J. P. Loria

发表

Substrate-dependent millisecond domain motions in DNA polymerase β.

J. Sweasy, S. Dalal, R. Berlow, 2012, Journal of molecular biology.

Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface.

Victor S Batista, Gregory A Manley, J Patrick Loria, 2016, Biochemistry.

Solution NMR Spectroscopy for the Study of Enzyme Allostery.

J. P. Loria, George P. Lisi, J. Loria, 2016, Chemical reviews.

Solution NMR and computational methods for understanding protein allostery.

Gregory A Manley, J Patrick Loria, Ivan Rivalta, 2013, The journal of physical chemistry. B.

Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity

Victor S Batista, J Patrick Loria, J. P. Loria, 2017, Proceedings of the National Academy of Sciences.

Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases.

J. P. Loria, D. S. Cui, Victor Beaumont, 2017, Journal of molecular biology.

Dissecting Dynamic Allosteric Pathways Using Chemically Related Small-Molecule Activators.

Gregory A Manley, Heidi P. Hendrickson, J. P. Loria, 2016, Structure.

Accelerating 2D NMR relaxation dispersion experiments using iterated maps

R. Blum, J. P. Loria, Jared Rovny, 2019, Journal of Biomolecular NMR.

Reaching the sparse-sampling limit for reconstructing a single peak in a 2D NMR spectrum using iterated maps.

R. Blum, J. P. Loria, Jared Rovny, 2019, Journal of biomolecular NMR.

Longitudinal and Transverse 1H−15N Dipolar/15N Chemical Shift Anisotropy Relaxation Interference: Unambiguous Determination of Rotational Diffusion Tensors and Chemical Exchange Effects in Biological Macromolecules

C. Kroenke, A. Palmer, J. P. Loria, 1998 .

Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules.

C D Kroenke, C. Kroenke, A. Palmer, 2001, Methods in enzymology.

Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates.

Yang Luo, J. P. Loria, D. S. Cui, 2021, Journal of the American Chemical Society.

MoD-QM/MM Structural Refinement Method: Characterization of Hydrogen Bonding in the Oxytricha nova G-Quadruplex.

J. P. Loria, V. Batista, J. Gascón, 2014, Journal of chemical theory and computation.

A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer

S. R. Marana, J. P. Loria, V. M. Almeida, 2022, PloS one.

Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Gene-Editing Technologies.

J. P. Loria, V. Batista, K. Reiss, 2020, Biochemistry.

A TROSY CPMG sequence for characterizing chemical exchange in large proteins

A. Palmer, J. P. Loria, M. Rance, 1999, Journal of biomolecular NMR.

Temperature dependence of the backbone dynamics of ribonuclease A in the ground state and bound to the inhibitor 5'-phosphothymidine (3'-5')pyrophosphate adenosine 3'-phosphate.

J. P. Loria, E. L. Kovrigin, R. Cole, 2003, Biochemistry.

Transverse-relaxation-optimized (TROSY) gradient-enhanced triple-resonance NMR spectroscopy.

A. Palmer, J. P. Loria, M. Rance, 1999, Journal of magnetic resonance.

The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.

J. P. Loria, N. Doucet, Eric D Watt, 2009, Biochemistry.

The effects of cosolutes on protein dynamics: The reversal of denaturant‐induced protein fluctuations by trimethylamine N‐oxide

J. P. Loria, V. Doan-Nguyen, 2007, Protein science : a publication of the Protein Society.

Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase.

J. P. Loria, R. Wierenga, J. Richard, 2013, Biochemistry.

Dynamic requirements for a functional protein hinge.

J. P. Loria, N. Sampson, J. Kempf, 2007, Journal of molecular biology.

Phosphorylation of the NBDY Microprotein Promotes Dissociation of Biomolecular Condensates

Yang Luo, J. P. Loria, D. S. Cui, 2021 .

Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds.

Xin Eric Wang, J. P. Loria, V. Dixit, 2022, Chem.

Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation

J. P. Loria, George P. Lisi, Allen A. Currier, 2018, Front. Mol. Biosci..

The Static Magnetic Field Dependence of Chemical Exchange Linebroadening Defines the NMR Chemical Shift Time Scale

Christopher D. Kroenke, Miquel Pons, Arthur G. Palmer, 2000 .

A Relaxation-Compensated Carr−Purcell−Meiboom−Gill Sequence for Characterizing Chemical Exchange by NMR Spectroscopy

A. Palmer, J. P. Loria, M. Rance, 1999 .

Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex

Scott A. Strobel, S. Strobel, J. P. Loria, 2006, Nucleic acids research.

The mechanism of rate-limiting motions in enzyme function

J. P. Loria, E. L. Kovrigin, Eric D Watt, 2007, Proceedings of the National Academy of Sciences.

Complexity of protein energy landscapes studied by solution NMR relaxation dispersion experiments.

J. P. Loria, Gennady Khirich, 2015, The journal of physical chemistry. B.

Allostery in enzyme catalysis.

J. P. Loria, George P. Lisi, J. Loria, 2017, Current opinion in structural biology.

A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi

M. Hochstrasser, J. P. Loria, Y. Xiong, 2020, Nature Communications.

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA.

J Patrick Loria, Hong Jin, P. Moore, 2007, Molecular cell.

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

L. Leng, R. Bucala, V. Bhandari, 2013, Proceedings of the National Academy of Sciences.

Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases

Sean J. Johnson, J. P. Loria, A. Hengge, 2021, Chemical science.

Allosteric pathways in imidazole glycerol phosphate synthase

Mohammad M. Sultan, Victor S Batista, Mohammad M Sultan, 2012, Proceedings of the National Academy of Sciences.

Reengineering rate-limiting, millisecond enzyme motions by introduction of an unnatural amino acid.

J. P. Loria, I. Rivalta, V. Batista, 2011, Biophysical journal.

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

J. P. Loria, A. Mesecar, Yan Wang, 2014, Biochemistry.

Eigenvector centrality for characterization of protein allosteric pathways

Christian F. A. Negre, Victor S. Batista, Heidi P. Hendrickson, 2017, Proceedings of the National Academy of Sciences.

Nanometer propagation of millisecond motions in V-type allostery.

J Patrick Loria, J. P. Loria, J. Lipchock, 2010, Structure.

NMR insights into protein allostery.

Gregory A Manley, J Patrick Loria, J. P. Loria, 2012, Archives of biochemistry and biophysics.

Protein dynamics from solution NMR

J. P. Loria, J. Kempf, 2002, Cell Biochemistry and Biophysics.

Multiple time scale backbone dynamics of homologous thermophilic and mesophilic ribonuclease HI enzymes.

C. Kroenke, A. Palmer, J. P. Loria, 2004, Journal of molecular biology.

Measurement of intermediate exchange phenomena.

J. P. Loria, J. Kempf, 2004, Methods in molecular biology.

FAST-Modelfree: A program for rapid automated analysis of solution NMR spin-relaxation data

J. P. Loria, R. Cole, 2003, Journal of biomolecular NMR.

Value of a hydrogen bond in triosephosphate isomerase loop motion.

R. Berlow, J. P. Loria, T. Igumenova, 2007, Biochemistry.

Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.

Yan Wang, J Patrick Loria, R. Berlow, 2009, Biochemistry.

Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function.

J. P. Loria, George P. Lisi, 2016, Progress in nuclear magnetic resonance spectroscopy.

What's in your buffer? Solute altered millisecond motions detected by solution NMR.

J. P. Loria, Gennady Khirich, M. Wong, 2013, Biochemistry.

Characterization of enzyme motions by solution NMR relaxation dispersion.

J Patrick Loria, R. Berlow, J. P. Loria, 2008, Accounts of chemical research.

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

Nan Yan, Zhijian J. Chen, J. P. Loria, 2013, Science.

Faithful estimation of dynamics parameters from CPMG relaxation dispersion measurements.

J Patrick Loria, J. P. Loria, E. L. Kovrigin, 2006, Journal of magnetic resonance.

A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases.

Sean J. Johnson, J. P. Loria, Victor Beaumont, 2018, Biochemistry.

Isotope Labeling Methods for Protein Dynamics Studies

J. P. Loria, Eric D Watt, 2009 .

Dynamics in Enzymes: Solution NMR Studies

J. P. Loria, 2012 .

Evidence for flexibility in the function of ribonuclease A.

J. P. Loria, R. Cole, J. Loria, 2002, Biochemistry.

Conservation of mus-ms enzyme motions in the apo- and substrate-mimicked state.

J. P. Loria, M. Gill, R. Cole, 2005, Journal of the American Chemical Society.

Uncovering the molecular interactions in the catalytic loop that modulate the conformational dynamics in protein tyrosine phosphatase 1B.

J. P. Loria, D. S. Cui, J. Lipchock, 2019, Journal of the American Chemical Society.

Millisecond dynamics in the allosteric enzyme imidazole glycerol phosphate synthase (IGPS) from Thermotoga maritima

J. P. Loria, J. Lipchock, 2009, Journal of biomolecular NMR.

Induced Fit in the Selection of Correct versus Incorrect Nucleotides by DNA Polymerase β.

M. Swain, J. P. Loria, Beth Moscato, 2016, Biochemistry.

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

S. Doublié, J. Sweasy, J. P. Loria, 2018, Nucleic acids research.

Movement and specificity in a modular DNA binding protein.

J. P. Loria, Cary Liptak, 2015, Structure.

1H, 15N, and 13C backbone resonance assignments for the yersinia protein tyrosine phosphatase YopH

J. P. Loria, Sean K. Whittier, 2014, Biomolecular NMR assignments.

Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality.

Sean J. Johnson, J. P. Loria, A. Hengge, 2021, Biochemistry.

Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid.

Heidi P. Hendrickson, J. P. Loria, I. Rivalta, 2017, Biochemistry.

Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide.

A. Miranker, J. P. Loria, J. A. Williamson, 2009, Journal of molecular biology.

Sensitivity improvement of transverse relaxation-optimized spectroscopy.

M Rance, J. P. Loria, M. Rance, 1999, Journal of magnetic resonance.

Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.

L. Leng, R. Bucala, V. Bhandari, 2018, Angewandte Chemie.

The crystal structure of ribonuclease A in complex with thymidine‐3′‐monophosphate provides further insight into ligand binding

J. P. Loria, N. Doucet, M. Simonović, 2010, Proteins.

The allosteric impact of the variable insert loop in Vaccinia H1-related (VHR) phosphatase.

J. P. Loria, V. Batista, Victor Beaumont, 2020, Biochemistry.

Monitoring molecular interactions by NMR.

J. P. Loria, J. Lipchock, 2009, Methods in molecular biology.

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing.

B. Bassler, D. Kojetin, J. P. Loria, 2004, Journal of molecular biology.

Characterization of the transition state of functional enzyme dynamics.

J. P. Loria, E. L. Kovrigin, 2006, Journal of the American Chemical Society.

Off-resonance TROSY (R1 rho - R1) for quantitation of fast exchange processes in large proteins.

J. P. Loria, N. Sampson, J. Kempf, 2003, Journal of the American Chemical Society.

Eigenvector centrality for characterization of protein allosteric pathways

Heidi P. Hendrickson, J. P. Loria, I. Rivalta, 2017, Proceedings of the National Academy of Sciences.

Letter to the Editor: 1H, 15N, and 13C chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU

B. Bassler, J. P. Loria, J. Cavanagh, 2004, Journal of biomolecular NMR.

Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases.

J. P. Loria, Victor Beaumont, J. Lipchock, 2017, Journal of molecular biology.

Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid.

Heidi P. Hendrickson, J. P. Loria, I. Rivalta, 2017, Biochemistry.

Eigenvector centrality for characterization of protein allosteric pathways

Heidi P. Hendrickson, J. P. Loria, I. Rivalta, 2017, Proceedings of the National Academy of Sciences.

Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase

J. P. Loria, I. Rivalta, F. Tofoleanu, 2023, Nature communications.

The Heat is On: Temperature Increase Mimics Allosteric Signaling in Imidazole-Glycerol Phosphate Synthase

B. Brooks, J. P. Loria, I. Rivalta, 2022 .