B. Welm

发表

A pharmacogenomic method for individualized prediction of drug sensitivity

Jeffrey T. Chang, Adam M. Gustafson, S. Jeffrey, 2011, Molecular systems biology.

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

H. Varmus, Z. Werb, B. Welm, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation.

Mustafa Ozen, Michael Ittmann, B. Foster, 2003, Cancer research.

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

B. Welm, R. Looper, Kaitlin J. Basham, 2014, Bioorganic & Medicinal Chemistry Letters.

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate

B. Welm, D. Ayer, Blake R Wilde, 2020, Cancer & metabolism.

Branching Morphogenesis Desmosomal Adhesion in Mammary Chemical Genetic Screen Reveals a Role for Developmental Biology

B. Welm, C. J. Leonard, D. Bearss, 2014 .

STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer

R. Myers, P. Yue, J. Turkson, 2020, Cancer Research.

Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant

D. Shelton, A. Shakya, D. Tantin, 2012, PLoS genetics.

Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice.

M. Ittmann, B. Welm, J. Rosen, 2003, Cancer research.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Steven B. Neuhauser, Yvonne A. Evrard, Michael W. Lloyd, 2019, Nature Genetics.

Incorporating calibrated functional assay data into the BRCA1 Ex-UV database

S. Tavtigian, R. Bell, B. Welm, 2016, bioRxiv.

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate

B. Welm, D. Ayer, Blake R Wilde, 2020, Cancer & metabolism.

HIF 1 α is a critical regulator of secretory differentiation and activation , but not vascular expansion , in the mouse mammary gland

J. McManaman, M. Neville, B. Welm, 2003 .

Inducible dimerization of FGFR1

B. Welm, J. Rosen, A. Contreras, 2002, The Journal of cell biology.

703 Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary

B. Welm, J. Rosen, A. Contreras, 2002 .

Use of stem cell markers in dissociated mammary populations.

D. Shelton, M. Barcellos-Hoff, B. Welm, 2010, Methods in molecular biology.

MET and MYC cooperate in mammary tumorigenesis.

A. Welm, B. Welm, J. Bishop, 2005, Proceedings of the National Academy of Sciences of the United States of America.

the shoulders of giants : A historical perspective of unique experimental ethods in mammary gland research

A. Welm, B. Welm, B. Smith, 2012 .

Session 6: Stem Cells

H. Varmus, Z. Werb, T. Graubert, 2004 .

Toward improved models of human cancer

A. Welm, B. Welm, C. Vaklavas, 2021, APL bioengineering.

Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis

D. Shelton, B. Welm, C. J. Leonard, 2012, The Journal of Biological Chemistry.

An inducible system for the study of FGF signalling in early amphibian development.

B. Welm, J. Rosen, D. Spencer, 2003, Developmental biology.

Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts

Matthew H Bailey, A. Milosavljevic, A. Welm, 2022, NPJ breast cancer.

A path to translation: How 3D patient tumor avatars enable next generation precision oncology.

Kristen M. Naegle, Benjamin J. Raphael, Clifford A. Meyer, 2022, Cancer cell.

A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Steven B. Neuhauser, Yvonne A. Evrard, Jeffrey H. Chuang, 2022, bioRxiv.

A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A.

B. Welm, Satya S. Pathi, R. Looper, 2018, ACS chemical biology.

PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer

J. Ostrander, B. Welm, Camila O. dos Santos, 2021, Oncogene.

PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

J. Ostrander, B. Welm, C. Lange, 2020, bioRxiv.

Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach

Alexander B. Saltzman, J. Lei, A. Malovannaya, 2022, iScience.

The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress

B. Welm, R. Jana, M. Sigman, 2014, Breast Cancer Research.

Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

B. Welm, Tejas P Pathak, M. Sigman, 2010, Journal of the American Chemical Society.

Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells

D. Shelton, B. Welm, C. Matsen, 2013, Breast Cancer Research.

Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

B. Welm, K. Kwon, R. Looper, 2015, The Journal of organic chemistry.

Synthesis of the reported structures for kealiinines B and C.

B. Welm, R. Looper, Keith M. Gligorich, 2012, Organic letters.

Synthesis and preliminary biological study of bisindolylmethanes accessed by an acid-catalyzed hydroarylation of vinyl indoles

B. Welm, Tejas P Pathak, M. Sigman, 2012 .

Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinyl Indoles.

B. Welm, Tejas P Pathak, M. Sigman, 2012 .

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

J. Yap, A. Welm, B. Welm, 2019, Nature Medicine.

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

T. Graubert, B. Welm, J. Rosen, 2002, Developmental biology.

Patient‐Derived Models of Human Breast Cancer: Protocols for In Vitro and In Vivo Applications in Tumor Biology and Translational Medicine

Samir J. Courdy, A. Welm, B. Welm, 2013, Current protocols in pharmacology.

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

Mark T. W. Ebbert, L. Neumayer, I. Stijleman, 2011, Nature Medicine.

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

Benjamin J. Raphael, Yvonne A. Evrard, Jeffrey H. Chuang, 2021, Nature Communications.

Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential

B. Welm, H. A. Ekiz, Katrin P. Guillen, 2015, Breast Cancer Research.

Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.

C. Perou, S. Hilsenbeck, R. Cardiff, 2010, Cancer research.

Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers.

L. Jorde, J. Rodriguez-Flores, B. Welm, 2021, Blood cancer discovery.

ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells

Jason Gertz, B. Welm, B. Graves, 2019, bioRxiv.

Human Primary Tumorgraft Models : Comparisons with Traditional Oncology Pre-Clinical Models and The Clinical Relevance and Utility of Primary Tumorgrafts in Basic and Translational Oncology Research

Alana L. Welm, A. Welm, B. Welm, 2013 .

Overview of Human Primary Tumorgraft Models: Comparisons with Traditional Oncology Preclinical Models and the Clinical Relevance and Utility of Primary Tumorgrafts in Basic and Translational Oncology Research

A. Welm, B. Welm, C. Matsen, 2012, Current protocols in pharmacology.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Yvonne A. Evrard, Michael W. Lloyd, Jeffrey H. Chuang, 2021, Nature Genetics.

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

Mikala Egeblad, Matthew F Krummel, Andrew J Ewald, 2008, Disease Models & Mechanisms.

Developmental Biology: Vasculogenesis is a Wreck Without RECK

Z. Werb, J. Mott, B. Welm, 2002, Current Biology.

Targeting the PyMT Oncogene to Diverse Mammary Cell Populations Enhances Tumor Heterogeneity and Generates Rare Breast Cancer Subtypes.

C. Perou, P. Bernard, D. Shelton, 2012, Genes & cancer.

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

Gabor T. Marth, Jeffrey H. Chuang, Mark E. Wadsworth, 2021, bioRxiv.

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Gabor T. Marth, Jeffrey H. Chuang, Mark E. Wadsworth, 2022, Nature Cancer.

Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancer

Jason Gertz, B. Welm, Adriana C. Rodriguez, 2017, bioRxiv.

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

Z. Werb, A. Welm, B. Welm, 2008, Cell stem cell.

Molecular and Cellular Pathobiology Cancer Research Fibroblast Growth Factor Receptor Signaling Dramatically Accelerates Tumorigenesis and Enhances Oncoprotein Translation in the Mouse Mammary Tumor Virus – Wnt-1 Mouse Model of Breast Cancer

C. Perou, S. Hilsenbeck, R. Cardiff, 2010 .

Bryan Generates Rare Breast Cancer Subtypes Targeting the PyMT Oncogene to Diverse Mammary Cell Populations Enhances Tumor Heterogeneity and

C. Perou, P. Bernard, D. Shelton, 2013 .

The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress

B. Welm, R. Jana, M. Sigman, 2014, Breast Cancer Research.

A Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenografts of Triple-Negative Breast Cancer

Alexander B. Saltzman, A. Malovannaya, M. Ellis, 2021, bioRxiv.

Limiting-dilution transplantation assays in mammary stem cell studies.

D. Shelton, M. Barcellos-Hoff, B. Welm, 2010, Methods in molecular biology.

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

J. Yap, A. Welm, B. Welm, 2019, Nature Medicine.

Isolation and characterization of functional mammary gland stem cells

B. Welm, J. Rosen, M. Goodell, 2003, Cell proliferation.

In situ analysis of cell populations: long-term label-retaining cells.

D. Shelton, M. Barcellos-Hoff, B. Welm, 2010, Methods in molecular biology.

Mapping mammary gland architecture using multi-scale in situ analysis.

Z. Werb, M. Barcellos-Hoff, B. Welm, 2009, Integrative biology : quantitative biosciences from nano to macro.

STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferation

R. Myers, P. Yue, J. Turkson, 2019, bioRxiv.

Proliferation in Vivo Signal-regulated Kinase Activation , and Increased Osteopontin Induction , Extracellular ( FGFR ) 1 , but not FGFR 2 , in Prostate Cancer Cells Leads to Conditional Activation of Fibroblast Growth Factor Receptor

B. Foster, M. Ittmann, B. Welm, 2003 .

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

Edward R. Polanco, P. Bernard, B. Welm, 2021, Communications Biology.

HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

Margaret C. Neville, J. McManaman, M. Neville, 2003 .

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

J. Yap, A. Welm, B. Welm, 2019, Nature Network Boston.

Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.

D. Shelton, B. Welm, C. J. Leonard, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer.

P. Bernard, B. Welm, K. Boucher, 2012, The American journal of pathology.

Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential

B. Welm, Katrin P. Guillen, Maria E. McDowell, 2015, Breast Cancer Research.

Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15

N. Camp, I. Stijleman, P. Bernard, 2018, Cancer Epidemiology, Biomarkers and Prevention.

Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a breast cancer susceptibility locus at 12q15

N. Camp, P. Bernard, Alun Thomas, 2017, bioRxiv.

Reframing Breast Cancer Molecular Subtypes: Modeling Expression Patterns with Orthogonal Dimensions

N. Camp, P. Bernard, Alun Thomas, 2017 .

Identification of Novel Breast Tumor Expression Dimensions within the PAM50 and Discovery of a Breast Cancer Susceptibility Locus at 12q15

N. Camp, P. Bernard, Alun Thomas, 2017 .

Reparameterization of PAM 50 expression identifies novel breast tumor dimensions and leads to discovery of a breast cancer susceptibility locus at 12 q 15

N. Camp, P. Bernard, Alun Thomas, 2017 .

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.

Bryan Welm, J. McManaman, M. Neville, 2003, Development.

A pharmacogenomic method for individualized prediction of drug sensitivity.

Jeffrey T. Chang, Adam M. Gustafson, S. Jeffrey, 2011, Molecular systems biology.

PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery

Yvonne A. Evrard, David M. Rocke, Jessica J. Andrews, 2022, NAR cancer.

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

Yvonne A. Evrard, Michael W. Lloyd, Jeffrey H. Chuang, 2021, bioRxiv.

Breast cancer PDxO cultures for drug discovery and functional precision oncology

A. Welm, B. Welm, Sandra D. Scherer, 2023, STAR protocols.

Adaptive genetic variation, stress and glucose regulation

J. C. Pastor-Pareja, B. Welm, Ming Wu, 2008, Disease Models & Mechanisms.

Mapping mammary gland architecture using multi-scale in situ analysis.

Z. Werb, M. Barcellos-Hoff, B. Welm, 2009, Integrative biology : quantitative biosciences from nano to macro.

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

A. Welm, B. Welm, Zena Werb, 2008, Cell stem cell.

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

B. Welm, R. Looper, Vasudev R. Bhonde, 2014, Bioorganic & medicinal chemistry letters.

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

Z. Werb, A. Ewald, B. Welm, 2008 .

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

A. Welm, B. Welm, Zena Werb, 2008, Cell stem cell.

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma

Yvonne A. Evrard, Jeffrey H. Chuang, Matthew A. Wyczalkowski, 2023, Cancer research.

Functional Characterization of Mammary Stem Cells

B. Welm, M. Goodell, Stacey B. Tepera, 2004 .