D. Robinson

发表

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

D. Lilley, R. Brenk, R. Batey, 2011, Chemistry & biology.

Targeting a critical step in fungal hexosamine biosynthesis

D. V. van Aalten, D. Robinson, O. Raimi, 2020, The Journal of Biological Chemistry.

Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions1

N. C. Price, J. Coggins, D. Robinson, 2002, FEBS letters.

Phosphorylation of Sli15 by Ipl1 Is Important for Proper CPC Localization and Chromosome Stability in Saccharomyces cerevisiae

D. Robinson, N. Morrice, N. Rachidi, 2014, PloS one.

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Robert H Bates, L. Stojanovski, K. Read, 2022, Nature Communications.

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

I. Gilbert, D. Robinson, L. S. Torrie, 2022, ACS infectious diseases.

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.

J. Naismith, D. Robinson, D. O'Hagan, 2006, Organic & biomolecular chemistry.

Mechanism of enzymatic fluorination in Streptomyces cattleya.

Xiaofeng Zhu, J. Naismith, D. Robinson, 2007, Journal of the American Chemical Society.

The fluorinase from Streptomyces cattleya is also a chlorinase.

J. Naismith, D. Robinson, D. O'Hagan, 2005, Angewandte Chemie.

University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2017 .

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Ian H. Gilbert, Chidochangu P. Mpamhanga, William N. Hunter, 2009, Journal of medicinal chemistry.

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor.

Chris Abell, T. Krell, J. Coggins, 2002, Structure.

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

D. Robinson, M. Gundogdu, V. Borodkin, 2013, The Biochemical journal.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

D. Svergun, T. Owen-Hughes, D. Robinson, 2014, Nucleic acids research.

Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

A. W. Schüttelkopf, D. V. van Aalten, D. Robinson, 2013, Open Biology.

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

G. F. Ruda, I. Gilbert, D. V. van Aalten, 2015, ACS chemical biology.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2018, Journal of medicinal chemistry.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Stuart P. McElroy, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

K. Read, I. Gilbert, A. Fairlamb, 2010, ChemMedChem.

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Ian H Gilbert, Manu De Rycker, Sujatha Manthri, 2017, ACS infectious diseases.

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

A. W. Schüttelkopf, D. V. van Aalten, D. Robinson, 2012, Nature chemical biology.

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

A. Fairlamb, D. Robinson, J. Frearson, 2010, Analytical biochemistry.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Stuart P. McElroy, S. Norval, L. Stojanovski, 2017, Journal of medicinal chemistry.

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.

Experiences with the shikimate-pathway enzymes as targets for rational drug design.

J. Coggins, D. Robinson, C. Abell, 2003, Biochemical Society transactions.

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014 .

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

David W. Gray, I. Gilbert, A. Fairlamb, 2020, ACS infectious diseases.

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

D. Robinson, P. Wyatt, 2015, Acta crystallographica. Section F, Structural biology communications.

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of medicinal chemistry.

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

David W. Gray, I. Gilbert, D. Robinson, 2019, PloS one.

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

D. Lilley, R. Brenk, R. Batey, 2011, Chemistry & biology.