S. Doublié

发表

Tryptophanyl-tRNA synthetase crystal structure reveals an unexpected homology to tyrosyl-tRNA synthetase.

C. Carter, G. Bricogne, C. Gilmore, 1995, Structure.

Overcoming non-isomorphism by phase permutation and likelihood scoring: solution of the TrpRS crystal structure.

C. Carter, G. Bricogne, C. Gilmore, 1994, Acta crystallographica. Section A, Foundations of crystallography.

Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase

S. Doublié, S. Wallace, A. Prakash, 2016, Nucleic acids research.

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation

C. Marsden, S. Doublié, J. Sweasy, 2017, Oncotarget.

Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).

R. Wood, S. Doublié, Andrew W. Malaby, 2017, Methods in enzymology.

The Motif D Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Critical for Nucleoside 5′-Triphosphate Selectivity*

S. Doublié, B. Canard, C. Richardson, 1999, The Journal of Biological Chemistry.

Probing the structure and function of polymerase θ helicase-like domain.

R. Wood, S. Doublié, Scott Vanson, 2022, DNA repair.

Cryocooling of macromolecular crystals: optimization methods.

E. Garman, S. Doublié, 2003, Methods in enzymology.

Crystallization and preliminary X-ray studies of human vascular anticoagulant protein.

S. Doublié, R. Fourme, G. Bodo, 1989, Journal of molecular biology.

The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage.

S. Doublié, S. Wallace, A. Prakash, 2012, Progress in molecular biology and translational science.

Structural and Biochemical Investigation of the Role in Proofreading of a β Hairpin Loop Found in the Exonuclease Domain of a Replicative DNA Polymerase of the B Family*

S. Doublié, W. Konigsberg, P. Aller, 2007, Journal of Biological Chemistry.

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

S. Doublié, T. Ellenberger, C. Richardson, 1998, Nature.

8-Oxoguanine DNA Glycosylases: One Lesion, Three Subfamilies

Z. Jia, S. Doublié, F. Faucher, 2012, International journal of molecular sciences.

Preparation of selenomethionyl proteins for phase determination.

S. Doublié, 1997, Methods in enzymology.

An open and closed case for all polymerases.

M. Sawaya, S. Doublié, T. Ellenberger, 1999, Structure.

[29] Preparation of selenomethionyl proteins for phase determination.

S. Doublié, 1997, Methods in enzymology.

Fluorescence Resonance Energy Transfer Studies of DNA Polymerase β

K. Anderson, S. Doublié, J. Sweasy, 2014, The Journal of Biological Chemistry.

Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase*

S. Doublié, E. Tchesnokov, M. Götte, 2011, The Journal of Biological Chemistry.

Determinants of substrate specificity in RNA-dependent nucleotidyl transferases.

S. Doublié, W. Keller, G. Martin, 2008, Biochimica et biophysica acta.

The mechanism of action of T7 DNA polymerase.

S. Doublié, T. Ellenberger, Sylvie Doublié, 1998, Current opinion in structural biology.

When DNA Polymerases Multitask: Functions Beyond Nucleotidyl Transfer

R. Wood, S. Doublié, Denisse Carvajal-Maldonado, 2022, Frontiers in Molecular Biosciences.

Macromolecular Crystallography Protocols

Sylvie Doublié, John M. Walker, S. Doublié, 2007, Methods in Molecular Biology.

Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

S. Doublié, S. Wallace, Matthew Hogg, 2004, The EMBO journal.

Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP

S. Doublié, W. Keller, G. Martin, 2000, The EMBO journal.

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

R. Wood, S. Doublié, P. Aller, 2015, Nature Structural &Molecular Biology.

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

David W. Wyatt, Kevin M. McBride, D. Ramsden, 2014, PLoS genetics.

Base Excision Repair in the Mitochondria

S. Doublié, A. Prakash, Aishwarya Prakash, 2015, Journal of cellular biochemistry.

A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol

S. Doublié, P. Aller, S. Wallace, 2007, Proceedings of the National Academy of Sciences.

Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

R. Wood, S. Doublié, S. Wallace, 2011, Journal of molecular biology.

Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases.

S. Doublié, W. Keller, G. Martin, 2014, Journal of molecular biology.

Unique structural features of mammalian NEIL2 DNA glycosylase prime its activity for diverse DNA substrates and environments

S. Doublié, J. Dragon, A. Averill, 2020, bioRxiv.

Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping.

Sylvie Doublié, S. Doublié, Qin Yang, 2011, Structure.

Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3′ processing

Sylvie Doublié, S. Doublié, Qin Yang, 2010, Proceedings of the National Academy of Sciences.

Crystal structure of the 25 kDa subunit of human cleavage factor Im

Sylvie Doublié, Gregory Gilmartin, Georges Martin, 2008, Nucleic acids research.

The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

S. Doublié, J. Sweasy, Khadijeh S. Alnajjar, 2018, The Journal of Biological Chemistry.

The E295K Cancer Variant of Human Polymerase β Favors the Mismatch Conformational Pathway during Nucleotide Selection*

S. Doublié, J. Sweasy, Jamie B. Towle-Weicksel, 2013, The Journal of Biological Chemistry.

DNA polymerase θ (POLQ), double-strand break repair, and cancer.

R. Wood, S. Doublié, 2016, DNA repair.

Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.

S. Doublié, F. Faucher, S. Wallace, 2009, DNA repair.

Structural insights into eukaryotic DNA replication

S. Doublié, K. Zahn, 2014, Front. Microbiol..

Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.

S. Doublié, F. Faucher, V. Bandaru, 2009, Structure.

The structure of human Cleavage Factor Im hints at functions beyond UGUA-specific RNA binding

S. Doublié, Qin Yang, G. Gilmartin, 2011 .

The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing.

S. Doublié, Qin Yang, G. Gilmartin, 2011, RNA biology.

Structural biology of poly(A) site definition

S. Doublié, Qin Yang, 2011, Wiley interdisciplinary reviews. RNA.

Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis

S. Doublié, B. Carroll, J. P. Hanley, 2021, bioRxiv.

Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin.

S. Doublié, P. Aller, C. Burrows, 2010, Biochemistry.

Genome Protection by DNA Polymerase θ.

R. Wood, S. Doublié, 2022, Annual review of genetics.

Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair.

R. Wood, S. Doublié, R. Jensen, 2021, Molecular cell.

The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ.

S. Doublié, M. Greenberg, D. Laverty, 2017, ACS chemical biology.

Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA*

S. Doublié, S. Wallace, K. Imamura, 2011, The Journal of Biological Chemistry.

A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.

S. Doublié, P. Aller, S. Wallace, 2011, Journal of molecular biology.

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions.

S. Doublié, S. Wallace, K. Zahn, 2011, Current opinion in structural biology.

Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69.

S. Doublié, S. Wallace, L. Reha-Krantz, 2010, Biochemistry.

Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase

T. Kunkel, S. Doublié, B. Eichman, 2004, The EMBO journal.

A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation

S. Doublié, A. Shen, B. Eckenroth, 2021, PLoS genetics.

Allosteric activation of CwlD amidase activity by the GerS lipoprotein during Clostridioides difficile spore formation

S. Doublié, A. Shen, C. Feliciano, 2021, bioRxiv.

Chemical modifications of Bacillus subtilis tryptophanyl-tRNA synthetase.

H. Xue, C. Carter, S. Doublié, 1997, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase

S. Doublié, A. Prakash, V. Cao, 2016, PloS one.

Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNA*

S. Doublié, S. Wallace, K. Imamura, 2009, The Journal of Biological Chemistry.

The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity.

S. Doublié, J. Bond, V. Bandaru, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.

S. Doublié, S. Wallace, Minmin Liu, 2013, Mutation research.

Look Ma, no PCNA: how DNA polymerase ε synthesizes long stretches of DNA without a processivity factor

S. Doublié, K. Zahn, 2014, Nature Structural &Molecular Biology.

Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.

S. Doublié, W. Keller, Andreas Möglich, 2004, Journal of molecular biology.

Purification, crystallization and preliminary X-ray diffraction of a disulfide cross-linked complex between bovine poly(A) polymerase and a chemically modified 15-mer oligo(A) RNA.

S. Doublié, F. Faucher, J. Heckman, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Production of selenomethionyl proteins in prokaryotic and eukaryotic expression systems.

S. Doublié, 2007, Methods in molecular biology.

Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damage.

S. Doublié, V. Bandaru, S. Wallace, 2004, Acta crystallographica. Section D, Biological crystallography.

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

S. Doublié, J. Sweasy, J. P. Loria, 2018, Nucleic acids research.

Pol β FRET studies of fingers movement during nucleotide selection 1 Fluorescence resonance energy transfer studies of DNA polymerase beta : The critical role of fingers domain movements and a novel non-covalent step during nucleotide selection

K. Anderson, S. Doublié, J. Sweasy, 2014 .

Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.

S. Doublié, M. Dizdaroglu, P. Aller, 2012, DNA repair.

Structural characterization of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo form and in complex with 8-oxodeoxyguanosine.

S. Doublié, F. Faucher, S. Wallace, 2009, Journal of molecular biology.

The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction.

S. Doublié, F. Faucher, S. Wallace, 2010, Journal of molecular biology.

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7

S. Doublié, T. Ellenberger, JohnB . Taylor, 2004, Nature Structural &Molecular Biology.

Caught bending the A-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide.

S. Doublié, H. Belrhali, S. Wallace, 2007, Biochemistry.

Activation of the Hetero-octameric ATP Phosphoribosyl Transferase through Subunit Interface Rearrangement by a tRNA Synthetase Paralog*

C. Francklyn, S. Doublié, M. Sissler, 2005, Journal of Biological Chemistry.

Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

S. Doublié, J. Sweasy, Antonia A. Nemec, 2017, Biochemistry.

Quantitative analysis of crystal growth. Tryptophanyl-tRNA synthetase crystal polymorphism and its relationship to catalysis.

C. Carter, D. Coleman, S. Doublié, 1994, Journal of molecular biology.

Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.

S. Doublié, S. Wallace, K. Imamura, 2013, Structure.

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

Sylvie Doublié, Cynthia J. Burrows, S. Doublié, 2014, Biochemistry.

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

S. Doublié, J. Sweasy, B. Carroll, 2014, DNA repair.

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

S. Doublié, A. Shen, M. Donnelly, 2018, bioRxiv.

Structural and Functional Analysis of the CspB Protease Required for Clostridium Spore Germination

S. Doublié, A. Shen, E. E. Putnam, 2013, PLoS pathogens.

Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability.

C. Marsden, S. Doublié, J. Sweasy, 2021, DNA repair.

Structural Studies of a Bacterial tRNAHIS Guanylyltransferase (Thg1)-Like Protein, with Nucleotide in the Activation and Nucleotidyl Transfer Sites

S. Doublié, J. Jackman, B. Rao, 2013, PloS one.

tRNAHis guanylyltransferase (THG1), a unique 3′-5′ nucleotidyl transferase, shares unexpected structural homology with canonical 5′-3′ DNA polymerases

Brian A. Smith, S. Doublié, N. Heintz, 2010, Proceedings of the National Academy of Sciences.

Bumps in the road: how replicative DNA polymerases see DNA damage.

S. Doublié, S. Wallace, Matthew Hogg, 2005, Current opinion in structural biology.

Infidelity out in the open.

S. Doublié, 2004, Structure.

A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92.

C. Carter, S. Doublié, A. Szabo, 1996, Journal of molecular biology.

The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site.

S. Doublié, S. Wallace, A. Averill, 2011, Biochemistry.

A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation

P. Sung, S. Doublié, J. Sweasy, 2014, PLoS genetics.

Structure of pseudoprotease CspC from Clostridioides difficile

S. Doublié, A. Shen, M. Donnelly, 2019 .

DNA polymerase θ (POLQ), double-strand break repair, and cancer.

R. Wood, S. Doublié, 2016, DNA repair.

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.

S. Doublié, J. Sweasy, Khadijeh S. Alnajjar, 2017, Biochemistry.

Structural and biochemical insights into NEIL2’s preference for abasic sites

S. Doublié, B. Eckenroth, Joshua D Bumgarner, 2023, Nucleic acids research.