F. Ni

发表

High-resolution NMR studies of fibrinogen-like peptides in solution: resonance assignments and conformational analysis of residues 1-23 of the A alpha chain of human fibrinogen.

H. Scheraga, F. Ni, S. Lord, 1988, Biochemistry.

Thrombin-bound structures of designed analogs of human fibrinopeptide A determined by quantitative transferred NOE spectroscopy: a new structural basis for thrombin specificity.

H. Scheraga, Y. Zhu, F. Ni, 1995, Journal of molecular biology.

High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen.

H. Scheraga, Y. Konishi, F. Ni, 1989, Biochemistry.

Thrombin hydrolysis of an N-terminal peptide from fibrinogen Lille: kinetic and NMR studies.

R. W. Ashton, H. Scheraga, F. Ni, 1992, Biochemistry.

Probing the kinetic landscape of transient peptide-protein interactions by use of peptide (15)n NMR relaxation dispersion spectroscopy: binding of an antithrombin peptide to human prothrombin.

F. Ni, P. Xu, D. Tolkatchev, 2003, Journal of the American Chemical Society.

Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Discovery of new antimalarial chemotypes through chemical methodology and library development

Aaron B. Beeler, X. Su, S. Schaus, 2011 .

Isolation of Monomeric Human VHS by a Phage Selection*

J. Tanha, F. Ni, P. Xu, 2005, Journal of Biological Chemistry.

Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface.

W. Vranken, J. Tanha, F. Ni, 2002, Biochemistry.

Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.

Claire Marie Filone, F. Ni, Andrew Platt, 2013, Chemistry & biology.

Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents.

A. Strosberg, F. Ni, J. Snyder, 2011, Bioorganic & medicinal chemistry letters.

Structural resiliency of an EGF‐like subdomain bound to its target protein, thrombin

E. Komives, R. Hrabal, F. Ni, 1996, Protein science : a publication of the Protein Society.

Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.

Y. Konishi, J. DiMaio, B. Edwards, 1996, Biochemistry.

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Ryan M. Evans, Anthony J. Kearsley, Robert G. Brinson, 2018, mAbs.

Converting Cytochrome c into a Peroxidase‐Like Metalloenzyme by Molecular Design

Haojie Lu, F. Ni, Peng-Yuan Yang, 2007, Chembiochem : a European journal of chemical biology.

The active‐site residue Cys‐29 is responsible for the neutral‐pH inactivation and the refolding barrier of human cathepsin B

F. Ni, P. Xu, A. C. Storer, 2000, FEBS letters.

Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7.

N. Seidah, M. Chrétien, F. Ni, 2000, Biochemistry.

An Insight of S‐Nitrosylation of Human GIF

F. Ni, Mingjie Zhang, Z. Huang, 2005 .

Conformation of a Cdc42/Rac interactive binding peptide in complex with Cdc42 and analysis of the binding interface.

W. Vranken, F. Ni, P. Xu, 1999, Biochemistry.

Reduction of fluorinated cyclopropene by nitrogenase.

F. Ni, Yilin Hu, C. McKenna, 2013, Journal of the American Chemical Society.

Solution structures of a 30‐residue amino‐terminal domain of the carp granulin‐1 protein and its amino‐terminally truncated 3‐30 subfragment: Implications for the conformational stability of the stack of two β‐hairpins

W. Vranken, F. Ni, H. Bennett, 2002 .

Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF).

Yuan Gao, F. Ni, Z. Huang, 2008, Journal of inorganic biochemistry.

Polypeptide Ligands Containing Switchable Flexible Linkers as Retractable Inhibitors of Protein-Protein Interactions

R. Filfil, F. Ni, D. Tolkatchev, 2006 .

Synthesis and Target Identification of a Novel Electrophilic Warhead, 2-Chloromethylquinoline.

K. Houk, J. N. Sanders, F. Ni, 2019, Biochemistry.

Neuronal growth‐inhibitory factor (metallothionein‐3): structure–function relationships

F. Ni, Z. Huang, Zhi-Chun Ding, 2010, The FEBS journal.

A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond

Y. Konishi, F. Ni, B. Gibbs, 1991, FEBS letters.

Direct Binding of a Hepatitis C Virus Inhibitor to the Viral Capsid Protein

A. Strosberg, F. Ni, J. Snyder, 2012, PloS one.

Bifunctional thrombin inhibitors based on the sequence of hirudin45-65.

Y. Konishi, J. DiMaio, F. Ni, 1990, The Journal of biological chemistry.

Improved methods for solvent suppression and baseline correction in two-dimensional transferred NOE experiments

F. Ni, 1992 .

Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.

R. Baron, F. Ni, R. Haiges, 2011, European journal of medicinal chemistry.

Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions.

F. Ni, D. Tolkatchev, A. Vinogradova, 2005, Bioorganic & medicinal chemistry letters.

A heteronuclear 3D NMR experiment which allows detection of all NOEs for a molecule while providing 15N frequency separation of degenerate amide protons

F. Ni, K. Carpenter, K. A. Carpenter, 1992 .

Residues 21–30 within the Extracellular N-terminal Region of the C5a Receptor Represent a Binding Domain for the C5a Anaphylatoxin*

W. Boyar, F. Ni, Zhigang Chen, 1998, The Journal of Biological Chemistry.

Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.

Lin Chen, F. Ni, Yongheng Chen, 2017, Journal of the American Chemical Society.

Identification and characterization of a factor Va-binding site on human prothrombin fragment 2

F. Ni, P. Xu, J. Weitz, 2019, Scientific Reports.

High-resolution NMR studies of fibrinogen-like peptides in solution: structure of a thrombin-bound peptide corresponding to residues 7-16 of the A alpha chain of human fibrinogen.

H. Scheraga, M. Vásquez, F. Ni, 1989, Biochemistry.

Structure dissection of human progranulin identifies well‐folded granulin/epithelin modules with unique functional activities

F. Ni, P. Xu, A. Bateman, 2008, Protein science : a publication of the Protein Society.

Optimized acquisition and processing of homonuclear 3D NMR spectra. Applications to transferred-NOE experiments

F. Ni, 1992 .

Complete relaxation matrix analysis of transferred nuclear overhauser effects

F. Ni, 1992 .

Three‐dimensional structure and ligand interactions of the low molecular weight protein tyrosine phosphatase from Campylobacter jejuni

F. Ni, D. Watson, P. Xu, 2006, Protein science : a publication of the Protein Society.

A peptide derived from the C-terminal part of a plant cysteine protease folds into a stack of two beta-hairpins, a scaffold present in the emerging family of granulin-like growth factors.

F. Ni, P. Xu, D. Tolkatchev, 2001, Journal of Peptide Research.

Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A.

W. Vranken, F. Ni, D. Tolkatchev, 2000, Biochemistry.

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

R. Hrabal, F. Ni, H. Bennett, 1996, Nature Structural Biology.

Structure dissection of zebrafish progranulins identifies a well‐folded granulin/epithelin module protein with pro‐cell survival activities

Babykumari P. Chitramuthu, F. Ni, P. Xu, 2018, Protein science : a publication of the Protein Society.

A 30-residue fragment of the carp granulin-1 protein folds into a stack of two beta-hairpins similar to that found in the native protein.

W. Vranken, F. Ni, P. Xu, 1999, The journal of peptide research : official journal of the American Peptide Society.

Early events in thermal unfolding of apocytochrome b562 and its double-cysteine mutant as revealed by molecular dynamics simulation

F. Ni, Ying-Wu Lin, T. Ying, 2009 .

Forced Unfolding of Apocytochrome b5 by Steered Molecular Dynamics Simulation

F. Ni, Z. Huang, Ying-Wu Lin, 2008, The protein journal.

Solution structure of the ligand binding domain of the fibroblast growth factor receptor: role of heparin in the activation of the receptor.

F. Ni, C. Yu, Chunyu Yang, 2005, Biochemistry.

New small molecule inhibitors of hepatitis C virus.

A. Strosberg, F. Ni, J. Snyder, 2010, Bioorganic & medicinal chemistry letters.

Molecular imaging of breast tumors using a near‐infrared fluorescently labeled clusterin binding peptide

Feng Ni, Ping Xu, Christiane Cantin, 2012, International journal of cancer.

Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects.

E. Komives, R. Hrabal, F. Ni, 1994, Biochemistry.

NMR for the design of functional mimetics of protein-protein interactions: one key is in the building of bridges.

F. Ni, J. Song, Jianxing Song, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Recombinant Production of Intrinsically Disordered Proteins for Biophysical and Structural Characterization

F. Ni, Zhengding Su, D. Tolkatchev, 2010 .

Improving solubility and refolding efficiency of human V(H)s by a novel mutational approach.

Feng Ni, Jamshid Tanha, Shannon Ryan, 2006, Protein engineering, design & selection : PEDS.

Recent developments in transferred NOE methods

Feng Ni, F. Ni, 1994 .

Binding of human angiogenin inhibits actin polymerization.

A. Kostyukova, F. Ni, P. Xu, 2010, Archives of biochemistry and biophysics.

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

F. Ni, J. Sheff, J. Kelly, 2021, Scientific Reports.

Thrombin-bound conformation of the C-terminal fragments of hirudin determined by transferred nuclear Overhauser effects.

H. Scheraga, Y. Konishi, F. Ni, 1990, Biochemistry.

HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.

F. Ni, R. Bethell, L. Chan, 2004, Bioorganic & medicinal chemistry letters.

Stability of protein-bound conformations of bioactive peptides: the folded conformation of an epidermal growth factor-like thrombomodulin fragment is similar to that recognized by thrombin.

F. Ni, P. Xu, Jianxing Song, 2002, Biopolymers.

Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy.

D. Y. Thomas, F. Ni, E. Leberer, 2001, The Journal of biological chemistry.

Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.

F. Ni, R. Overman, Ying-Chu Chen, 2016, Journal of the American Chemical Society.

The structural and biological significance of the EAAEAE insert in the α‐domain of human neuronal growth inhibitory factor

F. Ni, Z. Huang, Yang Wang, 2009, The FEBS journal.

Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor

F. Ni, Z. Huang, Xin-Chen Teng, 2009, BioMetals.

Incorporation of a glycine within the conserved TCPCP motif of human neuronal growth inhibitory factor significantly reduces its bioactivity.

F. Ni, Z. Huang, Yang Wang, 2008, Biochemical and biophysical research communications.

Solution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling properties.

Zhenbao Yu, W. Vranken, F. Ni, 2002, Biochemistry.

Inhibition of the pathogenically related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors.

F. Ni, Zhengding Su, Hongjian Li, 2007, Chemistry & biology.

Gradient-enhanced TOCSY experiments with improved sensitivity and solvent suppression

R. Hrabal, F. Ni, D. B. Fulton, 1996, Journal of biomolecular NMR.

Conformational stability of a thrombin-binding peptide derived from the hirudin C-terminus.

E. Purisima, D. Ripoll, F. Ni, 1992, Biochemistry.

Stabilization of an isolated helical capping box in solution by hydrophobic interactions: evidence from the NMR study of bioactive peptides from the C-terminus of human C5a anaphylatoxin.

D. Ripoll, F. Ni, T. Hugli, 1996, Biopolymers.

Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein.

F. Ni, Zhengding Su, P. Xu, 2004, European journal of biochemistry.

Structural prediction of the β‐domain of metallothionein‐3 by molecular dynamics simulation

F. Ni, Mingjie Zhang, Z. Huang, 2007 .

Vasonatrin peptide, a novel protector of dopaminergic neurons against the injuries induced by n-methyl-4-phenylpyridiniums

F. Ni, W. Fang, Xuelian Wang, 2013, Peptides.

A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor

F. Ni, S. So, K. Ruan, 2008, The FEBS journal.

The Roles of Individual γ-Carboxyglutamate Residues in the Solution Structure and Cation-dependent Properties of Conantokin-T*

L. Pedersen, F. Ni, F. Castellino, 1998, The Journal of Biological Chemistry.

Polymerization of the SAM domain of MAPKKK Ste11 from the budding yeast: Implications for efficient signaling through the MAPK cascades

Feng Ni, F. Ni, L. Johnston, 2005, Protein science : a publication of the Protein Society.

The Role of Ile476 in the Structural Stability and Substrate Binding of Human Cytochrome P450 2C8

F. Ni, Z. Huang, Xiangshi Tan, 2010, The protein journal.

Thrombin‐bound conformation of a cyclic anticoagulant peptide using transferred nuclear Overhauser effect (NOE), distance geometry, and NOE simulations

Y. Konishi, D. Ripoll, F. Ni, 1994, Biopolymers.

Conformational analyses of a partially-folded bioactive prodomain of human furin.

F. Ni, S. Bhattacharjya, P. Xu, 2007, Biopolymers.

Solution structure of the dimeric SAM domain of MAPKKK Ste11 and its interactions with the adaptor protein Ste50 from the budding yeast: implications for Ste11 activation and signal transmission through the Ste50-Ste11 complex.

M. Whiteway, F. Ni, S. Bhattacharjya, 2004, Journal of molecular biology.

High-resolution NMR studies of fibrinogen-like peptides in solution: structural basis for the bleeding disorder caused by a single mutation of Gly(12) to Val(12) in the A alpha chain of human fibrinogen Rouen.

H. Scheraga, Y. Konishi, F. Ni, 1989, Biochemistry.

Development of polyvalent peptide-conjugated magnetic nanoparticles for targeted in-vivo imaging of micro-thrombi.

P. Barber, R. Filfil, F. Ni, 2009, Advances in experimental medicine and biology.

Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone.

F. Ni, P. Xu, G. Willick, 2000, Biochemistry.

Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain.

C. Francis, D. Wagner, F. Ni, 1989, The Journal of clinical investigation.

Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display

A. Lenferink, F. Ni, L. Masson, 2023, mAbs.

Efficient expression of isotopically labeled peptides for high resolution NMR studies: Application to the Cdc42/Rac binding domains of virulent kinases in Candida albicans*

F. Ni, Zhengding Su, M. J. Osborne, 2003, Journal of biomolecular NMR.

The NMR solution structure of the NMDA receptor antagonist, conantokin‐T, in the absence of divalent metal ions

F. Ni, F. Castellino, S. Warder, 1997, FEBS letters.

pH‐induced conformational transitions of a molten–globule–like state of the inhibitory prodomain of furin: Implications for zymogen activation

N. Seidah, M. Chrétien, F. Ni, 2001, Protein science : a publication of the Protein Society.

Refinement of the thrombin‐bound structure of a hirudin peptide by a restrained electrostatically driven Monte Carlo method

D. Ripoll, F. Ni, 1992, Biopolymers.

Incorporation of a glycine within the conserved TCPCP motif of human neuronal growth inhibitory factor significantly reduces its bioactivity.

F. Ni, Z. Huang, Yang Wang, 2008, Biochemical and biophysical research communications.