vucetic, S. Parks, 2021, Advances in experimental medicine and biology.

Role of a Na+-dependent Cl-/HCO3- exchange in regulation of intracellular pH in fibroblasts.

J. Pouysségur, G. l'Allemain, J Pouysségur, 1985, The Journal of biological chemistry.

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.

J. Pouysségur, J. Chambard, E. Van Obberghen-Schilling, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.

J. Pouysségur, I. Marchiq, Yann Cormerais, 2016, Molecular aspects of medicine.

ARDent about acetylation and deacetylation in hypoxia signalling.

J. Pouysségur, R. Bilton, M. Brahimi-Horn, 2006, Trends in cell biology.

Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF*

J. Pouysségur, N. Mazure, M. Déry, 2005, Journal of Biological Chemistry.

G protein-controlled signal transduction pathways and the regulation of cell proliferation.

J. Pouysségur, K. Seuwen, Jacques Pouysségur, 1992, Advances in cancer research.

Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase

J. Pouysségur, K. Soliman, E. Mazzio, 2020, Cancer Genomics & Proteomics.

Thrombin and Its Receptor in Growth Control a

J. Pouysségur, J. Chambard, D. Grall, 1995, Annals of the New York Academy of Sciences.

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

A. Brunet, J. Pouysségur, G. Pagès, 1994, FEBS letters.

Overexpression of carbonic anhydrase XII in tissues from resectable non‐small cell lung cancers is a biomarker of good prognosis

J. Pouysségur, N. Mazure, P. Hofman, 2011, International journal of cancer.

Characterization of the neuropilin‐1 promoter; gene expression is mediated by the transcription factor Sp1

M. Klagsbrun, J. Pouysségur, M. Rossignol, 2003, Journal of cellular biochemistry.

SUMOylation of hypoxia-inducible factor-1α reduces its transcriptional activity

J. Pouysségur, N. Mazure, M. Brahimi-Horn, 2007 .

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis.

C. Dani, J. Pouysségur, Y. Le Marchand-Brustel, 2005, Diabetes.

Serotonin stimulates DNA synthesis in fibroblasts acting through 5–HT1B receptors coupled to a Gi-protein

J. Pouysségur, K. Seuwen, I. Magnaldo, 1988, Nature.

The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1.

J. Pouysségur, E. Berra, C. Chauvet, 2004, The Biochemical journal.

Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C.

J. Pouysségur, I. Magnaldo, S. Paris, 1988, The Biochemical journal.

Tie1 deficiency induces endothelial–mesenchymal transition

J. Pouysségur, J. Iovanna, M. Sandí, 2012, EMBO reports.

Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.

J. Pouysségur, J. Chiche, M. Brahimi-Horn, 2010, Advances in enzyme regulation.

The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53–p21 axis

J. Pouysségur, F. Dayan, N. Mazure, 2012, Oncogene.

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.

H. Sanjo, J. Pouysségur, G. Pagès, 2008, Immunity.

Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.

J. Pouysségur, Hong Sun, N. Tonks, 1995, Oncogene.

Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia

A. Schmidt, J. Pouysségur, N. Mazure, 2015, Molecular and Cellular Biology.

Local mitochondrial-endolysosomal microfusion cleaves the

A. Schmidt, J. Pouysségur, T. Voeltzel, 2015 .

Hypoxia and Tumour Angiogenesis

J. Pouysségur, N. Mazure, Julie Laferrière, 2008 .

The Na+:H+ antiport in cancer.

J. Pouysségur, A. Lagarde, 1986, Cancer biochemistry biophysics.

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

J. Pouysségur, N. Mazure, P. Gounon, 2009, Journal of cellular physiology.

Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

J. Pouysségur, N. Mazure, T. Virolle, 2008, Cell Death and Differentiation.

Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.

J. Pouysségur, E. Van Obberghen-Schilling, E. Obberghen-Schilling, 1998, Molecular biology of the cell.

Regulation of Tumor Cell Motility by ERK Mitogen‐Activated Protein Kinases

J. Pouysségur, E. Vial, 2004, Annals of the New York Academy of Sciences.

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

B. Viollet, J. Pouysségur, N. Mazure, 2015, Oncotarget.

Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway.

Frédéric Dayan, Elisabeth Pécou, J. Pouysségur, 2009, Journal of theoretical biology.

HIF at a glance

J. Pouysségur, M. Brahimi-Horn, 2009, Journal of Cell Science.

The hypoxia-inducible factor and tumor progression along the angiogenic pathway.

J. Pouysségur, M. Brahimi-Horn, 2005, International review of cytology.

Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.

S. Hunt, J. Lalouel, R. Lifton, 1991, Hypertension.

EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway

J. Pouysségur, V. Vouret-Craviari, C. Deroanne, 2003, Journal of Cell Science.

Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation

J. Pouysségur, G. Pagès, J. Chambard, 2005, Molecular and Cellular Biology.

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.

I. Tannock, J. Pouysségur, K. Newell, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Tumor hypoxia and metabolism -- towards novel anticancer approaches.

J. Pouysségur, J. Ricci, J. Chiche, 2013, Annales d'endocrinologie.

The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness.

I. Pastan, J. Pouysségur, 1979, Experimental Cell Research.

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

J. Pouysségur, J. Chambard, G. l'Allemain, 1987, Nature.

The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases.

M. Camps, S. Arkinstall, J. Pouysségur, 2001, Journal of cell science.

Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors.

A. Brunet, J. Pouysségur, V. Robert-Hebmann, 1998, Journal of immunology.

Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma

J. Pouysségur, G. Pagès, H. Endou, 2019, Journal of cellular and molecular medicine.

MDCK cells phenotype and morphogenesis in transdifferentiated Loss of active MEK1-ERK1/2 restores epithelial

J. Pouysségur, R. Montesano, H. Schramek, 2005 .

Use of tritium-labeled precursors to select mutants.

J. Pouysségur, A. Franchi, 1987, Methods in enzymology.

Transmembrane receptors and intracellular pathways that control cell proliferation.

J. Pouysségur, K. Seuwen, 1992, Annual review of physiology.

Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1).

C. Sardet, J. Pouysségur, S. Meloche, 1992, Reviews of physiology, biochemistry and pharmacology.

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

J. Pouysségur, N. Mazure, Joffrey Pelletier, 2012, Front. Oncol..

Effect of mutations affecting Na+:H+ antiport activity on tumorigenic potential of hamster lung fibroblasts

J. Pouysségur, A. Lagarde, A. Franchi, 1988, Journal of cellular biochemistry.

When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy.

J. Pouysségur, C. Brahimi-Horn, 2005, Critical reviews in oncology/hematology.

High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer

J. Pouysségur, N. Mazure, P. Hofman, 2010, British Journal of Cancer.

99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

J. Pouysségur, G. Pagès, Clara Savary, 2019, Cancers.

p70 S6 Kinase-mediated Protein Synthesis Is a Critical Step for Vascular Endothelial Cell Proliferation*

J. Pouysségur, J. Chambard, F. Viñals, 1999, The Journal of Biological Chemistry.

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.

J. Pouysségur, P. Lenormand, Jacques Pouysségur, 2002, European journal of biochemistry.

Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization (*)

J. Pouysségur, P. Auberger, E. Van Obberghen-Schilling, 1995, The Journal of Biological Chemistry.

Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications.

J. Pouysségur, N. Mazure, C. Brahimi-Horn, 2005, Cellular signalling.

Stimulation of Phosphatidylcholine Breakdown by Thrombin and Carbachol but Not by Tyrosine Kinase Receptor Ligands in Cells Transfected with M 1 Muscarinic Receptors

J. Pouysségur, Fergus R. McKenzieS, Klaus Seuwens, 2001 .

The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization.

C. Sardet, M. Mattei, J. Pouysségur, 1988, Cytogenetics and cell genetics.

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

Yasushi Kobayashi, S. Endo, Y. Satoh, 2015, Scientific Reports.

Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence.

J. Pouysségur, J. Chambard, E. Van Obberghen-Schilling, 1990, Nucleic acids research.

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.

J. Pouysségur, P. Lenormand, V. Volmat, 2003, Biochemical pharmacology.

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

A. Brunet, J. Pouysségur, G. Pagès, 1995, Oncogene.

Cell Growth Signaling in Fibroblasts: the Role of G-Proteins

J. Pouysségur, K. Seuwen, I. Magnaldo, 1990 .

Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway*

J. Pouysségur, M. McMahon, P. Lenormand, 1996, The Journal of Biological Chemistry.

protein kinase as a converging targetfordifferent growthfactor signaling pathways: useofpertussis toxin as a discrimination factor

J. Pouysségur, G. l'Allemain, 1991 .

Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells.

J. Pouysségur, A. Franchi, D. Perucca-Lostanlen, 1986, Proceedings of the National Academy of Sciences of the United States of America.

[MAP kinase module: role in the control of cell proliferation].

A. Brunet, J. Pouysségur, G. Pagès, 1995, Comptes rendus des seances de la Societe de biologie et de ses filiales.

Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients.

J. Pouysségur, N. Mazure, P. Brest, 2013, Lung cancer.

Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization

B. Lévy, J. Pouysségur, E. Berra, 2009, Circulation.

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

J. Pouysségur, I. Marchiq, 2015, Journal of Molecular Medicine.

Hypoxia: the tumor's gateway to progression along the angiogenic pathway.

J. Pouysségur, E. Berra, C. Brahimi-Horn, 2001, Trends in cell biology.

has the mechanism by which stabilization of HIF-1 ot leads to initiation of the transcription of target genes involved in growth of blood vessels.

J. Pouysségur, E. Berra, C. Brahimi-Horn, 2001 .

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

J. Pouysségur, G. Pagès, J. Durivault, 2018, BMC Cancer.

Hypoxia and energetic tumour metabolism.

J. Pouysségur, G. Bellot, M. Brahimi-Horn, 2011, Current opinion in genetics & development.

Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response

J. Pouysségur, M. Kreutz, G. Multhoff, 2021, Cancers.

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

J. Pouysségur, N. Mazure, Pascale Bayer, 2017, Oncotarget.

Hypoxia and cellular metabolism in tumour pathophysiology

J. Pouysségur, Yann Cormerais, S. Parks, 2017, The Journal of physiology.

Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

M. Ivan, W. Craigen, J. Pouysségur, 2015, Cancer & metabolism.

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer

J. Pouysségur, M. Vucetic, Yann Cormerais, 2020, International journal of molecular sciences.

HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs.

J. Pouysségur, F. Dayan, N. Mazure, 2004, Biochemical pharmacology.

RT-PCR method to quantify vascular endothelial growth factor expression.

J. Pouysségur, G. Pagès, J. Milanini, 2001, BioTechniques.

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

S. Endo, J. Pouysségur, M. Huber, 2018, Nature Immunology.

Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway

J. Pouysségur, V. Volmat, Véronique Volmat, 2002 .

Targeting amino acids transporters (SLCs) to starve cancer cells to death.

J. Pouysségur, M. Vucetic, Yann Cormerais, 2019, Biochemical and biophysical research communications.

Hif-2alpha mediates UV induced apoptosis through a novel ATF3 dependent death pathway

J. Pouysségur, N. Mazure, T. Virolle, 2008 .

Growth factor-stimulated protein phosphorylation in G0/G1-arrested fibroblasts. Two distinct classes of growth factors with potentiating effects.

J. Pouysségur, J. Chambard, A. Le Cam, 1983, The Journal of biological chemistry.

Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts

J. Pouysségur, A. Franchi, P. Silvestre, 1980, Nature.

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.

J. Pouysségur, K. Seuwen, T. Hartmann, 1990, The Journal of biological chemistry.

Transmembrane signalling pathways initiating cell growth in fibroblasts.

J. Pouysségur, K. Seuwen, J. Chambard, 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Pharmacological inhibition of the amino-acid transporter LAT1 demonstrates in vitro anti-neoplastic activity towards medulloblastoma

J. Pouysségur, G. Pagès, H. Endou, 2018, bioRxiv.

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α*

J. Pouysségur, G. Pagès, E. Berra, 2000, The Journal of Biological Chemistry.

Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters*

H. Fukuzawa, M. Nagao, J. Pouysségur, 2016, The Journal of Biological Chemistry.

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.

J P Lecocq, J. Pouysségur, E. Van Obberghen-Schilling, 1992, Molecular biology of the cell.

Growth factor requirements of Chinese hamster lung fibroblasts in serum free media: high mitogenic action of thrombin.

J. Pouysségur, A. Franchi, R. Perez-Rodriquez, 1981, Cell biology international reports.

Pertussis toxin inhibits thrombin‐induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

J. Pouysségur, S. Paris, 1986, The EMBO journal.

A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets.

J. Pouysségur, E. Van Obberghen-Schilling, E. Obberghen-Schilling, 1993, The Journal of biological chemistry.

Early and late mitogenic events induced by FGF on bovine epithelial lens cells are not triggered by hydrolysis of polyphosphoinositides.

J. Pouysségur, G. l'Allemain, D. Barritault, 1987, Biochemical and biophysical research communications.

α-Thrombin Receptors and Growth Signaling

J. Pouysségur, E. Obberghen-Schilling, 1993 .

A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor

Patrick England, J. Pouysségur, A. Eichmann, 2004, EMBO reports.

TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways.

J. Pouysségur, F. McKenzie, J. Blanchard, 1995, Oncogene.

Hypoxia-induced autophagy is mediated through the HIF-induction of BNIP3 and BNIP3L via their BH3-domains

J. Pouysségur, N. Mazure, Raquel García-Medina, 2008 .

Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas

J. Pouysségur, G. Pagès, M. McGargill, 2017, Front. Immunol..

Polar Opposites: Erk Direction of CD4 T Cell Subsets

J. Pouysségur, G. Pagès, S. Hedrick, 2012, The Journal of Immunology.

Hypoxic mitochondria: accomplices in resistance.

J. Pouysségur, N. Mazure, M. Brahimi-Horn, 2011, Bulletin du cancer.

Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance.

V. Shoshan-Barmatz, J. Pouysségur, N. Mazure, 2012, Cancer research.

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

S. Marcié, J. Pouysségur, J. Chiche, 2013, Front. Oncol..

The Na+/HCO3− Co‐Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

J. Pouysségur, S. Parks, 2015, Journal of cellular physiology.

In vivo pH in metabolic‐defective Ras‐transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

P. Cozzone, J. Pouysségur, Y. Fur, 2012, International journal of cancer.

Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells

J. Pouysségur, N. Mazure, F. Bost, 2019, Cellular & Molecular Biology Letters.

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

J. Pouysségur, N. Mazure, L. Counillon, 2013, Journal of cellular physiology.

Proton dynamics in cancer

R. Gatenby, J. Pouysségur, S. Fais, 2010, Journal of Translational Medicine.

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells

J. Pouysségur, J. Durivault, E. Tambutté, 2021, Cancers.

Structure, Function and Growth Factor Activation of the Na+/H+ Antiporter (NHE1)

J. Pouysségur, L. Counillon, 1992 .

Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.

J. Pouysségur, L. Counillon, 1993, Biochimica et biophysica acta.

Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O2‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

J. Pouysségur, E. Berra, D. Roux, 2001 .

Correction for Savadjiev et al., Heart wall myofibers are arranged in minimal surfaces to optimize organ function

J. Pouysségur, S. Critchlow, D. Roux, 2012, Proceedings of the National Academy of Sciences.

Effects of Cytotoxic Necrotizing Factor 1 and Lethal Toxin on Actin Cytoskeleton and VE-Cadherin Localization in Human Endothelial Cell Monolayers

J. Pouysségur, D. Grall, E. Van Obberghen-Schilling, 1999, Infection and Immunity.

CHAPTER 23 – G Proteins in Growth Factor Action

J. Pouysségur, 1990 .

Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains.

J. Pouysségur, M. Shigekawa, S. Wakabayashi, 1997, Journal of biochemistry.

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

J. Pouysségur, G. Pagès, J. Durivault, 2018, BMC Cancer.

Hypoxia in health and disease.

J. López-Barneo, J. Pouysségur, 2016, Molecular aspects of medicine.

Biochemical titration of glycogen in vitro.

J. Pouysségur, N. Mazure, Joffrey Pelletier, 2013, Journal of visualized experiments : JoVE.

Growth-Promoting Activity of Thrombin in Fibroblasts: Temporal Action and Early Biochemical Events in the G0 → G1 Transition

J. Pouysségur, J. Chambard, E. Obberghen-Schilling, 1983 .

Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

J. Pouysségur, M. Ždralević, 2019, Journal of Biological Chemistry.

Commentarydynamics in cancer

R. Gatenby, J. Pouysségur, S. Fais, 2010 .

Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.

J. Pouysségur, J. Chambard, S. Paris, 1988, The Journal of biological chemistry.

SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.

J. Pouysségur, N. Mazure, M. Brahimi-Horn, 2007, Biochemical and biophysical research communications.

Transduction of Mitogenic Signals in Normal and Malignant Cells Impaired in Na+:H+ Antiport-Mediated pH Regulation

J. Pouysségur, A. Lagarde, 2020 .

Gene Transfer in Vascular Cells Using an Engineered Na-H Exchanger (NHE1) as a Selectable Marker.

J. Pouysségur, D. Roux, 1999, Methods in molecular medicine.

Hypoxia and hypoxia‐inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula

J. Pouysségur, N. Mazure, F. Bost, 2021, The Journal of physiology.

Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients

S. Richard, W. Craigen, J. Pouysségur, 2020, Theranostics.

Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells

J. Pouysségur, N. Mazure, F. Bost, 2019, Cellular & Molecular Biology Letters.

alpha‐Thrombin‐induced early mitogenic signalling events and G0 to S‐phase transition of fibroblasts require continual external stimulation.

J. Pouysségur, J. Chambard, E. Van Obberghen-Schilling, 1985, The EMBO journal.

Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells.

I. Filippi, J. Pouysségur, J. Durivault, 2019, Biochemical and biophysical research communications.

Study of MAPK signaling using knockout mice.

J. Pouysségur, G. Pagès, 2004, Methods in molecular biology.

Oxygen, Hypoxia, and Stress

J. Pouysségur, C. Taylor, 2007, Annals of the New York Academy of Sciences.

N-terminal alanine-rich (NTAR) sequences drive precise start codon selection resulting in elevated translation of multiple proteins including ERK1/2

R. Buscà, J. Pouysségur, G. Pagès, 2023, Nucleic acids research.

Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality: Erk1 Deficiency Enhances the Impairment of Neurogenesis in Erk2-Deficient Mice

Yasushi Kobayashi, Y. Satoh, Atsuya Takeuchi, 2011, The Journal of Neuroscience.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

J. Pouysségur, F. Baltazar, S. Granja, 2014, Oncotarget.

SubsetsPolar Opposites: Erk Direction of CD4 T Cell

J. Pouysségur, G. Pagès, S. Hedrick, 2012 .

This information is current as Subsets Polar Opposites : Erk Direction of CD 4 T Cell

J. Pouysségur, S. Hedrick, Irene L. Ch’en, 2012 .

Signal transduction. An arresting start for MAPK.

J. Pouysségur, 2000, Science.

Emergence of hamster fibroblast tumors in nude mice—evidence for in vivo selection leading to loss of growth factor requirement

J. Pouysségur, J. Chambard, E. Obberghen-Schilling, 1981, Journal of cellular physiology.

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.

M. Caron, B. Kobilka, R. Lefkowitz, 1990, Cell regulation.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

Overexpression of carbonic anhydrase XII in tissues from resectable non‐small cell lung cancers is a biomarker of good prognosis

J. Pouysségur, N. Mazure, P. Hofman, 2011, International Journal of Cancer.

ERK implication in cell cycle regulation.

J. Pouysségur, J. Chambard, P. Lenormand, 2007, Biochimica et biophysica acta.

Hypoxia-induced autophagy: cell death or cell survival?

J. Pouysségur, N. Mazure, 2010, Current Opinion in Cell Biology.

Multiple division cycles and long‐term survival of hepatocytes are distinctly regulated by extracellular signal‐regulated kinases ERK1 and ERK2

D. Gilot, J. Pouysségur, G. Pagès, 2009, Hepatology.

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.

J. Pouysségur, I. Marchiq, Yann Cormerais, 2016, Molecular aspects of medicine.

Genetic approach to structure, function, and regulation of the Na+/H+ antiporter.

C. Sardet, J. Pouysségur, G. l'Allemain, 1987, Kidney international. Supplement.

High sensitivity in quantitative, competitive RT-PCR using QIAGEN ® enzymes*

J. Pouysségur, G. Pagès, J. Milanini, 2002 .

Role of cell surface carbohydrates and proteins in cell behavior: Studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant (cell surface glycoproteins/membrane mutant/growth control/phenotypic transformation/3T3 Balb cells)

I. Pastan, M. Willingham, J. Pouysségur, 2016 .

Conventional techniques to monitor mitochondrial oxygen consumption.

J. Pouysségur, Arnaud M. Vigneron, H. Simonnet, 2014, Methods in enzymology.

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

J. Pouysségur, N. Mazure, L. Counillon, 2013, Journal of cellular physiology.

Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients.

J. Pouysségur, N. Mazure, P. Brest, 2013, Lung cancer.

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.

C. Supuran, J. Pouysségur, Marie Lopez, 2011, Journal of medicinal chemistry.

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

J. Pouysségur, N. Mazure, P. Gounon, 2009, Journal of cellular physiology.

Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2).

J. Pouysségur, P. Little, M. Donowitz, 1993, Biochemical and biophysical research communications.