I. Samudio

发表

Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

S. Safe, V. Nair, Satya S. Pathi, 2013, Carcinogenesis.

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.

Marina Konopleva, L. Vassilev, M. Konopleva, 2005, Blood.

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) Directly Targets Mitochondrial Glutathione to Induce Apoptosis in Pancreatic Cancer*

M. Sporn, M. Konopleva, M. Andreeff, 2005, Journal of Biological Chemistry.

Transcriptional Activation of Deoxyribonucleic Acid Polymerase α Gene Expression in MCF-7 Cells by 17β-Estradiol.

S. Safe, I. Samudio, Fan Wang, 2001, Endocrinology.

Oncolytic virotherapy in hepato‐bilio‐pancreatic cancer: The key to breaking the log jam?

T. Liang, X. Bai, I. Samudio, 2020, Cancer medicine.

Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells.

S. Safe, I. Samudio, I. Chen, 2000, Endocrinology.

Transcriptional activation of rat creatine kinase B by 17β‐estradiol in MCF‐7 cells involves an estrogen responsive element and GC‐rich sites

S. Safe, I. Samudio, Fan Wang, 2001, Journal of cellular biochemistry.

Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models

A. Mes-Masson, I. Samudio, Yoshiki Narimatsu, 2022, Frontiers in Oncology.

Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemic cell lines

I. Samudio, L. Morales, Margarita González, 2017 .

3 , 3 0-Diindolylmethane ( DIM ) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR 5

M. Abdelrahim, I. Samudio, S. Safe, 2006 .

3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

M. Abdelrahim, I. Samudio, S. Safe, 2006, Carcinogenesis.

Cellular and molecular mechanisms of antioxidants in Parkinson's disease

I. Samudio, G. Barreto, Janneth González, 2012, Nutritional neuroscience.

Transcriptional activation of cathepsin D gene expression by 17β-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition

Stephen Safe, Ismael Samudio, S. Safe, 2001, Molecular and Cellular Endocrinology.

Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.

S. Safe, M. Abdelrahim, I. Samudio, 2003, Endocrinology.

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.

M. Konopleva, Z. Estrov, D. Harris, 2005, Cancer research.

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

E. Estey, M. Konopleva, M. Andreeff, 2009, Blood.

1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes Induce Peroxisome Proliferator-Activated Receptor γ-Mediated Growth Inhibition, Transactivation, and Differentiation Markers in Colon Cancer Cells

Wei Zhang, S. Safe, I. Samudio, 2004, Cancer Research.

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

E. Estey, M. Konopleva, M. Andreeff, 2006, Molecular Cancer Therapeutics.

All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages

I. Samudio, G. Krystal, Victor W H Ho, 2016, PloS one.

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

M. Konopleva, M. Andreeff, H. Kantarjian, 2008, Molecular Cancer Therapeutics.

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

M. Konopleva, M. Andreeff, S. Safe, 2005, Molecular Cancer Therapeutics.

A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis

M. Konopleva, M. Andreeff, I. Samudio, 2005, Molecular Pharmacology.

Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.

S. Safe, I. Samudio, R. Burghardt, 2002, Molecular endocrinology.

dependent on oxygen partial pressure CXCR4 expression and biological activity in acute myeloid leukemia are

M. Andreeff, M. Fiegl, I. Samudio, 2013 .

CXCR4 expression and biological activity in acute myeloid leukemia are dependent on oxygen partial pressure Short title: CXCR4 expression and pO2 in AML

M. Andreeff, M. Fiegl, I. Samudio, 2008 .

Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells

M. Andreeff, M. Fiegl, I. Samudio, 2010, Leukemia.

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor γ-Dependent and -Independent Pathways

M. Konopleva, I. Samudio, M. Andreef, 2005, Molecular Pharmacology.

Methyl 2-Cyano-3 , 12-dioxooleana-1 , 9-dien-28-oate ( CDDO-Me ) Decreases Specificity Protein ( Sp ) Transcription Factors and Inhibits Pancreatic Tumor Growth : Role of MicroRNA-27 a

M. Konopleva, M. Andreeff, S. Safe, 2010 .

Autologous Platelet Concentrates as an Adjunctive Treatment for Chronic Laminitis in a Mare with Pituitary Pars Intermedia Dysfunction

I. Samudio, J. U. Carmona, C. López, 2013 .

Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel

I. Samudio, J. U. Carmona, M. Álvarez, 2013, BMC Veterinary Research.

Targeting leukemia's "fatty tooth".

M. Konopleva, I. Samudio, 2015, Blood.

Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus

I. Samudio, W. Jia, I-Fang Lee, 2022, Viruses.

In vitro bactericidal activity of equine platelet concentrates, platelet poor plasma, and plasma against methicillin-resistant Staphylococcus aureus

I. Samudio, J. U. Carmona, M. Álvarez, 2011 .

Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.

M. Konopleva, M. Andreeff, I. Samudio, 2010, Cytotherapy.

Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins

Brad Saville, Stephen Safe, Ismael Samudio, 2004, Oncogene.

Cooperative Coactivation of Estrogen Receptor α in ZR-75 Human Breast Cancer Cells by SNURF and TATA-binding Protein*

Stephen Safe, Ismael Samudio, S. Safe, 2002, The Journal of Biological Chemistry.

Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements*

S. Safe, I. Samudio, E. Castro-Rivera, 2001, The Journal of Biological Chemistry.

Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide

I. Samudio, J. U. Carmona, M. Álvarez, 2015, BMC Musculoskeletal Disorders.

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

K. Baggerly, M. Konopleva, M. Andreeff, 2017, Haematologica.

A new class of peroxisome proliferator-activated receptor γ (PPARγ) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes

S. Safe, M. Abdelrahim, I. Samudio, 2004, Molecular Cancer Therapeutics.

The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

L. Pusztai, J. Hazle, D. Cody, 2015, Nature Communications.

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.

Jared K Burks, Ismael Samudio, M. Andreeff, 2009, Blood.

Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.

I. Samudio, R. Burghardt, R. Barhoumi, 2006, Cancer letters.

1,1‐bis(3′‐indolyl)‐1‐(p‐substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines

S. Safe, J. Hong, I. Samudio, 2008, Molecular carcinogenesis.

Effects of natural antioxidants in neurodegenerative disease

I. Samudio, G. Barreto, F. Capani, 2012, Nutritional neuroscience.

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis

I. Samudio, M. Hughes, G. Krystal, 2016, PloS one.

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis

I. Samudio, M. Hughes, G. Krystal, 2016, PloS one.

Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model

I. Samudio, G. Barreto, R. Cabezas, 2014, Human & experimental toxicology.

Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells

J. Velez, M. Konopleva, M. Andreeff, 2013, Front. Oncol..

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

John Calvin Reed, M. Konopleva, Z. Estrov, 2006, Cancer cell.

Estrogen‐dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP‐dependent pathways

Stephen Safe, Ismael Samudio, S. Safe, 2004, Molecular carcinogenesis.

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

J. Velez, Y. Qi, Xiaoping Su, 2016, Oncotarget.

Small Inhibitory RNA Duplexes for Sp1 mRNA Block Basal and Estrogen-induced Gene Expression and Cell Cycle Progression in MCF-7 Breast Cancer Cells*

M. Abdelrahim, I. Samudio, R. Burghardt, 2002, The Journal of Biological Chemistry.

Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

S. Safe, I. Samudio, M. Kladde, 1999, Molecular endocrinology.

HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

M. Konopleva, M. Andreeff, I. Samudio, 2013, Leukemia.

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.

K. Kaluarachchi, M. Konopleva, M. Andreeff, 2010, The Journal of clinical investigation.

Mechanisms of Transcriptional Activation of bcl-2Gene Expression by 17β-Estradiol in Breast Cancer Cells*

John Calvin Reed, S. Safe, I. Samudio, 1999, The Journal of Biological Chemistry.

A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.

I. Samudio, A. Weljie, G. Krystal, 2014, Carcinogenesis.

Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells

H. Kantarjian, I. Samudio, G. Borthakur, 2010, Leukemia & lymphoma.

Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal–Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase Pathways

E. Yeh, I. Samudio, J. Willerson, 2004, Circulation.

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

D. Sabatini, M. Konopleva, M. Andreeff, 2007, Blood.

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

M. Konopleva, M. Andreeff, H. Kantarjian, 2012, Cancer biology & therapy.

Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site.

S. Safe, I. Samudio, M. Kladde, 2000, Journal of molecular endocrinology.

Inhibition of Vascular Endothelial Growth Factor Expression in HEC1A Endometrial Cancer Cells through Interactions of Estrogen Receptor α and Sp3 Proteins*

S. Safe, I. Samudio, Fan Wang, 2000, The Journal of Biological Chemistry.

Inhibition of Tumor-Necrosis-Factor-αDELETEInduced Endothelial Cell Activation by a New Class of PPAR-γ Agonists

S. Safe, E. Yeh, I. Samudio, 2005, Journal of Vascular Research.

Inhibition of tumor-necrosis-factor-α induced endothelial cell activation by a new class of PPAR-γ agonists : An in vitro study showing receptor-independent effects

S. Safe, E. Yeh, I. Samudio, 2005 .

Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

J. Velez, M. Konopleva, M. Andreeff, 2014, Cancer Microenvironment.

Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer.

M. Andreeff, I. Samudio, K. Roby, 2013, Cytotherapy.

Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

M. Konopleva, M. Andreeff, S. Safe, 2010, Molecular Pharmacology.

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

M. Konopleva, Z. Estrov, D. Harris, 2008, Cancer research.

Cell-surface proteomics for the identification of novel therapeutic targets in cancer

T. Kislinger, I. Samudio, L. Kuhlmann, 2018, Expert review of proteomics.

Apoptosis in leukemias: regulation and therapeutic targeting.

M. Konopleva, M. Andreeff, I. Samudio, 2010, Cancer treatment and research.

Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.

M. Konopleva, M. Andreeff, I. Samudio, 2007, Cancer research.

Mitogen-Activated Protein Kinase Kinase Inhibition Enhances Nuclear Proapoptotic Function of p 53 in Acute Myelogenous Leukemia Cells

M. Konopleva, M. Andreeff, I. Samudio, 2007 .

PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin

K. Wiedemeyer, M. Köbel, B. Gilks, 2020, Journal for ImmunoTherapy of Cancer.

Concomitant Inhibition of MDM2 and Bcl-2 Protein Function Synergistically Induce Mitochondrial Apoptosis in AML

M. Konopleva, M. Andreeff, I. Samudio, 2006, Cell cycle.

UV Light–inactivated HSV-1 Stimulates Natural Killer Cell–induced Killing of Prostate Cancer Cells

I. Samudio, P. Rennie, G. Krystal, 2019, Journal of immunotherapy.

UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

K. Rezvani, I. Samudio, G. Krystal, 2016, Blood.

Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes

I. Samudio, W. Jia, X. Bu, 2020, Biomedicines.

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

J. Velez, M. Konopleva, M. Andreeff, 2016, Oncotarget.

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism.

M. Andreeff, M. Fiegl, I. Samudio, 2009, Cancer research.

The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation.

M. Andreeff, M. Fiegl, I. Samudio, 2008, Cancer research.

Asparaginase unveils glutamine-addicted AML.

M. Konopleva, I. Samudio, 2013, Blood.

Resistin Promotes

E. Yeh, I. Samudio, J. Willerson, 2004 .

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

M. Konopleva, M. Andreeff, I. Samudio, 2008, Leukemia.

Uncoupling Protein 2 Activation Mediated by Mitochondrial Uncoupling Associated with The Warburg Effect in Leukemia-Stroma Cocultures Is

M. Andreeff, M. Fiegl, I. Samudio, 2008 .

Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.

S. Safe, I. Samudio, I. Chen, 2000, Endocrinology.

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

G. Mills, Yiling Lu, M. Konopleva, 2006, Cancer research.

Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.

J. Hong, M. Abdelrahim, I. Samudio, 2004, Endocrinology.

The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death

M. Minden, I. Samudio, P. Spagnuolo, 2017, Leukemia & lymphoma.

Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1

I. Samudio, X. Bu, Guoyu Liu, 2023, Molecular therapy oncolytics.

Mechanisms of Inhibitory Aryl Hydrocarbon Receptor-Estrogen Receptor Crosstalk in Human Breast Cancer Cells

S. Safe, I. Samudio, M. Wormke, 2000, Journal of Mammary Gland Biology and Neoplasia.

Molecular and Biochemical Basis for the Reprogramming of Intermediary Metabolism in Leukemia Cells

J. Velez, I. Samudio, 2015 .

Targeting the Hypoxic Microenvironment by mTOR Inhibitors Sensitizes ALL Cells to Chemotherapy

M. Konopleva, M. Andreeff, H. Kantarjian, 2008 .

A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.

M. Abdelrahim, I. Samudio, T. Phillips, 2004, Molecular Cancer Therapeutics.

Synergistic Activation of p53 Family of Proteins by the Combination of Nutlin 3a and SAHA in Acute Myelogenous Leukemia.

M. Konopleva, M. Andreeff, I. Samudio, 2009 .

Rapamycin Analogs Reduce mTORC2 Signaling and Inhibit AKT Activation in AML.

D. Sabatini, M. Konopleva, M. Andreeff, 2006 .

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism.

M. Andreeff, M. Fiegl, I. Samudio, 2009, Cancer research.

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

E. Estey, M. Konopleva, M. Andreeff, 2009, Blood.

Metformin as a Novel Component of Metronomic Chemotherapeutic Use: A Hypothesis

J. Velez, I. Samudio, Enoch K Y Lai, 2012 .

Antitumor mechanisms of metformin: Signaling, metabolism, immunity and beyond

I. Samudio, Jorge Eduardo Duque, C. López, 2010 .

Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects.

S. Safe, E. Yeh, I. Samudio, 2005, Journal of vascular research.

Transcriptional Activation of Deoxyribonucleic Acid Polymerase α Gene Expression in MCF-7 Cells by 17β-Estradiol.

S. Safe, I. Samudio, Fan Wang, 2001, Endocrinology.

Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.

M. Abdelrahim, I. Samudio, B. Saville, 2004, Oncogene.

Targeting leukemia's "fatty tooth".

M. Konopleva, I. Samudio, 2015, Blood.