N. Grindley

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Conformational transitions in DNA polymerase I revealed by single-molecule FRET

J. Torella, A. Kapanidis, Y. Santoso, 2009, Proceedings of the National Academy of Sciences.

Mechanisms of site-specific recombination.

N. Grindley, K. Whiteson, P. Rice, 2003, Annual review of biochemistry.

Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence.

C. M. Joyce, N. Grindley, A. Delucia, 2007, Biochemistry.

Analysis of a nucleoprotein complex: the synaptosome of gamma delta resolvase.

N. Grindley, 1993, Science.

A model for the gamma delta resolvase synaptic complex.

G. Sarkis, A. Leschziner, N. Grindley, 2001, Molecular cell.

Tn552 transposase catalyzes concerted strand transfer in vitro.

A. Leschziner, N. Grindley, T. J. Griffin, 1998, Proceedings of the National Academy of Sciences of the United States of America.

In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis.

A. Leschziner, N. Grindley, K. Derbyshire, 1999, Nucleic acids research.

The Movement of Tn3-Like Elements: Transposition and Cointegrate Resolution

N. Grindley, 2002 .

Transpositional recombination in prokaryotes.

N. Grindley, R. Reed, 1985, Annual review of biochemistry.

A functional analysis of the inverted repeat of the γδ transposable element

N. Grindley, E. May, 1995 .

Uncoupling of transpositional immunity from gamma delta transposition by a mutation at the end of gamma delta

N. Grindley, L. Wiater, 1990, Journal of bacteriology.

Integration host factor increases the transpositional immunity conferred by gamma delta ends

N. Grindley, L. Wiater, 1990, Journal of bacteriology.

Gamma delta transposase and integration host factor bind cooperatively at both ends of gamma delta.

N. Grindley, L. Wiater, L. A. Wiater, 1988, The EMBO journal.

The basis of asymmetry in IS2 transposition

N. Grindley, N. Gadura, L. A. Lewis, 2001, Molecular microbiology.

IS1 insertion generates duplication of a nine base pair sequence at its target site

N. Grindley, 1978, Cell.

Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903.

C. M. Joyce, N. Grindley, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of the structure and function of the kanamycin-resistance transposon Tn903.

C. M. Joyce, N. Grindley, 1981, Cold Spring Harbor symposia on quantitative biology.

Insertion sequence duplication in transpositional recombination.

N. Grindley, T. Weinert, Nigel D. F. Grindley, 1983, Science.

Genetic analysis of the interaction of the insertion sequence IS903 transposase with its terminal inverted repeats.

N. Grindley, K. Derbyshire, L. Hwang, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Role of instability in the cis action of the insertion sequence IS903 transposase.

N. Grindley, K. Derbyshire, M. Kramer, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Binding of the IS903 transposase to its inverted repeat in vitro.

N. Grindley, K. Derbyshire, 1992, The EMBO journal.

Two abundant intramolecular transposition products, resulting from reactions initiated at a single end, suggest that IS2 transposes by an unconventional pathway

N. Grindley, L. A. Lewis, L. Lewis, 1997, Molecular microbiology.

Uncoupling of the recombination and topoisomerase activities of the γδ resolvase by a mutation at the crossover point

N. Grindley, E. Falvey, G. Hatfull, 1988, Nature.

Sequence analysis at IS1 insertion sites: models for transposition.

D. Sherratt, N. Grindley, 1979, Cold Spring Harbor symposia on quantitative biology.

Interactions of Group H Resistance Factors with the F Factor

E. S. Anderson, N. Grindley, G. Humphreys, 1973, Journal of bacteriology.

Preparation of heavy-atom derivatives using site-directed mutagenesis: Introduction of cysteine residues into γδ resolvase☆

T. Steitz, P. Freemont, N. Grindley, 1989 .

The γδ resolvase induces an unusual DNA structure at the recombinational crossover point

N. Grindley, G. Hatfull, S. Noble, 1987, Cell.

Gamma delta transposase. Purification and analysis of its interaction with a transposon end.

N. Grindley, L. Wiater, 1991, The Journal of biological chemistry.

Integration Host Factor Increases the Transpositional Immunity Conferred by y5 Ends

N. Grindley, Lawrence A. WIATERt, 2022 .

Mutants of the gamma delta resolvase: a genetic analysis of the recombination function.

N. Grindley, B. Newman, 1984, Cell.

Molecular Studies of R Factor Compatibility Groups

E. S. Anderson, N. Grindley, G. Humphreys, 1973, Journal of bacteriology.

Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically.

T. Steitz, S. Abdel-Meguid, N. Grindley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Transposition of Tn3 and related transposons

N. Grindley, 1983, Cell.

Replicative and conservative transposition in bacteria

N. Grindley, K. Derbyshire, 1986, Cell.

Genetic mapping and DNA sequence analysis of mutations in the polA gene of Escherichia coli.

C. M. Joyce, N. Grindley, C. Hughes, 1985, Journal of molecular biology.

Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment).

C. M. Joyce, N. Grindley, X. C. Sun, 1992, The Journal of biological chemistry.

Transfer of a Neomycin–Kanamycin Resistance Determinant by the F Factor of Escherichia coli K12

E. S. Anderson, N. Grindley, J. Mayhew, 1969, Nature.

DNA-protein complexes of Δ-mediated transfer systems

E. S. Anderson, N. Grindley, G. Humphreys, 1972 .

Helical phasing between DNA bends and the determination of bend direction.

J. J. Salvo, N. Grindley, J. Salvo, 1987, Nucleic acids research.

Transposon-mediated site-specific recombination: Identification of three binding sites for resolvase at the res sites of γδ and Tn 3

J. J. Salvo, R. Wityk, N. Grindley, 1982, Cell.

Distinct Roles of the Active-site Mg2+ Ligands, Asp882 and Asp705, of DNA Polymerase I (Klenow Fragment) during the Prechemistry Conformational Transitions*

C. M. Joyce, N. Grindley, Oya Bermek, 2010, The Journal of Biological Chemistry.

Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity.

C. M. Joyce, O. Potapova, N. Grindley, 2008, Biochemistry.

Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn 903 ( transposable element / insertion sequence / in vitro mutagenesis / " transposase " )

C. M. Joyce, N. Grindley, 2022 .

Deoxynucleoside Triphosphate and Pyrophosphate Binding Sites in the Catalytically Competent Ternary Complex for the Polymerase Reaction Catalyzed by DNA Polymerase I (Klenow Fragment) (*)

C. M. Joyce, N. Grindley, M. Astatke, 1995, The Journal of Biological Chemistry.

An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides.

C. M. Joyce, N. Grindley, Angela M DeLucia, 2003, Nucleic acids research.

A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides.

C. M. Joyce, N. Grindley, K. Ng, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

S. Benkovic, C. M. Joyce, N. Grindley, 1992, The Journal of biological chemistry.

Mapping interactions between the catalytic domain of resolvase and its DNA substrate using cysteine-coupled EDTA-iron.

J. Mazzarelli, N. Grindley, M. Ermácora, 1993, Biochemistry.

Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.

C. M. Joyce, N. Grindley, 1983, Proceedings of the National Academy of Sciences of the United States of America.

DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.

C. M. Joyce, O. Potapova, N. Grindley, 2006, Biochemistry.

Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment).

C. M. Joyce, N. Grindley, V. Purohit, 2003, Biochemistry.

Transposition of the Escherichia coli insertion element gamma generates a five-base-pair repeat.

R. Young, J. Steitz, N. Grindley, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Transposon-mediated site-specific recombination in vitro: DNA cleavage and protein-DNA linkage at the recombination site

N. Grindley, R. Reed, 1981, Cell.

Identification of Genes Encoding Exported Mycobacterium tuberculosis Proteins Using a Tn552′phoA In Vitro Transposition System

S. T. Friedman, W. Jacobs, M. Braunstein, 2000, Journal of bacteriology.

Method for determining whether a gene of Escherichia coli is essential: application to the polA gene

C. M. Joyce, N. Grindley, 1984, Journal of bacteriology.

Site-Specific Recombination

N. Grindley, 2001 .

The 3′‐5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

C. M. Joyce, N. Grindley, V. Derbyshire, 1991, The EMBO journal.

Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli.

C. M. Joyce, N. Grindley, V. Derbyshire, 1997, Journal of molecular biology.

The effects of Salmonella typhimurium on derepressed mutants of F-like factors.

E. S. Anderson, N. Grindley, H. Smith, 1971, Genetical research.

DNA transposition: From a black box to a color monitor

Andres E. Leschziner, A. Leschziner, N. Grindley, 1995, Cell.

Identification of two genes immediately downstream from the polA gene of Escherichia coli

C. M. Joyce, N. Grindley, 1982, Journal of bacteriology.

Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.

C. M. Joyce, N. Grindley, W. S. Kelley, 1982, The Journal of biological chemistry.

The Mutational Specificity of the Dbh Lesion Bypass Polymerase and Its Implications*

C. M. Joyce, O. Potapova, N. Grindley, 2002, The Journal of Biological Chemistry.

The 43 residue DNA binding domain of γδ resolvase binds adjacent major and minor grooves of DNA

N. Grindley, G. Hatfull, V. Rimphanitchayakit, 1989 .

Mapping of thepolA locus ofEscherichia coli K12: Orientation of the amino- and carboxy-termini of the cistron

N. Grindley, W. S. Kelley, 1976, Molecular and General Genetics MGG.

Molecular studies of an fi+ plasmid from strains of Salmonella typhimurium

E. S. Anderson, N. Grindley, G. Humphreys, 1973, Molecular and General Genetics MGG.

R factor compatibility groups

E. S. Anderson, N. Grindley, J. Grindley, 2004, Molecular and General Genetics MGG.

Derepression of F-lac in Salmonella typhimurium by a determinant for kanamycin resistance.

E. S. Anderson, N. Grindley, H. Smith, 1970, Genetical research.

Acridine treatment of F+ and Hfr strains of Escherichia coli K12 carrying a neomycin-kanamycin resistance determinant.

E. S. Anderson, N. Grindley, J. Grindley, 1970, Genetical research.

8 – Transpositional and Site-Specific Recombination Mediated by Bacterial Transposons

N. Grindley, 1988 .

Analysis of the γδ res site: Sites required for site-specific recombination and gene expression

N. Grindley, R. Wells, 1984 .

Analysis of the gamma delta res site. Sites required for site-specific recombination and gene expression.

N. Grindley, R. Wells, 1984, Journal of molecular biology.

Molecular Studies ofRFactor Compatibility Groups

E. S. Anderson, N. Grindley, 1973 .

Resolvase-Mediated Site-Specific Recombination

N. Grindley, 1994 .

Mutants of the γδ resolvase: A genetic analysis of the recombination function

N. Grindley, B. Newman, 1984, Cell.

Catalytic residues of gamma delta resolvase act in cis.

N. Grindley, M. Boocock, X. Zhu, 1995, The EMBO journal.

The crystal structure of the catalytic domain of the site-specific recombination enzyme γδ resolvase at 2.7 Å resolution

T. Steitz, A. Goldman, P. Freemont, 1990, Cell.

Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction

T. Steitz, R. E. Hughes, N. Grindley, 1990, Cell.

Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue

N. Grindley, J. Falkinham, K. Derbyshire, 2002, Molecular microbiology.

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

T. Steitz, C. M. Joyce, N. Grindley, 1990, The Journal of biological chemistry.

How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides.

C. M. Joyce, N. Grindley, M. Astatke, 1998, Journal of molecular biology.

A simple and efficient procedure for saturation mutagenesis using mixed oligodeoxynucleotides.

J. J. Salvo, N. Grindley, K. Derbyshire, 1986, Gene.

Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion

Timothy D. Craggs, A. Kapanidis, Louise Aigrain, 2013, Nature Communications.

Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis.

C. M. Joyce, N. Grindley, R. M. Turner, 2003, Biochemistry.

polA6, A mutation affecting the DNA binding capacity of DNA polymerase I.

N. Grindley, W. Kelly, 1976, Nucleic acids research.

Prechemistry Nucleotide Selection Checkpoints in the Reaction Pathway of DNA Polymerase I and Roles of Glu710 and Tyr766

C. M. Joyce, N. Grindley, Oya Bermek, 2013, Biochemistry.

The Properties of Steric Gate Mutants Reveal Different Constraints within the Active Sites of Y-family and A-family DNA Polymerases*

C. M. Joyce, O. Potapova, N. Grindley, 2006, Journal of Biological Chemistry.

Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation

T. Kunkel, C. M. Joyce, N. Grindley, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Coordination between the Polymerase and 5′-Nuclease Components of DNA Polymerase I of Escherichia coli *

C. M. Joyce, N. Grindley, Yang Xu, 2000, The Journal of Biological Chemistry.

The gamma delta resolvase bends the res site into a recombinogenic complex.

J. J. Salvo, N. Grindley, Joseph J. Salvo, 1988, The EMBO journal.

Escherichia coli is essential: application to the Method for determining whether a gene of

C. M. Joyce, N. Grindley, 2013 .

Contacts between the 5′ Nuclease of DNA Polymerase I and Its DNA Substrate*

A. Leschziner, C. M. Joyce, O. Potapova, 2001, The Journal of Biological Chemistry.

Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.

T. Steitz, N. Grindley, S. Kamtekar, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs.

Yong Xiong, Weikai Li, Thomas A Steitz, 2005, Science.

A Model for the ?d Resolvase Synaptic Complex

G. Sarkis, A. Leschziner, N. Grindley, 2001 .

Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity

N. Grindley, D. Blake, W. Stark, 1999, The EMBO journal.

The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution.

T. Steitz, A. Goldman, P. Freemont, 1990, Cell.

Cooperativity mutants of the gamma delta resolvase identify an essential interdimer interaction.

T. Steitz, R. E. Hughes, N. Grindley, 1990, Cell.

Analysis of gamma delta resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site I of res.

N. Grindley, G. Hatfull, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a Synaptic γδ Resolvase Tetramer Covalently Linked to Two Cleaved DNAs

Yong Xiong, Thomas A. Steitz, Weikai Li, 2005, Science.

The Architecture of the γδ Resolvase Crossover Site Synaptic Complex Revealed by Using Constrained DNA Substrates

A. Leschziner, N. Grindley, 2003 .

Site-specific recombination: Synapsis and strand exchange revealed

N. Grindley, 1997, Current Biology.

Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end

J. Marko, N. Grindley, Mingxuan Sun, 2012, Proceedings of the National Academy of Sciences.

DNA Transposons: Different Proteins and Mechanisms but Similar Rearrangements

N. Grindley, K. Derbyshire, 2005 .

Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase

Graham F Hatfull, Mingxuan Sun, J. Marko, 2011, Proceedings of the National Academy of Sciences.

Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase

J. Marko, N. Grindley, G. Hatfull, 2016, Nucleic acids research.

Effects of different alleles of the E. coli K12 polA gene on the replication of non-transferring plasmids

N. Grindley, W. S. Kelley, 1976, Molecular and General Genetics MGG.

Replicative and conservative transpositional recombination of insertion sequences.

N. Grindley, F. Hughson, T. Weinert, 1984, Cold Spring Harbor symposia on quantitative biology.

The tyrosine‐6 hydroxyl of γδ resolvase is not required for the DNA cleavage and rejoining reactions

A. Leschziner, N. Grindley, M. Boocock, 1995 .

Architecture of the γδ Resolvase Synaptosome Oriented Heterodimers Identify Interactions Essential for Synapsis and Recombination

N. Grindley, L. L. Murley, 1998, Cell.

Architecture of the gamma delta resolvase synaptosome: oriented heterodimers identity interactions essential for synapsis and recombination.

N. Grindley, L. L. Murley, 1998, Cell.

Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange.

N. Grindley, J. Gehman, M. Cocco, 2008, Biochimica et biophysica acta.

Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.

C. M. Joyce, N. Grindley, W. S. Kelley, 1982, The Journal of biological chemistry.

MethodforDetermining Whether a GeneofEscherichia coli Is Essential: Application tothepolAGene

C. M. Joyce, N. Grindley, 1984 .

Cis preference of the IS 903 transposase is mediated by a combination of transposase instability and inefficient translation

N. Grindley, K. Derbyshire, 1996, Molecular microbiology.

THE PRIMARY STRUCTURE OF DNA POLYMERASE I OF E. COLI

C. M. Joyce, N. Grindley, W. S. Kelley, 1980 .

The Study of Protein-DNA Contacts by Ethylation Interference

N. Grindley, V. Rimphanitchayakit, 1991 .

The two functional domains of gamma delta resolvase act on the same recombination site: implications for the mechanism of strand exchange.

N R Cozzarelli, N. Cozzarelli, N. Grindley, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Contacts between gamma delta resolvase and the gamma delta res site.

N. Grindley, E. Falvey, 1987, The EMBO journal.

Characterisation of derepressed mutants of an F-like R factor

N. Grindley, H. Smith, J. Grindley, 1973, Molecular and General Genetics MGG.

Distinct Roles of the Active-site Mg2+ Ligands, Asp882 and Asp705, of DNA Polymerase I (Klenow Fragment) during the Prechemistry Conformational Transitions*

C. M. Joyce, N. Grindley, Oya Bermek, 2010, The Journal of Biological Chemistry.