J. Sweasy

发表

K. Eckert, J. Sweasy, J. Lauper, 2006, Radiation research.

The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation

J. Sweasy, T. Lang, S. Dalal, 2007, Molecular and Cellular Biology.

Substrate-dependent millisecond domain motions in DNA polymerase β.

J. Sweasy, S. Dalal, R. Berlow, 2012, Journal of molecular biology.

Colon Cancer-associated DNA Polymerase β Variant Induces Genomic Instability and Cellular Transformation*

J. Sweasy, Antonia A. Nemec, K. Donigan, 2012, The Journal of Biological Chemistry.

Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway.

T. Schlick, Yunlang Li, J. Sweasy, 2012, Journal of the American Chemical Society.

Loop II of DNA polymerase beta is important for discrimination during substrate binding.

K. Eckert, J. Sweasy, J. Jaeger, 2009, DNA repair.

Synthesis of ortho-formylphenylphosphonic acids as covalent probes of active site lysines

J. Sweasy, C. McKenna, B. Kashemirov, 2019, Phosphorus, sulfur, and silicon and the related elements.

Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

Shuangge Ma, M. Krauthammer, Y. Kong, 2020, bioRxiv.

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation

J. Sweasy, S. Maher, A. Bothwell, 2022, PloS one.

Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes

J. Sweasy, J. Hohlbein, M. Mahmoud, 2020, The Journal of Biological Chemistry.

DNA polymerase β fingers movement revealed by single-molecule FRET suggests a partially closed conformation as a fidelity checkpoint

J. Sweasy, J. Hohlbein, M. Mahmoud, 2018, bioRxiv.

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation

C. Marsden, S. Doublié, J. Sweasy, 2017, Oncotarget.

MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

J. Sweasy, Ashley B Sjolund, A. Senejani, 2013, Mutation research.

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

J. Sweasy, D. Kidane, Scott D. Kathe, 2013, Proceedings of the National Academy of Sciences.

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates

J. Sweasy, S. Dalal, T. Nottoli, 2012, Proceedings of the National Academy of Sciences.

Population-specific variation in haplotype composition and heterozygosity at the POLB locus.

K. Kidd, J. Kidd, Eva Straka, 2009, DNA repair.

The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates.

J. Sweasy, S. Dalal, J. Jaeger, 2008, Biochemistry.

Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.

A. Warshel, J. Sweasy, D. Murphy, 2012, Biochemistry.

Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

F. Slack, D. Telesca, J. Weidhaas, 2015, Cell cycle.

Heterozygosity for a Hypomorphic Polβ Mutation Reduces the Expansion Frequency in a Mouse Model of the Fragile X-Related Disorders

J. Sweasy, K. Usdin, R. Lokanga, 2015, PLoS genetics.

The role of cysteines in the structure and function of OGG1

J. Sweasy, Khadijeh S. Alnajjar, Katarina Wang, 2020, The Journal of biological chemistry.

Tumor‐associated mutations in O6‐methylguanine DNA‐methyltransferase (MGMT) reduce DNA repair functionality

P. Sung, J. Sweasy, S. Rockwell, 2014, Molecular carcinogenesis.

DNA repair and systemic lupus erythematosus.

J. Sweasy, Rithy Meas, M. Burak, 2017, DNA repair.

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli.

J. Sweasy, J. McCall, V. Roegner-Maniscalco, 1987, Proceedings of the National Academy of Sciences of the United States of America.

A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice

P. Gaffney, L. Criswell, J. Sweasy, 2022, ACR open rheumatology.

Revealing an internal stabilization deficiency in the DNA polymerase β K289M cancer variant through combined use of chemical biology and X-ray crystallography.

Samuel H. Wilson, J. Sweasy, V. Batra, 2020, Biochemistry.

DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

J. Sweasy, K. Donigan, D. Tuck, 2012, Mutagenesis.

Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli.

L. Loeb, J. Sweasy, Lawrence A. Loeb, 1992, The Journal of biological chemistry.

Evelyn M. Witkin Awarded the National Medal of Science

J. Sweasy, 2004, Radiation research.

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

J. Weidhaas, J. Sweasy, K. Donigan, 2014, Nucleic acids research.

Title Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD 51 recombinase Permalink

J. Weidhaas, J. Sweasy, K. Donigan, 2015 .

Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes.

J. Sweasy, J. Hohlbein, M. Mahmoud, 2020, The Journal of biological chemistry.

Evidence against DNA polymerase β as a candidate gene for Werner syndrome

G. Schellenberg, C. Disteche, T. Ogihara, 1994, Human Genetics.

Cost-Effectiveness and Economic Burden Analyses on all First-Line Treatments of Chronic Lymphocytic Leukemia.

B. Erstad, J. Sweasy, I. Abraham, 2022, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

Fluorescence Resonance Energy Transfer Studies of DNA Polymerase β

K. Anderson, S. Doublié, J. Sweasy, 2014, The Journal of Biological Chemistry.

Evidence for a role for DNA polymerase β in mammalian meiosis

J. Sweasy, T. Ashley, A. Plug, 1997 .

The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.

J. Sweasy, I. Alvarado-Cruz, Mohammed Khan, 2019, Mutagenesis.

DNA polymerase beta is critical for genomic stability of sperm cells.

D. Zelterman, J. Sweasy, S. Dalal, 2011, DNA repair.

Is Base Excision Repair a Tumor Suppressor Mechanism?

J. Sweasy, T. Lang, D. DiMaio, 2006, Cell cycle.

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

J. Sweasy, T. Lang, S. Dalal, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Is There a Link Between DNA Polymerase Beta and Cancer?

J. Sweasy, S. Dalal, D. Starcevic, 2004, Cell cycle.

A genetic system to identify DNA polymerase β mutator mutants

B. Preston, K. Eckert, J. Sweasy, 1997 .

Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli.

L. Loeb, J. Sweasy, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of DNA polymeraseβ mutants with amino acid substitutions located in the C-terminal portion of the enzyme

J. Sweasy, M. S. Yoon, 1995, Molecular and General Genetics MGG.

A new perspective on oxidation of DNA repair proteins and cancer.

J. Sweasy, Khadijeh S. Alnajjar, 2019, DNA repair.

Targeting Cancer with a Lupus Autoantibody

P. Sung, J. Sweasy, S. Dalal, 2012, Science Translational Medicine.

Base excision repair and cancer.

J. Sweasy, D. Murphy, S. Wallace, 2012, Cancer letters.

Mutation of A DNA Repair Enzyme Causes Lupus in Mice

C. Zeiss, D. Zelterman, J. Sweasy, 2016 .

Mutation of POLB causes lupus in mice.

C. Zeiss, D. Zelterman, J. Sweasy, 2014, Cell reports.

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

Samuel H. Wilson, J. Sweasy, W. Beard, 2018, Biochemistry.

Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential

Joanna A Gibson, E. Stoffel, J. Sweasy, 2021, British Journal of Cancer.

Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

P. Glazer, J. Sweasy, S. Dalal, 2010, Cancer research.

Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA.

J. Sweasy, R. Lloyd, M. Dizdaroglu, 2022, DNA repair.

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity

C. Marsden, J. Sweasy, M. Dizdaroglu, 2020, Oncotarget.

Cellular Roles of DNA Polymerase Beta

J. Sweasy, M. Menezes, A. Senejani, 2013, The Yale journal of biology and medicine.

Interplay between DNA repair and inflammation, and the link to cancer

P. Glazer, K. Eckert, J. Sweasy, 2014, Critical reviews in biochemistry and molecular biology.

Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes.

C. Marsden, J. Sweasy, D. S. Pederson, 2017, DNA repair.

Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells.

Shuangge Ma, M. Krauthammer, Y. Kong, 2020, Biochemical pharmacology.

Y265H Mutator Mutant of DNA Polymerase β

K. Anderson, J. Sweasy, Amit M. Shah, 2001, The Journal of Biological Chemistry.

Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer–Associated R438W DNA Polymerase Lambda Protein

B. F. Taylor, J. Weidhaas, J. Sweasy, 2016, Molecular Cancer Research.

The S229L Colon Tumor-associated Variant of DNA Polymerase β Induces Cellular Transformation as a Result of Decreased Polymerization Efficiency*

J. Sweasy, Antonia A. Nemec, K. Donigan, 2014, The Journal of Biological Chemistry.

Tipping the Balance in the Powerhouse of the Cell to “Protect” Colorectal Cancer

J. Sweasy, D. Kidane, 2012, PLoS genetics.

The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.

K. Eckert, J. Sweasy, K. Donigan, 2012, DNA repair.

Sequence context‐specific mutagenesis and base excision repair

J. Sweasy, K. Donigan, 2009, Molecular carcinogenesis.

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

J. Sweasy, S. Dalal, A. Chikova, 2007, Nucleic acids research.

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site.

J. Sweasy, S. Dalal, J. Kosa, 2004, The Journal of biological chemistry.

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.

P. Glazer, J. Sweasy, C. Clairmont, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

C. Marsden, J. Sweasy, E. Rothenberg, 2016, PLoS genetics.

Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae

J. Sweasy, C. Clairmont, 1996, Journal of bacteriology.

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase (cid:2)

J. Sweasy, N. M. Hoitsma, Mallory R. Smith, 2020 .

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β

J. Sweasy, Khadijeh S. Alnajjar, N. M. Hoitsma, 2019, The Journal of Biological Chemistry.

The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

S. Doublié, J. Sweasy, Khadijeh S. Alnajjar, 2018, The Journal of Biological Chemistry.

The E295K Cancer Variant of Human Polymerase β Favors the Mismatch Conformational Pathway during Nucleotide Selection*

S. Doublié, J. Sweasy, Jamie B. Towle-Weicksel, 2013, The Journal of Biological Chemistry.

DNA polymerase beta participates in DNA End-joining

Gregory A. Breuer, D. Zelterman, J. Sweasy, 2017, Nucleic acids research.

DNA polymerase family X: function, structure, and cellular roles.

J. Sweasy, J. Yamtich, Jennifer Yamtich, 2010, Biochimica et biophysica acta.

RecA protein of Escherichia coli has a third essential role in SOS mutator activity

J. Sweasy, V. Roegner-Maniscalco, E. Witkin, 1990, Journal of bacteriology.

Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector

J. Sweasy, A. Senejani, 2010, Genome Integrity.

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

J. Sweasy, Antonia A. Nemec, D. Kidane, 2015, Oncotarget.

Timing Is Everything: Misincorporation of 8oxodG during Mitosis Is Lethal

J. Sweasy, Khadijeh S. Alnajjar, 2020, Cancer Research.

DNA Polymerase β Interacts with TRF2 and Induces Telomere Dysfunction in a Murine Mammary Cell Line

J. Sweasy, O. Henegariu, P. Fotiadou, 2004, Cancer Research.

Mechanistic understanding of cellular responses to genomic stress

P. Hanawalt, J. Sweasy, 2019, Environmental and molecular mutagenesis.

The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery

J. Sweasy, D. Kidane, P. Graumann, 2012, Critical reviews in biochemistry and molecular biology.

The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation.

B. F. Taylor, J. Sweasy, D. Sizova, 2015, DNA repair.

DNA polymerase beta can substitute for DNA polymerase I in the initiation of plasmid DNA replication

L. Loeb, J. Sweasy, M. Chen, 1995, Journal of bacteriology.

DNA Polymerase 4 of Saccharomyces cerevisiae Is Important for Accurate Repair of Methyl-Methanesulfonate-Induced DNA Damage

J. Sweasy, Catherine H. Sterling, 2006, Genetics.

Survival trends in chronic lymphocytic leukemia across treatment eras: US SEER database analysis (1985–2017)

B. Erstad, J. Sweasy, I. Abraham, 2021, Annals of Hematology.

Comparative Efficacy of First-Line Treatments of Chronic Lymphocytic Leukemia: Network Meta-Analyses of Survival Curves.

B. Erstad, J. Sweasy, I. Abraham, 2021, Clinical lymphoma, myeloma & leukemia.

Increased Activity and Fidelity of DNA Polymerase β on Single-nucleotide Gapped DNA*

B. Preston, J. Sweasy, A. Chagovetz, 1997, The Journal of Biological Chemistry.

Fidelity Mechanisms of DNA Polymerase β

J. Sweasy, 2003 .

A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation

J. Sweasy, Antonia A. Nemec, Joann B. Sweasy, 2012, PLoS genetics.

Title: Investigation of discordant sibling pairs from hereditary breast cancer families and analysis of a rare PMS1 variant

J. Sweasy, J. Dragon, M. Cuke, 2021, Cancer Genetics.

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

S. Doublié, J. Sweasy, J. P. Loria, 2018, Nucleic acids research.

A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant.

J. Sweasy, M. Goodman, C. McKenna, 2017, Biochemistry.

Pol β FRET studies of fingers movement during nucleotide selection 1 Fluorescence resonance energy transfer studies of DNA polymerase beta : The critical role of fingers domain movements and a novel non-covalent step during nucleotide selection

K. Anderson, S. Doublié, J. Sweasy, 2014 .

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity.

K. Anderson, J. Sweasy, A. M. Shah, 2001, The Journal of biological chemistry.

MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease

N. Kaminski, J. Sweasy, R. Bindra, 2020, JCI insight.

Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD

N. Kaminski, J. Sweasy, R. Bindra, 2020, bioRxiv.

DNA repair and personalized breast cancer therapy

L. Harris, J. Sweasy, Ashley B Sjolund, 2010, Environmental and molecular mutagenesis.

Variant base excision repair proteins: contributors to genomic instability.

J. Sweasy, Antonia A. Nemec, S. Wallace, 2010, Seminars in cancer biology.

Base Excision Repair Variants in Cancer.

C. Marsden, J. Sweasy, J. Dragon, 2017, Methods in enzymology.

NTHL1 in genomic integrity, aging and cancer.

J. Sweasy, Lipsa Das, Victoria Quintana, 2020, DNA repair.

Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection

J. Sweasy, D. Murphy, D. Kidane, 2014, Oncogenesis.

RecA kicks Pol V into gear

J. Sweasy, 2005, Nature Structural &Molecular Biology.

Novel SOS phenotypes caused by second-site mutations in the recA430 gene of Escherichia coli.

J. Sweasy, E. Witkin, 1991, Biochimie.

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

D. Zelterman, P. Glazer, J. Sweasy, 2017, Molecular Cancer Research.

Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β.

J. Sweasy, S. Dalal, J. Jaeger, 2013, Biochemistry.

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.

J. Sweasy, D. Murphy, J. Jaeger, 2008, Biochemistry.

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors.

K. Eckert, J. Sweasy, P. Opresko, 1998, Biochemistry.

Threonine 79 Is a Hinge Residue That Governs the Fidelity of DNA Polymerase β by Helping to Position the DNA within the Active Site*

K. Eckert, J. Sweasy, Y. Matsumoto, 2002, The Journal of Biological Chemistry.

Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

S. Doublié, J. Sweasy, Antonia A. Nemec, 2017, Biochemistry.

Fidelity mechanisms of DNA polymerase beta.

J. Sweasy, 2003, Progress in nucleic acid research and molecular biology.

Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair

A. Tomkinson, J. Sweasy, D. Murphy, 2011, Molecular and Cellular Biology.

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

Sylvie Doublié, Cynthia J. Burrows, S. Doublié, 2014, Biochemistry.

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

S. Doublié, J. Sweasy, B. Carroll, 2014, DNA repair.

Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors*

Daniel Zelterman, Xiangyu Cong, D. Zelterman, 2012, The Journal of Biological Chemistry.

Pools and Pols: Mechanism of a mutator phenotype

J. Sweasy, C. Sohl, Sreerupa Ray, 2015, Proceedings of the National Academy of Sciences.

DNA polymerase β is critical for mouse meiotic synapsis

Daniel Zelterman, Scott Keeney, S. Keeney, 2010, The EMBO journal.

Mouse models of DNA polymerases

J. Sweasy, M. Menezes, Joann B. Sweasy, 2012, Environmental and molecular mutagenesis.

A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity.

J. Sweasy, D. Murphy, J. Jaeger, 2011, Journal of the American Chemical Society.

Interaction of DNA polymerase beta with GRIP1 during meiosis.

J. Sweasy, A. Jonason, S. Baker, 2001, Chromosoma.

Evidence for a role for DNA polymerase beta in mammalian meiosis.

J. Sweasy, T. Ashley, A. Plug, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.

K. Eckert, J. Sweasy, S. Dalal, 2005, Biochemistry.

Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate.

J. Sweasy, Amit M. Shah, Mausumi Maitra, 2003, Biochemistry.

A DNA polymerase β mutant from colon cancer cells induces mutations

J. Sweasy, T. Lang, D. Starcevic, 2004 .

Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability.

C. Marsden, S. Doublié, J. Sweasy, 2021, DNA repair.

3′-Azido-3′-deoxythymidine-resistant Mutants of DNA Polymerase β Identified by in Vivo Selection*

J. Sweasy, J. Kosa, 1999, The Journal of Biological Chemistry.

Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells

J. Sweasy, D. Kidane, T. Nottoli, 2013, PloS one.

Loop II of DNA polymerase beta is important for polymerization activity and fidelity

J. Sweasy, J. Jaeger, G. Lin, 2007, Nucleic acids research.

Selection NucleotideConformational Pathway during Favors the Mismatch β Polymerase The E 295 K Cancer Variant of Human Protein Structure and Folding :

J. Sweasy, Sylvie, B. Eckenroth, 2013 .

The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.

J. Sweasy, K. Donigan, D. Murphy, 2012, Biochemistry.

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.

J. Sweasy, J. Lauper, J. Jaeger, 2010, Biochemistry.

Functional Roles and Cancer Variants of the Bifunctional Glycosylase NEIL2.

J. Sweasy, A. Hua, 2023, Environmental and molecular mutagenesis.

Cellular Roles of DNA Polymerase Beta

J. Sweasy, M. Menezes, A. Senejani, 2013, The Yale journal of biology and medicine.

A DNA polymerase beta mutant from colon cancer cells induces mutations.

J. Sweasy, T. Lang, D. Starcevic, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A genetic system to identify DNA polymerase beta mutator mutants.

B. Preston, K. Eckert, J. Sweasy, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Dna polymerases and their role in genomic stability

K. Eckert, J. Sweasy, 2012, Environmental and molecular mutagenesis.

The E249K Mutator Mutant of DNA Polymerase β Extends Mispaired Termini*

J. Sweasy, J. Kosa, 1999, The Journal of Biological Chemistry.

A pre-catalytic non-covalent step governs DNA polymerase β fidelity

J. Sweasy, M. Goodman, C. McKenna, 2019, Nucleic acids research.

The Pol β-14 Dominant Negative Rat DNA Polymerase β Mutator Mutant Commits Errors during the Gap-Filling Step of Base Excision Repair in Saccharomyces cerevisiae

J. Sweasy, C. Clairmont, 1998, Journal of bacteriology.

The Hydrophobic Hinge Region of Rat DNA Polymerase β Is Critical for Substrate Binding Pocket Geometry*

J. Sweasy, S. Dalal, J. Jaeger, 2005, Journal of Biological Chemistry.

A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation

P. Sung, S. Doublié, J. Sweasy, 2014, PLoS genetics.

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

J. Sweasy, M. Goodman, C. McKenna, 2017, Biochemistry.

DNA Polymerase Beta Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity Towards β - γ Bridging Group of the Incoming dNTP

J. Sweasy, M. Goodman, Khadijeh S. Alnajjar, 2017 .

A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability.

J. Sweasy, A. Capaldi, J. Jäger, 2001, Biochemistry.

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates.

J. Sweasy, J. A. Vaccaro, S. X. Li, 1999, Biochemistry.

Interaction of DNA polymerase β with GRIP1 during meiosis

J. Sweasy, A. Jonason, S. Baker, 2001, Chromosoma.

Pools and Pols: Mechanism of a mutator phenotype

J. Sweasy, C. Sohl, Sreerupa Ray, 2015, Proceedings of the National Academy of Sciences.

Loop II of DNA polymerase beta is important for polymerization activity and fidelity

J. Sweasy, J. Jaeger, G. Lin, 2007, Nucleic acids research.

DNA Polymerase β in the Context of Cancer.

J. Sweasy, D. Sawyer, 2022, Critical reviews in oncogenesis.

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.

S. Doublié, J. Sweasy, Khadijeh S. Alnajjar, 2017, Biochemistry.

Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.

A. Warshel, J. Sweasy, D. Murphy, 2012, Biochemistry.

Evelyn Witkin and the coordinated response to DNA damage.

J. Sweasy, H. Lieberman, M. Volkert, 2015, DNA repair.