M. Tsai

发表

DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

X. Zhong, B. Werneburg, J. Ahn, 1996, Biochemistry.

DNA Polymerase β: Structure−Fidelity Relationship from Pre-Steady-State Kinetic Analyses of All Possible Correct and Incorrect Base Pairs for Wild Type and R283A Mutant†

B. Werneburg, J. Ahn, M. Tsai, 1997 .

Investigation of the conformational states of Wzz and the Wzz.O-antigen complex under near-physiological conditions.

M. Tsai, K. Tang, Hongjie Guo, 2007, Biochemistry.

Structure and Function of the Phosphothreonine-Specific FHA Domain

Pei-Yu Wu, Ming-Daw Tsai, Anjali Mahajan, 2008, Science Signaling.

Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2.

D. Velmurugan, A. Jeyaprakash, M. Tsai, 2003, Journal of molecular biology.

Pancreatic phospholipase A(2): new views on old issues.

M. Tsai, C. Yuan, 1999, Biochimica et biophysica acta.

Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover.

M. Gelb, M. Tsai, M. Jain, 1992, Biochemistry.

Crystal structure of the Y52F/Y73F double mutant of phospholipase A2: Increased hydrophobic interactions of the phenyl groups compensate for the disrupted hydrogen bonds of the tyrosines

B. Ramakrishnan, M. Sundaralingam, M. Tsai, 1992, Protein science : a publication of the Protein Society.

Phospholipids chiral at phosphorus. Use of chiral thiophosphatidylcholine to study the metal-binding properties of bee venom phospholipase A2.

M. Tsai, R. Jiang, T. Tsai, 1985, Biochemistry.

Phospholipase A2 engineering: Design, synthesis, and expression of a gene for bovine (pro)phospholipase A2

J. Noel, M. Tsai, 1989, Journal of cellular biochemistry.

Phospholipase A2 engineering. 4. Can the active-site aspartate-99 function alone?

J. Noel, M. Tsai, T. Deng, 1990 .

Ankyrin repeat: a unique motif mediating protein-protein interactions.

M. Tsai, A. Mahajan, Junan Li, 2006, Biochemistry.

Mechanism of adenylate kinase. The "essential lysine" helps to orient the phosphates and the active site residues to proper conformations.

M. Tsai, L. Byeon, Z. Shi, 1995, Biochemistry.

Tumor Suppressor p16INK4A: Structural Characterization of Wild-Type and Mutant Proteins by NMR and Circular Dichroism†

V. Kraynov, M. Tsai, T. Selby, 1996 .

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

Y. Bessho, M. Tsai, J. Liao, 2018, Chembiochem : a European journal of chemical biology.

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

Y. Bessho, T. Hsiao, M. Tsai, 2018 .

Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.

M. Tsai, I. Byeon, Hongyuan Li, 2004, Journal of molecular biology.

Structure-based combinatorial protein engineering (SCOPE).

Paul E O'Maille, Ming-Daw Tsai, M. Tsai, 2002, Journal of molecular biology.

Splase: A new class IIs zinc-finger restriction endonuclease with specificity for Sp1 binding sites

M. Tsai, Baohua Huang, Qunhui Li, 1996, Journal of protein chemistry.

Structural delineation of MDC1-FHA domain binding with CHK2-pThr68.

M. Tsai, P. Wu, Hsin-Hui Wu, 2012, Biochemistry.

Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67

A. Gronenborn, M. Tsai, I. Byeon, 2005, Nature Structural &Molecular Biology.

The ligand specificity of yeast Rad53 FHA domains at the +3 position is determined by nonconserved residues.

Ming-Daw Tsai, Suganya Yongkiettrakul, M. Tsai, 2004, Biochemistry.

Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies.

Ming-Daw Tsai, Dongyan Qin, M. Tsai, 2003, Biochemical and biophysical research communications.

FHA: a signal transduction domain with diverse specificity and function.

M. Tsai, 2002, Structure.

Activation B κ Factor Alpha Stimulation and NF- and TIFA-pT Mediates Tumor Necrosis Intermolecular Binding between TIFA-FHA

M. Tsai, Shui-Tsung Chen, P. Hsu, 2012 .

Intermolecular Binding between TIFA-FHA and TIFA-pT Mediates Tumor Necrosis Factor Alpha Stimulation and NF-κB Activation

M. Tsai, A. H. Wang, Shui-Tsung Chen, 2012, Molecular and Cellular Biology.

Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

Y. Joti, K. Tono, Chiung-wen Chang, 2022, Nature Chemistry.

Database search algorithm for identification of intact cross-links in proteins and peptides using tandem mass spectrometry.

Michael A. Freitas, M. Tsai, P. Hsu, 2010, Journal of proteome research.

Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9.

M. Tsai, D. Pei, C. Yuan, 2000, Journal of molecular biology.

Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.

Y. Bessho, T. Matsui, M. Tsai, 2017, Biochemistry.

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

Ying-Ta Wu, Chung-Yi Wu, Chi-Huey Wong, 2010, Proceedings of the National Academy of Sciences.

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein.

Chi‐Huey Wong, M. Tsai, Jim-Min Fang, 2019, Journal of medicinal chemistry.

SUMOylation of Blimp‐1 is critical for plasma cell differentiation

H. Shih, M. Tsai, P. Hsu, 2012, EMBO reports.

Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells*

M. Tsai, Sheng‐Chung Lee, P. Hsu, 2013, The Journal of Biological Chemistry.

Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).

W. Melvin, S. Joo, M. Tsai, 2005, Biochemistry.

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.

Y. Bessho, M. Tsai, T. Ko, 2019, Journal of the American Chemical Society.

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors

B. Casto, W. Melvin, M. Tsai, 2003 .

Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing

M. Tsai, A. H. Wang, S. LinWu, 2019, Communications Biology.

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.

Y. Jeng, M. Tsai, Phang-lang Chen, 2012, Molecular cell.

Protein Kinase A-mediated Serine 35 Phosphorylation Dissociates Histone H1.4 from Mitotic Chromosome*

L. Tora, M. Tsai, Pei-wen Lo, 2011, The Journal of Biological Chemistry.

Phosphorylation of mRNA Decapping Protein Dcp1a by the ERK Signaling Pathway during Early Differentiation of 3T3-L1 Preadipocytes

M. Tsai, Sheng‐Chung Lee, P. Hsu, 2013, PloS one.

Mechanism of adenylate kinase. Does adenosine 5'-triphosphate bind to the adenosine 5'-monophosphate site?

M. Tsai, Y. Shyy, G. Tian, 1987, Biochemistry.

Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA

Y. Bessho, M. Tsai, L. Essen, 2018, IUCrJ.

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser 633

M. Tsai, Yi Fu, P. Hsu, 2009 .

Temperature-resolved Cryo-EM Uncovers Structural Bases of Temperature-dependent Enzyme Functions.

M. Tsai, Yuan-Chih Chang, Chun-Hsiang Huang, 2019, Journal of the American Chemical Society.

Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates.

M. Sundaralingam, J. Noel, M. Tsai, 1993, Biochemistry.

Does the Magnesium ( 11 ) Ion Interact with the a-Phosphate of Adenosine Triphosphate ? An Investigation by Oxygen-17 Nuclear Magnetic Resonance ?

M. Tsai, Shuyen L. Huang, 2001 .

Efficient and systematic syntheses of enantiomerically pure and regiospecifically protected myo-inositols

M. Tsai, K. Bruzik, 1992 .

Nonhydrolyzable Heptose Bis‐ and Monophosphate Analogues Modulate Pro‐inflammatory TIFA‐NF‐κB Signaling

M. Tsai, P. Wu, W. Herrebout, 2020, Chembiochem : a European journal of chemical biology.

STRENDA DB: enabling the validation and sharing of enzyme kinetics data

Barbara M. Bakker, A. Cornish-Bowden, H. Westerhoff, 2018, The FEBS journal.

Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

Y. Joti, K. Tono, Chiung-wen Chang, 2022, Nature Chemistry.

Phospholipids Chiral at Phosphorus. 13. Stereochemical Comparison of Phospholipase A2, Lecithin-Cholesterol Acyl Transferase, and Platelet-Activating Factor

J. Noel, M. Tsai, H. Pownall, 1987 .

Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor.

M. Tsai, D. Hanahan, R. Jiang, 1988, Biochemistry.

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response

H. Shih, M. Tsai, P. Hsu, 2013, The EMBO journal.

Humoral Immunity against Capsule Polysaccharide Protects the Host from magA+Klebsiella pneumoniae-Induced Lethal Disease by Evading Toll-Like Receptor 4 Signaling

Chi-Hung Lin, T. Chou, M. Tsai, 2008, Infection and Immunity.

Mechanism of adenylate kinase. The conserved aspartates 140 and 141 are important for transition state stabilization instead of substrate-induced conformational changes.

M. Tsai, T. Dahnke, 1994, The Journal of biological chemistry.

Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.

M. Tsai, C. Teng, S. Hsu, 2017, Cancer research.

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells

M. Tsai, P. Hsu, W. Wu, 2016, Cell Death and Differentiation.

Molecular and Cellular Pathobiology Histone Demethylase RBP 2 Promotes Lung Tumorigenesis and Cancer Metastasis

Hsien-Da Huang, Y. Jeng, F. Lin, 2013 .

Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.

M. Tsai, C. Weghorst, C. Yuan, 2013, Biochemical and biophysical research communications.

Nonhydrolyzable analogs of phosphatidylinositol as ligands of phospholipases C

M. Tsai, K. Bruzik, A. Kravchuk, 2010 .

SYNTHESIS OF ENANTIOMERICALLY PURE PHOSPHOROTHIOLATE ASSAY SUBSTRATE FOR PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C

M. Tsai, S. Riddle, K. Bruzik, 1997 .

Synthesis of a biotinylated heptose 1,7-bisphosphate analogue, a probe to study immunity and inflammation.

M. Tsai, Jun-Jun Cao, T. Wei, 2021, Organic & biomolecular chemistry.

Is the binding of magnesium (II) to calmodulin significant? An investigation by magnesium-25 nuclear magnetic resonance.

M. Tsai, S. Forsén, E. Thulin, 1987, Biochemistry.

Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C.

M. Tsai, S. Rhee, K. Bruzik, 1992, Biochemistry.

Phospholipids chiral at phosphorus. Stereochemical mechanism of reactions catalyzed by phosphatidylinositide-specific phospholipase C from Bacillus cereus and guinea pig uterus.

C. F. Bennett, M. Tsai, G. Lin, 1990, Biochemistry.

Reversible Acetylation Regulates Salt-inducible Kinase (SIK2) and Its Function in Autophagy*

Chau-Chung Han, M. Tsai, Sheng‐Chung Lee, 2013, The Journal of Biological Chemistry.

Mechanism of adenylate kinase. Is there a relationship between local substrate dynamics, local binding energy, and the catalytic mechanism?

C. Sanders, M. Tsai, G. Tian, 1989, Biochemistry.

The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner.

W. Melvin, M. Tsai, P. Muscarella, 2004, Biochemistry.

Phospholipids chiral at phosphorus. Properties of small unilamellar vesicles of chiral thiophosphatidylcholine.

M. Tsai, R. Jiang, T. Tsai, 1984, Biochemistry.

Phospholipids chiral at phosphorus: Synthesis of dioleoylthiophosphatidylcholine and stereospecificity of lecithin-cholesterol acyltransferase

M. Tsai, R. Jiang, T. Rosario-Jansen, 1990 .

PHOSPHOLIPIDS CHIRAL AT PHOSPHORUS. 2. PREPARATION, PROPERTY, AND APPLICATION N OF CHIRAL THIOPHOSPHOLIPIDS

M. Tsai, K. Bruzik, S. M. Gupte, 1982 .

Binding proteins on synaptic membranes for crotoxin and taipoxin, two phospholipases A2 with neurotoxicity.

M. Tsai, C. M. Dupureur, C. Yen, 1995, Toxicon : official journal of the International Society on Toxinology.

X-ray structure of the R69D phosphatidylinositol-specific phospholipase C enzyme: insight into the role of calcium and surrounding amino acids in active site geometry and catalysis.

M. Tsai, D. Apiyo, T. Selby, 2005, Biochemistry.

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

M. Tsai, Jaulang Hwang, M. Hwang, 2014, Developmental cell.

Natural Product Chemistry: From Plants to Human

M. Tsai, 1997 .

Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C?

M. Tsai, A. Hakeem, K. Bruzik, 1994, Biochemistry.

Efficient and Systematic Syntheses of Enantiomerically Pure and Regiospecifically Protected myo-Inositols.

M. Tsai, K. Bruzik, 1992 .

Phospholipids chiral at phosphorus: Synthesis and configurational assignment of phosphorothioate analogs of phosphatidylserine☆

M. Tsai, W. Loffredo, 1990 .

Phospholipids chiral at phosphorus. XVIII: Stereochemistry of phosphatidylinositide-specific phospholipase C

M. Tsai, G. Lin, 1989 .

Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A.

M. Tsai, T. Ko, Hung‐wen Liu, 2021, Journal of the American Chemical Society.

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.

M. Tsai, C. Chou, Yu-Ting Huang, 2011, Nature chemical biology.

Chiral methyl groups.

M. Tsai, H. Floss, 1979, Advances in enzymology and related areas of molecular biology.

Conformation-reactivity relationship for pyridoxal Schiff's bases. Rates of racemization and alpha-hydrogen exchange of the pyridoxal Schiff's bases of amino acids.

M. Tsai, S. Byrn, H. Floss, 1978, Biochemistry.

Toward the mechanism of phosphoinositide-specific phospholipases C.

M. Tsai, K. Bruzik, 1994, Bioorganic & medicinal chemistry.

Does the magnesium(II) ion interact with the alpha-phosphate of adenosine triphosphate? An investigation by oxygen-17 nuclear magnetic resonance.

M. Tsai, S. Huang, 1982, Biochemistry.

Conformational analysis of pyridoxal Schiff's bases. Nuclear magnetic resonance studies of the conformations about the C4-C4', Calpha-Cbeta, and N-Calpha bonds of the pyridoxal Schiff's bases of amino acids.

M. Tsai, S. Byrn, H. Floss, 1978, Biochemistry.

Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays.

M. Tsai, J. Heierhorst, E. Chen, 2017, Methods in enzymology.

Applicability of the phosphorus-31 (oxygen-17) nuclear magnetic resonance method in the study of enzyme mechanism involving phosphorus.

M. Tsai, J. Kozlowski, S. Huang, 1980, Biochemistry.

Use of phosphorus-31 nuclear magnetic resonance to distinguish bridge and nonbridge oxygens of oxygen-17-enriched nucleoside triphosphates. Stereochemistry of acetate activation by acetyl coenzyme A synthetase.

M. Tsai, 1979, Biochemistry.

Phospholipids chiral at phosphorus. Dramatic effects of phosphorus chirality on the deuterium NMR properties of the choline head group of phospholipids in the liquid crystalline phase.

M. Tsai, R. Jiang, W. Loffredo, 1990, Biochemistry.

Stereochemistry of biological reactions at proprochiral centers

M. Tsai, R. Woodard, H. Floss, 2007 .

Mechanism of adenylate kinase. Are the essential lysines essential?

M. Tsai, F. Kishi, R. Jiang, 1990, Biochemistry.

Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase.

M. Tsai, Tsung-Lin Li, Chang-Jer Wu, 2014, Acta crystallographica. Section D, Biological crystallography.

Terpenes and sterols of Cunninghamia konishii

M. Tsai, Y. S. Cheng, 1972 .

Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β.

M. Tsai, P. Balbo, E. Wang, 2011, Biochemistry.

A unified kinetic mechanism applicable to multiple DNA polymerases.

Michelle P. Roettger, M. Tsai, M. Bakhtina, 2007, Biochemistry.

Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.

M. Tsai, Yu-Ting Huang, Tsung-Lin Li, 2006, Journal of the American Chemical Society.

Phospholipids chiral at phosphorus. Preparation and spectral properties of chiral thiophospholipids.

M. Tsai, R. Jiang, K. Bruzik, 1983, Biochemistry.

Ligand-protein interactions via nuclear magnetic resonance of quadrupolar nuclei.

C. Sanders, M. Tsai, 1989, Methods in enzymology.

Steric Course of the Reaction Catalyzed by Phosphatidylserine Decarboxylase from Escherichia-Coli

C. Sanders, M. Tsai, W. Dowhan, 1988 .

Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions.

M. Tsai, E. Conn, H. Floss, 1978, Archives of biochemistry and biophysics.

Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.

M. Tsai, Tsung-Lin Li, Chang-Jer Wu, 2014, Journal of the American Chemical Society.

Stereochemistry and mechanism of reactions catalyzed by tryptophanase Escherichia coli.

J. Vederas, E. Schleicher, M. Tsai, 1978, The Journal of biological chemistry.

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.

Ming-Daw Tsai, M. Tsai, M. Poi, 2011, Biochemistry.

Human p16γ, a novel transcriptional variant of p16INK4A, coexpresses with p16INK4A in cancer cells and inhibits cell-cycle progression

Trees-Juen Chuang, A. Yang, M. Tsai, 2007, Oncogene.

Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression.

Trees-Juen Chuang, A. Yang, M. Tsai, 2007, Oncogene.

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.

H. J. Kim, M. Tsai, T. Selby, 1998, Molecular cell.

Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.

M. Tsai, Tsung-Lin Li, Chang-Jer Wu, 2014, Angewandte Chemie.

Phospholipase A2 engineering. 3. Replacement of lysine-56 by neutral residues improves catalytic efficiency significantly, alters substrate specificity, and clarifies the mechanism of interfacial recognition

J. Noel, M. Tsai, T. Deng, 1990 .

Stereochemistry of the hydrolysis of adenosine 5'-thiophosphate catalyzed by venom 5'-nucleotidase.

M. Tsai, 1980, Biochemistry.

Phospholipase stereospecificity at phosphorus.

M. Tsai, K. Bruzik, 1991, Methods in enzymology.

Practical synthesis of enantiomerically pure myo-inositol derivatives

M. Tsai, K. Bruzik, Jeffrey D. Myers, 1992 .

Ultrafast Water Dynamics at the Interface of the Polymerase–DNA Binding Complex

M. Tsai, Yi Yang, Lijuan Wang, 2014, Biochemistry.

ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.

M. Tsai, B. Lamarche, Sandeep Kumar, 2006, Biochemistry.

Phospholipids chiral at phosphorus. Absolute configuration of chiral thiophospholipids and stereospecificity of phospholipase D.

M. Tsai, Y. Shyy, R. Jiang, 1984, Biochemistry.

Amino Acid Substitutions of MagA in Klebsiella pneumoniae Affect the Biosynthesis of the Capsular Polysaccharide

A. Yang, Hung-Pin Peng, M. Tsai, 2012, PloS one.

How DNA polymerases catalyse replication and repair with contrasting fidelity

Wei Yang, M. Tsai, Wen-Jin Wu, 2017 .

Use of viscogens, dNTPalphaS, and rhodium(III) as probes in stopped-flow experiments to obtain new evidence for the mechanism of catalysis by DNA polymerase beta.

Soojin Lee, M. Tsai, C. Dunlap, 2005, Biochemistry.

Use of 2-aminopurine and tryptophan fluorescence as probes in kinetic analyses of DNA polymerase beta.

M. Tsai, C. Dunlap, 2002, Biochemistry.

A reexamination of the nucleotide incorporation fidelity of DNA polymerases.

Ming-Daw Tsai, M. Tsai, Alexander K Showalter, 2002, Biochemistry.

Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.

J. Liu, X. Zhong, M. Tsai, 2001, Biochemistry.

DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes.

X. Zhong, B. Werneburg, J. Ahn, 1998, The Biochemical journal.

Catalytic Mechanism of DNA Polymerases

Michelle P. Roettger, M. Tsai, M. Bakhtina, 2010 .

DNA polymerase beta: pre-steady-state kinetic analyses of dATP alpha S stereoselectivity and alteration of the stereoselectivity by various metal ions and by site-directed mutagenesis.

M. Tsai, J. Liu, 2001, Biochemistry.

Phospholipids chiral at phosphorus. Characterization of the sub-gel phase of thiophosphatidylcholines by use of X-ray diffraction, phosphorus-31 nuclear magnetic resonance, and Fourier transform infrared spectroscopy.

M. Tsai, R. Dluhy, L. Hernqvist, 1988, Biochemistry.

Phospholipids chiral at phosphorus. 5. Synthesis and configurational analysis of chiral [17O,18O]phosphatidylethanolamine

M. Tsai, K. Bruzik, 1984 .

Phospholipids chiral at phosphorus. 4. Could membranes be chiral at phosphorus

M. Tsai, R. Jiang, K. Bruzik, 1983 .

Phospholipids Chiral at Phosphorus .2. Preparation, Property, and Application of Chiral Thiophospholipids

M. Tsai, K. Bruzik, S. M. Gupte, 1982 .

Phospholipids chiral at phosphorus. 1. Stereochemistry of transphosphatidylation catalyzed by phospholipase D

M. Tsai, K. Bruzik, 1982 .

NMR Methods Involving Oxygen Isotopes in Biophosphates

M. Tsai, K. Bruzik, 1983 .

Mechanism of adenylate kinase. Demonstration of a functional relationship between aspartate 93 and Mg2+ by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR.

M. Tsai, H. Yan, 1991, Biochemistry.

Use of 31P(18O), 31P(17O), and 17O NMR methods to study enzyme mechanisms involving phosphorus.

M. Tsai, 1982, Methods in enzymology.

Identification of Histone Demethylases in Saccharomyces cerevisiae*

Michael A. Freitas, M. Tsai, E. M. Bulloch, 2007, Journal of Biological Chemistry.

A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi

C. Mello, J. Yates, S. Mitani, 2015, Cell.

DNA polymerase beta: contributions of template-positioning and dNTP triphosphate-binding residues to catalysis and fidelity.

J. Liu, X. Zhong, V. Kraynov, 2000, Biochemistry.

Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

Hung-Wen Li, M. Tsai, M. Ho, 2021, Nature Communications.

How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.

S. Wijmenga, M. Tsai, J. Doreleijers, 2014, Journal of the American Chemical Society.

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.

B. Casto, W. Melvin, M. Tsai, 2004, Carcinogenesis.

Author ' s personal copy 8 . 10 Catalytic Mechanism of DNA Polymerases

Michelle P. Roettger, M. Tsai, M. Bakhtina, 2010 .

A Correction to the Review Titled: "Structure and Function of the Phosphothreonine-Specific FHA Domain" by A. Mahajan, C. Yuan, H. Lee, E. S.-W. Chen, P.-Y. Wu, M.-D. Tsai

M. Tsai, A. Mahajan, C. Yuan, 2009, Science Signaling.

Somatic INK4a‐ARF locus mutations: A significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck

B. Casto, D. Pearl, M. Tsai, 2001, Molecular carcinogenesis.

PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase

M. Tsai, P. Hsu, S. Teng, 2014, Nature Communications.

Interfacial enzymology: the secreted phospholipase A(2)-paradigm.

O. Berg, M. Gelb, M. Tsai, 2001, Chemical reviews.

Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens

M. Tsai, P. Hsu, E. Lai, 2014, PLoS pathogens.

JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells

Chiung-wen Chang, M. Tsai, P. Hsu, 2009, Proceedings of the National Academy of Sciences.

The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression

M. Tsai, P. Wu, Wen-An Pan, 2015, RNA biology.

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

M. Tsai, Tsung-Chieh Lin, M. Hsiao, 2016, eLife.

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.

Hsien-Da Huang, Chih-Hung Hsu, Feng-Mao Lin, 2013, Cancer research.

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1

M. Tsai, P. Hsu, W. Lo, 2011, Nucleic acids research.

The histone H 3 K 36 demethylase Rph 1 / KDM 4 regulates the expression of the photoreactivation gene PHR 1

M. Tsai, P. Hsu, W. Lo, 2011 .

Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.

M. Tsai, B. Lamarche, Yu Wang, 2007, Biochemistry.

Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.

M. Tsai, M. Ho, Chun-Jung Chen, 2015, Biochemistry.

Phospholipase A2 engineering. The roles of disulfide bonds in structure, conformational stability, and catalytic function.

M. Tsai, H. Zhu, C. M. Dupureur, 1995, Biochemistry.

Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ.

M. Tsai, M. Ho, Wen-Jin Wu, 2016, Journal of the American Chemical Society.

Altered Order of Substrate Binding by DNA Polymerase X from African Swine Fever Virus†

M. Tsai, M. Bakhtina, Sandeep Kumar, 2008, Biochemistry.

DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics.

X. Zhong, B. Werneburg, J. Ahn, 1997, The Biochemical journal.

The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

Ming-Daw Tsai, M. Tsai, L. Juan, 2008, Nature Structural &Molecular Biology.

Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.

M. Tsai, Mahendra K. Jain, Bao-zhu Yu, 2003, Biochemistry.

Interfacial Enzymology: The Secreted Phospholipase A2‐Paradigm

O. Berg, M. Gelb, M. Tsai, 2001 .

Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.

O. Berg, R. Jain, S. Ramakumar, 2000, Biochemistry.

Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis, and activation.

M. Tsai, M. Jain, B. Yu, 1999, Biochemistry.

Structural analysis of phospholipase A2 from functional perspective. 1. Functionally relevant solution structure and roles of the hydrogen-bonding network.

M. Tsai, C. Yuan, Y. Li, 1999, Biochemistry.

Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2.

O. Berg, M. Tsai, M. Jain, 1998, Biochemistry.

Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.

M. Sundaralingam, A. Kumar, M. Tsai, 1995, Biochemistry.

Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.

M. Tsai, C. Weghorst, C. Yuan, 2010, Journal of molecular biology.

TIFA as a crucial mediator for NLRP3 inflammasome

Shuai Li, S. Chien, M. Tsai, 2016, Proceedings of the National Academy of Sciences.

A novel expression vector for high-level synthesis and secretion of foreign proteins in Escherichia coli: overproduction of bovine pancreatic phospholipase A2.

J. Noel, M. Tsai, T. Deng, 1990, Gene.

Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding: monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase A2.

D. Velmurugan, Z. Dauter, M. Tsai, 2006, Acta crystallographica. Section D, Biological crystallography.

Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2.

J Jeyakanthan, Ming-Daw Tsai, D Velmurugan, 2002, Journal of molecular biology.

Conversion of Bovine Pancreatic Phospholipase A at a Single Site into a Competitor of Neurotoxic Phospholipases A by Site-directed Mutagenesis (*)

M. Tsai, C. M. Dupureur, C. yen, 1995, The Journal of Biological Chemistry.

A small, high-copy-number vector suitable for both in vitro and in vivo gene expression.

M. Tsai, B. Huang, Z. Shi, 1994, Gene.

Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich.

M. Tsai, M. Jain, B. Yu, 1992, Biochemistry.

Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73.

J. Noel, M. Tsai, T. Deng, 1992, Biochemistry.

Binding proteins on synaptic membranes for certain phospholipases A2 with presynaptic toxicity.

M. Tsai, C. Yen, M. Tzeng, 1996, Advances in experimental medicine and biology.

Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity.

T. Matsui, M. Tsai, E. Chen, 2015, Biochemistry.

Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16INK4A

W. Melvin, M. Tsai, C. Weghorst, 2003 .

Expression and characterization of Syrian golden hamster p 16 , a homologue of human tumor suppressor p 16 INK 4 A

W. Melvin, M. Tsai, C. Weghorst, 2003 .

Function of the Rad53 Checkpoint Kinase Molecular Basis of the Essential S Phase

M. Tsai, A. Fazio, A. Chabes, 2014 .

Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase

M. Tsai, A. Fazio, J. Heierhorst, 2013, Molecular and Cellular Biology.

PHRF1 promotes genome integrity by modulating non-homologous end-joining

M. Tsai, Po-Chen Chu, M.-S. Chang, 2015, Cell Death and Disease.

determination of p 15 INK 4 B structure by comparative modeling and Tumor suppressor INK 4 : refinement of p 16 INK 4 A structure and service

M. Tsai, T. Selby, C. Yuan, 2000 .

Tumor suppressor INK4: Refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data

M. Tsai, T. Selby, C. Yuan, 2000, Protein science : a publication of the Protein Society.

Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.

Ming-Ru Wu, M. Tsai, J. Heierhorst, 2008, Molecular cell.

An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4.

S. Joo, M. Tsai, Junan Li, 2003, Biochemistry.

Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb.

M. Tsai, Junan Li, 2002, Biochemistry.

Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase.

P. Crooks, M. Tsai, R. Woodard, 1980, The Journal of biological chemistry.

E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

A. Yang, Chi‐Huey Wong, M. Tsai, 2011, Proceedings of the National Academy of Sciences.

Phospholipids chiral at phosphorus. Steric course of the reactions catalyzed by phosphatidylserine synthase from Escherichia coli and yeast.

G. Carman, M. Tsai, C. Raetz, 1987, Biochemistry.

Mdt1, a Novel Rad53 FHA1 Domain-Interacting Protein, Modulates DNA Damage Tolerance and G2/M Cell Cycle Progression in Saccharomycescerevisiae

M. Tsai, J. Heierhorst, S. Yongkiettrakul, 2004, Molecular and Cellular Biology.

Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity.

Honggao Yan, M. Tsai, H. Yan, 1999, Advances in enzymology and related areas of molecular biology.

Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).

M. Tsai, T. Selby, C. Yuan, 1999, Journal of molecular biology.

MECHANISM OF PHOSPHATIDYLINOSITOL-PHOSPHOLIPASE C. 2. REVERSAL OF A THIO EFFECT BY SITE-DIRECTED MUTAGENESIS

R. Hondal, M. Tsai, K. Bruzik, 1997 .

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

M. Tsai, Yi Fu, P. Hsu, 2009, Circulation research.

Global analysis of modifications of the human BK virus structural proteins by LC-MS/MS.

M. Tsai, P. Hsu, Chi-Fang Chang, 2010, Virology.

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53.

M. Tsai, H. Liao, I. Byeon, 1999, Journal of molecular biology.

Mechanism of adenylate kinase. 1H, 13C, and 15N NMR assignments, secondary structures, and substrate binding sites.

J. Markley, M. Tsai, F. Abildgaard, 1993, Biochemistry.

Chirality at a pro-pro-prochiral phosphorus center. Stereochemical course of the 5'-nucleotidase-catalyzed reaction

M. Tsai, Ting-Ting Chang, 1980 .

Structure and function of 2:1 DNA polymerase·DNA complexes

M. Tsai, K. Tang, 2008, Journal of cellular physiology.

Solution structures of 2 : 1 and 1 : 1 DNA polymerase–DNA complexes probed by ultracentrifugation and small-angle X-ray scattering

M. Tsai, K. Tang, A. Aulabaugh, 2007, Nucleic acids research.

CHAPTER 6 – Use of Chiral Thiophosphates and the Stereochemistry of Enzymatic Phosphoryl Transfer

M. Tsai, 1984 .

II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptides.

M. Tsai, D. Pei, H. Liao, 2000, Journal of molecular biology.

Mismatched and Matched dNTP Incorporation by DNA Polymerase β Proceed via Analogous Kinetic Pathways†

Michelle P. Roettger, M. Tsai, M. Bakhtina, 2008, Biochemistry.

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways†

C. Tung, M. Tsai, K. Tang, 2008, Nucleic acids research.

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.

M. Tsai, H. Zhu, M. Jain, 1994, Biochemistry.

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.

M. Sundaralingam, M. Tsai, K. Sekar, 1994, Biochemistry.

Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures.

M. Tsai, C. Chou, Yu-Ting Huang, 2011, Molecular bioSystems.

Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.

M. Tsai, K. Bruzik, Li Zhao, 2010, Journal of the American Chemical Society.

A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity.

M. Tsai, K. Bruzik, Li Zhao, 2003, Journal of the American Chemical Society.

A calorimetric study of the thermotropic behavior of pure sphingomyelin diastereomers.

M. Tsai, K. Bruzik, 1987, Biochemistry.

Mechanism of adenylate kinase. 12. Prediction and demonstration of enhancement of phosphorus stereospecificity by site-directed mutagenesis

M. Tsai, R. Jiang, T. Dahnke, 1991 .

Phospholipids chiral at phosphorus. Synthesis of chiral phosphatidylcholine and stereochemistry of phospholipase D.

M. Tsai, K. Bruzik, 1984, Biochemistry.

DNA Polymerase β: Multiple Conformational Changes in the Mechanism of Catalysis†

X. Zhong, B. Werneburg, M. Tsai, 1997 .

Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53 in Vivo

M. Tsai, J. Heierhorst, E. Chen, 2013, Molecular & Cellular Proteomics.

Diverse but Overlapping Functions of the Two Forkhead-associated (FHA) Domains in Rad53 Checkpoint Kinase Activation*

M. Tsai, J. Heierhorst, S. Yongkiettrakul, 2003, Journal of Biological Chemistry.

Functions of Some Capsular Polysaccharide Biosynthetic Genes in Klebsiella pneumoniae NTUH K-2044

M. Tsai, Shih-Hsiung Wu, Tsung-Lin Li, 2011, PloS one.

Mechanism of adenylate kinase: site-directed mutagenesis versus X-ray and NMR.

M. Tsai, H. Yan, 1991, Biochemistry.

Mechanism of adenylate kinase. What can be learned from a mutant enzyme with minor perturbation in kinetic parameters?

M. Tsai, R. Jiang, I. Byeon, 1993, Biochemistry.

Mechanism of adenylate kinase. Structural and functional roles of the conserved arginine-97 and arginine-132.

M. Tsai, R. Jiang, Z. Shi, 1992, Biochemistry.

Mechanism of adenylate kinase. 10. Reversing phosphorus stereospecificity by site-directed mutagenesis

M. Tsai, R. Jiang, T. Dahnke, 1991 .

Mechanism of adenylate kinase. Critical evaluation of the X-ray model and assignment of the AMP site.

M. Tsai, H. Yan, B. Zhou, 1990, Biochemistry.

Mechanism of adenylate kinase. Structural and functional demonstration of arginine-138 as a key catalytic residue that cannot be replaced by lysine.

M. Tsai, Z. Shi, H. Yan, 1990, Biochemistry.

Mechanism of adenylate kinase. Histidine-36 is not directly involved in catalysis, but protects cysteine-25 and stabilizes the tertiary structure.

C. Sanders, M. Tsai, F. Kishi, 1988, Biochemistry.

Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii

M. Tsai, M. Mittag, L. Essen, 2018, Nucleic acids research.

Third calcium ion found in an inhibitor-bound phospholipase A2.

D. Velmurugan, T. Yamane, M. Tsai, 2006, Acta crystallographica. Section D, Biological crystallography.

Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2.

D. Velmurugan, Z. Dauter, M. Tsai, 2004, Acta crystallographica. Section F, Structural biology and crystallization communications.

1.72 A resolution refinement of the trigonal form of bovine pancreatic phospholipase A2.

M. Sundaralingam, M. Tsai, K. Sekar, 1998, Acta crystallographica. Section D, Biological crystallography.

Use of damaged DNA and dNTP substrates by the error-prone DNA polymerase X from African swine fever virus.

M. Tsai, B. Lamarche, Sandeep Kumar, 2007, Biochemistry.

Solution structure of a viral DNA polymerase X and evidence for a mutagenic function

M. Tsai, I. Byeon, M. Su, 2001, Nature Structural Biology.

DNA polymerase beta. 5. Dissecting the functional roles of the two metal ions with Cr(III)dTTP

X. Zhong, M. Tsai, Smita S. Patel, 1998 .

DNA Polymerase β: Multiple Conformational Changes in the Mechanism of Catalysis†

X. Zhong, B. Werneburg, M. Tsai, 1997 .

The Catalytic Role of Aspartate in a Short Strong Hydrogen Bond of the Asp274–His32 Catalytic Dyad in Phosphatidylinositol-specific Phospholipase C Can Be Substituted by a Chloride Ion*

M. Tsai, H. Liao, Li Zhao, 2004, Journal of Biological Chemistry.

A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor.

M. Gelb, M. Tsai, N. Andersen, 2003, Journal of molecular biology.

Unusual four-bond secondary H/D isotope effect supports a short-strong hydrogen bond between phospholipase A2 and a transition state analogue inhibitor.

M. Gelb, M. Tsai, S. Tu, 2005, Biochemistry.

Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy.

Michael A. Freitas, M. Tsai, E. M. Bulloch, 2010, Analytical biochemistry.

Use of Viscogens , dNTP R S , and Rhodium ( III ) as Probes in Stopped-Flow Experiments To Obtain New Evidence for the Mechanism of Catalysis by DNA Polymerase â

Soojin Lee, M. Tsai, C. Dunlap, 2022 .

Cryo-EM in Enzymology

M. Tsai, 2020 .

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.

M. Tsai, T. Ko, Yuan-Chih Chang, 2019, Journal of the American Chemical Society.

alpha-Helical burst on the folding pathway of FHA domains from Rad53 and Ki67.

M. Tsai, A. Mahajan, H. Kihara, 2010, Biochimie.

Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship.

M. Tsai, A. Mahajan, C. Yuan, 2004, Biochemistry.

Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.

M. Tsai, C. Weghorst, A. Mahajan, 2007, Journal of molecular biology.

An error-prone viral DNA ligase.

M. Tsai, B. Lamarche, A. K. Showalter, 2005, Biochemistry.

Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis

Y. Jeng, M. Tsai, Sheng‐Chung Lee, 2011, Cell cycle.

Use of short-chain cyclopentano-phosphatidylcholines to probe the mode of activation of phospholipase A2 from bovine pancreas and bee venom.

J. Noel, M. Tsai, G. Lin, 1988, The Journal of biological chemistry.

Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.

R. Hondal, M. Tsai, S. Riddle, 1998, Biochemistry.

Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.

R. Hondal, M. Tsai, S. Riddle, 1997, Biochemistry.

Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins.

S. Joo, M. Tsai, C. Weghorst, 2009, Biochemistry.

Structure of the complex of bovine pancreatic phospholipase A2 with a transition-state analogue.

M. Sundaralingam, M. Gelb, A. Kumar, 1998, Acta crystallographica. Section D, Biological crystallography.

Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53.

M. Tsai, S. Zhou, C. Yuan, 2001, Journal of Molecular Biology.

Conformational analysis of pyridoxal amino acid schiff's bases

M. Tsai, S. Byrn, H. Floss, 2009 .

Solution structure of the yeast Rad53 FHA2 complexed with a phosphothreonine peptide pTXXL: comparison with the structures of FHA2-pYXL and FHA1-pTXXD complexes.

M. Tsai, I. Byeon, S. Yongkiettrakul, 2001, Journal of molecular biology.

A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation.

M. Tsai, Yu-Ting Huang, Tsung-Lin Li, 2007, Journal of the American Chemical Society.

A DNA polymerase with specificity for five base pairs.

M. Tsai, A. K. Showalter, 2001, Journal of the American Chemical Society.

Phospholipids chiral at phosphorus. XII: Configurational effect on the thermotropic properties of chiral dipalmitoylthiophosphatidylcholine

M. Tsai, T. Rosario-Jansen, D. A. Wisner, 1986 .

Phospholipids chiral at phosphorus: Fourier-transform infrared study on the gel-liquid crystalline transition of chiral thiophosphatidylcholine.

M. Tsai, J. O. Alben, D. A. Wisner, 1986, Biochemistry.

Atomic resolution structure of the double mutant (K53,56M) of bovine pancreatic phospholipase A2.

D. Velmurugan, Z. Dauter, M. Tsai, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Manipulating phosphorus stereospecificity of adenylate kinase by site-directed mutagenesis.

M. Tsai, R. Jiang, Z. Shi, 1995, Methods in enzymology.

Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis.

M. Tsai, C. Yuan, M. Poi, 1999, Biochemistry.

Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond.

R. Hondal, M. Tsai, K. Bruzik, 2001, Biochemistry.

How DNA polymerases catalyze DNA replication, repair, and mutation.

M. Tsai, 2014, Biochemistry.

DNA polymerase β : effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes1

X. Zhong, B. Werneburg, V. Kraynov, 1998 .

Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity.

M. Tsai, Hongyuan Li, Junan Li, 2003, Biochemistry.

Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate‐dependent autoproteolysis activity

Y. Bessho, M. Tsai, Masaki Yamamoto, 2020, IUBMB life.

FHA domain-ligand interactions: importance of integrating chemical and biological approaches.

M. Tsai, J. Heierhorst, A. Mahajan, 2005, Journal of the American Chemical Society.

Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: Absence of the conserved structural water

B. Ramakrishnan, M. Sundaralingam, M. Tsai, 1994, Protein science : a publication of the Protein Society.

First observation of amino acid side chain dynamics in membrane proteins using high field deuterium nuclear magnetic resonance spectroscopy.

E. Oldfield, M. Tsai, N. Janes, 1981, The Journal of biological chemistry.

Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.

M. Tsai, M. Rebecchi, K. Bruzik, 2009, Journal of the American Chemical Society.

Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity.

M. Tsai, K. Bruzik, A. Kravchuk, 2003, Biochemistry.

Effects of oxygen-17 and oxygen-18 on phosphorus-31 NMR: further investigation and applications

P. Frey, M. Tsai, K. Bruzik, 1983 .

Gene library synthesis by structure-based combinatorial protein engineering.

J. Noel, M. Tsai, J. Chappell, 2004, Methods in enzymology.

Phospholipase A2 engineering. 10. The aspartate...histidine catalytic diad also plays an important structural role

M. Tsai, Yi-Shan Li, 1993 .

Catalytic mechanism of DNA polymerases—Two metal ions or three?

M. Tsai, 2018, Protein science : a publication of the Protein Society.

Contribution of the reverse rate of the conformational step to polymerase beta fidelity.

Michelle P. Roettger, M. Tsai, M. Bakhtina, 2009, Biochemistry.

Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing

M. Tsai, A. H. Wang, S. LinWu, 2019, Communications Biology.

TIFA protein expression is associated with pulmonary arterial hypertension

Wen-Chung Yu, M. Tsai, Chen-Huan Chen, 2021, Scientific Reports.

Stereochemistry and mechanism of reactions catalyzed by indolyl-3-alkane alpha-hydroxylase.

M. Tsai, H. Floss, H. Rosenfeld, 1979, The Journal of biological chemistry.

Stereochemistry and mechanism of reactions catalyzed by tryptophan synthetase and its beta2 subunit.

E. Schleicher, M. Tsai, H. Floss, 1978, The Journal of biological chemistry.

Phospholipids chiral at phosphorus. synthesis, absolute configurations and applications

M. Tsai, R. Jiang, K. Bruzik, 1983 .

Identification of in Vivo Phosphorylation Sites and Their Functional Significance in the Sodium Iodide Symporter*

M. Tsai, S. Jhiang, E. Chen, 2007, Journal of Biological Chemistry.

An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria

M. Tsai, M. Ho, K. Hsu, 2023, Nature Metabolism.

Identification of a Novel Catalytic Triad with Dual Functions in Enzymatic Cleavage of the P−O Bond

R. Hondal, M. Tsai, K. Bruzik, 1999 .

Contributions of an endonuclease IV homologue to DNA repair in the African swine fever virus.

M. Tsai, B. Lamarche, 2006, Biochemistry.

Application of Brønsted-type LFER in the study of the phospholipase C mechanism.

M. Tsai, K. Bruzik, A. Kravchuk, 2003, Journal of the American Chemical Society.

a-Helical burst on the folding pathway of FHA domains from Rad 53 and Ki 67

M. Tsai, A. Mahajan, H. Kihara, 2010 .

Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair.

M. Tsai, K. Tang, M. Su, 2006, Chemical reviews.

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

M. Tsai, Yi Fu, P. Hsu, 2009, Circulation research.

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

M. Tsai, Jaulang Hwang, M. Hwang, 2014, Developmental cell.

Watching conformational- and photo-dynamics of single fluorescent proteins in solution

W. E. Moerner, Randall H. Goldsmith, W. Moerner, 2010, Nature chemistry.

Dissection of CDK 4-Binding and Transactivation Activities of p 34 SEI-1 and Comparison between Functions of p 34 SEI-1 and p 16 INK 4 A †

W. Melvin, S. Joo, M. Tsai, 2022 .

Application of Brønsted-type LFER in the study of the phospholipase C mechanism.

M. Tsai, K. Bruzik, A. Kravchuk, 2003, Journal of the American Chemical Society.

Phosphatidylinositol-specific phospholipase C .3. Elucidation of the catalytic mechanism and comparison with ribonuclease A1

R. Hondal, M. Tsai, S. Riddle, 1997 .

PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase

M. Tsai, P. Hsu, S. Teng, 2014, Nature Communications.

Tumor suppressor INK4: quantitative structure-function analyses of p18INK4C as an inhibitor of cyclin-dependent kinase 4.

M. Tsai, T. Selby, M. Poi, 2000, Biochemistry.

Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A.

M. Tsai, T. Selby, M. Poi, 1999, Biochemistry.

Probing the active site of deubiquitinase USP30 with non-canonical tryptophan analogues.

M. Tsai, Yane-Shih Wang, Prashant Kurkute, 2020, Biochemistry.