D. R. Laybutt

发表

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

R. Palmiter, S. Bonner-Weir, Arun J Sharma, 2002, Diabetes.

Induction of c-Myc Expression Suppresses Insulin Gene Transcription by Inhibiting NeuroD/BETA2-mediated Transcriptional Activation*

S. Bonner-Weir, Arun J Sharma, H. Kaneto, 2002, The Journal of Biological Chemistry.

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

L. Groop, C. Ling, J. Fadista, 2016, PLoS genetics.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Susan M. Schlenner, D. Lambrechts, N. Petrovsky, 2016, Nature Genetics.

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

D. R. Laybutt, J. Jonas, M. Bensellam, 2021, Biology.

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

D. R. Laybutt, T. Herbert, 2016, Diabetes.

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

D. R. Laybutt, W. E. Hughes, T. Biden, 2005, Diabetes.

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

D. R. Laybutt, T. Biden, M. C. Åkerfeldt, 2005, Diabetes.

Glucose-induced O ( 2 ) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells . "

J. Pouysségur, D. R. Laybutt, C. Magnan, 2019 .

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

J. Pouysségur, D. R. Laybutt, C. Magnan, 2012, PloS one.

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

E. Kraegen, D. R. Laybutt, N. Ruderman, 1999, American journal of physiology. Endocrinology and metabolism.

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

D. R. Laybutt, T. Biden, C. Bartley, 2009, Diabetologia.

The Role of Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy

D. R. Laybutt, J. Proietto, J. Chan, 2022, Frontiers in Endocrinology.

Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.

E. Kraegen, D. R. Laybutt, N. Ruderman, 1998, Advances in experimental medicine and biology.

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

D. R. Laybutt, P. Gilon, H. Thomas, 2019, Diabetologia.

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

C. Ip, D. R. Laybutt, W. E. Hughes, 2022, Diabetologia.

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

A. Biankin, Jianmin Wu, A. Mawson, 2015, PloS one.

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats

S. Bonner-Weir, D. R. Laybutt, G. Weir, 2007, Diabetologia.

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

D. R. Laybutt, J. Chan, M. Montgomery, 2015, Diabetologia.

The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets

D. R. Laybutt, J. Proietto, S. Andrikopoulos, 2006, Diabetologia.

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

G. Cooney, D. R. Laybutt, T. Biden, 2011, Diabetologia.

Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo.

E. Kraegen, D. R. Laybutt, I. Klimeš, 1999, The American journal of physiology.

Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets

D. R. Laybutt, T. Biden, J. Chan, 2012, Diabetologia.

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

G. Cooney, D. R. Laybutt, J. Burchfield, 2007, Cell metabolism.

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

D. Sgroi, S. Bonner-Weir, Arun J Sharma, 2002, The Journal of biological chemistry.

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

D. R. Laybutt, C. King, H. McGuire, 2008, Diabetes.

Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time

S. Bonner-Weir, D. R. Laybutt, G. Weir, 2003, The Journal of Biological Chemistry.

EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE

L. Quek, D. R. Laybutt, M. Morris, 2020, bioRxiv.

A fluorescent timer reporter enables sorting of insulin secretory granules by age

D. R. Laybutt, H. Thomas, P. Thorn, 2020, The Journal of Biological Chemistry.

Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.

D. Sgroi, S. Bonner-Weir, Arun J Sharma, 2002, Diabetes.

Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells.

J. Chan, D. R. Laybutt, M. He, 2010, Life sciences.

Genetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia*

D. Sgroi, S. Bonner-Weir, Arun J Sharma, 2002, The Journal of Biological Chemistry.

Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.

D. R. Laybutt, L. Campbell, S. Hesselson, 2019, Diabetes research and clinical practice.

Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats.

E. Kraegen, D. Chisholm, D. R. Laybutt, 1997, The American journal of physiology.

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

D. R. Laybutt, C. Rantzau, J. Proietto, 2008, Diabetes.

The Role of Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy

D. R. Laybutt, J. Proietto, J. Chan, 2022, Frontiers in Endocrinology.

p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

S. Bonner-Weir, Arun J Sharma, D. R. Laybutt, 2009, Molecular endocrinology.

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia

S. Bonner-Weir, H. Kaneto, G. King, 2007, Diabetes.

Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes

J. Chan, D. R. Laybutt, Yixiang Deng, 2012, Diabetologia.

Selective chronic regulation of GLUT1 and GLUT4 content by insulin, glucose, and lipid in rat cardiac muscle in vivo.

G. Cooney, E. Kraegen, D. R. Laybutt, 1997, The American journal of physiology.

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

J. Kench, A. Biankin, D. R. Laybutt, 2007, Diabetologia.

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

D. R. Laybutt, T. Biden, J. Chan, 2013, Diabetes.

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

D. R. Laybutt, J. Jonas, M. Bensellam, 2012, Molecular and Cellular Endocrinology.

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.

S. Bonner-Weir, D. R. Laybutt, G. Weir, 2003, The Journal of biological chemistry.

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance

D. R. Laybutt, M. C. Åkerfeldt, Mia C. Åkerfeldt, 2011, Diabetes.

Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes*

Sean J. Humphrey, D. James, A. Coster, 2016, The Journal of Biological Chemistry.

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Margaret J. Morris, D. R. Laybutt, J. Owens, 2010, Nature.

Beta-cell adaptation and decompensation during the progression of diabetes.

S. Bonner-Weir, Arun J Sharma, H. Kaneto, 2001, Diabetes.

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

J. Kjems, D. R. Laybutt, R. Regazzi, 2018, Molecular metabolism.

Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion

A. C. Marques, D. R. Laybutt, C. Widmann, 2020, Scientific Reports.

On-target action of anti-tropomyosin drugs regulates glucose metabolism

Nicole S. Bryce, J. Stehn, E. Hardeman, 2018, Scientific Reports.

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions.

D. R. Laybutt, J. Jonas, M. Bensellam, 2017, The Journal of endocrinology.

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

E. Kraegen, D. R. Laybutt, A. Jenkins, 1994, Diabetes.

Inhibition of PKCɛ Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance

G. Cooney, D. R. Laybutt, J. Burchfield, 2007 .

Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo.

Demetrios Vavvas, Iwar Klimes, Eleazar Shafrir, 1999, American journal of physiology. Endocrinology and metabolism.

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

Andrew V Biankin, James G Kench, Thomas Loudovaris, 2010, The Journal of clinical investigation.

Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance.

D. R. Laybutt, C. Achard, 2012, Endocrinology.

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

D. R. Laybutt, J. Chan, J. Jonas, 2016, Diabetologia.

High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic β Cells*

G. Steil, D. R. Laybutt, G. Weir, 2001, The Journal of Biological Chemistry.

Title : Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

M. Prentki, D. R. Laybutt, R. Regazzi, 2016 .

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

M. Prentki, D. R. Laybutt, R. Regazzi, 2013, Diabetologia.

Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes

S. Bornstein, D. R. Laybutt, C. Parish, 2021, PloS one.

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance

Nigel Turner, T. Iseli, N. Turner, 2012, PloS one.

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

P. Meikle, D. R. Laybutt, T. Biden, 2011, The Biochemical journal.

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion

D. R. Laybutt, C. Rantzau, J. Proietto, 2008, Diabetes.

FRUCTOSE-1 , 6-BISPHOSPHATASE OVER-EXPRESSION IN PANCREATIC β-CELLS RESULTS IN REDUCED INSULIN SECRETION : A New Mechanism For Fat-Induced Impairment Of β-Cell function

D. R. Laybutt, J. Proietto, N. Wong, 2008 .

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes

D. R. Laybutt, J. Chan, Kailun Lee, 2019, Diabetologia.

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo

D. R. Laybutt, M. Leitges, L. Carpenter, 2011, Diabetologia.

Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets.

S. Grey, D. R. Laybutt, S. Walters, 2013, Journal of molecular endocrinology.

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

D. R. Laybutt, J. Lau, H. Herzog, 2015, Endocrinology.

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

D. R. Laybutt, C. Widmann, Jiang-Yan Yang, 2008, Diabetes.

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

D. R. Laybutt, J. Chan, M. Bensellam, 2015, Molecular and Cellular Endocrinology.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

M. Febbraio, D. R. Laybutt, G. Lancaster, 2018, Molecular metabolism.

Phlda3 regulates beta cell survival during stress

M. Joglekar, A. Hardikar, D. R. Laybutt, 2019, Scientific Reports.

β Cell Hypoxia-Inducible Factor-1 α Is Required for the Prevention of Type 1 Diabetes

D. R. Laybutt, C. King, F. Gonzalez, 2019, Cell reports.

Osteoglycin, a novel coordinator of bone and glucose homeostasis

J. Center, D. R. Laybutt, I. Lee, 2018, Molecular metabolism.

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

P. Timpson, C. Ip, D. R. Laybutt, 2021, Nature Communications.

Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents

E. Van Obberghen, M. Prentki, D. R. Laybutt, 2018, Diabetes.

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

L. Eliasson, M. Prentki, D. R. Laybutt, 2017, Molecular metabolism.

Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

D. R. Laybutt, H. Herzog, Yanchuan Shi, 2018, Scientific Reports.

Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure

D. R. Laybutt, R. Lin, J. Chan, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of Y1 receptor signaling improves islet transplant outcome

S. Grey, C. Ip, D. R. Laybutt, 2017, Nature Communications.

Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity

D. R. Laybutt, M. Swarbrick, K. Ho, 2022, Scientific reports.

Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling

Min Zhang, C. Mackay, G. Cooney, 2012, PloS one.

On-target action of anti-tropomyosin drugs regulates glucose metabolism

Nicole S. Bryce, J. Stehn, E. Hardeman, 2018, Scientific Reports.

Hypoxia induces beta cell death by inhibiting the adaptive UPR.

D. R. Laybutt, J. Chan, J. Jonas, 2015 .

Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

D. R. Laybutt, H. Herzog, Yanchuan Shi, 2018, Scientific Reports.

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

J. Kench, C. Kahn, A. Biankin, 2010, The Journal of clinical investigation.

Tau suppresses microtubule-regulated pancreatic insulin secretion.

D. R. Laybutt, S. Andrikopoulos, Lunzhi Dai, 2023, Molecular psychiatry.

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

D. R. Laybutt, T. Biden, M. Fuller, 2011, The Biochemical journal.

p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

S. Bonner-Weir, Arun J Sharma, D. R. Laybutt, 2009, Molecular endocrinology.

Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents

M. Prentki, D. R. Laybutt, R. Regazzi, 2018, Diabetes.