C. Roberts

S. Argov, C. Roberts, D. Leroith, 1998, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression

H. Werner, C. Roberts, D. Leroith, 1995, Molecular and cellular biology.

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

C. Roberts, D. Leroith, S. Neuenschwander, 1995, Endocrinology.

Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5'-untranslated regions are expressed in a tissue-specific manner.

H. Werner, C. Roberts, D. Leroith, 1995, DNA and cell biology.

Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid.

H. Werner, C. Roberts, D. Leroith, 1993, Journal of Clinical Endocrinology and Metabolism.

Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat.

C. Roberts, S. Zanconato, D. Moromisato, 1996, Critical care medicine.

Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth.

C. Roberts, D. Leroith, M. Karas, 1995, Progress in growth factor research.

Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol.

M. Phillip, C. Roberts, D. Leroith, 1995, Endocrinology.

Insulin-like Growth Factor (Igf) Signaling

C. Roberts, 2003 .

The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration.

B. Burguera, H. Werner, C. Roberts, 1992, Advances in experimental medicine and biology.

Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75

C. Roberts, D. Leroith, A. Schally, 1993, Regulatory Peptides.

Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains

H. Werner, C. Roberts, D. Leroith, 1991, Regulatory Peptides.

Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes.

H. Werner, C. Roberts, D. Leroith, 1991, Endocrinology.

Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.

C. Roberts, M. Rechler, K. Gabbay, 1986, The Journal of biological chemistry.

Plasma distribution and signaling activities of IGF-II precursors.

C. Roberts, J. Purnell, Alicia G. Marks, 2011, Endocrinology.

The Role of the Insulin-Like Growth Factor System in Pre- and Postnatal Growth, Development, and Tumorigenesis

C. Roberts, 2004 .

Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells.

H. Werner, C. Roberts, D. Leroith, 1990, Endocrinology.

Developmental regulation of rat brain/Hep G2 glucose transporter gene expression.

H. Werner, C. Roberts, D. Leroith, 1989, Molecular endocrinology.

Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome.

C. Roberts, D. Leroith, A. Koval, 1994, DNA and cell biology.

Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats.

H. Werner, C. Roberts, D. Leroith, 1992, Endocrinology.

Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary.

E. Adashi, C. Roberts, D. Leroith, 1992, The Journal of clinical endocrinology and metabolism.

Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary.

E. Adashi, C. Roberts, D. Leroith, 1992, Endocrinology.

Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells.

C. Roberts, D. Leroith, M. Sheikh, 1992, Biochemical and biophysical research communications.

Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.

C. Roberts, D. Leroith, M. Sheikh, 1992, Biochemical and biophysical research communications.

Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver.

C. Roberts, D. Leroith, S. Lasky, 1988, Molecular endocrinology.

Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.

H. Werner, C. Roberts, D. Leroith, 1991, Advances in experimental medicine and biology.

Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells.

C. Roberts, C. Roselli, Rebecca A Mallinson, 2004, Endocrinology.

Paradoxical biological effects of overexpressed insulin‐like growth factor‐1 receptors in chinese hamster ovary cells

Simeon I. Taylor, C. Roberts, D. Leroith, 1993, Journal of cellular physiology.

Defects in human insulin receptor gene expression.

A. Ullrich, C. Roberts, S. Taylor, 1988, Molecular endocrinology.

Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.

C. Roberts, D. Leroith, G. Werther, 1995, Endocrinology.

Insulin and Insulin‐like Growth Factor‐I Induced Phosphorylation in Neurally Derived Cells

C. Roberts, D. Leroith, M. Adamo, 1993, Annals of the New York Academy of Sciences.

Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation.

E. Adashi, C. Roberts, D. Leroith, 1989, Endocrinology.

Developmental regulation of the rat insulin-like growth factor I receptor gene.

H. Werner, C. Roberts, D. Leroith, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor

B. Burguera, H. Werner, C. Roberts, 1989 .

Live‐cell imaging demonstrates rapid cargo exchange between lipid droplets in adipocytes

R. Somwar, C. Roberts, O. Varlamov, 2011, FEBS letters.

Nutritional Regulation of Insulin-Sensitive Glucose Transporter Gene Expression in Rat Cardiac Muscle

C. Roberts, D. Leroith, Z. Shen-Orr, 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Rat Brain/Hep G2 Glucose Transporter Gene Expression in Brain

H. Werner, C. Roberts, D. Leroith, 1992 .

Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors.

W. Millard, C. Roberts, D. Leroith, 1991, Neuroendocrinology.

Molecular Biology of the Somatomedins

C. Roberts, D. Leroith, M. Adamo, 1993 .

Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney.

C. Roberts, D. Leroith, M. Adamo, 1992, Endocrinology.

The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis.

A. Shuldiner, C. Roberts, D. Leroith, 1990, Endocrinology.

Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture.

H. Werner, C. Roberts, D. Leroith, 1988, Endocrinology.

Spatiotemporal dynamics of triglyceride storage in unilocular adipocytes

R. Somwar, H. Sampath, C. Roberts, 2014, Molecular biology of the cell.

Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation.

C. Roberts, D. Leroith, A. Saltiel, 1994, Endocrinology.

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor

C. Roberts, D. Leroith, A. Ferber, 1992, Molecular and cellular biology.

Developmental Regulation of the Insulin and Insulin-Like Growth Factor Receptors in the Central Nervous System

H. Werner, C. Roberts, D. Leroith, 1993 .

Identification of multiple transcription start sites in the human insulin-like growth factor-I gene

C. Roberts, D. Leroith, J. Sussenbach, 1991, Molecular and Cellular Endocrinology.

Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat.

M. Phillip, C. Roberts, D. Leroith, 1992, Endocrinology.

Atrial Natriuretic Peptide Induces Natriuretic Peptide Receptor-cGMP-dependent Protein Kinase Interaction*

C. Roberts, M. Silberbach, Yong-feng Yang, 2003, Journal of Biological Chemistry.

Erratum: Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPS): Characterization of connective tissue growth factor as a member of the IGFBP superfamily (Proceeding of National Academy of USA (November 25, 1997) 94:25 (12981-12986))

E. Wilson, C. Roberts, S. Nagalla, 1998 .

Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels.

H. Werner, C. Roberts, D. Leroith, 1993, Journal of molecular endocrinology.

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

H. Werner, C. Roberts, D. Leroith, 1992, Molecular endocrinology.

Large‐scale generation of highly enriched neural stem‐cell‐derived oligodendroglial cultures: maturation‐dependent differences in insulin‐like growth factor‐mediated signal transduction

S. Back, C. Roberts, S. Nagalla, 2007, Journal of neurochemistry.

Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries.

N. Ling, C. Roberts, D. Leroith, 1994, The Journal of clinical endocrinology and metabolism.

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

L. Hennighausen, C. Roberts, D. Leroith, 1996, The Journal of clinical investigation.

Antiproliferative Effects of Insulin-like Growth Factor-binding Protein-3 in Mesenchymal Chondrogenic Cell Line RCJ3.1C5.18

C. Roberts, V. Hwa, R. Rosenfeld, 2001, The Journal of Biological Chemistry.

Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques.

C. Roberts, C. True, J. Hennebold, 2020, Human reproduction.

Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins.

C. Roberts, D. Leroith, M. Karas, 1996, Endocrinology.

Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum.

E. Adashi, C. Roberts, D. Leroith, 1991, Endocrinology.

The role of insulin-like growth factors in diabetic kidney disease.

M. Phillip, H. Werner, C. Roberts, 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis.

C. Roberts, D. Leroith, B. Stannard, 1995, Endocrinology.

A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene.

H. Werner, C. Roberts, M. Rubinstein, 2007, Cancer letters.

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

F. Ismail-Beigi, M. Lawrence, C. Roberts, 2012, Proceedings of the National Academy of Sciences.

Vesicle Traf ﬁ cking and RNA Transfer Add Complexity and Connectivity to Cell – Cell Communication

C. Roberts, P. Kurre, 2013 .

Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats.

C. Roberts, D. Leroith, A. Haramati, 1992, Endocrinology.

Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats.

C. Roberts, D. Leroith, A. Haramati, 1991, Endocrinology.

Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

C. Roberts, D. Leroith, H. Foyt, 1991, The Journal of biological chemistry.

Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.

C. Roberts, D. Leroith, H. Ben‐Hur, 1991, Molecular endocrinology.

IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma.

C. Roberts, D. Leroith, M. Sheikh, 1992, Cancer research.

Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor*

H. Werner, E. Woo, C. Roberts, 1997, The Journal of Biological Chemistry.

Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.

C. Roberts, D. Leroith, Y. Zick, 1994, The Biochemical journal.

Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat

P. Gluckman, C. Roberts, D. Leroith, 1996, Molecular and Cellular Endocrinology.

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

C. Roberts, D. Leroith, S. Lasky, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells.

H. Werner, C. Roberts, D. Leroith, 1989, Endocrinology.

Insulin‐like Growth Factor Receptors: Implications for Nervous System Function

H. Werner, C. Roberts, D. Leroith, 1993, Annals of the New York Academy of Sciences.

Developmental regulation of somatostatin gene expression in the brain is region specific.

C. Roberts, D. Leroith, W. Lowe, 1987, Molecular endocrinology.

The intra-ovarian IGF system.

E. Adashi, C. Roberts, D. Leroith, 1992, Growth regulation.

The Ovarian and Testicular IGF-I System: A Comparative Analysis

E. Adashi, C. Roberts, D. Leroith, 1992 .

Insulin‐like Growth Factor I as an Intraovarian Regulator: Basic and Clinical Implications a

E. Adashi, C. Roberts, D. Leroith, 1991, Annals of the New York Academy of Sciences.

Intraovarian IGF-I System

E. Adashi, C. Roberts, D. Leroith, 1991 .

Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene.

H. Werner, M. Rubini, C. Roberts, 1994, Experimental cell research.

Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation.

C. Roberts, D. Leroith, Y. Sharoni, 1995, Human reproduction.

Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species.

E. Adashi, H. Werner, C. Roberts, 1991, Molecular endocrinology.

Control Regulat of lnsulin-L ion of IGF-l ike Growth Receptor Ex Factor ( IGF ) Action by pression

C. Roberts, 2006 .

Control of insulin-like growth factor (IGF) action by regulation of IGF-I receptor expression.

C. Roberts, C. T. Roberts, 1996, Endocrine journal.

Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.

C. Roberts, D. Leroith, D. Bikle, 1994, The American journal of physiology.

Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations.

C. Roberts, D. Leroith, H. Foyt, 1992, Molecular endocrinology.

Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites.

C. Roberts, D. Leroith, H. Ben‐Hur, 1991, Biochemical and biophysical research communications.

Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene.

C. Roberts, D. Leroith, H. Ozer, 1993, The Journal of biological chemistry.

Rat IGF-I cDNA's contain multiple 5'-untranslated regions.

C. Roberts, D. Leroith, S. Lasky, 1987, Biochemical and biophysical research communications.

The IGF system : molecular biology, physiology, and clinical applications

C. Roberts, R. Rosenfeld, 1999 .

Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats.

C. Roberts, D. Leroith, F. Cassorla, 1993, Endocrinology.

Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor.

J. Swantek, C. Roberts, D. Leroith, 1995, Experimental cell research.

Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen

C. Roberts, D. Leroith, R. Meidan, 1994, Regulatory Peptides.

Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP)-2 gene expression in spleens of juvenile rats.

C. Roberts, D. Leroith, R. Meidan, 1994, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors.

C. Roberts, D. Leroith, A. Schally, 1993, The Journal of clinical endocrinology and metabolism.

Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor.

C. Roberts, K. Tajinda, J. Carroll, 1999, Endocrinology.

Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.

C. Roberts, C. Daniel, P. Strickland, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

V. Sukhatme, H. Werner, C. Roberts, 1994, The Journal of biological chemistry.

Differential Activation of Insulin Receptor Substrates 1 and 2 by Insulin-Like Growth Factor-Activated Insulin Receptors

C. Roberts, J. Wallace, A. Denley, 2007, Molecular and Cellular Biology.

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

H. Werner, C. Roberts, D. Leroith, 1992, Neuroscience.

Sex-Specific Differences in Lipid and Glucose Metabolism

C. Roberts, O. Varlamov, C. Bethea, 2014, Front. Endocrinol..

Molecular and cellular aspects of the insulin-like growth factor I receptor.

C T Roberts, H. Werner, C. Roberts, 1995, Endocrine reviews.

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

V. Sukhatme, H. Werner, C. Roberts, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Protective hinge in insulin opens to enable its receptor engagement

Brian J. Smith, Virander S. Chauhan, J. Menting, 2014, Proceedings of the National Academy of Sciences.

Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence.

E. Adashi, C. Roberts, D. Leroith, 1993, Endocrinology.

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.

C T Roberts, C. Roberts, D. Leroith, 1991, Brain research. Molecular brain research.

Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man

C. Roberts, D. Leroith, J. Roth, 1986, Experientia.

Evolutionary aspects of the endocrine and nervous systems.

J. Shiloach, C. Roberts, D. Leroith, 1986, Recent progress in hormone research.

Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man.

C. Roberts, D. Leroith, J. Roth, 1986, Experientia.

The IGF System

Ronald Rosenfeld, C. Roberts, R. Rosenfeld, 1999, Contemporary Endocrinology.

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.

H. Werner, C. Roberts, D. Leroith, 1989, The Journal of clinical investigation.

The insulin-like growth factor system and cancer.

C. Roberts, D. Leroith, 2003, Cancer letters.

Interaction between the Insulin Receptor and Its Downstream Effectors

C. Roberts, D. Leroith, Y. Zick, 1996, The Journal of Biological Chemistry.

Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers

B. Geiger, C. Roberts, D. Leroith, 1993, Molecular and Cellular Endocrinology.

Insulin‐like Growth Factors

C. Roberts, D. Leroith, 1993, Biological signals.

Natriuretic peptide signalling: molecular and cellular pathways to growth regulation.

C. Roberts, M. Silberbach, 2001, Cellular signalling.

Apoptosis in breast cancer

H. Werner, C. Roberts, Y. Oh, 2001 .

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

D. Harlan, R. Stein, L. Goodrich, 2016, American journal of physiology. Endocrinology and metabolism.

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

E. Pietras, C. Roberts, S. Sureshchandra, 2022, Stem cell reports.

Maternal Obesity Dysregulates Fetal Hematopoietic Stem and Progenitor Cell Development in Rhesus Macaques

C. Roberts, S. Sureshchandra, I. Messaoudi, 2021 .

Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective.

A. Shuldiner, C. Roberts, D. Leroith, 1989, The Journal of biological chemistry.

Identification of STAT-1 as a Molecular Target of IGFBP-3 in the Process of Chondrogenesis*

C. Roberts, V. Hwa, F. Chiarelli, 2002, The Journal of Biological Chemistry.

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.

E. Wilson, C. Roberts, S. Nagalla, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.

C. Roberts, D. Leroith, Z. Shao, 1992, Endocrinology.

Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line

Z. Shao, C. Roberts, D. Leroith, 1994, Journal of cellular physiology.

Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells.

C. Roberts, D. Leroith, M. Sheikh, 1993, Biochemical and biophysical research communications.

Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary.

C. Roberts, D. Leroith, S. Yen, 1993, The Journal of clinical endocrinology and metabolism.

Regulation of insulin‐like growth factor‐binding‐protein‐1, 2, 3, 4, 5, and 6: Synthesis, secretion, and gene expression in estrogen receptor‐negative human breast carcinoma cells

Z. Shao, C. Roberts, D. Leroith, 1993, Journal of cellular physiology.

REVIEW Insulin-like growth factors: the ovarian connection

E. Adashi, C. Roberts, D. Leroith, 1991 .

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells.

C. Roberts, D. Leroith, K. Catt, 1989, Molecular endocrinology.

Structure, expression, and regulation of the IGF-I gene.

C T Roberts, C. Roberts, D. Leroith, 1993, Advances in experimental medicine and biology.

Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro.

C. Roberts, D. Leroith, M. Bach, 1990, Molecular endocrinology.

How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?

C. Roberts, D. Leroith, P. Sampson, 1994, Hormone research.

Insulin-like growth factors: the ovarian connection.

E. Adashi, C. Roberts, D. Leroith, 1991, Human reproduction.

Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution.

E. Adashi, C. Roberts, D. Leroith, 1990, Endocrinology.

Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney

B. Burguera, H. Werner, C. Roberts, 1990, Diabetes.

Characterization of a salmon insulin-like growth factor I promoter.

C. Roberts, D. Leroith, M. Adamo, 1994, DNA and cell biology.

Structure of the chum salmon insulin-like growth factor I gene.

D. Steiner, C. Roberts, D. Leroith, 1993, DNA and cell biology.

Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid.

J. Mersey, C. Roberts, D. Leroith, 1989, The Journal of clinical endocrinology and metabolism.

Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.

C. Roberts, D. Leroith, Y. Zick, 1998, The Biochemical journal.

Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line.

C. Roberts, D. Leroith, M. Adamo, 1989, Biochemical and biophysical research communications.

Analysis of the human type I insulin-like growth factor receptor promoter region.

D. Cooke, C. Roberts, D. Leroith, 1991, Biochemical and biophysical research communications.

Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain.

G. Booker, C. Roberts, J. Wallace, 2006, Endocrinology.

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

C. Roberts, D. Marks, M. Slifka, 2009, International Journal of Obesity.

Insulin-like growth factor I (IGF-I): A molecular basis for endocrine versus local action?

C. Roberts, D. Leroith, D. Leroith, 1991, Molecular and Cellular Endocrinology.

The IGFI receptor gene: A molecular target for disrupted transcription factors

H. Werner, C. Roberts, 2003, Genes, chromosomes & cancer.

Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein

H. Werner, C. Roberts, J. Wright, 2002, Oncogene.

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.

H. Werner, C. Roberts, D. Leroith, 1990, Biochemical and biophysical research communications.

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

C T Roberts, C. Roberts, D. Leroith, 1994, Molecular endocrinology.

The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma

Patrick E Carroll, P. Rose, A. Moses, 2007, Oncogene.

Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats.

M. Phillip, H. Werner, C. Roberts, 1994, Journal of molecular endocrinology.

The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.

C. Roberts, W. Cheung, R. Mak, 2008, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

Y. Yarden, C. Roberts, D. Leroith, 1992, The Journal of biological chemistry.

Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells

C. Corless, C. Roberts, O. Varlamov, 2011, Diabetologia.

Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

E. Pietras, C. Roberts, S. Sureshchandra, 2022, bioRxiv.

Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat.

Jesse D. Roberts, C. Roberts, W. Zapol, 1995, Circulation research.

Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

S. Fei, L. Carbone, C. Roberts, 2019, Scientific Reports.

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

J. Chevillet, C. Roberts, B. Chang, 2015, Leukemia.

RNA trafficking by acute myelogenous leukemia exosomes.

C. Roberts, P. Kurre, Charles T Roberts, 2013, Cancer research.

Androgen effects on adipose tissue architecture and function in nonhuman primates.

C. Roberts, O. Varlamov, C. Bethea, 2012, Endocrinology.

Regulation of Insulin-Like Growth Factor I Receptor Promoter Activity by Wild-Type and Mutant Versions of the WT1 Tumor Suppressor1.

C. Roberts, K. Tajinda, J. Carroll, 1999, Endocrinology.

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.

R. Carson, D. Orloff, C. Roberts, 1992, The Journal of clinical investigation.

Tumor and Stem Cell Biology RNA Traf fi cking by AcuteMyelogenous Leukemia Exosomes

C. Roberts, P. Kurre, J. Huan, 2013 .

Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.

C. Roberts, V. Hwa, P. Fang, 2009, The Journal of clinical endocrinology and metabolism.

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.

C. Roberts, D. Leroith, L. Helman, 1996, Endocrinology.

Mechanisms of glucagon degradation at alkaline pH

W. Ward, C. Roberts, L. David, 2013, Peptides.

Effects of Pre and Postnatal Protein Restriction on Maternal and Offspring Metabolism in the Nonhuman Primate.

C. Roberts, M. Kirigiti, Baylin Bennett, 2020, American journal of physiology. Regulatory, integrative and comparative physiology.

Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model.

S. Chugh, C. Roberts, S. Nagalla, 2003, Cardiovascular research.

Estradiol Replacement Timing and Obesogenic Diet Effects on Body Composition and Metabolism in Postmenopausal Macaques.

C. Roberts, H. Urbanski, J. Purnell, 2019, Endocrinology.

Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.

C. Roberts, C. True, O. Varlamov, 2017, Advances in experimental medicine and biology.

Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.

C. Roberts, D. Leroith, B. Stannard, 1994, The Journal of biological chemistry.

INTEGRATED SYSTEMS AND TECHNOLOGIES 3206 Application of Raman Spectroscopy to Identify Microcalcifications and Underlying Breast Lesions at Stereotactic Core Needle Biopsy

R. Dasari, W. Wick, T. Saga, 2013 .

Ovarian cycle-specific regulation of adipose tissue lipid storage by testosterone in female nonhuman primates.

J. Cameron, C. Roberts, R. Stouffer, 2013, Endocrinology.

The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors.

H. Werner, C. Roberts, D. Leroith, 1993, Advances in experimental medicine and biology.

Androgen receptor (AR) expression in AR‐negative prostate cancer cells results in differential effects of DHT and IGF‐I on proliferation and AR activity between localized and metastatic tumors

S. Plymate, C. Roberts, M. Marcelli, 2004, The Prostate.

The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels

M. Phillip, H. Werner, C. Roberts, 1995, Endocrine.

A Novel, Stable, Aqueous Glucagon Formulation Using Ferulic Acid as an Excipient

W. Ward, C. Roberts, L. David, 2014, Journal of diabetes science and technology.

Biochemical stabilization of glucagon at alkaline pH.

W. Ward, C. Roberts, L. David, 2014, Diabetes technology & therapeutics.

Cell-autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques.

H. Sampath, C. Roberts, A. Cornea, 2015, Endocrinology.

Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates

C. Roberts, O. Varlamov, Sathya Srinivasan, 2017, Human reproduction.

Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cells.

S. Plymate, C. Roberts, C. Sprenger, 2001, Endocrinology.

Genetic architecture of human obesity traits in the rhesus macaque

Asia D. Mitchell, J. Curran, C. Roberts, 2018, Obesity.

Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication.

C. Roberts, P. Kurre, Charles T Roberts, 2013, Cancer research.

Stable Liquid Glucagon Formulations for Rescue Treatment and Bi-Hormonal Closed-Loop Pancreas

W. Ward, C. Roberts, L. David, 2012, Current Diabetes Reports.

Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.

H. Werner, C. Roberts, D. Leroith, 1990, Molecular endocrinology.

Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Decreased Expression of Wilms ’ Tumor Gene WT-1 and Elevated Expression of Insulin Growth Factor-II (IGF-II) and Type 1 IGF Receptor Genes in Pros

A. Hoffman, P. Cohen, C. Roberts, 2022 .

Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons

C. Roberts, M. Sleeman, M. Cowley, 2019, Molecular metabolism.

Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I

P. Arvan, C. Roberts, M. Weiss, 2009, The Journal of Biological Chemistry.

Evolution of Insulin and Insulin Receptors

C. Roberts, D. Leroith, W. Lowe, 1987 .

Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat.

D. Stephan, C. Roberts, D. Leroith, 1994, The Journal of endocrinology.

Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

H. Werner, C. Roberts, D. Leroith, 1996, Journal of Molecular Neuroscience.

A phase I trial and pharmacokinetic study of IMC-A12 in pediatric patients with relapsed/refractory solid tumors: A Children's Oncology Group Phase I Consortium study.

C. Ahern, C. Roberts, P. Adamson, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.

C. Roberts, D. Leroith, M. Adamo, 1995, Endocrinology.

Transcriptional Diversity in Rat Insulin-Like Growth Factor I Gene Expression

C. Roberts, D. Leroith, W. Lowe, 1989 .

Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach

C. Roberts, D. Leroith, V. Kavsan, 1993, Molecular reproduction and development.

In Vitro and in Vivo Evaluation of Native Glucagon and Glucagon Analog (MAR-D28) during Aging: Lack of Cytotoxicity and Preservation of Hyperglycemic Effect

W. Ward, C. Roberts, R. DiMarchi, 2010, Journal of diabetes science and technology.

TITLE : Biochemical Stabilization of Glucagon at Alkaline pH RUNNING TITLE : Glucagon Formulation for Parenteral Use

W. Ward, C. Roberts, L. David, 2014 .

IGF-1 and prostate cancer.

C. Roberts, 2004, Novartis Foundation symposium.

Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins.

C. Roberts, D. Leroith, M. Sheikh, 1993, Growth regulation.

Preliminary Examination of Olanzapine and Diet Interactions On Metabolism in a Female Macaque.

C. Roberts, O. Varlamov, P. Kievit, 2014, Journal of endocrinology and diabetes.

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

D. Harlan, R. Stein, L. Goodrich, 2016, American journal of physiology. Endocrinology and metabolism.

Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.

C. Roberts, V. Hwa, P. Fang, 2009, Journal of Clinical Endocrinology and Metabolism.

Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism.

P. Rust, C. Roberts, D. Leroith, 1994, The American journal of physiology.

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

F. Ismail-Beigi, M. Lawrence, C. Roberts, 2012, Proceedings of the National Academy of Sciences.

Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I

P. Arvan, C. Roberts, M. Weiss, 2009, The Journal of Biological Chemistry.

The IGF system : molecular biology, physiology, and clinical applications

C. Roberts, R. Rosenfeld, 1999 .

Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication.

C. Roberts, P. Kurre, 2013, Cancer research.

Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes.

R. Somwar, C. Roberts, A. Cornea, 2010, American journal of physiology. Endocrinology and metabolism.

Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens.

C. Roberts, D. Leroith, H. Kato, 1996, Bioscience, biotechnology, and biochemistry.