N. Wong

N. Wong, A. Fox-Robichaud, A. Mooradian, 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1.

R. Arai, M. Fujimiya, N. Wong, 2001, The Journal of clinical endocrinology and metabolism.

Phlorizin or Vanadate Treatment Reverses Impaired Expression of Albumin and Hepatocyte Nuclear Factor 1 in Diabetic Rats

N. Wong, G. Barrera-Hernandez, Irene Wanke, 1996, Diabetes.

Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat.

N. Wong, G. Shillabeer, D. Lau, 1990, Journal of lipid research.

Identification of the thyroid hormone-responsive messenger RNA spot 11 as apolipoprotein-A1 messenger RNA and effects of the hormone on the promoter.

N. Wong, A. Mooradian, F. Carr, 1992, Molecular endocrinology.

TNF-alpha stimulation of MCP-1 expression is mediated by the Akt/PKB signal transduction pathway in vascular endothelial cells.

N. Wong, J. Takahara, H. Imachi, 2000, Biochemical and biophysical research communications.

Apolipoprotein A1 expression in young and aged rats is modulated by dietary carbohydrates.

N. Wong, G. Shah, A. Mooradian, 1997, Metabolism: clinical and experimental.

Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2.

N. Wong, M. Haas, A. Mooradian, 2004, Metabolism: clinical and experimental.

Apolipoprotein A-I Expression in Rats is Not Altered by Troglitazone1

N. Wong, M. Haas, A. Mooradian, 2002, Experimental biology and medicine.

Effect of glucosamine on apolipoprotein AI mRNA stabilization and expression in HepG2 cells.

N. Wong, M. Haas, A. Mooradian, 2004, Metabolism: clinical and experimental.

Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome

K. Kalantar-Zadeh, K. Buhr, N. Wong, 2021, Clinical journal of the American Society of Nephrology : CJASN.

Advances in our understanding of thyroid hormone action at the cellular level.

N. Wong, H. Freake, C. Mariash, 1987, Endocrine reviews.

RNA Spot 11 as Apolipoprotein-Al Messenger RNA and Effects of the Hormone on the Promoter

N. Wong, F. Carr, J. Romney, 1992 .

Effect of chromium on apolipoprotein A-I expression in HepG2 cells.

N. Wong, M. Haas, A. Mooradian, 2003, Nutrition.

Effects of dehydroepiandrosterone on rat apolipoprotein AI gene expression in the human hepatoma cell line, HepG2.

N. Wong, M. Haas, A. Mooradian, 2002, Metabolism: clinical and experimental.

Induction of the apolipoprotein AI gene by fasting: a relationship with ketosis but not with ketone bodies.

N. Wong, M. Haas, A. Mooradian, 2000, Metabolism: clinical and experimental.

Cyclosporin A inhibits apolipoprotein AI gene expression.

N. Wong, Xi-Long Zheng, 2006, Journal of molecular endocrinology.

Beneficial effects of a novel thyromimetic on lipoprotein metabolism.

N. Wong, A. Taylor, Z. F. Stephan, 1997, Molecular pharmacology.

High-density lipoprotein is a potential growth factor for adrenocortical cells.

T. Ishida, N. Wong, H. Imachi, 2006, Biochemical and biophysical research communications.

Insulin-like growth factor-i regulation of hepatic scavenger receptor class BI.

T. Ishida, N. Wong, H. Imachi, 2004, Endocrinology.

Expression of Human Scavenger Receptor B1 on and in Human Platelets

T. Ishida, N. Wong, J. Takahara, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling.

N. Wong, M. Haas, A. Mooradian, 2006, Biochemistry.

The beneficial effects of plant sterols on serum cholesterol.

N. Wong, 2001, The Canadian journal of cardiology.

Functional mapping of tissue-specific elements of the human α-fetoprotein gene enhancer

N. Wong, H. Nakabayashi, Y. Miura, 2004 .

A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter.

N. Wong, L. Agellon, V. Drover, 2002, Molecular endocrinology.

RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease

N. Shenoy, P. Young, N. Wong, 2017, Molecular Pharmacology.

Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes

P. Young, S. Wasiak, N. Wong, 2016, Data in brief.

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

S. Wasiak, N. Wong, B. Rakai, 2020, Cardiovascular therapeutics.

Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

S. Wasiak, N. Wong, D. Gilham, 2017, Journal of Cardiovascular Translational Research.

Effects of a thyromimetic on apolipoprotein B-100 in rats.

N. Wong, J. Dufresne, Z. F. Stephan, 2000, Journal of molecular endocrinology.

ects of a thyromimetic on apolipoprotein B100 in rats

N. Wong, J. Dufresne, Z. F. Stephan, 2000 .

Hepatocyte nuclear factor 4 inhibits the activity of site A from the rat apolipoprotein AI gene.

N. Wong, K. Murao, A. Taylor, 1997, Biochemistry.

An evaluation of RVX-208 for the treatment of atherosclerosis

M. Banach, D. Mikhailidis, N. Wong, 2015, Expert opinion on investigational drugs.

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

S. Wasiak, N. Wong, B. Rakai, 2019, Clinical Epigenetics.

Adenovirus Vector-Induced Expression of the C-X-C Chemokine IP-10 Is Mediated through Capsid-Dependent Activation of NF-κB

T. Libermann, N. Wong, D. Muruve, 2000, Journal of Virology.

Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease.

M. Tonelli, K. Kalantar-Zadeh, C. Zoccali, 2019, Atherosclerosis.

Diabetes mellitus increases endothelin-1 gene transcription in rat kidney.

N. Wong, C. Whiteside, J. Dufresne, 2000, Kidney international.

Endoplasmic reticulum stress in HepG2 cells inhibits apolipoprotein A-I secretion.

N. Wong, M. Haas, A. Mooradian, 2013, Life sciences.

Induction of the apolipoprotein AI promoter by Sp1 is repressed by saturated fatty acids.

N. Wong, M. Haas, A. Mooradian, 2004, Metabolism: clinical and experimental.

Hormonal and dietary regulation of a mammalian gene introduced into rat liver by direct injection.

N. Wong, I. Wanke, 1999, Human gene therapy.

N. Wong, G. Shah, A. Mooradian, 1995, Biochimica et biophysica acta.

Insulin induction of apolipoprotein AI, role of Sp1.

N. Wong, K. Mihara, Xi-Long Zheng, 2003, Biochemistry.

Characteristics of a negative thyroid hormone response element.

N. Wong, F. Carr, 1994, The Journal of biological chemistry.

Thyroid hormone inhibits thyrotropin gene expression via a position-independent negative L-triiodothyronine-responsive element.

N. Wong, F. Carr, L. L. Kaseem, 1992, The Journal of biological chemistry.

Effects of Diabetes Mellitus on Hepatocyte Nuclear Factor 1 Decrease Albumin Gene Transcription (*)

N. Wong, G. Barrera-Hernandez, Irene Wanke, 1996, The Journal of Biological Chemistry.

N. Wong, A. Mooradian, Arshag D. Mooradian, 1994, European journal of endocrinology.

Labile proteins are necessary for T3 induction of growth hormone mRNA in normal rat pituitary and rat pituitary tumor cells.

N. Wong, J. Oppenheimer, A. Pérez-Castillo, 1987, The Journal of biological chemistry.

Triiodothyronine regulation of multiple rat hepatic genes: requirement for ongoing protein synthesis.

N. Wong, P. Hamblin, J. Oppenheimer, 1987, Molecular endocrinology.

Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells

T. Ishida, N. Wong, H. Imachi, 2006, FEBS letters.

Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.

S. Wasiak, N. Wong, B. Rakai, 2021, Atherosclerosis.

The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression.

H. Tokumitsu, T. Ishida, N. Wong, 2004, Diabetes.

Role of calcium-calmodulin-dependent protein kinase cascade in thyrotropin (TSH)-releasing hormone induction of TSH and prolactin gene expression.

H. Tokumitsu, T. Ishida, N. Wong, 2004, Endocrinology.

PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP

T. Ishida, N. Wong, H. Imachi, 2009, Journal of cellular and molecular medicine.

The multiple endocrine neoplasia type 1 gene product, menin, inhibits the human prolactin promoter activity.

N. Wong, H. Imachi, K. Murao, 2002, Journal of molecular endocrinology.

Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression*

N. Wong, K. Murao, A. Mooradian, 1998, The Journal of Biological Chemistry.

Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts

N. Wong, M. Haas, A. Mooradian, 2014, Pharmaceutical biology.

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro

N. Wong, S. Reid, Abenaya Muralidharan, 2021, bioRxiv.

Functional mapping of tissue-specific elements of the human alpha-fetoprotein gene enhancer.

N. Wong, H. Nakabayashi, Y. Miura, 2004, Biochemical and biophysical research communications.

Effects of ketoacidosis on rat apolipoprotein A1 gene expression: a link with acidosis but not with ketones.

N. Wong, M. Haas, A. Mooradian, 2000, Journal of molecular endocrinology.

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Sean J. Humphrey, D. James, D. Elliott, 2021, Cell.

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

Sean J. Humphrey, D. James, D. Elliott, 2020 .

Regulation of apoA1 gene expression with acidosis: requirement for a transcriptional repressor.

N. Wong, M. Haas, A. Mooradian, 2001, Journal of molecular endocrinology.

Fatty acid synthase and adipsin mRNA levels in obese and lean JCR:LA-cp rats: effect of diet.

N. Wong, G. Shillabeer, D. Lau, 1992, Journal of lipid research.

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.

M. Fujimiya, M. Kudo, N. Wong, 2002, Diabetes.

Transcription factors and age-related decline in apolipoprotein A-I expression.

M. Fujimiya, N. Wong, A. Fox-Robichaud, 1999, Journal of lipid research.

The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.

N. Wong, M. Haas, A. Mooradian, 2006, Endocrine reviews.

Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases

N. Wong, B. Rakai, E. Kulikowski, 2020, Medicinal research reviews.

Regulation of apolipoprotein A‐I gene expression by the histamine H1 receptor: Requirement for NF‐&kgr;B

N. Wong, M. Haas, A. Mooradian, 2018, Life sciences.

Inhibition of hepatic apolipoprotein A‐I gene expression by histamine

N. Wong, M. Haas, A. Mooradian, 2018, European journal of pharmacology.

Epidermal Growth Factor Induction of Apolipoprotein A-I Is Mediated by the Ras-MAP Kinase Cascade and Sp1*

M. Hollenberg, N. Wong, Xi-Long Zheng, 2001, The Journal of Biological Chemistry.

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

P. Young, N. Wong, K. McLure, 2014, Atherosclerosis.

Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors

N. Wong, V. Holers, J. Bartlett, 2008, Journal of Virology.

Interferon α decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes

N. Wong, H. Imachi, K. Murao, 2007, Gut.

Apabetalone downregulates factors and pathways associated with vascular calcification.

K. Kalantar-Zadeh, S. Wasiak, N. Wong, 2019, Atherosclerosis.

Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial.

J. Cummings, K. Kalantar-Zadeh, N. Wong, 2019, American heart journal.

Role of Sp1 in insulin regulation of gene expression.

S. Samson, N. Wong, 2002, Journal of molecular endocrinology.

Hyperglycemia suppresses hepatic scavenger receptor class B type I expression.

T. Ishida, Ke Chen, N. Wong, 2008, American journal of physiology. Endocrinology and metabolism.

Thyroid hormone-, carbohydrate, and age-dependent regulation of a methylation site in the hepatic S14 gene.

N. Wong, K. Strait, J. Oppenheimer, 1989, Molecular endocrinology.

N. Wong, G. Shah, A. Mooradian, 1996, American Journal of Physiology.

24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression.

N. Wong, M. Haas, A. Mooradian, 2011, Life sciences.

N. Wong, A. Mooradian, L. Deebaj, 1991, The Journal of endocrinology.

RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

P. Young, S. Wasiak, N. Wong, 2013, PloS one.

Beneficial Effects of a Novel Thyromimetic on Lipoprotein Metabolism

N. Wong, A. Taylor, Z. F. Stephan, 1997 .

Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.

T. Libermann, N. Wong, D. Muruve, 2002, Human gene therapy.

Arterial embolization: a novel approach to thyroid ablative therapy for Graves' disease.

N. Wong, Haipeng Xiao, Wenquan Zhuang, 2002, The Journal of clinical endocrinology and metabolism.

HDL—is it too big to fail?

R. Hegele, N. Wong, D. Ng, 2013, Nature Reviews Endocrinology.

Oestradiol decreases rat apolipoprotein AI transcription via promoter site B.

N. Wong, A. Fox-Robichaud, A. Taylor, 2000, Journal of molecular endocrinology.

Induction of apolipoprotein A-I gene expression by glucagon-like peptide-1 and exendin-4 in hepatocytes but not intestinal cells.

N. Wong, M. Haas, A. Mooradian, 2013, Metabolism: clinical and experimental.

Induction of hepatic apolipoprotein A-I gene expression by the isoflavones quercetin and isoquercetrin.

N. Wong, M. Haas, A. Mooradian, 2014, Life sciences.

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

S. Wasiak, N. Wong, B. Rakai, 2019, Clinical Epigenetics.

Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease

N. Wong, S. Nicholls, G. Schwartz, 2018, American Journal of Cardiovascular Drugs.

Insulin mimetic effect of D-allulose on apolipoprotein A-I gene.

N. Wong, M. Haas, M. Tokuda, 2022, Journal of food biochemistry.

Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study

K. Kalantar-Zadeh, K. Buhr, N. Wong, 2021, Cardiovascular Diabetology.

Multihormonal regulation and kinetics of induction of a hepatic mRNA sequence which is slowly responsive to triiodothyronine.

N. Wong, J. Oppenheimer, 1986, The Journal of biological chemistry.

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial.

C. Cobelli, P. Meikle, D. Sviridov, 2016, Metabolism: clinical and experimental.

Transcriptional control of apolipoprotein A-I gene expression in diabetes.

N. Wong, M. Haas, A. Mooradian, 2004, Diabetes.

RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.

N. Wong, J. Genest, G. Wagner, 2010, Journal of the American College of Cardiology.

Human scavenger receptor class b type 1 is regulated by activators of peroxisome proliferators-activated receptor-γ in hepatocytes

T. Ishida, N. Wong, H. Imachi, 2009, Endocrine.

Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia.

N. Wong, M. Haas, M. Sheikh-Ali, 2012, Life sciences.

Suppression of apolipoprotein AI gene expression in HepG2 cells by TNF alpha and IL-1beta.

N. Wong, M. Haas, A. Mooradian, 2003, Biochimica et biophysica acta.

Nicotinic acid induces apolipoprotein A-I gene expression in HepG2 and Caco-2 cell lines.

N. Wong, M. Haas, A. Mooradian, 2011, Metabolism: clinical and experimental.

The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells.

T. Ishida, N. Wong, H. Imachi, 2002, Endocrinology.

Glucocorticoid stimulates primate but inhibits rodent alpha-fetoprotein gene promoter.

N. Wong, H. Nakabayashi, S. Nishi, 2001, Biochemical and Biophysical Research Communications - BBRC.

Glucose regulates secretion of exogenously expressed insulin from HepG2 cells in vitro and in a mouse model of diabetes mellitus in vivo.

N. Wong, D. Muruve, I. Wanke, 2013, Journal of molecular endocrinology.

Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation

N. Wong, H. Iwama, H. Imachi, 2006, Diabetologia.

Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1*

M. Hollenberg, N. Wong, Xi-Long Zheng, 2000, The Journal of Biological Chemistry.

Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells.

N. Wong, J. Takahara, H. Imachi, 2000, European journal of biochemistry.

Cycloheximide inhibits S-14 gene transcription and abolishes DNase I hypersensitive S-14 sites in the livers of euthyroid but not hypothyroid rats.

N. Wong, J. Oppenheimer, H. Schwartz, 1987, Molecular Endocrinology.

Regulation of protamine gene expression in an in vitro homologous system.

N. Wong, P. Cannon, F. A. van der Hoorn, 1996, Acta biochimica Polonica.

Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1.

J. Haefliger, G. Waeber, T. Ishida, 2004, Endocrinology.

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial.

C. Cobelli, P. Meikle, D. Sviridov, 2016, Metabolism: clinical and experimental.

Regulation of gene S-14 by triiodothyronine in liver.

N. Wong, C. Mariash, W. Kinlaw, 1987, Hormone and metabolic research. Supplement series.

Pro-inflammatory signaling by 24,25-dihydroxyvitamin D3 in HepG2 cells.

N. Wong, M. Haas, A. Mooradian, 2016, Journal of molecular endocrinology.

Discovery of drugs to treat cytokine storm-induced cardiac dysfunction using human cardiac organoids

Sean J. Humphrey, D. James, D. Elliott, 2020, bioRxiv.

Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.

S. Wasiak, N. Wong, B. Rakai, 2022, Atherosclerosis.

Transcriptional control of apolipoprotein A-I gene expression in diabetes.

N. Wong, M. Haas, A. Mooradian, 2004, Diabetes.